Essential Drugs List- Fourth Revision 2003- Federal Republic of Nigeria

Publication date: 2003

Essential Drugs List - Fourth Revision 2003 - Federal Republic of Nigeria Published by The Federal Ministry of Health Abuja, Nigeria. In Collaboration with World Health Organization I. FOREWORD It gives me a great pleasure to write the Foreword for this Fourth Revision of the National Essential Drugs List. This revised edition is the product of the hard work of the National Drug Formulary/Essential Drugs Review Committee, which was inaugurated in September 1999. The establishment of the Committee is in compliance with the Decree 43 of 1989 later amended by Decree 13 of 1992. I commend the doggedness and perseverance of the Chairman and members of the Committee in producing this document in spite of constraints of facilities and funding. I also commend the Country Office of the World Health Organisation (WHO) for contributing technically and financially towards the conclusion of this work. I am particularly thankful to WHO for undertaking to print of 50,000 copies of the EDL. This will ensure its wide circulation. As I have declared at every available opportunity, the intensification of the war against fake drugs is one of the five-action health agenda of the Obasanjo administration whose first term will expire in a few months from now. Nigerians are the best judges to assess whether we have kept faith on this agenda. The widespread acclaim of the activities of the National Agency for Food and Drug Administration and Control (NAFDAC) under its current management team is sufficient proof that we have matched our word with positive action in this regard. While the war is yet to be totally won, we are definitely on the right course to winning it. The adoption of an Essential Drugs List is a key strategy for achieving one of the goals of the National Drug Policy which is to make available at all times, in adequate dosage forms, drugs that satisfy the health care needs of the majority of the population at all levels of the health care delivery system. The adoption of the list of essential drugs is also a factor in the promotion of rational use of drugs, another key element of our Drug Policy. All these accord with the cardinal health agenda of this administration of eradicating fake drugs from our health care system. This is because with the adoption of a limited drugs list, the administration, regulation and control of drugs can be done more effectively and efficiently. As revealed by a recent survey, the circulation of the Essential Drugs List has not been as wide as it should be, particularly at the primary health care level. This shall no longer be so with this revised edition. My Ministry will ensure that the document is circulated as widely as possible to all the three tiers of our health care delivery system. I however wish to advise all Chief Executives of our tertiary hospitals, state ministries of Health as well as local Government health departments that only drugs on the EDL are procured, stored and used in their respective health institutions in compliance with the enabling law. My Ministry will monitor compliance strictly. In conclusion, I commend this important document to all stakeholders in the health sector: health care professionals and those who train them in our institutions of higher learning, professional associations/societies, drug manufacturers as well as Non-governmental organisations working in health. Page 1 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. Professor A.B. C. Nwosu, Honourable Minister of Health. 3rd April 2003 II. PREFACE TO THE FOURTH REVISION It is my honour and privilege to write the preface to this fourth revision of the Essential Drugs List for the Nigerian public health care system. This fourth revision is much delayed due to several constraints. The National Drug Formulary and Essential Drugs List Review Committee has been working constantly on this revision since 2000. This fourth revision is the product of several reviews. This edition has also taken care of the current concerns in the management of HIV/AIDS, tuberculosis, Integrated Management of Childhood Illnesses (IMCI) and malaria. The reader may also discover that new internationally accepted names of some drugs, formulations and dosage forms have been adopted. Essential Drugs have been defined as those drugs that satisfy the health care needs of the majority of the population. They should therefore be available at all times in adequate amounts and in appropriate dosage forms at all levels of the health care delivery system of the country. The Essential Drugs Programme of the Federal Republic of Nigeria came on stream in 1988 and received legal backing when in 1989 Decree 43 was promulgated. That same year the first Revision was published. The second revision soon followed in 1991 and the third in 1996. The programme and its legal instrument came under severe criticism by the Drug Manufacturing/Distribution concerns as well as several health practitioners for obvious reasons as the impression was created that whatever drug was not included in the list could neither be imported nor used legally. The amendment to this decree that appeared in 1992, limiting the provision of the earlier decree to the Public Sector only, had the salutary effect of removing the pressure on the programme as well as on those who implemented it. The expected advantages of an Essential Drugs Programme include: - Limiting the number of drugs deployed in the health care system, - Creating opportunity for the provision of concise, accurate and comprehensive information in the form of a National Drug Formulary on all the drugs in the essential drugs list, - Improving the knowledge of prescribers regarding the pharmacological properties of the prescribed drugs thus improving the quality of drug - Improving drug utilisation by the various sectors of the health care system through better monitoring. Sound policy, legislation and en essential drugs programme that includes education of health professionals and patients in rational use of drugs are measures that should ensure better health care in all countries. The National Drug Formulary and Essential Drugs Review Committee working with Page 2 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. the Food and Drugs Services in collaboration with the World Health Organisation have worked out the modalities of ensuring that this fourth revised edition gets to the authorities and individuals that the programme is intended for and ensuring maximum derivation of the advantages of the essential drugs programme. In this revision there are no drugs marked for deletion as all drugs so labelled in the third revision have been appropriately taken care of. There are fewer drugs in this list than in the third revision. About one hundred and fifty drugs and dosage forms have been deleted. The newly added drugs or dosage forms number about fifty. A new restricted list has been appended. These drugs are considered essential for specialist and tertiary health care facilities and need to be available for the Public