Scale-Up Strategy for Essential Medicines for Child Health: Pakistan

Publication date: 2012

SCALE-UP PLAN FOR ESSENTIAL MEDICINES FOR CHILD HEALTH Diarrhea, Pneumonia and Malaria PAKISTAN Jai Das & Zulfiqar. A. Bhutta AGA KHAN UNIVERSITY KARACHI 1 Abbreviations ACT ARI BFHI BHUs CDD CME CSR DHQs DHS DOH DRAP DTU EDL EML EMR EPI FMG GAVI GDP GFATM GP HMIS IMCI IPR IRS ITN LHS LHV LHW LLIN LMIC MCHC MDG MNCH MOH MPR NCHD NGO NID NIH NNS NRSP NSP NWFP OECD ORS ORT PDHS PKR Artemisinin-Combination Therapy Acute Respiratory Illness Baby Friendly Hospital Initiative Basic Health Units Control of Diarrhoeal Diseases Continued Medical Education Corporate Social Responsibility District Headquarters Demographic Health Survey Departments of Health Drug Regulatory Agency of Pakistan Diarrhoea Treatment Units Essential Drug List Essential Medicines List Eastern Mediterranean Region Expanded Program of Immunization Fast Moving Goods Global Alliance for Vaccines and Immunization Good Distribution Practices Global Fund to Fight AIDS, Tuberculosis and Malaria General Practitioners Health Management Information System Integrated Management of Childhood Illnesses Intellectual Property Rights Indoor Residual Spraying Insecticide-Treated Nets Lady Health Supervisor Lady Health Visitor Lady Health Worker Long Lasting Insecticide Nets Low and Middle Income Countries Maternal and Child Health Centers Millennium Development Goals Maternal, Neonatal and Child Health Ministry of Health Median Price Ratio National Commission for Human Development Non-Government Organization National Immunization Days National Institute of Health National Nutrition Survey National Rural Support Program Non-Severe Pneumonia North West Frontier Province Organization of Economic Cooperation and Development Oral Rehydration Solution Oral Rehydration Therapy Pakistan Demographic Health Survey Pakistan Rupees 2 POUZN PPHI RBM RCT RDT RHC SMS SMX THQs TMP UN UNDP UNICEF WHO WTO Point-of-Use Disinfection and Zinc Treatment People’s Primary Healthcare Initiative Roll Back Malaria Randomized Control Trial Rapid Diagnostic Tool Rural Health Centers Short Message Service Sulfamethaoxazole Tehsil/Taluka Headquarters Trimethoprim United Nations United Nations Development Fund United Nations International Child Emergency Fund World Health Organization World Trade Organization 3 Contents Abbreviations . 1 EXECUTIVE SUMMARY . 5 1) Drug Management . 6 2) Scaling Up Community Programs . 6 3) Partnering with Pharmaceutical Industry . 6 4) Advocacy and Demand Generation . 6 5) Warehouse and Logistics . 6 6) Educate GPs and chemists . 6 BACKGROUND . 7 HEALTH CARE SYSTEM IN PAKISTAN . 10 Public sector landscape . 11 Private sector landscape . 13 DRUG REGULATION AND LOGISTICS . 13 CROSS DISEASE BARRIERS . 16 DIARRHEA . 16 Access to diarrhea treatment . 18 ORS . 18 Zinc . 19 Diarrhea treatment barriers . 21 PNEUMONIA . 22 Access to pneumonia treatment . 23 Pneumonia treatment barriers . 24 MALARIA . 25 Access to malaria treatment . 26 Malaria treatment barriers . 27 HEALTH INITIATIVES. 28 Cross Disease initiatives . 29 Immunization . 29 Baby Friendly Hospital Initiative / Breast Feeding Promotion . 29 National Program for Control of Diarrheal Diseases (CDD) and Acute Respiratory Infections Control Project . 29 4 The Lady Health Worker Program . 29 IMCI . 30 Diarrhea Specific Initiatives . 30 Pneumonia Specific Initiatives . 32 Malaria Specific Initiatives . 34 PROPOSED INTERVENTIONS . 35 Drug Management . 35 Partnering with Pharmaceutical Industry . 37 Warehouse and Logistics . 38 Scaling Up Community Programs . 38 Advocacy and Demand Generation . 39 Educate private practitioners and chemists . 40 Financial schemes . 41 REFERENCES . 45 5 EXECUTIVE SUMMARY With an under-five mortality rate of 89 per 1000 live births, Pakistan is lagging behind the desired MDG 4. There is still a need to reduce the under-five mortality rate by 45 percentage points in order to achieve the MDG target by 2015. This seems to be an improbable outcome considering the recent trends and a persistent rate of under five deaths since the past decade. Each year around 91,000 and 53,300 children die from pneumonia and diarrhea respectively, in Pakistan. Diarrhea, pneumonia and malaria collectively contribute to around 50% of deaths in children. These three diseases, thus, represent a challenging but surmountable obstacle towards achieving the MDG 4 target. Implementation of large-scale interventions and scale-up plan focusing on these three major killers of children in Pakistan is essential. Lack of access to appropriate management and medicines are amongst the major contributors to the high rate of mortality from diarrhea, pneumonia and malaria in Pakistan. Only 37% of children suffering from diarrhea receive ORS and only 2.8% receive zinc. About half of children suffering from suspected pneumonia receive an antibiotic and only 3% of children having fever receive an anti-malarial. These figures show that lack of access to essential medicines is a major barrier to reduce the burden of these diseases. This report identifies the major barriers towards accessing essential medicines by care givers. Interventions are required at all the three levels: public, private and community in order to improve access. There seems to be a significant knowledge-practice gap in the use of ORS for diarrhea. 91% of mothers have heard about ORS but only 2.5% have it available in their homes. Pharmaceutical industries are not primarily interested in producing ORS due to its low cost and do not appreciate the demand for ORS and zinc. Partnering with these industries can help them acknowledge the demand for essential medicines and expanding access of these medicines to far flung and remote areas. The demand side can also be further strengthened through home visits by LHWs and imparting health messages for improving care giver knowledge and treatment these childhood diseases through radio, short message service (SMS) and cable TV channels. National Drug Policy covers selection of essential medicines, medicines pricing, procurement, distribution, regulation, pharmaco-vigilance, rational use of medicines, human resource development, research, monitoring and evaluation. Despite of the existing policy, an implementation plan does not exist. Corruption in drug supply and registration and reduced access to essential medicines, including ORS, zinc, amoxicillin and ACTs exists in both public and private sector. The Drug Control Organization or a control body should be set at national level to survey and scientifically forecast the availability, distribution, procurement and sales for medicines (ORS, zinc, amoxicillin), as well as take into account the seasonal and demographic variability in the demand of these medicines. Proper storage facilities don’t exist at the national level and because of which drugs are destroyed and not adequately stored. GDP certified warehouses need to be built and lists of these should be available with the public facilities. Drug procurement reforms centered on electronic bidding will have to be introduced and phased-in for enhancing transparency. A Real-Time Inventory Management System can be designed to ensure effective management and monitoring of medicine consumption in health facilities. 6 Over burdening of LHWs and lack of awareness regarding recognition of signs for pneumonia and zinc’s role in diarrhea management also contributes as a barrier to access of proper medicines. Hiring more LHWs, providing them with regular refresher courses and rapid diagnostic tools and assigning LHWs with specific responsibilities can help increase the effectiveness of their performance. Providing them with incentives such as pay per performance after regular evaluations to see if the area they cover show positive trends, can encourage them to perform more effectively. There also needs to be a strict evaluation and monitoring of the LHW system. In Pakistan, mandatory continuing education that includes pharmaceutical issues is not required for doctors, nurses and paramedical staff. More than 70% of care givers seek help from GPs. Unfortunately, knowledge of GPs regarding the recognition of important signs for pneumonia and appropriate management for pneumonia, diarrhea and malaria is lacking. Continued Medical Education (CME) seminars and workshops emphasizing on these three illness and the guidelines for their management can help in influencing GPs in providing appropriate management. GPs who participate in CME seminars would be provided with accreditation. Some level of training regarding the appropriate use of essential medicines can also be provided to chemists since care givers often directly refer to chemists for medicines. The effectiveness of “Diarrhea Package” (comprising low osmolality ORS, Zinc, water purification tablets and pictorial instruction sheet in a single pack) has been tested in a trial and it was found that that Diarrhea Pack is acceptable in the community. It has also been found that diarrhea pack can substantially reduce diarrhea burden and cost. The intervention has full potential to be scaled up at National level through the LHWs National programme. In Pakistan 63% of the total drug expenditure is borne by households, so financial schemes can be designed to ensure patient compliance with therapy and protect households against this catastrophic expenditure. PROPOSED INTERVENTIONS 1) Drug Management 2) Scaling Up Community Programs Central Body for Drug Control Quality Control Post Marketing Survey Introducing New Vaccines Monitoring and Evaluation Revision of LHW Curriculum Provision of appropriate diagnostic tools Distribution of work Incentives or Pay-on-performance Up gradation of Referral facilities 3) Partnering with Pharmaceutical Industry 4) Advocacy and Demand Generation Price regulation and rational selection Meet Demand Improving coverage and access Introduction of “Diarrhea Management Pack” Mass Media Marketing Campaigns Collaborating with producers of FMGs Community Education 5) Warehouse and Logistics 6) Educate GPs and chemists Building Warehouses Real-Time Inventory Management System Electronic Bidding CME seminars and workshops Training Chemists Regular monitoring 7) Financial schemes 7 BACKGROUND The Islamic Republic of Pakistan is a geographically diverse country spanning over 796,095 sq. km, encompassing snow covered peaks of the Himalayas and Karakoram ranges, barren deserts, fertile irrigated plains of the Indus River and costal stretches along the Arabian Sea. Situated in South Asia, Pakistan shares its borders with four neighboring countries— Iran to the west, Afghanistan to the north-west, the People’s Republic of China to the north and India to the east. Pakistan is rich in ethnic and culturally diversity. Pakistan is the sixth most populous country with a population of 175,867,987, and growing at roughly 1.6 percent per annum.1Much of the population resides in rural areas; however rapid urbanization has led to the emergence of megacities resulting in dramatic social changes. As of 2010, 37% of the population lives in urban centers, growing at an annual rate of 3.1%.2 Geographically, the country is divided into four provinces: Punjab, Sindh, Baluchistan and Khyber Pakhtunkhwa. The provinces are divided into 105 districts called zillahs, which are further divided into Tehsils. Tehsils may contain villages or municipalities. Pakistan is modeled as a three branched federal republic. The Executive Branch of the government consists of a chief of staff, prime minister and cabinet. The Legislative Branch also known as the Majilis-e-Shoora consists of a 100 seat Senate and a 342 seat National Assembly, which reserves seats for women and non-Muslims. The Judicial Branch is divided into a Supreme Court system with justices appointed by the president as well a Federal Islamic or Sharia Court.3Local governance is divided into eight administrative units and four provincial governments. Pakistan being a developing country has faced multiple challenges ranging from political, social and economical over the course of its history. The domain of health has been no exception. The first Burden of Disease Study for Pakistan was reported in 2000.4It showed that an equal burden could be attributable to infectious vs. non-infectious diseases (38.4 % vs. 37.7%), the latter surpassing if the burden of injures (11.4%) is added. However, data from the year 2008 has shown a much greater burden of infectious diseases as compared to non-infectious5 Diarrheal diseases rank number three amongst the top causes of mortality in the country and infectious diseases in general are the number one cause of morbidity/ disability. The MDG Goal 4 “reduce child mortality” focuses on six indicators: under-5 mortality rate, infant mortality rate, proportion of fully-immunized children 12 -23 months of age, proportion of 1 year children immunized against measles, proportion of children under five who have suffered from diarrhea and Lady Health worker coverage of target population. Pakistan has one of the highest childhood deaths burden in the world. Nearly 465,000 under- five children die each year in Pakistan and one in ten children does not survive till their fifth birthday. Most of these deaths are caused by preventable illnesses. The earliest available data shows that in the period of 1986-’90, the under 5 mortality rate in Pakistan was as high 117 per 1000 (PDHS 1990-91). According to a UNICEF statistic this rate peaked at 130 per 1000 in 1990. However, in subsequent years there has been a steady decline to 92 per 1000 as reported in the 1997-2001 period by the DHS.6Since 1997, the rate has fluctuated in the 90’s until finally hitting a low of 87 per 1000 in 2009 (UNICEF). Despite this decline, there is still a 8 need to reduce the under-five mortality rate by 42% points by 2015. If the trends observed during the first four years of MDGs could be achieved, it might be possible to achieve the targets by 2015. Presently, the greatest burden of under-five mortality is in the Sindh province with a rate 101 per 1000, followed by Punjab (97 per 1000), Kyber-Pakhtunkhwa (75 per 1000) and lastly the province of Baluchistan with a rate of 59 per 1000.6 However, considerable progress has been made since a study reported rates well above 100 per 1000 in all four provinces in 1995-’96, with Baluchistan then having a under-five child mortality rate of 148 per 1000. Studies have also shown consistently that there is a greater burden of under-five deaths among rural regions when compared to urban settings.6, 7 The diseases that contribute the most to mortality in children under five and neonates in Pakistan are illustrated in figures (1) and (2). Diarrhea and pneumonia are the top in the list, each being the cause of around 20% of deaths in children under five years of age. Pakistan