Health Care system. A reviewed list for Primary Health Care is included as well as the list of products suggested to be stocked and sold by Patent Medicine Dealers/Vendors. The current National Drug Formulary and Essential Drugs List (NDF/EDL) Review committee inherited a revised but unpublished National Drug Formulary which needs to be reviewed in line with this fourth revision of the Essential Drugs List. It is hoped that this exercise will soon take place to ensure that this important component of the Essential Drugs Programme is fully achieved in Nigeria. We are encouraged by the support given to the Federal Ministry of Health in the area of Essential Medicines. We hope that the proposed interest in the development of the Standard Treatment Guidelines proposed by the immediate past chairman of the NDF/EDL Review Committee shall be followed by the necessary motions to put Nigeria in line with countries with a viable Health Care delivery system for their peoples. Professor Ibrahim Abdu-Aguye, Chairman, National Drug Formulary and Essential Drugs Review Committee, January 2003 III. NATIONAL DRUG FORMULARY AND ESSENTIAL DRUGS LIST REVIEW COMMITTEE 1999 - 2002 CHAIRMAN 1. Prof. Ibrahim Abdu-Aguye, MBBS (Ib.), M.Sc. (ABU), FMCP (Nig.) Clinical Pharmacology Unit Department of Medicine Ahmadu Bello University Teaching Hospital Zaria. MEMBERS 2. Prof. A.F.B. Mabadeje, MB (London) FRCPE, - Representing NMA FWACP, FMCP Consultant Physician, Mabadeje Specialist Clinic 3 Adenike Moyosore Close Somolu, Lagos. P.O.Box 191, UNILAG. 3. Pharm. R.K. Omotayo mni, B. Pharm., FPC Pharm. Director, Page 3 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. Food and Drugs Services Department, Federal Ministry of Health, Abuja. 4. Dr. (Chief) D. Ikedife, B.Sc. (London); M.B. Ch. B. (Glasgow); FMCOG (Nigeria); FMACS; FRCOG; FICS Ikedife Hospital, 33 Igwe Orizu Road, Nnewi, Anambra State. 5. Pharm. G.O. Obiaga, B.Sc. Pharm. (Manchester); FPSN; FPC Pharm. - Representing PSN 112 Adetokunbo Ademola Crescent, Wuse II, Abuja. 6. Pharm. S.D. Ahmed, B.Sc. Pharm. (ABU) Director, Pharmaceutical Services, Kaduna State Ministry of Health, Kaduna. 7. Pharm. E. Ebere, - Representing PMG-MAN PMG-MAN, MAN CENTRE 5 Eleruwa Street, Off Ajao Road/Adeniyi Jones Ave. Ikeja, Lagos 8. Pharm. I.S. Bamisaiye, B. Pharm. (Ife) Director, Pharmaceutical Services, Ekiti State Ministry of Health, Ekiti. 9. Pharm. C.U. Chime, B. Pharm. (Hons); Diploma Health Systems Management (Isreal) Director, Pharmaceutical Services, Enugu State Ministry of Health, Enugu. 10. Dr. S. Sani, MBBS (ABU); M. Comm. Health; FMCGP; FWACP; MFR Director, Hospital Services Department, Federal Ministry of Health, Abuja. 11. Dr. (Mrs.) E. Abebe, mni; MBBS; MPH Director, Department of Public Health, Federal Ministry of Health, Abuja. 12. Dr. E.I.E Umo mni, MBBS (Ibadan); DA FNC Anaethetics Page 4 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. Consultant, University of Calabar Teaching Hospital, Calabar, Cross River State. 13. Dr. A.O. Isah, MBBS (Ibadan); FMCP (Nigeria); MD (Newcastle) Consultant, University of Benin Teaching Hospital, Benin City, Edo State. 14. Pharm. MacDonald N. Garba, -Representing Director, Pharmaceutical Services Gombe State Ministry of Health, Gombe State. CO-OPTED MEMBER 15. Prof. Reuben Ola Arowolo, DVM (Ib.); M.Sc. (Guelph); Ph.D (Ib.) - Rep. Vet. Med. Association Veterinary Pharmacology Department, Faculty of Veterinary Medicine, University of Ibadan, Ibadan. OBSERVER 16. Pharm. S.O. Aiyegbusi, B. Pharm. (Ife) - Representative of NAFDAC Deputy Director, National Agency for Food and Drugs Administration & Control Area 2, Garki, Abuja. SECRETARY 17. Pharm. M.I. Okpeseyi, B. Pharm. (Ife) Assistant Director, Food & Drugs Services Department, Federal Ministry of Health, Abuja. WORLD HEALTH ORGANISATION Dr. (Mrs.) O. Taylor, B. Pharm. (Ife); Ph.D. Grenoble Essential Drugs and Medicine Policy (EDM) Adviser V. LIST OF ESSENTIAL DRUGS NIGERIAN ESSENTIAL DRUGS LIST 2003 1. ANAESTHETICS 1.1 General Anaesthetics and Oxygen Name of Drug Dosage Forms and Strengths Page 5 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 1.2 Premedication Drugs And Analgesic Adjuvants 1.3 Skeletal Muscle Relaxants and Antagonists 1.4 Local Anaesthetics 2. ANALGESICS, ANTIPYRETICS AND NON-STEROIDAL ANTI- INFLAMMATORY DRUGS 2.1 Narcotic Analgesics Ether, Anaesthetic - Inhalation, liquid in bottle of 500 mL Halothane - Inhalation, liquid in bottle of 250 mL Ketamine - Injection, 10 mg/mL (hydrochloride) in 20 mL vial, 50 mg/mL in 10 mL vial, 100 mg/mL in 5 mL vial Nitrous oxide - Inhalation, Medicinal gas Oxygen - Inhalation, Medicinal gas Thiopental - Powder for IV Injection (sodium salt), 0.5 g, 1.0 g and 2.5 g in ampoules Name of Drug Dosage Forms and Strengths Atropine - Injection (sulphate) 0.5 mg, 1 mg in 1 mL ampoules Diazepam - Injection, 5 mg/mL in 2 mL ampoule Morphine - Injection, (sulphate or hydrocholride) 10 mg, 15 mg in 1 mL ampoules Promethazine - Elixir or Syrup for children, (hydrochloride), 5 mg/5 mL Name of Drug Dosage Forms and Strengths Atracurium - Injection, 10 mg/mL Neostigmine - Injection, (methylsulphate) 2.5 mg/mL in 1 mL ampoule Pancuronium - Injection, (bromide), 2 mg/mL in 2 mL ampoule Suxamethonium - Injection, 50 mg (chloride)/mL in 2 mL ampoule - Powder for injection (chloride) in vial Name of Drug Dosage Forms and Strengths Bupivacaine - Injection, (hydrochloride), 0.25%, 0.5% with or without epinephrine (adrenaline) 1:200,000 in 10 mL ampoule Lidocaine - Injection (hydrochloride) 1%, 2% in vial - Injection, 5%, for spinal anaesthesia - Injection, 1%, 2% plus epinephrine (adrenaline) 1:200,000 in vial - Topical, Cream or Ointment, 2 - 5% - Topical, Spray (Aerosol), 10% - Topical, Gel or Solution, 2 -4% - Dental Cartridges, 2% plus epinephrine (adrenaline) 1:80,000 Name of Drug Dosage Forms and Strengths Dihydrocodeine - Tablet (tartrate), 30 mg Page 6 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 2.2 Narcotic Antagonist 2.2 Narcotic Antagonist (Drugs for Treatment of Opioid Dependence) 2.3 Non-narcotic Analgesics and Antipyretics 2.4 Non-steroidal Anti-inflammatory Drugs and Drugs used for Gout 3 ANTI-ALLERGICS 3.1 Antihistamines - Injection, 50 mg/mL in 1 mL ampoule Fentanyl - Injection (citrate) 0.05 mg/mL in 1 mL ampoule Morphine - Tablet, 10 mg - Injection (sulphate or hydrochloride) 10 mg, 15 mg in 1 mL ampoule Pentazocine - Capsule, 50 mg - Tablet, 25 mg - Injection (lactate), 30 mg in 1 mL ampoule Pethidine - Tablet, 50 mg - Injection (hydrochloride), 50 mg/mL in 1 mL and 2 mL ampoule Name of Drug Dosage Forms and Strengths Naloxone - Injection (hydrochloride), 0.4 mg in 1 mL ampoule Name of Drug Dosage Forms and Strengths Acetylsalicylic acid - Capsule, Tablet, 300 mg Paracetamol - Tablet, 125 mg, 500 mg - Suspension, 125 mg/5 mL - Syrup, 125 mg/5 mL - Suppository, 100 mg Name of Drug Dosage Forms and Strengths Allopurinol - Tablet, 100 mg Diclofenac - Tablet, 25 mg, 100 mg - Injection, 25 mg/mL ampoule - Gel, 1% Ibuprofen - Capsule, Tablet, 200 mg and 400 mg Indomethacin - Capsule, 25 mg Ketoprofen - Gel (2.5%), 2.5 g/100 g Name of Drug Dosage Forms and Strengths Chlorphenamine - Tablet (maleate), 4 mg - Syrup, 2 mg/5 mL - Injection (maleate), 10 mg in 1 mL ampoule Promethazine - Tablet, (hydrochloride), 10 mg, 25 mg Page 7 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 3.2 Anti-anaphylactics 4 ANTIDOTES 4.1 Non-specific (General) Antidotes 4.2 Specific Antidotes 5 ANTICONVULSANTS (ANTI-EPILEPTICS) - Syrup, (hydrochloride), 5 mg/5 mL - Injection, (hydrochloride), 25 mg/mL in 1 mL and 2 mL ampoule Name of Drug Dosage Forms and Strengths Epinephrine (Adrenaline) - Injection, (acid tartrate or hydrochloride), 1 mg/mL (1 in 1000) in 1 mL ampoule Hydrocortisone - Injection, (sodium succinate), powder for reconstitution, 100 mg in vial Charcoal, activated - Tablet, 1 g - Powder, granules, 5 g/sachet Ipecacuanha - Syrup, containing 0.14% Ipecacuanha alkaloids calculated as emetine Atropine - Injection, 1 mg (sulphate) in 1 mL ampoule Deferoxamine - Injection, (mesilate), 500 mg in vial Dimercaprol - Injection, 50 mg/mL in 2 mL ampoule Methionine - Tablet, 250 mg Naloxone - Injection, (hydrochloride), 0.4 mg in 1 mL ampoule Protamine sulphate - Injection, 10 mg/mL in 5 mL ampoule Phytomenadione (Vitamin K1)- - Injection, 10 mg/mL in 1 mL ampoule Sodium calcium edetate - Injection, 200 mg/mL in 5 mL ampoule Sodium nitrite - Injection, 30 mg/mL in 10 mL vial Sodium thiosulphate - Injection, 500 mg/mL Name of Drug Dosage Forms and Strengths Carbamazepine - Tablets, 100 mg, 200 mg Clonazepam - Tablets, 0.5 mg, 2 mg - Injection, 1 mg/mL in 1 mL ampoule Diazepam - Injection, 5 mg/mL in 2 mL ampoule Ethosuximide - Capsule, Tablet, 250 mg - Syrup, 250 mg/5 mL Magnesium sulphate - Injection, 50% (500 mg/mL) in 2 mL ampoules Paraldehyde - Injection, 5 mL, 10 mL ampoules Phenobarbitone - Tablet, 15 mg, 30 mg, 60 mg - Elixir/Syrup, 15 mg/5 mL Phenytoin sodium - Capsule, Tablet, 25 mg, 50 mg, 100 mg Sodium valproate - Tablet, Enteric-coated, 100 mg, 200 mg, 500 mg Page 8 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 6 ANTI-INFECTIVE DRUGS 6.1 Amoebicides 6.2 Anthelmintics 6.3 Antifilarial Drugs 6.4 Antischistosomal Drugs 6.5 Antitrypanosomal and Antileishmaniasis Drugs 6.6 Antimalarial Drugs - Elixir/Syrup, 200 mg/5 mL Name of Drug Dosage Forms and Strengths Metronidazole - Tablet, 200 mg - Suspension, Oral, 200 mg/5 mL Name of Drug Dosage Forms and Strengths Albendazole - Tablet, 200 mg - Suspension, Oral, 100 mg/5 mL Levamisole - Tablet, 40 mg - Syrup, 40 mg/5 mL Mebendazole - Tablet, 100 mg, 500 mg - Suspension, 100 mg/5 mL Niclosamide - Tablet, Chewable, 500 mg Pyrantel - Tablet, 125 mg - Syrup, 125 mg/5 mL Name of Drug Dosage Forms and Strengths Diethylcarbarmazine - Tablet (citrate), 50 mg Ivermectin - Tablet, 6 mg Name of Drug Dosage Forms and Strengths Praziquantel - Tablet, 600 mg Name of Drug Dosage Forms and Strengths Meglumine antimonate - Injection, containing 8.5% of total antimony Melarsoprol - Injection, 3.6% solution Pentamidine - Injection, Powder, 200 mg/vial Sodium stibogluconate - Injection, containing 10% of total antimony Suramin - Injection, powder, 1 g/vial Name of Drug Dosage Forms and Strength Artemether - Injection, 80 mg/mL in 1 mL ampoule Page 9 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 6.7 Antiflagellate Drugs 6.8 Antibacterial Drugs Chloroquine - Capsule, (phosphate or sulphate), 150 mg Base, 300 mg Base (Adult); Tablet 150 mg Base; 50 mg base (Paediatric) - Syrup (phosphate or sulphate), 50 mg base/5 mL - Injection, 40 mg base/mL in 5 mL ampoule Dihydroartemisinin - Tablet, 60 mg Mefloquine - Tablet, 250 mg (base) Mefloquine plus Sulphadoxine Plus Pyrimethamine - Tablet, Mefloquine 250 mg plus Sulphadoxine 500 mg Plus Pyrimethamine 25 mg Proguanil - Tablet, (hydrochloride), 100 mg Pyrimethamine - Tablet, 12.5 mg, 25 mg Pyrimethamine plus Sulphadoxine - Tablet, Pyrimethamine 25 mg plus Sulphadoxine 500 mg - Syrup, Pyrimethamine 25 mg plus Sulphadoxine 500 mg/5 mL - Injection, Pyrimethamine 25 mg plus Sulphadoxine 500 mg in 2.5 mL ampoule Quinine - Tablet (bisulphate or sulphate), 300 mg - Injection (dihydrochloride) 300 mg/mL in 2 mL ampoule Name of Drug Dosage Forms and Strength Metronidazole - Tablet, 200 mg - Suspension, Oral, 200 mg/5 mL Tinidazole - Tablet, 500 mg Name of Drug Dosage Forms and Strength Amoxicillin - Capsule, 250 mg - Powder for Suspension, 125 mg/5 mL - Injection, 250 mg, 500 mg in vial Ampicillin plus Cloxacillin - Capsule, 250 mg of each - Powder for oral suspension, 125 mg of each/5 mL - Neonatal Drops, Ampicillin 60 mg plus Cloxacillin 30 mg/0.6 mL - Neonatal Injection, Ampicillin 50 mg plus Cloxacillin 25 mg/vial - Injection, powder (sodium salt) 250 mg of each in vial Benzathine benzylpenicillin - Injection, powder equivalent to 0.72 g (1.2 million Units), 1.44 g (2.4 million Units) of Benzylpenicillin in vial Benzylpenicillin - Injection, powder (sodium or potassium salt) 0.6 g (1 million Units), 3.0 g (5 million Units) in vial Ceftriaxone - Injection, 250 mg, 500 mg IM; 1 g IV Cefuroxime - Tablets (axetil), 125 mg, 250 mg, 500 mg - Suspension (axetil), 125 mg/5 mL - Injection (sodium salt), 250 mg, 750 mg Chloramphenicol - Capsule, 250 mg Page 10 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 6.9 Antileprosy Drugs - Suspension, Oral (palmitate), 125 mg/5 mL - Injection, Powder (sodium succinate), 1 g/vial Ciprofloxacin - Tablet (hydrochloride), 250 mg, 500 mg - Injection, (lactate) IV 2 mg/mL in 50 mL, 100 mL vial Cloxacillin - Capsule, 250 mg - Suspension, Oral, 125 mg/5 mL - Injection, Powder, 250 mg, 500 mg vial Co-amoxiclav - Capsule, Tablet, Amoxycillin (trihydrate) 250 mg plus Clavulanic Acid (potassium salt) 125 mg - Powder for Oral Suspension, Amoxycillin (trihydrate) 125 mg plus Clavulanic Acid (potassium salt) 31.25 mg/5 mL - Injection powder for IV injection, Amoxycillin (trihydrate) 500 mg plus Clavulanic Acid (potassium salt) 100 mg/vial; Amoxycillin (trihydrate) 1 g plus Clavulanic Acid 200 mg/vial Co-trimoxazole - Tablet, Sulphamethoxazole 400 mg plus Trimethoprim 80 mg - Suspension, Sulphamethoxazole 200 mg plus Trimethoprim 40 mg/5 mL Doxycycline - Capsule, 100 mg Erythromycin - Capsule, Tablet, enteric/film-coated (stearate or ethylsuccinate), 250 mg, 500 mg - Suspension, oral (stearate or ethylsuccinate), 125 mg/5 mL - Injection powder (lactobionate), 500 mg in vial Fortified procaine penicillin - Injection powder, 0.4 million Units containing Procaine Penicillin 0.3 million Units (300 mg) and Benzylpenicillin 0.1 million Units (60 mg)/vial; 4 million Units containing Procaine Penicillin 3 million Units (3 g) and Benzylpenicillin 1 million Units (600 mg)/vial Gentamicin - Injection (sulphate), 10 mg/mL, 40 mg/mL in 2 mL vial Lincomycin - Capsule, 500 mg - Syrup, 250 mg/5 mL - Injection (phosphate), 150 mg/mL in 2 mL, 4 mL ampoule Metronidazole - Injection, 500 mg in 100 mL bottle Nalidixic acid - Tablet, 500 mg Neomycin - Tablet, 500 mg - Suspension, 100 mg/5 mL Nitrofurantoin - Tablet, 50 mg, 100 mg Phenoxymethylpenicillin - Tablet (potassium salt), 250 mg - Suspension, 250 mg/5 mL Streptomycin - Injection powder (sulphate), 1 g, 5 g in vial Tetracycline - Capsule, Tablet, (hydrochloride), 250 mg - Powder for Injection, 100 mg, 250 mg in vial Name of Drug Dosage Forms and Strength Clofazimine - Capsule, 50 mg, 100 mg Dapsone - Tablet, 50 mg, 100 mg Page 11 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 6.10 Antituberculosis Drugs 6.11 Systemic Antifungal Drugs 6.12 Antiviral Drugs 6.13 Antiretroviral (ARV) Drugs 6.13.1 Protease Inhibitors 6.13.2 Nucleoside Reverse Transcriptase Inhibitors Rifampicin - Capsule, Tablet, 150 mg, 300 mg Name of Drug Dosage Forms and Strength Ethambutol - Tablet (hydrochloride) 100 - 500 mg Isoniazid - Tablet, 100 - 300 mg Pyrazinamide - Tablet, 400 mg Rifampicin - Capsule, Tablet, 150 mg, 300 mg Rifampicin plus Isoniazid - Tablet, Rifampicin 150 mg plus Isoniazid 100 mg; Rifampicin 300 mg plus Isoniazid 150 mg Streptomycin - Injection powder (sulphate), 1 g, 5 g in vial Thiacetazone plus Isoniazid - Tablet, Thiacetazone 50 mg plus Isoniazid 100 mg; Thiacetazone 150 mg plus Isoniazid 300 mg Name of Drug Dosage Forms and Strength Amphotericin B - Injection powder, 50 mg in vial Fluconazole - Capsule, 50 mg, 150 mg - Injection, IV 2 mg/mL in 0.9% NaCl Miconazole - Tablet, 250 mg Nystatin - Tablet, 500,000 Units - Suspension, 100,000 Units/mL - Pessary, 100,000 Units Name of Drug Dosage Forms and Strength Acyclovir - Tablet, 200 mg, 400 mg - Suspension, 200 mg/5 mL - Injection, IV (sodium salt), 250 mg/vial - Cream, 5% Idoxuridine - Solution, 5% in Dimethylsulphoxide (for external application) Name of Drug Dosage Forms and Strength Indinavir - Capsules, (sulphate), 200 mg, 333 mg, 400 mg Nelfinavir - Tablet, 250 mg Name of Drug Dosage Forms and Strength Lamivudine - Tablet, 150 mg Page 12 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 6.13.3 Non-nucleoside Reverse Transcriptase Inhibitors 7. ANTIMIGRAINE DRUGS 8. ANTINEOPLASTIC AND IMMUNOSUPPRESSIVE DRUGS - Solution, 5 mg/mL - Injection, Stavudine - Tablet, 40 mg Zidovudine - Capsule, 100 mg, 250 mg - Syrup, 50 mg/mL Name of Drug Dosage Forms and Strength Nevirapine - Tablet, 200 mg - Syrup, 50 mg/mL Name of Drug Dosage Forms and Strength Ergotamine - Tablet, (tartrate), 2 mg Pizotifen - Tablet, (hydrogen malate), 0.5 mg, 1.5 mg Elixir, (hydrogen malate), 0.25 mg/mL Name of Drug Dosage Forms and Strengths Actinomycin D - Injection powder, 0.5 mg/vial Azathioprine - Tablet, 50 mg - Injection powder, (sodium salt), 50 mg in vial Bleomycin - Injection powder, (sulphate), 15 Units/ampoule Busulphan - Tablet, 2 mg Chlorambucil - Tablet, 2 mg, 5 mg Cisplastin - Injection powder, 10 mg, 50 mg in vial Cyclophosphamide - Tablet, 25 mg, 50 mg - Injection powder, 100 mg, 500 mg, 1 g in vial Cyclosporin - Oral Solution, 100 mg/mL solution - Injection, IV 50 mg/mL in ampoule Cytarabine - Injection powder, 100 mg/vial Dexamethasone - Tablet, 0.5 mg, 4 mg - Injection (sodium phosphate), 4 mg/mL Doxorubicin - Injection powder (hydrochloride), 10 mg, 50 mg in vial Fluorouracil - Injection, 50 mg/mL in 5 mL ampoule Mercaptopurine - Tablet, 50 mg Methotrexate - Tablet (sodium salt), 2.5 mg - Injection powder (sodium salt), 50 mg/vial Prednisolone - Tablet, 5 mg - Injection (sodium phosphate or sodium succinate), 20 mg/mL, 25 mg/mL in vial Procarbazine - Capsule (hydrochloride), 50 mg Stilboestrol - Tablet, 1 mg, 5 mg, 25 mg Page 13 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 9. DRUGS FOR PARKINSONISM AND OTHER NEUROLOGICAL DISORDERS 9.1 Antiparkinsonism Drugs 9.2 Drugs for Myasthenia Gravis 9.3 Drug for Subarachnoid Haemorrhage 10. ANTISEPTICS AND DISINFECTANTS Tamoxifen - Tablet (citrate), 10 mg, 20 mg Vincristine - Injection powder, (sulphate), 1 mg, 2 mg, 5 mg in vial Name of Drug Dosage Forms and Strengths Benzhexol - Tablet, (hydrochloride), 2 mg, 5 mg Biperiden - Tablet, (hydrochloride), 2 mg - Injection, (lactate), 5 mg/mL in 1 mL ampoule Levodopa plus Carbidopa - Tablet, Levodopa 100 mg, 250 mg plus Carbidopa 10 mg, 25 mg respectively Neostigmine Pyridostigmine - Tablet, (bromide), 15 mg Tablet, (bromide), 60 mg Name of Drug Dosage Forms and Strengths Neostigmine - Tablet, (bromide), 15 mg Pyridostigmine - Tablet, (bromide), 60 mg Name of Drug Dosage Forms and Strengths Aminocaproic acid plus Lipid thromboplastin - Injection, containing Aminocaproic Acid, 100 mg, Lipid Thromboplastin, 2 mg/mL in 5 mL ampoule Name of Drug Dosage Forms and Strengths Benzoin - Compound Tincture of Benzoin Cetrimide plus Chlorhexidine - Solution, Cetrimide 15% plus Chlorhexidine (gluconate), 1.5% for dilution Chlorhexidine - Solution, (gluconate), 5% for dilution Coal tar - 5% Solution Dichloroxylenol plus Chlorophenol - Soap, solution Formaldehyde - Solution, 1.5 - 10% Glutaraldehyde (Glutaral) - Solution, 2% (in buffered base) Iodine - Weak Solution of iodine, 1% Methylated spirit - Solution Povidone- iodine - Solution, 10% Potassium permanganate - Solution, 0.1% Sodium hypochlorite - Solution. Different preparations with available Chlorine from 1 - 10% Page 14 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 11. DRUGS AFFECTING THE BLOOD 11.1 Anti-anaemia Drugs 11.2 Anticoagulants and Antiplatelets 11.3 Antifibrinolytic and Haemostatic Drug 11.4 Plasma Substitutes 11.5 Plasma Fraction for Specific Use 12. CARDIOVASCULAR DRUGS Trichlorophenol - Cream, Liquid, Ointment, mixture of halogenated phenols and Salicylic acid. Name of Drug Dosage Forms and Strengths Cyanocobalamin/Hydroxocobalamin - Tablet, 0.05 mg - Injection, 0.25 mg, 1 mg/mL (injection, hydroxocobalamin preferred) Ferrous sulphate - Tablet, 200 mg equivalent to 60 mg Iron Ferric ammonium citrate - Mixture, 400 mg/5 mL of Ferric ammonium citrate Folic acid - Tablet, 5 mg Name of Drug Dosage Forms and Strengths Acetylsalicylic acid - Tablet, 75 mg Enoxaparin - Injection, 100 mg/mL Heparinoid hyaluronidase - Ointment, Hyaluronidase 15,000 Units/100 mg, Heparinoid equivalent to 5000 Units of heparin Heparin sodium - Injection, 1000 Units/mL and 25,000 Units/mL in ampoule Warfarin Sodium - Tablet, 1 mg, 5 mg Name of Drug Dosage Forms and Strengths Aminocaproic acid (with or without lipid thromboplastin) - Tablet, Aminocaproic acid, 500 mg - Injection, containing Aminocaproic acid 100 mg/mL plus TPT 2 mg/mL in 5 mL, 10 mL ampoules Name of Drug Dosage Forms and Strengths Dextran 70 - Injection, IV 6% in 5% glucose or normal saline solution in bottle of electrolytes, 500 mL Polygeline - Injection, IV 3.5% solution in bottle of 500 mL Name of Drug Dosage Forms and Strengths Human albumin - Injection, 20% solution Page 15 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 12.1 Anti-anginal Drugs 12.2 Anti-arrhythmic Drugs 12.3 Antihypertensive Drugs 12.4 Medicines Used in Heart Failure Name of Drug Dosage Forms and Strengths Glyceryl trinitrate - Tablet, sublingual, 0.5 mg Propranolol - Tablet, (hydrochloride), 10 mg, 40 mg - Injection, (hydrochloride), 1 mg/mL in ampoule Isosorbide dinitrate - Tablet, sublingual, 5 mg - Tablet, oral 10 mg Name of Drug Dosage Forms and Strengths Disopyramide - Capsule, tablet, 100 mg, 150 mg Lidocaine - Injection, (hydrochloride), 20 mg/mL in 5 mL ampoule Procainamide - Tablet, (hydrochloride), 250 mg - Injection, (hydrochloride), 100 mg/mL in 10 mL ampoule Propranolol - Tablet, (hydrochloride), 10 mg, 40 mg - Injection, (hydrochloride), 1 mg/mL in ampoule Name of Drug Dosage Forms and Strengths Amiloride (1 Part) plus Hydrochlorothiazide (10 Parts) (Co-amilozide) - Tablet, Amiloride 2.5 mg plus Hydrochlorothiazide 25 mg, respectively Amlodipine - Tablet, (besylate), 5 mg, 10 mg Atenolol - Tablet, 50 mg, 100 mg Captopril - Tablet, 12.5 mg, 25 mg, 50 mg Hydralazine - Tablet, 25 mg, 50 mg - Injection powder, (hydrochloride), 20 mg in ampoule Labetalol - Tablet, (hydrochloride), 100 mg, 200 mg - Injection powder, 5 mg/mL in 20 mL ampoule Lisinopril - Tablet, (without hydrochlorothiazide), 5 mg, 10 mg Methyldopa - Tablet, 250 mg, 500 mg Nifedipine - Tablet, (slow release), 20 mg Prazosin plus Polythiazide - Tablet, Prazosin (hydrochloride) 0.5 mg plus Polythiazide 0.25 mg Propranolol - Tablet, (hydrochloride), 40 mg, 80 mg Reserpine plus Dihydroergocristine plus Clopamide - Tablet, Reserpine 0.1 mg plus Dihydroergocristine 0.5 mg plus Clopamide 5.0 mg Name of Drug Dosage Forms and Strengths Captopril - Tablet, 12.5 mg, 25 mg Digoxin - Tablet, 0.0625 mg, 0.125 mg, 0.25 mg Page 16 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 13. DENTAL DRUGS 13.1 Local Anaesthetics 13.2 Mouthwashes 13.3 Anti-inflammatory Dental Drugs 14. DERMATOLOGICAL DRUGS 14.1 Anti-infective Drugs 14.2 Anti-inflammatory and Antipruritic Drugs - Elixir, 0.05 mg/mL in 60 mL bottle - Injection, 0.25 mg/mL in 2 mL ampoule and 0.1 mg/mL in 1 mL ampoule Name of Drug Dosage Forms and Strengths Benzocaine - Lozenges, 10 mg Lidocaine - Injection, Anhydrous Lignocaine (hydrochloride), 2% with Epinephrine (Adrenaline) 1 in 80,000 in dental cartridge - Cream, 5% - Spray, 0.2% Prilocaine - Injection, 3% with Felypressin 0.03 Units/mL Name of Drug Dosage Forms and Strengths Hexetidine - Solution, 0.1% Nystatin - Solution, 100,000 Units/mL Zinc chloride plus Zinc sulphate - Compound Mouthwash, containing Zinc chloride 1% plus Zinc sulphate 2% Name of Drug Dosage Forms and Strengths Triamcinolone - Paste, (acetonide), 0.1% Name of Drug Dosage Forms and Strengths Gentian violet (methylrosalinilium chloride) - Aqueous solution, 0.5% Neomycin plus Bacitracin - Cream, Ointment, containing: Neomycin sulphate 5 mg plus Bacitracin zinc 500 Units per gram in 5 g, 30 g tube - Dusting powder, containing: Neomycin Sulphate 5 mg plus Bacitracin zinc 250 Units/g - Spray, containing: Bacitracin, 12,500 Units plus Neomycin sulphate, 165,000 Units Silver sulphadiazine - Cream, 1% Sulphur plus Mesulphen - Ointment, Sulphur 10 - 20% plus Mesulphen 64% Name of Drug Dosage Forms and Strengths Page 17 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 14.3 Astringent Drugs 14.4 Anti-acne Drugs 14.5 Antifungal Drugs 14.6 Keratolytic And Keratoplastic Drugs Betamethasone - Cream, Ointment, (valerate), 0.1% Calamine lotion - Lotion Hydrocortisone - Cream, Ointment, (acetate), 1% Hydrocortisone plus Neomycin - Cream, Ointment, Hydrocortisone 0.5 - 1% plus Neomycin 0.25 - 0.5% Methyl salicylate - Ointment, Liniment: Methyl salicylate 4 - 20%, Name of Drug Dosage Forms and Strengths Aluminium diacetate - Solution, 13% for dilution Calamine plus Zinc oxide - Lotion, Plaster Name of Drug Dosage Forms and Strengths Benzoyl peroxide - Cream, 2.5%, 5%, 10% - Gel, 2.5%, 5%, 10% Name of Drug Dosage Forms and Strengths Benzoic acid plus Salicylic acid - Cream, Ointment, containing Benzoic acid, 6% and Salicylic acid, 3% Clotrimazole - Cream, Ointment, 1% - Aerosol, Spray, 1% - Dusting powder, 1% - Pessaries, 100 mg, 200 mg Miconazole - Cream, (nitrate), 2% - Lotion, Tincture, 2% - Gel, 2 - 2.5% - Dusting powder, (nitrate), 2% - Gel (Oral), (nitrate), 2 - 2.5% - Vaginal Ovule, 200 mg, 400 mg Miconazole plus Hydrocortisone - Cream, Miconazole, 2%, Hydrocortisone, 1% Nystatin - Cream, Ointment, 100,000 Units Name of Drug Dosage Forms and Strengths Coal tar - Solution 1 - 10%, Cream, etc (topical) Dithranol - Ointment, 0.1 - 2% Podophyllum resin - Solution, Topical, 10 - 25% Salicylic acid - Solution, 12% in flexible collodion - Ointment, 2 -5% Page 18 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 14.7 Scabicides and Pediculicides 15. IN VIVO DIAGNOSTIC AGENTS 15.1 Radio-contrast Media 15.1.1 Alimentary Tract 15.1.2 Angiography 15.1.3 Bronchography 15.1.4 Cholecystography (Oral) 15.1.5 Cholecystography (Intravenous) 15.1.6 Myelography 15.1.7 Urography Name of Drug Dosage Forms and Strengths Benzyl benzoate - Emulsion, 25% Permethrin - Cream, 5% - Lotion, 1% Name of Drug Dosage Forms and Strengths Barium sulphate - Suspension, 75 - 100% Name of Drug Dosage Forms and Strengths Meglumine iothalamate - Injection, 60% in ampoule Sodium iothalamate - Injection, 80% in vial Name of Drug Dosage Forms and Strengths Propyliodone - Injection, 50% (aqueous), 60% (oily) in 20 mL vial Name of Drug Dosage Forms and Strengths Iopanoic acid - Tablet, 500 mg Name of Drug Dosage Forms and Strengths Meglumine iodipamide - Injection, 52% in 20 mL ampoule Name of Drug Dosage Forms and Strengths Iophendylate - Injection, 1 mL, 3 mL ampoule Metrizamide - Injection, 3.75 g/20 mL, 6.75 g/50 mL with diluents Name of Drug Dosage Forms and Strengths Iohexol - Injection, 140 - 350 mg Iodine in ampoule Meglumine diatrizoate - Injection, 60% in 20 mL ampoule Sodium diatrizoate - Injection, 50% in 20 mL ampoule Page 19 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 15.2 Tuberculosis 16. DIURETICS 17. EAR, NOSE AND THROAT DRUGS 17.1 Ear Drugs 17.1.1 Anti-infective Drugs 17.1.2 Anti-inflammatory Drug 17.1.3 Combined Anti-infective and Anti-inflammatory Drugs 17.1.4 Removal of Ear Wax Preparations 17.2 Nose Drugs Meglumine diatrizoate plus Sodium diatrizoate - Injection, Name of Drug Dosage Forms and Strengths Tuberculin PPD (Purified Protein Derivative) - Injection, 10, 100, 1000, 100,000 Units/mL in 1 mL ampoule Name of Drug Dosage Forms and Strengths Amiloride plus Hydrochlorothiazide (co- amilozide) - Tablet, Amiloride hydrochloride 5 mg plus Hydrochlorothiazide 50 mg Bendrofluazide - Tablet, 2.5 mg, 5 mg Frusemide - Tablet, 40 mg - Injection, 10 mg/mL in 2 mL ampoule Hydrochlorothiazide - Tablet, 25 mg, 50 mg Spironolactone - Tablet, 25 mg, 50 mg Name of Drug Dosage Forms and Strengths Chloramphenicol - Ear Drops, 5% Gentamicin - Ear Drops, (sulphate), 0.3% Name of Drug Dosage Forms and Strengths Betamethasone - Ear Drops, (sodium phosphate), 0.1% Name of Drug Dosage Forms and Strengths Flumethasone plus Clioquinol - Ear Drops, Flumethasone pivalate 0.02% plus Clioquinol 1% Hydrocortisone plus Neomycin - Ear Drops, Hydrocortisone (acetate), 1.5% plus Neomycin (sulphate), 0.5% Name of Drug Dosage Forms and Strengths Glycerol plus Sodium bicarbonate - Ear Drops, Glycerol 30 mL plus Sodium bicarbonate 5 g in 100 mL solution Page 20 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 17.2.1 Anti-allergic and Nasal Decongestants (Topical and Systemic) 17.2.2 Cauterization of Nose Preparations 18. GASTRO-INTESTINAL DRUGS 18.1 Antacid Drugs 18.2 Anti-emetic Drugs 18.3 Anti-haemorrhoidal Drugs Name of Drug Dosage