has shown considerable progress in infant mortality reductions as well. In the period of 1986-’90, Pakistan Demographic Health Survey found an infant mortality rate of 91 per 1000. Subsequent trends have shown a decrease to a rate of 71 per 1000 in 2009.2 According to the MDG report, 2010, these numbers are not very optimistic and need to be further investigated further as to why this indicator, despite lot of efforts, is off-track.8With regards to provincial data, Balochistan has seen the greatest improvement in infant mortality reductions, with infant mortality rates as high 117 per 1000 in 19995-’96 and now only 49 per 1000. In the ten year study period of 1996-2006, Kyber-Pakhtunkhwahad an infant mortality rate of 63 per 1000 and both Sindh and Punjab had rates of 81 per 1000.9 Similar to trends seen with under-five mortality rates, infant mortality was consistently greater in rural setting than urban centers.9 The Demographic Health Survey from 2006-’07 reports that neonatal mortality has been fairly constant over the years around50 per 1000.9According to the most recent data in 2006-’07, the Neonatal sepsis 11% Pneumo nia 23% Diarrhea 23% Congenit al abnorma lities 6% Injuries 2% Prematur ity 15% Other 20% Figure 1: Causes of under-five deaths (source: WHO 2008) Preterm 20% Diarrhea 4% Congenit al 8% Tetanus 7% Other 6% Asphyxia 22% Infection 33% Figure 2: Causes of neonatal deaths (source: WHO 2006) 9 neonatal mortality rate in Pakistan was 54 per 1000. By province, Baluchistan has the least neonatal mortality burden with 30 deaths per 1000, followed by Khyber-Pakhtunkhwa with 41 per 1000, then Sindh with 53 per 1000 and the greatest burden being in Punjab with 58 deaths per 1000.9 Variations between places of residence, urban vs. rural, are less demarcated than in under-five mortality and infant mortality rates. In a ten year study period between 1996 and 2006, the DHS reports neonatal mortality rates to be 48 per 1000 in urban residencies as opposed to 55 per 1000 in rural geographies.9 (Table 1) Figure 3: Trends in achieving MDG 4 indicators Source: MDG Report – Pakistan, 2010 The proportion of children immunized against six preventable diseases shows improvement to 78% in 2008-09 from 53% in 2001-02. These numbers are not very impressive and there is an urgent need to improve the immunization process.8 Since its launch, the Lady health Worker’s Program is considered to be one of the most successful program in Pakistan’s heath sector in terms of providing primary health care services at doorstep in rural areas.8 Immunization rates also show that in 2004, 33% of children under 12-months of age did not get immunized against measles and 20% against tuberculosis.10 Pakistan’s performance to achieve the desired targets of MDG 4 by 2015 has been unsatisfactory, particularly in case of under-five mortality rate and infant mortality rate.8(Figure 3) 10 Table 1: Early childhood mortality rates Background characteristic Neonatal mortality Infant mortality Under-five mortality Residence Urban 48 66 78 Rural 55 81 100 Province Punjab 58 81 97 Sindh 53 81 101 Khyber Pakhtunkhwa 41 63 75 Baluchistan 30 49 59 Wealth quintile Lowest Second Middle Fourth Highest 63 60 52 47 38 94 87 74 67 53 121 102 90 79 60 Source: Pakistan DHS 2006-07 Even though the prevalence of both diarrhea and pneumonia amongst under-five children is high in the country, a relatively low proportion of children receive appropriate treatment. Only 37% of children suffering from diarrhea are appropriately treated with Oral Rehydration therapy6 and only 2.8% receive zinc appropriately (table 2).11Moreover, only about half of the children suffering from pneumonia receive an appropriate antibiotic.6 20.1% of children suffering from diarrhea receive no treatment, whereas 31% receive no treatment for pneumonia.6 Table 2: Child health indicators for diarrhea, malaria and pneumonia in Pakistan Disease Child Deaths (under five) Percentage of total child deaths Proportion Receiving Appropriate Treatment Proportion of untreated cases per year Malaria 0.8 per 100,000 1% 3% Pneumonia 91,000 14% 50% 31% Diarrhea 53,300 19% 37% (ORT) 2.8% (Zinc) 20.9% This highlights the burden of diarrhea, pneumonia and malaria in Pakistan and an urgent need to find efficient ways to address them. Preventing these illnesses holds its importance but treating them accurately and timely has its significance. We in this review would analyze the barriers which are hindering the correct treatment with a special focus on provision of essential medicines and finding ways to scaling up their availability and augmenting use. HEALTH CARE SYSTEM IN PAKISTAN The health system in Pakistan consists of public and private sectors. The private sector provides health services to 70% of the population, whereas the public sector covers the remaining 30%. 11 The total annual expenditure on health in Pakistan in 2008 was PKR.299,651million which is 2.9% of the total GDP. The annual expenditure on health per capita was PKR 1,828 (US$ 24). Out of the total expenditure on health, government accounts for 29.7%, while the private health expenditure covers the remaining 70.3%. In Pakistan, there is an existent system for public health services like public health insurance, social insurance and other sickness fund that provides at least partial coverage for medicines that are on the Essential Medicines List (EML) for inpatients and outpatients. Sales of medicines in Pakistan are regulated by the Drugs Control Organization, Ministry of Health, which requires the registration of all drugs, licensing of pharmaceutical units and also develops the National List of Essential Medicines. Figure 4: Health care structure. Source: Health profile Pakistan – WHO, 2006 Public sector landscape The public sector was until recently led by the Federal Ministry of Health, however the Ministry was abolished in June 2011 and all health responsibilities (mainly planning and fund allocation) were devolved to Provincial Health Departments which had until now been the main implementers of public sector health programs. The amendment has granted provinces greater autonomy, and has devolved decision making in many sectors including health. In principle, devolution of powers can improve governance and has the potential to improve health equity. However, it is vital that national health matters are identified, and related responsibilities are entrusted to a federal institution. There are many national responsibilities for health in federal systems, including health information, regulation, international commitments, trade in health, Ministry of health Private sector (70%)  Clinics  Medical centers  Maternity homes  Hospitals  Hakims  Homeopathies Public sector (30%)  Teaching/ tertiary care hospitals  District headquarter hospitals  Tehsil headquarter hospitals  Rural health center  Basic Health Unit  Community Health workers WAPDA, PTCL, PIA, OGDC, Sui Northern, Pakistan Railways Employees’ social security organization Not for profit: NGOs Philanthropists 12 establishment of policy norms and standards, and interprovincial policy coordination. These responsibilities have to be centrally managed as in other developed nations.12 There are many other areas where central coordination on behalf of the provinces even in the scenario of enhanced provincial autonomy can spare provinces from unnecessary duplicative work for which they neither have human resource capacity nor the institutional arrangements in place. Other than normative functions, economic coordination with donors and bulk procurement of medicine and supplies where cost saving can be achieved, and medicines and human resource regulation fall in this space. Currently most arrangements, the Central Licensing Board, Drug Regulatory Board and the Drug Appellate Board exist at the federal level whilst Quality Control Boards exist at the provincial level. It would be an unnecessary duplication to try and recreate the former category, provincially13 Public health delivery system functions as an integrated health complex that is administratively managed at a district level.14 The state provides healthcare through a three-tiered healthcare delivery system and a range of public health interventions. The former includes Basic Health Units (BHUs) and Rural Health Centers (RHCs), forming the core of the primary healthcare structure. Secondary care including first and second referral facilities providing acute, ambulatory and inpatient care is provided through Tehsil/taluka Headquarter Hospitals (THQs), and District Headquarter Hospitals (DHQs) which are supported by tertiary care from teaching hospitals. Maternal and Child Health Centers (MCHCs) are also a part of the integrated health system; however, the number of MCHC remains limited.14 Figure 5: Organization of the public health system Administrative Levels Health Facilities Referral The vast majority of rural households are more than 10 kilometers from the district headquarters, ambulance services, ultrasound services for pregnant women, a functioning maternal and child health center, and a hospital.14 The distance from the health center has even been a disincentive to seek care especially in case of women who would need somebody to accompany them. The distance factor gets strongly adhered to other factors such as availability of transport, total cost of one round trip and women’s restricted mobility. Teaching / Tertiary Care Hospitals District Headquarter Hospital Tehsil Headquarter Hospital Basic Health Units (Outreach Workers: CDC, EPI, etc.) (Health Houses: Lady Health Workers) Federal and Provincial (Ministry / Dept. of Health) Districts Tehsils Union Councils Community 13 Private sector landscape Amongst those who seek treatment for diarrhea, around 21% seek treatment from the public sector, where as 77% seek treatment from the private sector.15 Pakistan’s private health sector system consists of 972 hospitals with a total of 104,137 hospital beds, 4,842 dispensaries and 5,344 basic health units (BHUs) mostly in rural areas. In 2007, the Government of Pakistan reported that there is one hospital available for over 170,000 persons, one rural health center available for more than 184,000 persons living in rural areas; one basic health unit available for more than 19,000 persons in rural areas; and one maternal and child health center available for more than 4,400 expecting mother and newborns.14, 16 DRUG REGULATION AND LOGISTICS Access to essential medicines/technologies as part of the fulfillment of the right to health, is recognized in the constitution.17 The Drug Act 1976 currently regulates the pharmaceutical sector and is a comprehensive document setting out extensive stipulations for industry licensing, drug registration, quality control etc. The question of policy norms related to the three levels of regulation—quality, price and Intellectual Property Rights (IPR) regulation—is deeply related to the functioning of Drug regulatory Agency of Pakistan (DRAP). Currently, the Drug Policy 1997 and Drug Act 1976 are in force, but many weaknesses exist. The drug rules are exploitable, particularly in relation to warranty of drug sale, Nutritional and traditional medicines, prescribed by 130,000 practitioners of traditional medicine and devices and related healthcare technologies are outside of the drug act’s purview. Policy norms lag behind in relation to trends in technology, advertising and WTO agreements. There is need for a predictable and transparent pricing policy related to branded and generic medicines. These considerations call for updating norms and eliminating room for maneuvering.18 Pakistan meets 70% of its domestic demand of medicines from local production and 30% through imports.19 Although at the time of independence in 1947, there was hardly any pharmaceutical industry in the country there are currently 30 multinational and 411 local units involved in pharmaceutical manufacturing.19In Pakistan, there are legal provisions for controlling the pharmaceutical market. The total pharmaceutical expenditure in Pakistan for 2007 was PKR 12,000 million (US$ 1,844 million). The pharmaceutical expenditure per capita was PKR 683.20The annual growth rate of the generic pharmaceuticals market value in 2009 was 20%.21 National drug Policy exists in Pakistan but is not regularly monitored which covers selection of essential medicines , medicines pricing, procurement, distribution, regulation, pharmacovigilance, rational use of medicines, human resource development, research, monitoring and evaluation and traditional medicine. Despite of the existing policy, implementation plan does not exist. There is an existing system also present for the check and balance of drug quality and market control. Elaborate regulatory arrangements exist even today at the federal and provincial levels. The real issue is at the level of capacity and transparency. Inspectors are poorly paid resulting in ‘subsistence corruption’. The numbers are paltry— 250 for a population of 170 million. Drug- testing laboratories are few. Less than 2000 out of the 50,000 retail outlets employ qualified 14 pharmacists while all the universities put together train less than 2000 pharmacists per year. Sale and resale of second‐hand machinery is unregulated, raw materials are traded in the open market, tariff collusion is rampant, hospitality-based incentive‐intense marketing practices are endemic and back street manufacturing and spurious drugs continue to burgeon.18 Laboratory exists in Pakistan for quality control testing. Samples are collected by government inspectors for undertaking post-marketing surveillance testing. In the past 2 years, 60,000 samples were taken for quality control testing. 1,194 of the samples tested failed to meet the quality standards. The results are not publicly available.22 The government supply system department in Pakistan does not have a Central Medical Store at National Level, but stores exist at district level. There are national guidelines on Good Distribution Practices (GDP). There is a licensing authority that issues GDP licenses. The licensing authority does accredit public distribution facilities. Lists of GDP certified warehouses and distributors do not exist in the public sector.23, 24 Procurement of drugs is based on an essential list of medicines specific for each facility tier; however procurement in practice has also frequently involved purchasing of other drugs not on the list. Although a computerized Health Management Information System (HMIS) exists there is little link between case volume and morbidity generated by HMIS reports and the process of forecasting and budgeting. Purchasing is done on the basis of cheapest tender submitted by any licensed drug production company. This has often been criticized as it results in low quality threshold as company registration is used as the only quality criteria and with the presence of 500-650 licensed production companies in Pakistan, it does not serve to discriminate on quality aspects. The onwards supply chain essentially relies on manual record keeping and although a computerized drug logistics management systems is in place for the GFATM it is yet to be applied to the public sector. Existing public sector procurement practice has resulted in curtailing drug expenditure. A median price ratio (MPR) compares local price to international price and a MPR of greater than 2.5 indicates excessive medicine prices. Generics purchased by public sector are either below or equal to the international price index however branded drugs have been bought up to 3.5 times the international reference prices .25 The price index of public sector, for both generics and branded drugs, is more efficient than that of the private sector in Pakistan. Whether efficiency has been achieved as a result of quality compromise, needs serious exploration. In Pakistan basic generic medicines in private retail outlets have a MPR range of 1.2-7.3 and originator brands for basic therapy have a range between 0.8-15.8.25 The government runs an active national medicines price monitoring system for retail prices. Regulations exist mandating that retail medicine price information should be publicly accessible. The information is made publically available through the Official Gazette Notification. Counterfeit medicines constitute between 40-50% of total supply in Nigeria and Pakistan.26 Counterfeit medicines result in either under-dosage or even active harm causing injury or death. It also undermines the incentives of registered pharmaceutical producers to invest in quality control. At the same time the gap between generics and originator brands is extremely high and needs to be reduced through both price regulation and rational selection. Anecdotal evidence highlights institutionalized malpractices in procurements where standard mark-ups are charged 15 as a result of collusion between public entities and production companies.27 Procurement has traditionally been done at the provincial level with supply onwards to different districts however as a result of devolution to district level under the Local Governance Ordinance of 2001 drug budgeting, procurement and management took place at the district level for a stretch of nearly ten years. With lapse of the ordinance in 2010, it is uncertain whether there will be a shift back to centralized procurement and supply. As yet there has been no study to assess the relative performance of district versus provincial based drug management. A survey of first level care facilities, district hospitals and tertiary hospitals conducted as part of Emergency Drug Supply Project in NWFP, Punjab and Balochistan, highlighted issues related to drug storage and dispensation.28, 29 Dispensing time on average was merely half a minute which is inadequate for good dispensing while communication with patients was poor and is a cause for concern given low awareness level of patients. Preparation of prescriptions by dispensers is often unhygienic, prone to mistakes and every one in five prescription is dispensed without validation. Preparation, labeling and record keeping of drugs were also inadequate. Storage issues were also examined at public sector facilities. It was found that while stock auditing was satisfactory at majority of sites, presence of essential drug list was seen in only one facility, storage conditions including temperature maintenance, hygiene and pest control were unsatisfactory at majority of places, and actual store capacity was not known by 97% of storekeepers. Store keepers lacked both pre-service and in-service training on proper stock handling. Another study reports labeling and storage of anesthetic medications across 58 operation rooms. Only 15% of operating rooms were compliant with proper drug labeling.29 In Pakistan, mandatory continuing education that includes pharmaceutical issues is not required for doctors, nurses and paramedical staff.30 Many drug sellers have minimal formal education and little or no professional training; of those with training, most are absent from pharmacies31 a practice also observed in other developing countries. While there are regulatory checks on drug quality at retail outlets there is little regulation of quality of retail outlet. A cross-sectional survey of 311 pharmacies /medical stores in Rawalpindi showed that the proportion of pharmacies meeting licensing requirements was only 19.3% [95% C.I: 15.1, 24.2].32 Qualified staff was present in only 22% of pharmacies. Only 10% had a temperature monitoring device and only 4% had an alternative power supply for refrigerators as a back-up for frequent power outages. A study in Karachi revealed that only 11% of pharmacies in Karachi have a visible license and only 12% are pharmacologically trained.12 Availability of even essential recommended generics is extremely low in public sector facilities with a 3.3.% median availability and is much lower than the range of 29-54% found in LMICs while originator brand medicines are generally not available in public sector facilities in Pakistan as well as other LMICs.25. Availability of medicines for acute care range between 30-67% while availability of essential chronic care drugs for management of cardiovascular disease, diabetes, chronic respiratory disease, glaucoma and palliative cancer therapy ranges between 3-57% .25, 33 The Government of Pakistan launched a country wide program known as the People’s Primary Healthcare Initiative (PPHI) involving contracting the management of BHUs for improved service 16 delivery. Out-sourcing of BHUs has been done to the National Rural Support Program (NRSP) and the initiative is administratively housed under and financially assisted by the Federal Ministry of Industries. It is an example of contracting-in through management contracts and involves outsourcing the operation budget of BHUs by the department of health to the contractor accompanied with financial and administrative powers for flexible usage of budget and staffing to improve BHU utilization. Overall,2391 BHUs and 701 other health facilities including dispensaries and MCH centers have been contracted out over 127 districts including 36 in Punjab, 23 Sindh, 30 in Balochistan, 31 in NWFP and 7 in Gilgit-Baltistan. Further experiments with alternative financing models are underway with performance based contracting out, contracting in and competitive voucher schemes being rolled out in the province of Sindh with Norwegian government and one with UN Program assistance. A study to evaluate the pilot of BHU contracting in Rahim Yar district of Pakistan was conducted using intervention and control districts. Although it found mixed result with improvements in curative care and under performance in preventive and promotive care, drug availability was improved in contracted BHUs. Users reported 30% availability of medicines in contracted BHUs as compared to only 7% in non-contracted.34 CROSS DISEASE BARRIERS In Pakistan, political instability and corruption in public health care systems is a major obstacle to the effective implementation of national disease control programs. Lady Health Workers, general practitioners and pediatricians are not well-trained to identify important signs for pneumonia and diarrhea in children. Moreover, there are widespread “quacks” and unlicensed health care providers across the country, especially in the less privileged areas that are providing unregistered medicines. Even doctors who are well-trained spend less time in consultations and do not explain the treatment properly. Care givers are not aware of the signs that should prompt them to seek treatment from a health facility. Cultural misconceptions amongst care givers are also a hindrance in seeking appropriate care. Diarrhea and ARI are viewed as the influence of super-natural forces as a result of which many people do not access health care settings for proper management and treatment; rather they access folk sector or transpersonal healers for treatment purposes. Mothers also frequently change healers due to over-expectations of treatment outcomes. In addition, GPs in 76.5% of patient encounters dispense drug formulations of unknown composition, commonly known as 'mixtures', made in their own drug dispensing corner, a practice which is not open to monitoring and needs to be actively discouraged. DIARRHEA The burden of diarrhea diseases in Pakistan represents a significant but, with proper treatment, surmountable challenge. Trends show that the burden of diarrheal disease amongst children in Pakistan has increased over the years, with a higher prevalence in rural areas as compared to the urban ones (Table 3).6 Amongst the provinces, the highest prevalence is in Punjab and Sindh while lowest in Baluchistan.6 17 Table 3: Trends in prevalence of diarrhea in Pakistan Year 1990-91 (DHS) 1995-96 2006-07(DHS) 2010-11 (NNS) Total 14.5 18.9 21.8 22.3 Urban 15.0 16.7 21.1 23.2 Rural 14.3 21.0 22.1 22.0 Province Punjab 14.4 22.8 20.6 28.5 Sindh 19.6 14.5 23.6 23.4 NWFP 9.6 18.3 24.7 4.3 Baluchistan 8.3 13.9 16.2 12.9 According to data reported by Arif, in 1995-’96 approximately 8.5% of childhood deaths were attributable to diarrheal diseases. The WHO reports that during 2000-03, diarrheal disease was the principal cause of death in 14% of childhood mortality cases. And as of 2007, the burden of mortality from diarrheal diseases made 17.7% of all childhood deaths. Rotavirus is the leading cause of acute diarrheal episodes, as well as the primary culprit to an estimated 40% of all hospital admissions due to diarrhea in under-five, worldwide.14 In Pakistan, the incidence of rotavirus infection in children less than 5 years of age is 5.7-8.1 per thousand children, which is lower than that in developing countries and is mostly detected in infants and children less than 2 years of age.14, 35 The most common strains of rotavirus in Pakistan are G9P (15%), G1P (13%) and G1 (8.4%). Phan et al. confirmed the presence of Astrovirus, Norovirus (GI, GII), Sapovirus as causes of viral diarrhea, other than rotavirus in children in Karachi, Pakistan.15 Amongst bacteria, species of the family Enterobacteriaceae are the most common agents associated with diarrhea. It consists of a large, heterogeneous group of gram- negative rods amongst which species of E. Coli, Salmonella and Shigella are the most common causative agents. Strains of pathogenic E. Coli are found to be the most common amongst the bacterial causes of diarrhea in Pakistani children.16 Campylobacter Jejuni also has an increased incidence rate amongst all age groups in the country due to a high presence of Campylobacter organisms in food commodities used by the common man. Oral rehydration therapy for diarrhea, the miracle discovery of the 1960s, is perhaps the single best intervention that is both curative and preventive Trends have shown that the global coverage of ORS has not increased since 1995 and is still less than 40%. In Pakistan, the use of ORS in under five children has been declining and currently only 37% children are given ORS for treatment of diarrhea.6 18 Figure 6: Trends in Pakistan coverage of ORS Access to diarrhea treatment Diarrhea prevalence amongst under-five in the country as per DHS 2006-07 is around 21.8% with a mortality of 53,300. The Millennium Development Goal 4 aims to reduce this prevalence to less than 10% by 2015. 20.9% of children suffering from diarrhea receive no treatment. On average, 37% receive ORS, whereas only 2.8% receive zinc.11 50% were given an anti-microbial while 10% an anti-diarrheal for diarrhea treatment. Amongst those who use ORS, 20.9% obtain it through Lady Health Care workers, 7.9% from private health centers, 67% from private pharmacies and 3.4% from government health facilities. (POUZN report).11 The standard World Health Organization guidelines for diarrhea management recommend:  Oral Rehydration therapy with low osmolarity oral rehydration salt and zinc (Glucose:20g/Sachet, Sodium Chloride:3.5g/Sachet, Potassium Chloride:1.5g/Sachet, Sodium Citrate:2.9g/Sachet  Zinc (10-20mg) for 10 days: give 20mg / day for children aged 6 months to 5 years; 10mg/ day for children aged less than 6 months Both ORS and Zinc are available over the counter in Pakistan and both are included in the Essential Medicines List of Pakistan, 2007. ORS The Control of Diarrheal Diseases Programme (CDD) was initiated in 1980s and laid emphasis on the prompt recognition of dehydration, the correct preparation and use of ORS, continued breastfeeding, proper feeding practices during and after diarrhea and improved hygienic practices. The National Commission for Human Development launched an ORS campaign with the objective of training at least one woman in each household regarding preparation and use of ORS. Through this campaign, NCHD trained almost 13 million women in 80 districts of Pakistan. 0 10 20 30 40 50 60 70 80 90 PIHS 1998-99 PIHS 2001-02 PSLSMS 2004-05 PSLSMS 2005-06 PSLM 2006-0 DHS 2006-07 19 ORS is typically available as packages of 20 sachets, with each sachet costing around Rs. 5-7 (US$0.08-0.12) on average and are widely available in both sectors throughout the country.11 Though 91% of mothers have heard about ORS,36 only about 2.5% of homes have ORS available.37 56% of mothers believe that ORS is the best way to prevent dehydration. These figures show the existence of a possible knowledge-accessibility barrier. The table below shows the ORS manufacturers available in Pakistan: Table 4: ORS manufacturers in Pakistan ORS (Powder) Trade Name Company Price/Sachet (PKR) Arosal Alliance Babysalt Polyfine 5.50 Baby-s Saydon 5.40 Dirosal Bloom 5.10 Durasal Drug 6.10 Geofman SP Salt Geofman 7.30 Hydrolyte Mendoza 5.5 Kemytral Alkemy 5.15 Merisole Miracle 5.0 Orasal-F Wilson ‘s 7.0 Oral Rehydration Salt Frontier Orsigen Genera 6.0 Osmolar Atco 6.0 Osmoless Genera 5.0 Paeditol Wise 7.35 Paeditrex ORS Helicon 6.5 Pediawin Jinnah 5.0 Pedisal ORS Sharex 7.35 Peditral Searle 10 Ralyte Dr. Raza 5.4 Rehydrate Wise 5.0 Safelyte O.R.S Heal 5.0 Scots ORS Scotmann 6.0 Sodalite Macquin ‘s Teknosol Technovision 6.5 Valosal Valor 6.0 Werisol Werrick 7.5 Zinc Zinc is available in both tablets and syrup formulations. 95.8% use the syrup form.11pediatric zinc diarrhea treatment products Is produced locally by four Pakistani pharmaceutical manufacturers including ATCO Laboratories, ZAFA Pharmaceuticals, GenixPharma and Macter International. These products are registered for sale in Pakistan by the Pakistan drug regulatory authority and were tested by the Government of Pakistan pharmaceutical laboratory for quality. These products sell for PKR 35 – PKR 150 (US$0.41-$1.76), depending upon the brand and dosage strength.11 A number of other pharmaceutical companies produce zinc products, but these are primarily nutritional supplements rather than for diarrhea treatment. Table below shows the zinc manufacturers available in Pakistan. 