Forms and Strengths (a) Topical Beclomethasone - Nasal Spray, (aerosol) (dipropionate), 0.05 mg/metered Spray Ephedrine - Nasal drops (hydrochloride), 0.5% (b) Systemic Pseudoephedrine hydrochloride - Tablet, 60 mg - Syrup, 30 mg/5 mL Name of Drug Dosage Forms and Strengths Silver nitrate - Sticks, Crystals - Solution, 0.5% in water, freshly prepared Name of Drug Dosage Forms and Strengths Aluminium hydroxide - Tablet, 500 mg - Mixture, “B.P.” Aluminium hydroxide plus Magnesium trisilicate - Tablet, Aluminium hydroxide 120 mg plus Magnesium trisilicate 250 mg - Mixture, “B.P.” Magnesium trisilicate - Tablet, 500 mg - Mixture, 250 mg/5 mL Name of Drug Dosage Forms and Strengths Metoclopramide - Tablet, (hydrochloride), 10 mg - Syrup, (hydrochloride), 5 mg/5 mL - Injection, (hydrochloride), 5 mg/mL in 2 mL ampoule Prochlorperazine - Tablet, (maleate), 5 mg, 25 mg - Syrup, (mesylate), 5 mg/5 mL - Injection, (mesylate), 12.5 mg/mL in 1 mL and 2 mL ampoule Promethazine - Tablet, (hydrochloride), 10 mg, 25 mg or (theoclate), 25 mg - Syrup, (hydrochloride), 5 mg/5 mL - Injection, (hydrochloride), 25 mg/mL in 1 mL and 2 mL ampoule Name of Drug Dosage Forms and Strengths Preparations containing: - Rectal suppository or Page 21 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 18.4 Antispasmodic Drugs and Smooth Muscle Stimulants 18.5 Laxatives 18.6 Anti-diarrhoeal Drugs 18.6.1 Symptomatic Drug 18.6.2 Replacement Fluid (Oral Rehydration Therapy) 18.7 Peptic Ulcer Drugs 19. HORMONES AND SYNTHETIC SUBSTITUTES 19.1 Corticosterids and Synthetic Substitutes Hydrocortisone acetate with or without Lidocaine HCl plus astringent(s) ointment Name of Drug Dosage Forms and Strengths Hyoscine N-butylbromide - Tablet, 10 mg - Liquid, 1 mg/mL - Injection, 20 mg/mL in 1 mL ampoule Propantheline bromide - Tablet, 15 mg Name of Drug Dosage Forms and Strengths Bisacodyl - Tablet, 5 mg - Suppositories, 5 mg, 10 mg Paraffin, Liquid - Emulsion, Oral, as faecal softner, 5 mg/10 mL of Emulsion Senna - Tablet and Granules Name of Drug Dosage Forms and Strengths Codeine - Tablet, 30 mg Name of Drug Dosage Forms and Strengths Oral Rehydration Salts - Powder, Composition/Litre of solution; Glucose anhydrous 13.5 g, Potassium Chloride 1.5 g, Sodium Citrate Dihydrate 2.9 g, Sodium Chloride 2.6 g (The sodium citrate dihydrate may be replaced by sodium bicarbonate 2.5 g, in the absence of the former) Name of Drug Dosage Forms and Strengths Cimetidine - Tablet, 200 mg, 400 mg - Injection, 100 mg/mL in 2 mL ampoule Omeprazole - Tablet, 10 mg, 20 mg Ranitidine - Tablet, 150 mg, 300 mg - Effervescent tablets (hydrochloride), 150 mg, 300 mg - Injection, 25 mg/mL in 2 mL ampoule Page 22 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 19.2 Oestrogens 19.3 Progestogens 19.4 Contraceptives 19.4.1 Oral Contraceptives 19.4.2 Injectable Contraceptives 19.4.3 Intrauterine Contraceptive Devices (IUCD) 19.4.4 Barrier Methods Condoms with or without Spermicide (Nonoxynol) Name of Drug Dosage Forms and Strengths Dexamethasone - Tablet, 0.5 mg, 4 mg - Injection, 2 mg/mL, 4 mg/mL in 2 mL ampoule Hydrocortisone - Injection powder, (sodium succinate), 100 mg/vial Prednisolone - Tablet, 1 mg, 5 mg Name of Drug Dosage Forms and Strengths Ethinyloestradiol - Tablet, 0.01 mg, 0.05 mg Name of Drug Dosage Forms and Strengths Norethisterone - Tablet, 5 mg - Injection, 200 mg/mL Hydroxyprogesterone hexanoate - Injection, 250 mg/mL in 1 mL, 2 mL ampoule Name of Drug Dosage Forms and Strengths Ethinyloestradiol plus Levonorgestrel - Tablet, Ethinyloestradiol 30 micrograms mg plus Levonorgestrel 0.15 mg Ethinyloestradiol plus Levonorgestrel - Tablet, Ethinyloestradiol 30 micrograms plus Levonorgestrel 50 - 150 micrograms Ethinyloestradiol plus Norethisterone - Tablet, Ethinyloestradiol 0.05 mg plus Norethisterone 1 mg Norethisterone - Tablet, 35 micrograms (28 tablets) Name of Drug Dosage Forms and Strengths Levonorgestrel - Implant, Subdermal, 36 mg Medroxyprogesterone Acetate - Injection, Depot, 150 mg/mL in 3 mL vial Norethisterone Enanthate - Injection, 200 mg/mL in 1 mL ampoule Name of Drug Dosage Forms and Strengths Copper - IUCD, Various Copper- containing devices Lippe’s Loop - IUCD, Various sizes, A, B, C and D with insertion tubes Page 23 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. Diaphragms with Spermicide (Nonoxynol) 19.5 Drugs Acting on Pituitary Ovarian Axis 19.6 Antidiabetic Drugs 19.6.1 Insulins 19.6.2 Oral Antidiabetic Drugs 19.7 Thyroid Hormones and Antithyroid Drugs 19.7.1 Thryroid Hormone 19.7.2 Antithyroid Drugs 20. IMMUNOLOGICALS 20.1 Sera and Immunoglobulins Name of Drug Dosage Forms and Strengths Bromocriptine - Capsule, Tablet, (mesylate), 1 mg, 2.5 mg Clomiphene - Tablet, (citrate), 50 mg Name of Drug Dosage Forms and Strengths Human Insulin - Injection, 100 Units/mL Insulin, Soluble - Injection, short acting, 40 Units, 80 Units, 100 Units/mL in 10 mL vial Insulin Zinc Suspension (I.Z.S) - Injection, 40 Units, 80 Units, 100 Units/mL in 10 mL vial Name of Drug Dosage Forms and Strengths Chlorpropamide - Tablet, 250 mg Glibenclamide - Tablet, 5 mg Metformin - Tablet, (hydrochloride), 500 mg Name of Drug Dosage Forms and Strengths Levothyroxine - Tablet, (sodium salt), 0.05 mg, 0.1 mg Name of Drug Dosage Forms and Strengths Carbimazole - Tablet, 5 mg Iodine plus Potassium iodide (Lugol’s Solution) - Oral Solution, containing: Iodine 5% and Potassium iodide 10% in purified water Propylthiouracil - Tablet, 50 mg Name of Drug Dosage Forms and Strengths Anti-D Immunoglobulin (Human) - Injection, 0.25 mg/mL Anti Gas-gangrene - Injection, 10,000 Units, 30,000 Units in vial Page 24 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 20.2 Vaccines (All Vaccines should comply with the W.H.O. requirements for biological substances) 20.2.1 Vaccines for Universal Immunization 20.2.2 Vaccines for Specific Immunization 21. OPHTHALMOLOGICAL DRUGS 21.1 Anti-infective Drugs Antirabies Hyperimmune Serum - Injection, 1000 Units in 5 mL ampoule Antiscorpion Serum - Injection, 1 mL in ampoule Antisnake-bite Serum - Injection, Polyvalent, 10 mL, 20 mL in ampoule Gas-gangrene Antitoxin - Injection, containing 4000 Units, 10,000 Units in vial Normal Immunoglobulin - IV Injection, 30 mg/mL, 165 mg/mL Tetanus Antitoxin - Injection, 1,500 Units in ampoule, 10,000 Units, 50,000 Units in vial Name of Drug Dosage Forms and Strengths B.C.G. Vaccine (Dried) - Injection powder for reconstitution in multidose ampoules of 1 mL, 5 mL Diphtheria, Tetanus and Pertussis Vaccine - Injection, 0.5 mL, 5 mL ampoule Measles Vaccine - Injection, 0.5 mL, ampoule Measles, Mumps & Rubella Vaccine - Injection, 0.5 mL Poliomyelitis Vaccines (Live attenuated) - Oral Suspension Tetanus Vaccine - Injection, formol toxoid, 0.5 mL ampoule and 5 mL vial Name of Drug Dosage Forms and Strengths Cholera Vaccine - Injection, 1.5 mL, 5 mL, 10 mL and 50 mL in ampoule or vial Hepatitis B Vaccine - Injection, 0.02 mg/mL in 0.5 mL, 1 mL vial Meningococcal Vaccine - Injection powder for reconstitution in multidose vials of 0.5 mg, 2.5 mg Rabies Vaccine (inactivated, prepared in cell culture) - Injection, 