20 Table 5: Zinc manufacturers in Pakistan Trade Name Company Price (PKR) CNIZ Genix 60 DELUX-ZINC Delux 59 E-ZINC Woodwards 64 MELBEK Wilshire 50 OK-ZINC Fynk 75 OPTIZINC Idress 75 PEDISAFE NovaMed 50 PROZINK Hansel 50 YES 2 ZINC Zafa 45 ZINCASA Macter 35 ZINCAT Atco 60 ZINKROL Lisko 45 ZINCOR Genome 60 ZING Nexus 60 ZINKIN Semos 75 ZINKITT Lowitt 75 ZYNQ Nabiqasim ZINCOB Bio-lab DIAZINC Searle ZinCat brand of ATCO laboratories is the most commonly used which is available in both tablet and syrup formulations. On average, zinc sulphate packaged as 60 ml. bottle costs around Rs. 4. Tablets are available as packages of 10 tablets and each tablet costs around Rs 5. A vast majority of caretakers obtain zinc through purchasing (75%) while the remaining 25% obtain it free of cost. The mean price paid for zinc products reported by care givers is 60±8.5. 26.1% of mothers believe that the zinc is affordable and 17.4% of mothers are of the opinion that it is expensive.11 On inquiring whether they would continue to buy Zinc products if the price increased by 50 percent, 55% responded in affirmation.11 Most mothers obtain zinc from private pharmacies (62.7%) or lady health workers (21%); whereas some mothers obtain it from government health facilities (17%).11 The reasons mothers reported for using zinc for diarrhea treatment included: prescription by the health provider (37%), easy accessibility (17%), good quality product (30%) and affordability (13%). Most mothers have reported that they do not have a shop nearby their homes that has zinc available. 30% of mothers do not know where they can get zinc from (POUZN report 2011). As mentioned earlier, only 2.8% of children under five suffering from diarrhea receive zinc.11Only 10.7% of mothers that use zinc, give it to their child for complete 10 days. Amongst those receiving zinc, only 58% are given ORS along with zinc. Most mothers who do not use ORS with zinc did not know whether ORS should be given with or without zinc.11 Only 3% of mothers have reported that they had heard a message or received information regarding zinc for diarrhea 3 months prior to the survey. 50% of those who received messages/information regarding its use, had heard it through a lady health worker.11 21 Table 6: Care-giver knowledge, attitude and practices towards diarrhea treatment in Pakistan. ORS Zinc Source of obtaining ORS/Zinc Government Health Facility Private Health Centre LHW Private Pharmacy Traditional healer Don’t know Community distributor Percentage of mothers who have heard about ORS11 Percentage of homes with ORS available at home11 Percentage of mothers who believe ORS is the best way to prevent dehydration11 3.4% 7.9% 20.9% 67.0% 0.2% 0.6% - 91% 2.5% 56% (knowledge- practice gap) 7.4% - 60% 32.7% - 1.8% 7.3% - Willingness to pay for zinc products for diarrhea If price increased to (amount paid +50%) If price increased to (amount paid +100%) If the price increased to (amount paid + 25%) Maximum price willing to pay for zinc, mean+-std (Pakistani rupee) - Yes: 55.6%, don’t know: 16.7% No: 100% Yes: 90% 63±65.6 Mothers’ opinion about the price of zinc not expensive affordable expensive too expensive no opinion don’t know Use of zinc for complete 10 days 4.3% 26.1% 17.4% 13% 4.3% 34.8% 10.9% Source: POUZN report 2011 According to in-depth interviews with physicians, flagyl is widely known as a diarrhea treatment and often requested by caregivers or pharmacists, without a prescription. ORS plus flagyl is the current standard treatment recommended by most providers.38 Diarrhea treatment barriers Though 91% of mothers in Pakistan have heard about ORS and 56% believe that it is the best treatment for dehydration due to diarrhea; only 2.5% of mothers have ORS available in their homes. These figures reflect the existence of a knowledge-practice gap amongst mothers for the use of ORS. A survey in Karachi revealed that 76% of pharmacies had pharmacists who did not have the knowledge regarding the current frequency of ORS administration. Only 2.8% of mothers utilize zinc for the treatment of diarrhea and amongst these, only around 58% use ORS along with zinc since most of them who use zinc are not aware that ORS and 22 zinc need to be given together. Moreover, they do not give zinc for complete duration of ten days because of difficulty in remembering to give it to the child once diarrhea settles. Mothers are not willing to pay for the current price of zinc since they are not aware of the cost- effectiveness of zinc for treating diarrhea and preventing future episodes of diarrheal illness. Information sources for zinc’s role in diarrhea treatment are also very limited and only around 5% of mothers reported that they had heard a message or received information about zinc in the past 3 months. Mothers are also unsure as to where they can obtain zinc from. Around 41% of mothers reported that they do not have a shop nearby that has zinc available and 30% did not have zinc available at walking distance from their homes. A study showed that infants were self-medicated particularly during diarrheal episodes, which is a dangerous trend as improper management of childhood diarrhea is the penultimate cause of death in children under five.39General practitioners were also found to prescribe anti-diarrheals more frequently than doctors working in the public sector (p < 0.01).40 Table 7: Diarrhea Treatment Barriers Demand Side Public sector Private sector  Lack of awareness regarding the cost-effectiveness of zinc for diarrhea treatment  Knowledge-usage gap for ORS  Lack of information sources regarding zinc and ORS for diarrhea treatment  Unavailability of zinc for sale at shops nearby home  Unwillingness to pay for the current price of zinc  Lack of awareness regarding the effectiveness of zinc in reducing diarrheal severity  Misconception regarding antibiotics being more effective than zinc and ORS for treatment of diarrhea  Difficulty in remembering to give zinc for complete 10 days once diarrhea has settled  No national line of action on communication and social mobilization  Lack of awareness and prescription practices for zinc amongst lady health workers  Unavailability of zinc at government health facilities  Lack of public efforts to increase awareness amongst caregivers regarding appropriate diarrhea treatment  The vaccine for rotavirus, which is the most common cause of diarrhea in Pakistan, is not a part of EPI.  Lack of coordination among govt and pharmaceutical industry regarding production of zinc  Poor regulatory mechanisms regarding osmolarity of ORS  Around 50% of general practitioners and pediatricians prescribe antimicrobials for diarrhea  Most private practitioners are not aware of the inclusion of zinc with ORS for treatment of diarrhea  Differences between self-reported and prescribing practices of GPs and pediatricians for diarrhea12 PNEUMONIA Globally, around 2 million children die of pneumonia each year and currently pneumonia accounts for 18% of annual deaths in children under five globally, 99% of these deaths occur in developing countries.41, 42 Pneumonia remains the leading cause of death in children under 5 years in low and middle income countries despite the introduction of case management guidelines and the development of new preventative strategies including effective vaccines.2 74% of new pneumonia cases occur in just 15 countries and more than half in just 6 countries: India, China, Pakistan, Bangladesh, Indonesia and Nigeria.43 Around 91,000 children under-five 23 years of age die each year from pneumonia in Pakistan. It contributes to 14% of deaths in under-five aged children of the country.44 Table 8 shows the trends in prevalence of ARI in Pakistan. One in six children (16 %) had suffered from symptoms of ARI during the two weeks preceding the DHS 1990-91 survey. ARI symptoms were least prevalent (8 %) in Balochistan, while the highest prevalence was observed in Punjab and Sindh. 14 % of children under age five had symptoms of ARI in the two weeks preceding the DHS 2006-07 survey. ARI symptoms were less evident among children whose mothers had secondary or more education. Table 8: Trends in prevalence rate (%) of ARI Year DHS 1990-91 DHS 2006-07 Total Urban Rural Province Punjab Sindh KP Baluchistan 16.0 13.8 17.0 17.0 17.2 12.2 8.3 14.1 12.8 14.6 13.0 17.0 16.5 3.1 In 1989 the government of Pakistan launched the National ARI Control Program, with the primary objective of reducing mortality from pneumonia in under-5-year-olds and of rationalizing the use of drugs in ARI case management.45As part of this programme, the standardized ARI case management approach recommended by WHO for the control of ARI, was adopted and modified to meet local needs. Doctors and health care providers were trained with this new technique.46 This modified strategy was based on the assessment of clinical signs in children presenting with a cough or difficult breathing: fast breathing, indrawing of lower chest wall, and other specified danger signs. Antibiotics are recommended for treatment of pneumonia. A study on the impact of the new treatment guidelines at the Islamabad Children's Hospital from 1990-92 revealed that death rates among children admitted to hospital with severe pneumonia fell from about 10% in 1989 to about 5% in 1992. Meanwhile the rational use of drugs, a key strategy in preventing the overuse of antibiotics and curbing microbial resistance, led to a major reduction in the use of antibiotics (from 56% of cases in 1989 to only 30% in 1992).47 The current WHO guidelines for pneumonia recommend that for children 2 months to 5 years of age with non-severe pneumonia, five days of antibiotic therapy with either amoxicillin or cotrimoxazole should be used. Children with wheeze and fast breathing and/or lower chest indrawing should be given a trial of rapid acting inhaled bronchodilator, before they are classified as having pneumonia and prescribed antibiotics. Access to pneumonia treatment According to DHS 2006-07, prevalence of pneumonia in the country was around 14.4%.6 The estimated mortality rate per 10,000 is 48.1.41 Overall, around 50% of children under five who had symptoms of Acute Respiratory Illness received antibiotics.6However 69.9% of children with 24 suspected pneumonia are taken to a health facility and 31.1% receive no treatment for ARI symptoms.6 In 1989, the Government of Pakistan adopted WHO’s recommendation of using cotrimoxazole as first-line outpatient treatment for non-severe pneumonia due to its cost, twice-daily dosage schedule, efficacy and bio availability. Changing from cotrimoxazole to amoxicillin would cost an estimated US$ 25 million; a significant proportion of the national health budget.42 A study published in the Bulletin of WHO in 2005 revealed that both standard and double strength cotrimoxazole were equally effective in treating non-severe pneumonia.42 A recent study by Hazir et al. has shown that the clinical outcome in children aged 2-59 months with WHO-defined non-severe pneumonia is not different when treated with amoxicillin or placebo. Further trials are, however, needed to rationalize the use of antibiotics in these communities for non-severe pneumonia.44 There are currently no registered amoxicillin tablets in Pakistan that are suitable for children. However, many registered amoxicillin suspensions are available. Most of them are packaged as 60 ml. bottles of amoxicillin 125 mg/5ml. The prices range from Rs.30 to 35 per 60 ml. bottle. Amoxicillin is included in the Essential Medicines List of Pakistan 2007, but Cotrimoxazole isn’t. However, both are available over the counter in Pakistan. Pneumonia treatment barriers It is expensive to treat children with pneumonia especially as inpatients. In Pakistan, the average cost to treat a child with pneumonia as an outpatient was estimated by activity-based costing as US$ 13.44, representing 82% of annual health expenditure per person at the time. In comparison, inpatient costs were estimated as US$ 71 and US$ 235 for pneumonia and severe pneumonia. Care givers and health care providers lack awareness regarding the recognition of fast breathing and chest in drawing as important signs for pneumonia. Most mothers seek care from unqualified practitioners who over prescribe antibiotics and are not aware of the WHO guidelines for pneumonia management. Mothers frequently change healers due to unrealistic expectations of cure. Health care providers do not spend enough time in counseling the mothers regarding the importance of completing the duration of antibiotic and the danger signs that should prompt health seeking. The National ARI Control Program was launched by the government in 1989 with the primary objective of reducing mortality from pneumonia in under-5-year-olds and of rationalizing the use of drugs in ARI case management. Appropriate monitoring and evaluation of the impact of the ARI control programme is lacking. Lack of funding for programmatic activities, lack of coordination with other child survival programs, inadequate training for community health workers and general practitioners in the private sector, lack of public awareness about seeking timely and appropriate care, and insufficient planning and support for ARI programmatic activities at provincial and district levels are major hindrances in decreasing the burden of ARI in the country. 25 Table 9: Pneumonia Treatment Barriers Demand side Public sector17 Private sector  Delay in care seeking for ARI  Half of the children with ARI in rural areas seek help from untrained practitioners  Lack of awareness regarding recognition of chest in drawing and rapid breathing as important signs for pneumonia  Unrealistic expectations of cure leading to change in physicians and treatment regimen  Expensive treatment of pneumonia for inpatients  Do not give antibiotic for full duration  Lack of appropriate monitoring and evaluation of the impact of the ARI-control program.  Inadequate training of lady health workers (LHWs)  Insufficient planning and support for ARI programmatic activities at provincial and district levels  Lack of funding for programmatic activities  Lack of close collaboration between MNCH, EPI and LHW Programme  Pneumoccocal vaccine not a part of EPI yet  Lack of diagnostic ability and correct prescription  No checks on the quality of drugs  Availability of drugs  Over prescription of antibiotics in children with wheezing and underutilization of bronchodilator  Failure of GPs and pediatricians to recognize fast breathing and chest in drawing as signs on pneumonia  Incorrect antibiotic prescription MALARIA Malaria is a deadly mosquito-borne disease, which takes almost one million lives per year and afflicts as many as a half a billion people in 109 countries in Africa, Asia and Latin America.7 Malaria was nearly eliminated in Pakistan during the 1960s, but in 1972 it made a massive resurgence. Since then, malaria has remained a major public health threat, as common irrigation practices and monsoon rains create favorable conditions for malaria-transmitting mosquitoes. Pakistan is endemic for malaria, though only 7% of the population lives in areas of high transmission.48 Along with other “Category 3” countries (Somalia, Sudan, Yemen, Afghanistan, Djibouti and Pakistan) of the Eastern Mediterranean Region (EMR), malaria accounts for more than 95% of the regional burden.49 Figure 7 shows the geographical distribution of malaria in Pakistan. Most of the malaria burden in the country is shared by Baluchistan and Sindh.49 Figure 7: Geographical distribution of confirmed malaria cases (per 1000 population) Source: WHO Malaria Report - Pakistan 2009 26 Malaria has a prevalence of around 20% in under five children of Pakistan.6 In 2009, more than 24,000 cases were reported in this age group and 47% of the deaths occurred in children under the age of five. While Pakistan uses both indoor residual spraying (IRS) and insecticide-treated nets (ITNs) for malaria prevention, neither is sufficiently addressing the problem. 176.2 million Pakistanis are at risk of contracting malaria, only 240,000 Pakistanis have ITNs and only 327,360 households are protected by IRS.6 Table 10: Trends in malaria admissions in under five children Year All cause admissions Malaria admissions 2004 151 855 24 714 2006 90 834 21 847 2007 100 896 18 812 Access to malaria treatment With an annual incidence of 0.8 cases per 1000 under five children and a mortality rate of 0.8 per 100,000 population, malaria contributes to 1% of under-five deaths in the country. Most of the population of Pakistan (<84%) live in areas of low malaria transmission. A total of 4.2 million probable and confirmed malaria cases were reported in 2009, of which only 167,579 cases were confirmed by either microscopy or RDT. Approximately 30% of the confirmed cases were caused by P. falciparum and almost 42% of the confirmed cases originated in Balochistan province.49 Nearly 2.3 million full treatment courses of antimalarial medicine per year were delivered during 2007–2009 and approximately 34,900 courses of ACT were delivered in 2009, which is not sufficient to treat all reported Falciparum cases in the public sector.50 Malaria diagnosis is free of charge in the public sector since 1961. However, only 3% of children under five with fever receive an antimalarial drug and only 10% of febrile children under 5 years are treated in a public health facility.6 The current National Malaria case management guidelines formed by the Directorate of Malaria Control, Ministry of Health, Pakistan recommend the following:  For uncomplicated malaria, confirmed vivax malaria: chloroquine for 3 days  For uncomplicated malaria, confirmed as falciparum malaria: Artisunate for 3 days, plus quinine for 7 days.  For clinical malaria not yet confirmed as vivax or falcipuram: chloroquine for 3 days  Treatment failure: Sulphadoxine+pyrimethamine  Severe malaria: quinine  Sulfadoxine + pyrimethamineis not recommended for children under 5 years of age and women in their first trimester of pregnancy.  Antimalarial should be given by weight, especially in children  Primaquine should Not be given to: Patients without microscopic confirmation of vivax. Pregnant women & children under 4 years of age Patients with Glucose-6-Phosphate Dehydrogenase deficiency 27 Patients who have received complete dose of Artesunate The National List of Essential Medicines states that for curative treatment, medicines for P. falipuram malaria should be used in combination. Oral artemesinin monotherapies are not registered in the country. The following combinations are included for curative treatment in the EML, 2007: Table 11: Antimalarials included in the National Essential Medicines List 2007 AMODIAQUINE Tablet: 153 mg or 200 mg (as hydrochloride). * To be used (a) in combination with artesunate 50 mg OR (b) may be used alone for the treatment of P.vivax, P.ovale and P.malariae infections. ARTEMETHER Oily injection: 80 mg/ml in 1‐ml ampoule. For use in the management of severe malaria. ARTEMETHER + LUMEFANTRINE Tablet: 20 mg + 120 mg. * Not recommended in the first trimester of pregnancy or in children below 5 kg. ARTESUNATE* Injection: ampoules, containing 60 mg anhydrous artesunic acid with a separate ampoule of 5% sodium bicarbonate solution. For use in the management of severe malaria. Tablet: 50 mg. * To be used in combination with either amodiaquine, mefloquine or sulfadoxine + pyrimethamine. CHLOROQUINE* Oral liquid: 50 mg (as phosphate or sulfate)/5 ml. Tablet: 100 mg; 150 mg (as phosphate or sulfate). * For use only for the treatment of P.vivax infection. DOXYCYCLINE* Capsule: 100 mg (as hydrochloride). Tablet (dispersible): 100 mg (as monohydrate). * For use only in combination with quinine. MEFLOQUINE* Tablet: 250 mg (as hydrochloride). * To be used in combination with artesunate 50 mg. PRIMAQUINE* Tablet: 7.5 mg; 15 mg (as diphosphate) * Only for use to achieve radical cure of P.vivax and P.ovale infections, given for 14 days QUININE* Injection: 300 mg quinine hydrochloride/ml in 2‐ml ampoule. Tablet: 300 mg (quinine sulfate) or 300 mg (quinine bisulfate). * For use only in the management of severe malaria, and should be used in combination with doxycycline. SULFADOXINE + PYRIMETHAMINE* Tablet: 500 mg + 25 mg. * Only in combination with artesunate 50 mg. For prophylaxis, chlorquine, doxycline, mefloquine and proguanil are included in the National EML. Malaria treatment barriers Ever since the inception of RBM project in 2001, Malaria Control Programme has made tangible progress in partnership building, policy guidelines for new interventions such as LLINs, RDTs and ACTs, and imposing bans on the production of oral artemisinin montherapies, injection chloroquine and halofantrine, which were injudiciously prescribed by private care providers. WHO has been the major agency providing technical assistance and supporting the programme in its initiatives. However, low technical and managerial capacities of the programme at national and provincial levels and low coverage of interventions of the population at risk are the major challenges faced by the Programme. 28 Despite the ban on the production of monotherapies, there is still continued high demand and sales of monotherapies. This may be due to the lack of awareness amongst health care providers and care givers regarding the effectiveness of ACTS as the effective treatment for malaria. Moreover, the cost of ACTs is high as compared to monotherapies which leads to non- compliance. Table 12: Malaria Treatment Barriers Demand side Public sector Private sector  Continued high demand and sales of SP and monotherapies  Delayed seeking of health care for febrile children with suspected malaria  High cost of ACTs leading to non- compliance  Low coverage of National Malaria control Program  Weak technical leadership at both federal and provincial level and managerial capacities of the National malaria control program  Staffing constraints for the national malaria control program  Provincial-level control programmes struggle with phasing out old “eradication” strategies such as active case detection,  Inadequate access to rapid diagnosis and prompt treatment in health facilities  Lack of monitoring and evaluation in districts where “roll-back malaria” activities have been initiated.  Inconsistent reporting on financing by the national government for malaria control efforts  Poor Availability of drugs  Poor availability and high cost of ACTs in the private sector  Lack of awareness regarding recent guidelines for malaria treatment with ACTs instead of monotherapies amongst GPs and pediatricians HEALTH INITIATIVES The Federal Ministry of Health (MoH) and Provincial Departments of Health (DoH) are implementing a number of initiatives, which focus on addressing the challenges of child health. Key present initiatives related to maternal and child health are:  National Program for Family Planning and Primary Health care  National EPI Programme  Nutrition Project  MNT-Special Immunization Activities.  National Program for Control of Diarrheal Diseases (CDD)  Acute Respiratory Infections Control Project  Polio Eradication  Integrated management of childhood illnesses (IMNCI) strategy (1998 – ongoing)  Women’s Health Project (in 20 districts)  Reproductive Health Project  Baby Friendly Hospital Initiative / Breast Feeding Promotion  Malaria eradication 29  RBM  Child survival program 1992  Social action plan 1993  Maternal, Newborn & Child Health program 2005 Cross Disease initiatives Immunization EPI (Expanded Program on Immunization) program is running effectively, with broader but variable coverage in various districts of the country. EPI aims to reduce morbidity and mortality amongst children under 1 year of age, due to vaccine preventable diseases namely Poliomyelitis, Diphtheria, Pertussis, Tuberculosis, Tetanus, Hepatitis & Measles. Hepatitis B has been introduced countrywide in EPI program since 2002. Polio is near eradication because of intense supplementary immunization activities (NIDs and SNIDs) in addition to regular EPI program. Baby Friendly Hospital Initiative / Breast Feeding Promotion A UNICEF supported programme of promotion, protection and support of breast-feeding was started through Baby Friendly Hospital Initiative (BFHI) in teaching hospitals and health facilities of the provinces during 1995. It was expanded to district hospitals in the following years. There is no separate budget allocation for breast-feeding promotion, as it is an integral part of health education. National Program for Control of Diarrheal Diseases (CDD) and Acute Respiratory Infections Control Project Program to effectively control the Diarrheal diseases and ARI was initiated with the assistance of international agencies. Under this program following activities have been undertaken: 1. Development of simplified and specific treatment protocols 2. Printing and wide distribution of these protocols 3. Training to all level of services providers for better patient management 4. Development / modification of information system for these diseases for better data management. The Lady Health Worker Program The National Programme for Family Planning and Primary Health Care in Pakistan (commonly called the Lady Health Workers or the LHW program) was launched in 1994 by the government of Pakistan. Programme objectives contribute to the overall health sector goals of improvement in maternal, newborn & child health; provision of family planning services; and integration of other vertical health promotion programmes. This country wide initiative with community participation constitutes the main thrust of the extension of outreach health services to the rural population and urban slum communities through deployment of over 100,000 Lady Health Workers (LHWs) and covers more than 65% of the target population. As the largest community based initiative in the country, ‘the Lady Health Worker model’ is built around the concept of providing easy and continued access to primary health care services at 30 the door steps of the community through women volunteers from the community. The Programme however adopted the model of paying a ‘stipend’ to the community workers (Lady Health Workers) in order to keep them motivated and for retaining trained human resource. The conceived role of the Lady Health Workers (LHWs) includes helping communities identifying and addressing their health needs on their own as well as serving as a link between communities and the health system. They bridge the gap between the health facility and communities, through provision of quality integrated primary health care services. The Programme began with strength of a little over 30,000 LHWs and over the years has expanded to a strength of over a 100,000 LHWs currently deployed across all provinces and regions of the country. The Programme coverage extends to more than 65% of the target population which is the rural population and communities living in urban slums across the entire country. The Programme operates in all 135 districts of the country. However within certain districts there are still hard to reach areas where the Programme does not exist. The main constraints for absent Programme coverage are non-functional health facilities or low female literacy with women not meeting the selection criteria for recruitment as LHWs and LHSs. IMCI The Integrated Management for Childhood Illnesses (IMCI) strategy was formally endorsed by the Ministry of Health of Pakistan in September 1998 but the early implementation phase completed at district level in October 2000. Two years later, the community component of IMCI was launched and IMCI was introduced in pre-service education on a pilot basis at Nishtar Medical College, Multan in October 2002. In 2003, the project was expanded to two more districts. By 2005, the strategy covered all four provinces, 6% districts, only 2% health facilities and 9% under five aged children of the country. However, by 2010, 70.5% of districts have at least one health facility that has implemented IMCI strategy and the percentage of health facilities that are implementing IMCI rose to 24.4%.51 Diarrhea Specific Initiatives To promote the use of oral rehydration therapy (ORT), a training programme was launched by Pakistan National Programme for Control of Diarrheal Disease (CDD) by establishing the Diarrhoea Training Units (DTUs). Physicians trained at DTU were designated to establish functioning oral rehydration therapy (ORT) corners at their health centers and train health workers in delivery of facilities on standard diarrhea case management.52 Twenty-four out of 49 ORT corners were non-functional after three years of their establishment, mainly due to frequent transfers of trained staff. In 22 ORT corners evaluated, performance of health professionals was far from satisfactory, 19 out of 22 doctors were found to have inadequate performance in diarrhea management and only 3 out of 7 LHVs performed adequately. LHVs could not consistently deliver health education messages to mothers. There seems to be a lack of interest and willingness to participate actively, as more than 50% of both doctors and LHVs did not consider ORT work as their job.52 Both public and private sectors are working to address diarrhea related needs via their own distribution and promotion channels. In 2009, the Ministry of Health (MOH), working through its own Zinc Technical Advisory Committee, began to focus greater attention on diarrhea through 31 its Lady Health Worker (LHW) Program. The