1 mL ampoule Typhoid Vaccine (Vi antigen) - Injection, 0.5 mL/syringe, 10 mL/vial (20 doses) 25 mL/vial (50 doses) Typhoid Vaccine (TAB) - Injection, 1.5 mL/vial Yellow Fever Vaccine - Injection powder for reconstitution, 1, 5 and 10 dose vial Name of Drug Dosage Forms and Strengths Acyclovir - Eye Ointment, 3.0% Page 25 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 21.2 Anti-inflammatory and Anti-allergic Drugs 21.3 Local Anaesthetics 21.4 Miotics and Antiglaucoma Drugs 21.4.1 Topical Drugs 21.4.2 Systemic Drugs 21.5 Mydriatic Drugs 21.6 Diagnostic Eye Drug Chloramphenicol - Eye Drops, 0.5% - Eye Ointment, 1.0% Gentamicin - Eye Drops, (sulphate), 0.3% - Eye Ointment, (sulphate), 0.3% Idoxuridine - Eye Drops, 0.1% - Eye Ointment, 0.5% Miconazole - Injection, 10 mg/mL - Eye Drops, 1% Oxytetracycline plus Polymyxin B - Eye Ointment, Oxytetracycline hydrochloride, 5 mg plus Polymyxin B (sulphate) 10,000 Units Name of Drug Dosage Forms and Strengths Antazoline - Eye Drops, (hydrochloride), 0.5 mg; Tetrahydrozoline hydrochloride 0.4 mg, Methylhydroxypropylcellulose Prednisolone - Eye Drops, 1% (acetate), 5% (sodium phosphate) Name of Drug Dosage Forms and Strengths Amethocaine - Eye Drops, (hydrochloride), 0.5%, 1% Name of Drug Dosage Forms and Strengths Pilocarpine - Eye Drops, (hydrochloride), 1%, 2%, 3%, 4% Timolol - Eye Drops, (maleate), 0.25%, 0.5% Name of Drug Dosage Forms and Strengths Acetazolamide - Tablet, 250 mg - Injection, 500 mg/vial Name of Drug Dosage Forms and Strengths Homatropine - Eye drops, (hydrobromide), 1%, 2% Phenylephrine - Eye drops, (hydrochloride), 0.25%, 0.5%, 2.5%, 10% Tropicamide - Eye drops, 0.5%, 1% Name of Drug Dosage Forms and Strengths Page 26 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 21.7 Miscellaneous Eye Preparations 22. OXYTOCICS AND TOCOLYTICS 23. PERITONEAL DIALYSIS SOLUTIONS 24. PREPARATIONS FOR CORRECTING WATER, ELECTROLYTE AND ACID-BASE DISTURBANCES 24.1 Oral Preparations 24.2 Parenteral Preparations Fluorescein Sodium - Eye drops, 1%, 2% - Eye strips Name of Drug Dosage Forms and Strengths Methylcellulose - Eye drops, 1%, 2% Name of Drug Dosage Forms and Strengths Ergometrine - Tablet, (maleate), 0.5 mg - Injection, (maleate), 0.5 mg/mL Oxytocin - Injection, 5 Units, 10 Units/mL in ampoules Salbutamol - Tablet, (sulphate), 2 mg, 4 mg - Injection (sulphate), 500 micrograms/mL, 1 mg/mL - Syrup, (sulphate), 2 mg/5 mL Name of Drug Dosage Forms and Strengths Intraperitoneal Dialysis Fluid B.P.C - Parenteral Solution Composition/litre of solution: Calcium chloride, 0.22 g Dextrose, (anhydrous), 17.0 g Magnesium chloride, 0.152 g Sodium acetate, 4.76 g Sodium chloride, 5.56 g Sodium metabisulphate, 0.15 g Haemodialysis Fluid - Haemodialysis Fluid B.P. Name of Drug Dosage Forms and Strengths Oral Rehydration Salts - See 18.6.2 Potassium chloride - Tablet, slow release, 600 mg - Oral solution, 5%, 10%, 20% Name of Drug Dosage Forms and Strengths Darrow’s solution - Injection, B.P., Half Strength, Full Strength Glucose - Injection, 5%, 10%, 50% in water Glucose plus Sodium chloride - Injection, 4.3% plus 0.18% respectively; 5.0% plus 0.9% respectively Page 27 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 25. PSYCHOTHERAPEUTIC DRUGS 25.1 Hypnotics and Sedatives 25.2 Tricyclic Antidepressants 25.3 Antipsychotics (Major Tranquilizers) 25.4 Antidotes to Antipsychotic Drugs Mannitol - Injection, 10%, 20% Potassium chloride - Injection, Strong, 15% in 10 mL ampoule Ringer’s solution - Injection, B.P. Sodium bicarbonate - Injection, (isotonic), 1.4% in 10 mL ampoule Sodium chloride - Injection, Normal Strength, 0.9%; ½ Normal Strength, 0.45% Sodium lactate compound solutions - Injection, Solutions B.P. Water for Injection - Injection, 2 mL, 5 mL, 10 mL, 20 mL, 50 mL ampoule/vial Name of Drug Dosage Forms and Strengths Diazepam - Tablet, 2 mg, 5 mg, 10 mg - Syrup, 2 mg/5 mL - Injection, 5 mg/mL in 2 mL ampoule Lorazepam - Tablet, 1 mg, 2.5 mg Nitrazepam - Capsule, Tablet, 5 mg Name of Drug Dosage Forms and Strengths Amitriptyline - Tablet, (hydrochloride), 25 mg, 50 mg Imipramine - Tablet, (hydrochloride), 10 mg, 25 mg Name of Drug Dosage Forms and Strengths Chlorpromazine - Tablet, (hydrochloride), 25 mg, 50 mg, 100 mg - Syrup, (hydrochloride), 25 mg/5 mL - Injection, (hydrochloride), 25 mg/mL in 2 mL ampoule Flupenthixol - Tablet, (decanoate), 1.5 mg, 3 mg - Injection, (oily), (decanoate), 20 mg/mL Fluphenazine - Injection, (decanoate or enanthate), 25 mg/mL in 1 mL ampoule Haloperidol - Tablet, 2 mg, 5 mg, 10 mg - Injection, 2 mg/mL, 5 mg/mL, 50 mg/mL, 100 mg/mL - Drops, (oral), 2 mg/mL, 10 mg/mL Name of Drug Dosage Forms and Strengths Benzhexol (trihexyphenidyl) - Tablet, (hydrochloride), 2 mg, 5 mg Biperiden - Tablet, (hydrochloride), 2 mg - Injection, (lactate), 5 mg/mL Page 28 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 26. RESPIRATORY SYSTEM DRUGS 26.1 Anti-asthmatic Drugs 26.2 Antitussives, Expectorants and Mucolytics 27. VITAMINS AND MINERALS 27.1 Vitamins Name of Drug Dosage Forms and Strengths Epinephrine (Adrenaline) - Injection, (bitartrate or hydrochloride), 1 mg/mL (1 in 1000) in 1 mL ampoule Aminophylline - Tablet, 100 mg, 200 mg - Injection, 25 mg/mL in 10 mL ampoule Beclomethasone - Aerosol inhalation, (diprioponate), 0.05 mg/metered dose Hydrocortisone - Injection, (sodium succinate), 100 mg/vial Salbutamol - Tablet, (sulphate), 2 mg, 4 mg - Syrup, (sulphate), 2 mg/5 mL - Aerosol inhalation, 0.1 mg/metered dose - Injection, (sulphate), 500 micrograms/mL Name of Drug Dosage Forms and Strengths Dextromethorphan hydrobromide - Syrup, 15 mg per 5 mL Name of Drug Dosage Forms and Strengths Ascorbic Acid (Vitamin C) - Tablet, 100 mg, 200 mg, 500 mg - Effervescent Tablet, 1 g - Syrup, 100 mg, 200 mg, 500 mg/5 mL, respectively Cyanocobalamin (Vitamin B12) - Tablet, 0.05 mg - Injection, 0.25 mg/mL, 1 mg/mL, in ampoules (Injection hydroxycobalamin preferred) Ergocalciferol - Capsule, Tablet, 0.25 mg (10,000 Units), 1.25 mg (50,000 Units) - Oral solution, 0.25 mg/mL Folic acid - Tablet, 5 mg Pyridoxine (Vitamin B6) - Tablet, (hydrochloride), 10 mg, 20 mg, 50 mg Retinol (Vitamin A) - Capsule, Tablet, 1.5 mg, 7.5 mg, 15 mg (5,000 Units, 25,000 Units, 50,000 Units), respectively Riboflavine (Vitamin B2) - Tablet, 5 mg Thiamine (Vitamin B1) - Tablet, (hydrochloride), 25 mg, 50 mg Vitamin B Complex - Capsule, Tablet, Syrup Various safe combinations are acceptable (see Appendix 1 for the approved strengths of various vitamins) - Injection, (see Appendix 1) Page 29 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 27.2 Minerals VI. THE PRIMARY HEALTH CARE LIST LEVEL A FOR HEALTH CENTRES Name of Drug Dosage Forms and Strengths Calcium salts - Tablet, (gluconate), 600 mg Sodium fluoride - Tablet, 2.2 mg provides approximately 1 mg of fluoride ion ANAESTHETICS, LOCAL - Lidocaine, Topical, Injection ANALGESICS - Acetylsalicylic Acid, Tablet. NOT FOR CHILDREN - Paracetamol, Tablet, Syrup ANTI-ALLERGICS - Epinephrine (Adrenaline), Injection - Chlorphenamine, Tablet, Syrup - Promethazine, Tablet, Syrup ANTIDOTES - Atropine, Injection - Charcoal, (activated) powder