LHW National Directorate purchased 4.5 million bottles of zinc syrup from local pharmaceutical manufacturers for the 2009 diarrhea season (primarily May through August) providing each LHW with a supply of 5-6 bottles/month for free distribution. In 2010 the MOH’s LHW Program again procured 5 million bottles of zinc syrup in order to provide each of their 103,000 LHWs with 8-10 bottles/month (or more as individually required). All LHWs have been trained in management of diarrhea using zinc and it is included in the training curriculum. The MOH also featured oral rehydration salts (ORS) and zinc during its spring 2010 Child Health Week and placed diarrhea management with zinc as one if its two priority best practices (along with birth spacing). At the same time several firms from the Pakistani pharmaceutical industry were developing pediatric zinc products, registering them with regulatory authorities and distributing them through their normal distribution channels. In January 2009, the USAID Mission to Pakistan invited the Social Marketing Plus for Diarrheal Disease Control: Point-of-Use Disinfection and Zinc Treatment (POUZN) Project, implemented by Abt Associates, to conduct an assessment of the role of the private sector in diarrhea treatment and to present options for supporting private sector firms in their efforts to market and distribute pediatric zinc for diarrhea treatment through both commercial channels and community distribution systems. Based on that assessment, the POUZN project developed a program in Pakistan to support local manufacture of pediatric zinc products with mass media generic advertising and training for providers. Diarrhea Pack Project was carried out from January 2009 to December 2010 at 8 union councils in Taluka Khairpur and Taluka Pind Dada Khan. ORS, Zinc Tabs, Water purification Tabs and pictorial instruction sheet were packaged into a single pack and were distributed through GPs, pharmacies and LHWs. An evaluation of the impact of the project showed that 94% of participants in the intervention group considered the diarrhea pack to be useful and 93% expressed willingness to pay for it. Further, it is feasible to introduce Diarrhea Pack for the treatment of diarrhea in health systems at scale. Table 13: Current efforts for diarrhea Barriers Current efforts Demand side Lack of awareness regarding the cost- effectiveness of zinc for diarrhea treatment Knowledge-usage gap for ORS Lack of information sources regarding zinc and ORS for diarrhea treatment Unavailability of zinc for sale at shops nearby home Unwillingness to pay for the current price of zinc Lack of awareness regarding the effectiveness of zinc in reducing diarrheal severity Misconception regarding antibiotics being more effective than zinc and ORS for treatment of diarrhea The POUZN project developed in 2009 helped in improving caregiver knowledge and treatment of childhood diarrhea so that caregivers provide ORS together with zinc as the first-line treatment for uncomplicated diarrhea. Public sector Lack of awareness and prescription practices for zinc amongst lady health workers Unavailability of zinc at government health facilities Lack of public efforts to increase awareness amongst mothers The Pakistan National Programme for Control of Diarrhoeal Disease (CDD) launched a training program for physicians to promote ORT in 1997. 32 Barriers Current efforts regarding appropriate diarrhea treatment In 2009, the Ministry of Health (MOH), working through its own Zinc Technical Advisory Committee, began to focus greater attention on diarrhea through its Lady Health Worker (LHW) Program Diarrhea pack project (Diarrhea Package, comprising low osmolality ORS, Zinc, water purification tablets and pictorial instruction sheet, distributed through GPs, pharmacies and CHWs in 8 union councils; social marketing of the package Private sector Most private practitioners are not aware of the inclusion of zinc with ORS for treatment of diarrhea Flood affected areas led to increase outbreaks in diarrhea due to lack of clean water drinking resources In 2009, the Point-of-Use Disinfection and Zinc Treatment (POUZN) developed a program in Pakistan support local manufacture of pediatric zinc products with mass media generic advertising and training for providers Safe drinking Water Alliance: Centre for disease Control developed PuR- a new water purification technology provided to areas of the country affected by 2010 floods. Funded by USAID ($1 million), Proctor and Gamble ($0.5 million Pneumonia Specific Initiatives Pakistan is all set to becoming the world’s 16th country to introduce the pneumococcal conjugate vaccine for protection of children against pneumonia. The vaccine, will be available as part of free immunization service for children all over the country by March 2012, funds have been secured with the support of the Global Alliance for Vaccines and Immunization (GAVI) against a total cost of 618 million dollars and for a period of five years, with the government of Pakistan bearing only 19 million dollars of the cost. The National ARI control program was launched in 1989 in Pakistan to reduce childhood mortality from pneumonia. In this programme, peripheral health workers are trained using recognizable signs, such as increased respiratory rate and the presence of chest retractions, to detect pneumonia that requires treatment with antibiotics at home or referral to hospital. The national ARI control programme in Pakistan recommends oral cotrimoxazole as the first-line antibiotic for the treatment of pneumonia because of its low cost, convenient twice-daily dosage schedule and wide availability. A community-based study reported a clinical treatment failure rate of 9% in children with non-severe pneumonia (NSP) treated with oral cotrimoxazole, but hospital-based studies had a higher failure rate of around 19%. Noorani et al. found that failure with cotrimoxazole therapy was significantly higher in those children who presented with wheezing on examination, which shows that the decision to prescribe antibiotic should be made after a trial of bronchodilator therapy.53 The World Health Organization (WHO) recommends a 5-day course of co-trimoxazole (TMP/SMX) or amoxicillin for children <5 years of age with non-severe pneumonia living in less- developed countries. Pakistani investigators compared the WHO recommendation of 5 days to 33 3 days of antibiotic treatment in a double-blind, placebo controlled study conducted at 7 sites in 5 cities in Pakistan.54 The proportion treated successfully was not statistically different between the 2 groups analyzed. A shorter course, if effective, would be more appropriate because it would decrease the overall antibiotic use in the treatment of pneumonias.54 LHWs currently treat severe pneumonia with one dose of cotrimoxazole and refer to the nearest health facility for treatment. When referral is refused or not possible, no strategy exists to treat these children at home. Parents often seek care from local pharmacies or untrained providers, and in other instances receive nothing. A new study in Lancet followed 1,857 children who were treated at home with oral amoxicillin for five days and 1,354 children in a control group who were given standard care: one dose of oral cotrimoxazole and instructions to go to the nearest hospital or clinic.45 The home-treated group had only a 9 percent treatment-failure rate, while the control group children failed to improve 18 percent of the time.45 This study shows that lady health workers treating children with severe pneumonia in low socioeconomic areas can potentially work better than the established practice of advising parents to take them to a nearby hospital.45 A randomized controlled multicenter trial was implemented in seven hospital outpatient departments and two community health programmes to compare the clinical efficacy of twice- daily cotrimoxazole in standard versus double dosage for treating non-severe pneumonia in children. The results showed that both were equally effective in treating non-severe pneumonia.55 Another RCT showed that cotrimoxazole and amoxicillin had similar failure rates for treatment of non-severe pneumonia.56 Table 14: Current efforts for pneumonia Barriers Current efforts Demand side  Expensive treatment of severe pneumonia for inpatients  Lack of affordability and resources to seek care at health facility for severe pneumonia  MASCOT pneumonia study done by Pakistani investigators showed that 3 days of oral amoxicillin is equally effective as 5 days of amoxicillin for non-severe pneumonia.19  Hazir et al. recently showed that treating severe pneumonia at home with oral amoxicillin for 5 days can potentially work better.11 Public sector  Pneumococcal vaccine not a part of EPI in the country as yet  Failure of LHWs to recognize signs of pneumonia  ARI control program was launched in 1989 in Pakistan with emphasis on adopting WHO standardized guidelines of treatment, awareness on seeking medical care once respiratory symptoms appear in a young child.  The pneumococcal vaccine will be available as part of EPI for free to all children in the country with support of GAVI by March 2012  LHWs are being trained in the recognition of pneumonia and prompt referral, but the program has, as yet, not focused on home management of severe pneumonia Private sector  Over prescription of antibiotics in children with wheezing and underutilization of bronchodilator  Failure of GPs and pediatricians to recognize fast breathing and chest in drawing as signs on pneumonia 34 Malaria Specific Initiatives History of malaria control in Pakistan dates back to the early sixties, when it started as the malaria eradication programme. After the resurgence of the disease during the early seventies, the programme strategy switched from “Eradication” to “Control”. At the same time it was decided to integrate the programme into Primary Health Care in 1975. This strategic policy shift was in line with the WHO’s call for “Health for All”. The National Malaria Control Programme was initiated in Pakistan in 1950. Later in 1961, Malaria Control Programme was revamped to Malaria Eradication Program, with the financial and technical support from WHO, United Nations Development Programme and The United States Agency for International Development. In 1977, Malaria control activities were integrated with the Communicable Disease Control Selection the Provinces. Pakistan joined Roll Back Malaria partnership in 1999 initiated by the WHO in collaboration with the World Bank, Bill & Melinda Gates Foundation, UNDP and The United Nations Children’s Fund. Since then it has been endeavoring to strengthen malaria control system in the country to achieve the Millennium Development Goal of near zero malaria induced deaths by 2015. At present, Pakistan is a member of WHO Global Roll Back Malaria (RBM) Initiative, with a commitment to intensify its efforts for effective control of malaria in the country. Since its inception in 1948, WHO has been the major technical partner with the MOH in malaria control activities. Currently WHO provides technical and financial support to the RBM Programme for strengthening early diagnosis, prompt and effective treatment and epidemic control and operational research. Objectives of the RBM Programme  To reduce malaria morbidity by 50 % by end of the year 2010  To reduce malaria mortality to minimum  To prevent and control malaria outbreaks The Directorate of Malaria Control was successful to win a grant of over US$23 million in Round 7 of the Global Fund (GFATM). Anti-malarial drug resistance has become a major challenge in providing an effective malaria treatment within many regions of the world. Recent P. falciparum resistance surveys indicated high failure rates (83%) in Chloroquine and Amodiaquine treated patients after 28 days of follow up y areas. WHO encourages the Combination therapy (Artemisnin-Based combination therapy ACT) as a major tool to control falciparum malaria. Based on these results national treatment policy has been revised to include the combination therapies with artemisinin derivatives (Artesunate + SP). which will be freely available at all malaria diagnosis and treatment centers in the target districts during the life of current proposal and will be sustained by the district, provincial and federal government after the completion of the project. Recently, Ministry of Health has taken a very bold step recently to put a ban on the production and use of monotherapies, consequently there is an urgent need for ACTs. As per national malaria policy, all confirmed falciparum malaria cases will be treated with ACT as first line drug. Some ACTs were received as a donation from some international agency during 2006 and were distributed among the high risk districts of the country. The results so far received are excellent against 35 complicated malaria cases. This shows the effectiveness of ACTs against complicated malaria in our scenario. Table 15: Current efforts for malaria Barriers Current efforts Public sector  Continued high demand and sales of SP and mono therapies  Lack of monitoring and evaluation in districts where “roll-back malaria” activities have been initiated.  Inconsistent reporting on financing by the national government for malaria control efforts  Inconsistent reporting on financing by the national government for malaria control efforts  During 2007, MoH imposed a ban on the use and production of oral artemisinin mono‐therapies in Pakistan to ensure the rational use of anti‐Malarial drugs and counter drug resistance.  Existing outdated data recording and reporting tools have been reviewed and introduced in nineteen high‐risk districts where Global Fund R‐7 interventions are under implementation. The activity is being replicated in other parts of the country  During 2009 the 1st ever Malariometric survey has been conducted in nineteen high endemic districts of the country through GFATM R‐7 grant support  Since the initiation of RBM Program in Pakistan in 2001 allocations from the public sector development program (PSDP) although have been increased from 239 million rupees to  658 million rupees for the years 2001‐05 and 2008‐2013 respectively Private sector  Lack of awareness regarding recent guidelines for malaria treatment among GPs and pediatricians  Guidelines and training manuals have been developed by directorate of malaria control, MOH on case management and vector control interventions in local languages PROPOSED INTERVENTIONS This section proposes interventions and solutions that can help overcome the barriers to access of ORS, Zinc, amoxicillin and ACTS mentioned in the previous section. These barriers need to be addressed by combining efforts in both private and public sectors as well as increasing the demand. Drug Management Objectives:  A central drug control body to cover all aspects of drug regulation  Convene stakeholders to decide a framework and timeline for Implementation of drug policy  Plan and conduct regular post marketing surveillance to assess the barriers at implementation level and keep a check and balance at the quality control  Develop road map for introduction of newer vaccines like rotavirus . Rationale: As mentioned in the earlier sections, the drug policy exists but is not implemented. After the devolution, powers have been transferred to the provinces and there is no clear roadmap, how it would be devolved. Many issues were cited regarding the regarding the regulation, procurement and supply of drugs. The current practice relied on incremental increase in inventory rather than a scientific forecasting based on morbidity data and patient volume statistics. Stock outs were a 36 commonly reported problem and felt to be more a problem of management of funds rather than non-availability of funds. Currently the drugs are procured from the cheapest tender submitted thus compromising with quality. Within the industry, the low threshold for drug registration was cited as a disincentive for manufacturers investing in quality. Those manufacturers with high quality products were driven by internal quality checks rather than regulatory pressures and relied on private market and exports for sales. Quality producers of drugs also tended to stay away from public sector procurement due to low priced tenders as well as concerns over government being a reliable payer. To overcome these issues, following activities are proposed Activities:  Central Body for Drug Control: A central body should be set up or the Drug Control Organization or NIH should have an epidemiological wing which would be responsible for forecasting and budgeting. It would carry out a survey and analyze the disease burden and scientifically analyze the requirements of essential drugs including ORS and zinc according to the districts of Pakistan. It should take into account the seasonal variations, demographics and the various age groups affected by diarrhea, malaria and pneumonia. Based on which forecasts should be made to improve the availability, distribution, procurement and sales for medicines (ORS, zinc, amoxicillin). This information would be shared with the district authorities who would ultimately be responsible for the procurement and supply of the drugs. This central body should keep a regular evaluation and monitoring system in place to ensure optimal supply of drugs round the year.  Quality Control: Seven laboratories exist in Pakistan for Quality Control. Along with increase in laboratories, the strength of existing drug inspectors should also be increased and trained for efficient systems. The central body constituted would be responsible for approving brands for ORS, zinc and amoxicillin which meet all the quality standards. This will ensure consistency in the quality of the medicines by testing and approving brands for ORS, zinc, amoxicillin and ACTs. The district and provincial authorities would then be responsible for the purchase and storage of the medicines from only the approved brands. This measure will protect the public from hazards of substandard, counterfeit and unsafe drugs. This mechanism would also ensure consistent availability and quality of medicines.  Post Marketing Survey: Independent post marketing surveillance on quality of medicine should be regularly conducted to keep a track of the issues and barriers for effective functionality.  Introducing New Vaccines: Road maps should be developed for the introduction of Rota vaccine in the EPI program. Efforts should be made to improve the coverage rates for measles and HiB.  Monitoring and Evaluation: Strict penalty should be implemented for violations of the law which make it possible for spurious drugs to gain access to the market such as fake licenses to sell, duplicate documents, absence of warranty of purchase of all products, gaps in the sale purchase record of all products, inadequate storage practices at outlets, and the absence of unqualified personnel at outlets. Hygiene and pest control should also be given a priority. 37 Partnering with Pharmaceutical Industry Objectives:  To develop a road map to reduce price gap between procurement and generic rates  Develop collaborations with pharmaceuticals to identify existing demand and finding ways to meet them  To ensure uniformity in quality among different producers.  Develop plans to improve coverage and access to ORS and Zinc. Rationale: Initially NIH used to produce ORS but currently there is no public sector involvement in the production of drugs, therefore collaboration with pharmaceuticals is required to improve the quality, coverage and price of these medicines. There exists a wide gap in the procurement price of originator and generic brands. Also a knowledge-practice gap exists in the use of ORS amongst mothers. Mothers although being aware of the effectiveness of ORS for diarrhea, do not use it. One of the reasons for this gap is that mothers do not have easy access to ORS and zinc. To identify solutions to bottlenecks in the production and distribution of ORS and zinc and to increase the profitability of both products and encourage increased production, this collaboration is essential. Activities:  Price regulation and rational selection: The price gaps between procurement and generic brand rates need to be narrowed and could be done by partnering with pharmaceutical industry through price regulation and rational selection. Another cost cutting measure could be by providing incentives to suppliers in terms of reduced tariffs.  Meet Demand: Pharmaceutical industries are not primarily interested in producing ORS due to its low cost. While Pakistan having enough capacity to meet zinc requirements, is not producing enough because pharmaceutical companies are unaware of the demand. Establishing partnership with pharmaceutical industry will help the industry to know the actual demand of ORS and zinc thus helping in creating a sustainable supply of ORS and Zinc. Information regarding the seasonal, demographic and age- group variability in the sales of the medicines would be shared with the pharmaceutical industry so they can have an understanding of the variations in the demand side for zinc, ORS and amoxicillin, so that these firms manufacture, distribute, and market their own brands accordingly. This increase demand will also invite competition which will help control price.  Improving coverage and access: Through pharmaceutical industries, access can also be obtained to far flung and remote areas that otherwise do not have access to these commodities. Apart from improving coverage of these medicines, it would also help in controlling the price.  Introduction of “Diarrhea Management Pack”: The effectiveness of “Diarrhea Pack” (comprising low osmolarity ORS, Zinc, water purification tablets and pictorial instruction sheet in a single pack) has been tested in a trial and it was found that Diarrhea Pack is 38 acceptable in the community for the treatment of diarrhea. It has also been found that diarrhea pack can substantially reduce diarrhea burden and cost. The intervention has full potential to be scaled up at National level through the LHWs of National programme. By this collaboration, Diarrhea Packs can be introduced and promoted on a larger scale. Warehouse and Logistics Objectives:  Develop appropriate storage facilities to preserve the drugs and ensure its availability  Devise system to ensure the effective management and monitoring of medicine consumption in health facility  Develop a system to enhance transparency in correct medicine use Rationale: Proper storage facilities don’t exist at the national level and because of which drugs are destroyed and not adequately stored like following the floods in Pakistan in 2010, stocks of essentials medicines were destroyed. Activities:  Building Warehouses: Warehouses need to be built as drugs get destroyed and wasted due to lack of proper storage facilities. GDP certified warehouses and lists of these should be available with the public facilities. This would ensure continuous supply of medicines and reduce stock outs. Since medicines would be purchased and transported in bulk, warehouses would also help in reducing costs of transport of these medicines.  Real-Time Inventory Management System: A Real-Time Inventory Management System (computerized drug management system) can be designed to ensure effective management and monitoring of medicine consumption in health facilities. In addition to providing comprehensive reports on medicine consumption patterns and regular updates on expired/out of stock medicines; this system will also allow key stake holders of the department to manage medicine requisitions and allocation to facilities. This system would ensure transparency in the supply of medicines. Storekeepers should also be trained on proper stock handling. EDL should be kept at all facilities. This system will also help keep a check on the correct use of medicines.  Electronic Bidding: Drug procurement reforms centered on electronic bidding will have to be introduced and phased-in for enhancing transparency. . Scaling Up Community Programs Objectives:  To improve the existing knowledge base of LHW’s  To improve the functional capacity of LHW’s  Devise a plan to improve the referral facility Rationale: 39 Currently, the burden on LHWs is high since one LHW covers around 1000 households. The refresher courses are also not that frequent. Activities:  Revision of LHW Curriculum: Revision of curriculum of LHWs, laying emphasis on the recognition of signs, appropriate management and counseling of care givers for diarrhea, pneumonia and malaria is required. Awareness amongst LHWs regarding the recent guidelines for the three diseases should also be increased and updated by refresher courses. Special emphasis should also be made to recognize the need to complete the duration of treatment. LHWs would be provided with pictoral algorithm cards which they can carry with them all the time to correctly diagnose and treat these diseases. The community part of IMCI should also be implemented.  Provision of appropriate diagnostic tools: Providing them with up to date kits and appropriate diagnostic tools such as Rapid Diagnostic Tool for malaria and Breath Count Meter for pneumonia can help them in reaching to correct diagnosis and in giving referrals when required. There needs to be a strict evaluation and monitoring of the LHW system.  Distribution of work: Reducing the burden on LHWs by either hiring more thus reducing load or dividing them for managing specific tasks for example, group of LHW should be responsible for providing immunizations, a separate group of LHWs for maternal health and family planning, and another group for providing disease management. This would help in ensuring that the lady health workers are focused towards their specific responsibility and are not over-burdened.  Incentives or Pay-on-performance: Providing them with incentives such as pay per performance after regular check and evaluation to see if the area they cover has led to a reduction in one of the three diseases, can encourage them to perform more effectively.  Up gradation of Referral facilities: These facilities need to improve in terms of equipment and supplies and also presence of specialists be ensured wherever possible. Advocacy and Demand Generation Objectives:  Devise strategies to improve demand generation through mass media campaigns and other innovative means. Rationale: The demand for the treatment modalities lacks among the caregivers. Demand for ORS and zinc needs to be increased both at the consumer and prescriber levels. Education regarding the prompt recognition and consequently early treatment lacks. Awareness regarding the recognition of signs for pneumonia needs to be imparted among the GP’s, LHW’s as well as mothers. Activities:  Mass Media: Imparting health messages for improving care giver knowledge and treatment of the three childhood diseases through radio, short message service (SMS) 40 and cable TV channels so that care givers provide ORS together with zinc as the first- line treatment for uncomplicated diarrhea and are able to recognize danger signs in their child. Short daily messages in local languages could be beneficial. With SIM registration now in Pakistan, targeted SMS can be sent. Radio is a cheap medium and also has wide rural coverage, so local figures can convey key messages through regular daily broadcasting.  Marketing Campaigns: Distribution of posters, pamphlets and calendars carrying these messages in local language will be distributed among the masses. Road shows carrying these messages can also be displayed through projectors.  Collaborating with producers of fast moving goods (FMGs): A survey should be conducted to identify the most widely used products (like tea sachets, milk, soap) and brands in specific areas and then by collaborating with the producers, public service messages regarding use of ORS and zinc can be imprinted on identified products. This will help in advocacy and organizations can also help fulfill their corporate social responsibility (CSR).  Community Education: Education can be provided to care givers by LHWs through home visits and group activities at community level Collaborating with schools and Montessori can help in reaching mothers. Messages can be sent through the children in the form of written material to increase the awareness of mothers regarding zinc and ORS and change their perception regarding diarrhea treatment. Teachers can be involved by organizing “health days” in school imparting health messages on specific days. Mothers can be provided incentives in the form of basic necessities to encourage their attendance at such events Educate private practitioners and chemists Objective:  Devise strategies for continuous education of the practitioners and chemists Rationale: In Pakistan, mandatory continuing education that includes pharmaceutical issues is not required for doctors, nurses and paramedical staff More than 70% of care givers seek help from private sector with a major portion shared by General Practitioners. Unfortunately, knowledge of GPs regarding the recognition of important signs for pneumonia and appropriate management for pneumonia, diarrhea and malaria is lacking. The mean number of drugs per prescription is higher for general practitioners than public providers. Prescription rate is particularly higher for antibiotics and injections amongst GPs as compared to public sector. Similarly more GP prescriptions had an intravenous infusion compared with public providers. General practitioners also prescribe anti-diarrheals more frequently than doctors working in the public sector. Care givers also often refer directly to chemists for purchasing drugs for diarrhea, pneumonia and malaria, so they also need to be educated and medicines retail associations involved in this process. 41 Activities:  Continued Medical Education (CME) seminars and workshops: Organizing Continued Medical Education (CME) seminars and workshops emphasizing on these three illness and the guidelines for their management can help in influencing GPs in providing appropriate management. GPs who participate in CME seminars would be provided with accreditation.  Training Chemists: Providing some level of training to chemists regarding management of these diseases would prove beneficial. Education materials in the form of brochures, posters and hand bills providing information in local language advocating the usage of ORS and zinc for diarrhea and usage of zinc for the complete duration can be placed at point-of-sales. Apart from regulating quality of drugs, regulation of drug retail outlet be ensured. Financial schemes Objectives:  Devise a plan for implementing various financial schemes to scale up treatment uptake by caregivers. Rationale: 63% of the total drug expenditure is borne by households, one of the highest in developing countries, as opposed to only 18% in OECD countries and leads to non-compliance with chronic care treatment and risk of catastrophic expenditure. The public sector in Pakistan spends merely $5 per capita when compared with other countries with similar income levels. Spending by public sector is only 34% of total health expenditure and of that less than 25% is spent on non-salary items including medicines. Patients incur costs for medicines at both public and private sector facilities with drug shortages in public sector forcing patients to private retail pharmacies. Patient spending on medicines at public sector facilities is considerable at Rs198 on medicines / visit versus Rs258 per visit at private sector facilities. At present there are no pre paid schemes and commodity vouchers to ensure patient compliance with therapy and protect households against catastrophic expenditure. Activities:  Conditional Cash transfers or Voucher Schemes can be introduced for rapid uptake of desired treatments. This would also ensure compliance. Possible mechanisms include franchising with GPs, contracting with NGOs, commodity vouchers, health equity funds and pre-payment schemes, to supplement public sector provision. Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Q1 Q2 Q3 Q4 Intervention 1 Drug Management Activi ty 1.1 Central Body for Drug Control Activi ty 1.1.1 Epideiological Survey and Forecasting Activi ty 1.2 Quality Control Activi ty 1.2.1 Hiring and Training of Drug Inspectors Activi ty 1.2.2 Approving brands Activi ty 1.3 Post Marketing Survey Activi ty 1.4 Introducing New Vaccines Activi ty 1.4.1 Rotavirus Vaccine Activi ty 1.4.2 Pneumococcal Activi ty 1.4.3 Increase Coverage of Hib and Measles Activi ty 1.5 Monitoring and Evaluation Intervention 2 Partnering with Pharmaceutical Industry Activi ty 2.1 Price regulation and rational selection Activi ty 2.2 Meet Demand Activi ty 2.3 Improving coverage and access Activi ty 2.4 Introduction of “Diarrhea Management Pack” Intervention 3 Warehouse and Logistics Activi ty 3.1 Building Warehouses Activi ty 3.2 Real-Time Inventory Management System Activi ty 3.3 Electronic Bidding ESSENTIAL MEDICINE INITIATIVE 2012 2013 2014 2015 PROPOSED INTERVENTIONS TIMEFRAME PROPOSED INTERVENTIONS TIMELINE Intervention 4 Scaling Up Community Programs Activity 4.1 Revision of LHW Curriculum Activity 4.2 Provision of appropriate diagnostic tools Activity 4.2.1 Rapid Diagnostic Tool Activity 4.2.2 Breath Count Meter Activity 4.3 Distribution of work Activity 4.4 Incentives or Pay-on-performance Activity 4.5 Up gradation of Referral facilities Intervention 5 Advocacy and Demand Generation Activity 5.1 Mass Media Activity 5.1.1 SMS Activity 5.1.2 Radio Activity 5.1.3 Cable TV Activity 5.2 Marketing Campaigns Activity 5.2.1 Posters, Pamphlets and Calendars Activity 5.2.2 Projector Road show s Activity 5.3 Collaborating with producers of FMGs Activity 5.4 Community Education Activity 5.4.1 School Health Days Activity 5.4.2 Community Group Activities Intervention 6 Educate GPs and chemists Activity 6.1 CME seminars and workshops Activity 6.2 Training Chemists Activity 6.2.1 Training Activity 6.2.2 Promotion Materials Activity 6.3 Regular monitoring Intervention 7 Financial Schemes Activity 7.1 CCTs or Voucher Schemes PROPOSED INTERVENTIONS TIMELINE (Contd) BUDGET Budget per category - Diarrhea, pneumonia and malaria treatment scale-up (in millions $) (Approx Figures) 2012 2013 2014 2015 TOTAL Cost categories 1 Human resources 4.000 4.500 5.000 5.000 18.500 2 Technical & management assistance 0.000 3 Training 12.000 12.000 12.000 12.000 48.000 4 Health products & equipment (NOT pharmaceuticals) 1.000 0.500 1.500 5 Pharmaceutical products (medicines) (ORS, ZINC and Amoxicillin) 28.255 36.625 44.221 52.894 161.995 6 Procurement & supply management costs (5%) 1.250 1.650 2.000 2.433 7.333 7 Infrastructure & other equipment 30.130 20.000 10.000 10.000 70.130 8 Communication materials 5.000 5.000 5.000 5.000 20.000 9 Monitoring & evaluation 0.100 0.100 0.150 0.150 0.500 10 Planning & administration 0.000 11 Overhead (10%) 5.348 4.325 3.465 3.458 16.596 12 Other 0.000 0.000 Total 87.083 84.200 82.336 90.935 344.554 Budgeting assumptions Assumptions Exchange rate 1$= PKR 90 Inflation not taken into account for the calculations. All figures are approximates 1 Quantification of commodities - Zinc & ORS 2011 2012 2013 2014 2015 Source 1 Population of children under five years Total population millions 187 190 193 196 199 UNDP 0-5 years (under five year olds) millions 25.103 25.499 25.89 26.307 26.721 UNDP and PDHS 2 Diarrhea prevalence & incidence Incidence rate in children under five years cases/child/year 3.2 3 Number of diarrhea/pneumonia episodes Total number of diarrhea episodes millions 80.329 81.597 82.848 84.182 85.507 Total number of pneumonia episodes millions 7.533 7.65 7.767 7.892 8.016 4 Treatment seeking behavior % of patients seeking care percentage 54.5 60 65 70 75 5 Scale-up targets: baseline & target treatment coverage Zinc percentage 30 40 50 60 ORS percentage 37 60 70 75 80 Amoxicillin percentage 50 60 70 80 85 6 Total need for Zinc / ORS Zinc: x tablets (treatment for 14 days) millions of tablets 342.707 463.949 589.274 718.259 ORS: x sachets (2/episode) millions of sachets 97.916 115.477 117.854 136.811 7 Costing of Zinc & ORS Unit cost Zinc: US$ 0.055/ tablet US$ millions 18.849 25.517 32.411 39.504 (inflation rates not considered) Unit cost ORS: US$ 0.067 / sachet US$ millions 6.56 7.737 7.896 9.166 (inflation rates not considered) Cost of Amoxicillin: US$ 0.62/treatment 2.846 3.371 3.914 4.224 (inflation rates not considered) 28.255 36.625 44.221 52.894 2 REFERENCES 1. Pakistan Census Organization. http://www.census.gov.pk/index.php 2. UNICEF. Demographic Indicators http://www.unicef.org/infobycountry/pakistan_pakistan_statistics.html, 2009. 3. Anon. CIA - The World Factbook: Pakistan. Available at: https://www.cia.gov/library/publications/the-world-factbook/geos/pk.html. 4. Hyder AA, Morrow RH. Lost healthy life years in Pakistan in 1990. American Journal of Public Health. 2000;90(8):1235-1240. 5. Pakistan – Health Profile. World Health Organization. Last updated: 4 April 2011. 6. Pakistan Demographic and Health Survey 2006-07. 7. Pakistan Demographic and Health Survery. 1990-91. 8. Millennium Development Goals Report 2010. 9. National Institute of Population Studies Islamabad PaMIIC, Maryland, USA Pakistan: DHS-Final Report 2006-2007. 10. Akram M. Health Care Services and Government Spending in Pakistan. Islamabad, Pakistan Institute of Development Economics 2007. 11. Marketing Plus for Diarrheal Disease Control: Point-of-Use Water Disinfection and Zinc Treatment (POUZN) Project 2005-2010. 12. Nishtar S, Mehboob AB. Pakistan prepares to abolish Ministry of Health. The Lancet. 2011. 13. Nishtar S. The vanishing ministry The News International;, Saturday, December 25, 2010. 14. Nishio O, Matsui K, Oka T, et al. Rotavirus infection among infants with diarrhea in Pakistan. Pediatrics international. 2000;42(4):425-427. 15. Phan TG, Okame M, Nguyen TA, et al. Human astrovirus, norovirus (GI, GII), and sapovirus infections in Pakistani children with diarrhea. Journal of medical virology. 2004;73(2):256-261. 16. Huilan S, Zhen LG, Mathan MM, et al. Etiology of acute diarrhoea among children in developing countries: a multicentre study in five countries. Bulletin of the World Health Organization. 1991;69(5):549. 17. 8 National drug policy. Available at: http://www.dcomoh.gov.pk/publications/ndp.php. Islamabad: Drugs Control Organization; 1997. 18. Nishtar S. Drug regulation and beyond The News International;, Saturday, June 25, 2011. 19. MOH. MOH 2011 Available At. http://202.83.164.26/wps/portal/Moh. Islamabad 2011. 20. NHA. National health accounts: country information Pakistan.2008, Available at: http://www.who.int/nha/country/pak/en/, . Geneva: World Health Organization; 2009. 21. The Federal Ministry of Health of Pakistan, Islamabad. Website available at: http://202.83.164.26/wps/portal/Moh. 22. 10 Drugs Control Organization.Website available at: http://www.dcomoh.gov.pk/. Islamabad. 23. The Federal Ministry of Health of Pakistan, Islamabad. http://202.83.164.26/wps/portal/Moh. 24. Drugs Control Organization; Ministry of Health of Pakistan, Islamabad. http://www.dcomoh.gov.pk/,. 25. WHO-EMRO. WHO- EMRO 2007b. Regional Office for Eastern Mediterranean Technical discussion on Medicine prices and access to medicines in the Eastern Mediterranean Region. World Health Organization. Regional Office for the Eastern Mediterranean. Accessed online at http://www.emro.who.int/edb/media/pdf/EMRC54TECHDISC01en.pdf 2007. 3 26. Morris J, Stevens P. Counterfeit medicines in less developed countries, Problems and solutions, London, International Policy Network, Accessed online at http://www.fightingdiseases.org/pdf/ipn_counterfeit.pdf. Disponible en. 2006. 27. Nishtar. Nishtar S. 2010. Choked pipes Oxford University Press. 2010. 28. DFID. DFID. 2002. Prescription, dispensing and storage practices in the provinces of NWFP, Baluchistan and Punjab in collaboration with Network for Consumer Protection. 2002. 29. Imran M, Khan FA, Abbasi S. Standards for labelling and storage of anaesthetic medications—an audit. JPMA. The Journal of the Pakistan Medical Association. 2009;59(12):825. 30. PHARMACEUTICAL COUNTRY PROFILE Available at http://www.who.int/medicines/areas/coordination/pakistan.pdf. 31. Rabbani F, Cheema FH, Talati N, et al. Behind the counter: pharmacies and dispensing patterns of pharmacy attendants in Karachi. JOURNAL-PAKISTAN MEDICAL ASSOCIATION. 2001;51(4):149-153. 32. Butt ZA, Gilani AH, Nanan D, Sheikh AL, White F. Quality of pharmacies in Pakistan: a cross-sectional survey. International Journal for Quality in Health Care. 2005;17(4):307. 33. Mendis S, Fukino K, Cameron A, et al. The availability and affordability of selected essential medicines for chronic diseases in six low-and middle-income countries. Bulletin of the World Health Organization. 2007;85(4):279-288. 34. Loevinsohn B, Couffinhal A, Pande A. Contracting-in management to strengthen publicly financed primary health services--The experience of Punjab, Pakistan. Health policy. 2009;91(1):17-23. 35. Qazi R, Sultana S, Sundar S, Warraich H, Rais A, Zaidi AKM. Population-based surveillance for severe rotavirus gastroenteritis in children in Karachi, Pakistan. Vaccine. 2009;27:F25-F30. 36. Morisky DE, Kar SB, Chaudhry AS, Chen KR, Shaheen M, Chickering K. Update on ORS Usage in Pakistan: Results of a National Study. Pakistan Journal of Nutrition. 2002;1(3):143-150. 37. Anti-inflammatory NS, Nsaid D. Exploring health seeking behavior, medicine use and self medication in urban and rural Pakistan. Hypertension. 2010;102:3.8. 38. Marketing Plus for Diarrheal Disease Control: Point-of-Use Water Disinfection and Zinc Treatment (POUZN) Project 2005-2010. Bethesda, MD: Point-of-Use Water Disinfection and Zinc Treatment (POUZN) Project. In: Inc. AA, ed; 2005-2010. 39. Haider S, Thaver IH. Self medication or self care: implication for primary health care strategies. JPMA. The Journal of the Pakistan Medical Association. 1995;45(11):297. 40. Siddiqi S, Hamid S, Rafique G, et al. Prescription practices of public and private health care providers in Attock District of Pakistan. The International journal of health planning and management. 2002;17(1):23-40. 41. Mathers C, Fat DM, Boerma JT. The global burden of disease: 2004 update: World Health Organization; 2008. 42. Wardlaw T, Salama P, Johansson EW, Mason E. Pneumonia: the leading killer of children. Lancet. 2006;368(9541):1048-1049. 43. Black RE, Morris SS, Bryce J. Where and why are 10 million children dying every year? The Lancet. 2003;361(9376):2226-2234. 44. USAID. Country Health Statistical Report Pakistan May 2010. 45. National ARI Control Programme. Management of the young child with acute respiratory infection. Islamabad: (unpublished document); 1990. 46. National ARI Control Programme. Acute respiratory infections in children: case management in small hospitals in developing countries. A manual for doctors and other senior health workers. In: Cell FA, ed. Islamabad,: unpublished document; 1990. 4 47. Qazi SA, Rehman GN, Khan MA. Standard management of acute respiratory infections in a children's hospital in Pakistan: impact on antibiotic use and case fatality. Bulletin of the World Health Organization. 1996;74(5):501. 48. Kakar. Malaria and it control in Pakistan Epidemiology, Progress and Challenges. 49. Kakar Q, Khan MA, Bile KM. Malaria control in Pakistan: new tools at hand but challenging epidemiological realities. Eastern Mediterranean Health Journal. 2010;16:S54. 50. Friends Of The Global Fight Country Profile. Pakistan July 2009. 51. WHO-EMRO. Implementation of IMCI in Pakistan. Child and Adolescent Health and Development [http://www.emro.who.int/cah/imci-implementation-pak.htm. Accessed November, 2011. 52. Pakistan Social and Living Standards Measurement Survey (PSLM) – 2008-09, Federal Bureau of Statistics, Statistics Division, Government of Pakistan. Islamabad February, 2010. 53. Thea DM, Qazi SA. Community case management of severe pneumonia with oral amoxicillin in children aged 2–59 months in Haripur district, Pakistan: a cluster randomised trial. Lancet 2011. 54. Economic survey of pakistan. 2011. 55. Rudan I, Boschi-Pinto C, Biloglav Z, Mulholland K, Campbell H. Epidemiology and etiology of childhood pneumonia. Bulletin of the World Health Organization. 2008;86(5):408-416B. 56. Stene, Angela, MacDonald V, Mitchell S, Bishop A. Social. November 2010.

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