ANTICONVULSANTS - Diazepam, Injection - Paraldehyde, Injection - Phenobarbitone, Tablet ANTI-INFECTIVE DRUGS - (a) Amoebicide - Metronidazole, Tablet (b) Anthelmintics - Mebendazole, Tablet - Praziquantel, Tablet - Pyrantel, Tablet, Syrup (c) Antifilarial Drug - Diethylcarbamazine, Tablet (d) Antimalarials - Chloroquine, Tablet, Syrup, Injection - Pyrimethamine, Tablet - Pyrimethamine plus sulphadoxine, Tablet, Syrup - Quinine, Tablet, Injection (e) Antibacterial Drugs - Amoxicillin - Benzathine Penicillin, Injection - Benzylpenicillin, Injection - Co-trimoxazole, Tablet, Syrup - Chloramphenicol, Injection (use under supervision) - Erythromycin, Tablet - Gentamicin, Injection - Nalidixic acid, Tablet - Phenoxymethyl Penicillin, Tablet - Procaine Penicillin, Injection - Streptomycin, Injection - Tetracycline, Capsule Page 30 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. NOT FOR CHILDREN AND PREGNANT WOMEN (f) Antileprosy and Anti- tuberculosis Drugs - Clofazimine, Capsule - Dapsone, Tablet - Rifampicin, Capsule or Tablet - Thiacetazone + Isoniazid, Tablet - Pyrazinamide, Tablet ANTISEPTICS AND DISINFECTANTS - Benzoin, Compound Tincture - Chlorhexidine, Solution - Iodine, Solution - Methylated Spirit, Solution - Sodium Hypochlorite, Solution DRUGS AFFECTING THE BLOOD - Ferrous salts, Tablet, Mixture - Folic acid, Tablet DERMATOLOGICAL DRUGS - Benzoic Acid + Salicylic Acid, (Whitfield’s), Ointment - Benzyl benzoate, Emulsion - Benzoyl peroxide, Cream or Gel - Calamine, Lotion - Methyl salicylate, Ointment - Neomycin + Bacitracin, Ointment, Powder - Nystatin, Ointment, Cream - Zinc oxide, Ointment DIAGNOSTIC AGENT - Tuberculin PPD, Injection EAR, NOSE AND THROAT DRUGS - Chloramphenicol, Ear Drops GASTRO-INTESTINAL DRUGS - Betamethasone plus Lidocaine, Ointment, Cream, Suppository - Hyoscine N-butylbromide, Tablet - Magnesium trisilicate Compound, Tablet, Mixture - Oral Rehydration Salts - Propantheline bromide, Tablet - Senna, Tablet HORMONES AND SYNTHETIC SUBSTITUTES - Barrier Methods, Condoms with or without Spermicide - Oral Contraceptives, Tablet IMMUNOLOGICALS - Anti-rabies Serum, Injection - Anti-snake bite serum, Injection - Anti-tetanus serum, (ATS), Injection - B.C.G. Vaccine, Injection - D.P.T. Vaccine, Injection - Measles Vaccine - Poliomyelitis Vaccine, oral suspension - Tetanus vaccine, Injection OPHTHALMOLOGICAL DRUGS - Chloramphenicol, Eye Drops, Ointment Page 31 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. LEVEL B FOR VILLAGE DISPENSARIES (HEALTH WORKERS) - Chlortetracycline Eye Ointment OXYTOCIC - Ergometrine, Tablet, Injection PSYCHOTHERAPEUTIC DRUG - Chlorpromazine, Injection RESPIRATORY SYSTEM DRUGS - Beclomethasone, Inhaler - Salbutamol, Tablet, Inhaler VITAMINS AND MINERALS - Ascorbic Acid, (Vitamin C), Tablet - Calcium Salts, Tablet - Calcium Gluconate, Injection - Folic acid, Tablet - Vitamin A, Capsule - Water for Injection, Injection DRESSING AND MEDICAL DEVICES - Absorbent Gauze Bandages Cotton Wool (Absorbent) - Disposable Gloves, Disposable Syringes, 5 cc. with needles (19, 21 guage) - Disposable Syringes, 2 cc. with Needles (19, 21 gauge) - Spatula Acetylsalicylic acid (Aspirin) - Tablet, NOT FOR CHILDREN Paracetamol - Tablet, Syrup Chloroquine - Tablet, Syrup Pyrantel - Tablet, Syrup Ferrous Salts - Tablet Folic acid - Tablet Sulphadimidine - Tablet Condoms - Barrier Method Calamine Lotion - Lotion Benzyl benzoate - Emulsion Methyl salicylate - Ointment Salicylic acid + Benzoic acid (Whitfield’s) - Ointment Chlorhexidine - Solution Iodine - Tincture Methylated spirit - Solution Absorbent gauze - Dressing Cotton wool/Crepe bandages - Dressing Zinc oxide plaster - Dressing Clinical Thermometer - Surgical blades - Plastic aprons - Page 32 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. VII. LIST OF PRODUCTS TO BE STOCKED AND SOLD BY PATENT MEDICINE DEALERS/VENDORS (1) Analgesics and Antipyretics (a) Acetylsalicylic acid (Aspirin) Capsules/Tablets, 300 mg; Capsules/Tablets - 300 mg (b) Paracetamol Capsules/Tablets/Syrup/Suspension Capsules/Tablets - 125 mg (Paediatric), 500 mg (Adults) Syrup/Suspension - 125-mg/5 mL (60 mL, 100 mL packs) (c) Ibuprofen Capsules/Tablets - 200 mg, 400 mg (2) Non-specific (General) Antidotes: (a) Charcoal, Activated Powder/Granules/Tablets Powder/Granules, 5 mg/Sachet Tablet, 1 g (3) Anthelmintics (a) Levamisole - Tablets/Syrup Tablets, 40 mg Syrup, 40-mg/5 mL (b) Pyrantel Tablets/Syrup Tablets, 125 mg Syrup, 125-mg/5 mL (4) Antimalarials (a) Chloroquine Capsules/Tablets/Syrup Capsules/Tablets, 50 mg base (Paediatric) Page 33 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 150 mg (Adult) (b) Pyrimethamine, 25 mg plus Sulphadoxine 500 mg Tablets/Syrup (per 5 mL) (c) Pyrimethamine Tablets, 12.5 mg, 25 mg (5) Antiseptic and Disinfectant Solutions: (a) Benzoin compound tincture (b) Cetrimide plus chlorhexidine solution, 15% plus 1.5% respectively for dilution (c) Chlorhexidine gluconate solution 5% (for dilution) (d) Chloroxylenol 5% solution (for dilution) (e) Dichloroxylenol plus Chlorophenol soap/solution (f) Iodine solution, 30 mL, 60 mL (g) Methylated spirit, 50 mL, 100 mL (h) Sodium hypochlorite (1 - 10%), 250 mL, 500 mL (6) Anti-anaemia Drugs (a) Ferrous salts - Capsules/Tablets (As fumarate, gluconate, sulphate, succinate) (b) Ferric ammonium citrate mixture, 400 mg/5 mL (c) Folic acid, tablet, 5 mg (7) Mouthwashes (a) Hexetidine solution, 0.1% (8) Dermatological (Anti-infective Drugs) (a) Gentian violet tincture, 1% (b) Silver sulphadiazine cream, 1% (c) Sulphur plus Mesulphen ointment (Sulphur 10 - 20% plus Mesulphen 64%) (9) Antipruritic and Astringent Drugs (a) Calamine lotion (b) Calamine plus Zinc oxide - Lotion/Plaster Page 34 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. (10) Rubefacients and Inhalers (a) Methyl salicylate compound preparations: Balms, Creams, Embrocations, Liniments, Rubs, Ointments, Oils and Inhalers. (11) Dusting Powder Zinc, starch and talc dusting powder with or without menthol (12) Fungicides: (a) Benzoic acid (6%) plus Salicylic acid (3%) - Ratio 2:1, Cream, Ointment (b) Clotrimazole Cream, ointment, 1% Aerosol spray, 1% Dusting powder, 1% (c) Selenium sulphide shampoo, 2.5% (13) Keratolytic and Keratoplastic Drugs (a) Coal tar Solution/Ointment Coal tar solution B.P. Coal tar ointment U.S.P. (b) Dithranol ointment, 0.1 - 2% (c) Salicylic acid, Ointment/Solution Ointment, 2.5% Solution, 12% in flexible collodion (14) Scabicides and Pediculicides: (a) Benzyl benzoate emulsion, 25% (b) Monosulfiram solution/soap, 25% (15) Throat Antiseptic Preparations Page 35 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. (a) Dequalinium hydrochloride (250 mg) Lozenges (b) Domiphen bromide (0.5 mg) (c) Hexetidine mouthwash/gargle, 0.1% (d) Menthol plus Eucalyptus Oil plus Camphor plus Thymol (0.207% plus 0.069% plus 0.0007% plus 0.0007% respectively) Lozenges (e) Menthol plus ascorbic acid plus hydrous citric acid (0.09% plus 2.9412% plus 0.8332 respectively) Lozenges (16) Antacid Drugs (a) Magnesium trisilicate mixture - 100 mL; 200 mL (b) Magnesium trisilicate compound tablets (c) Aluminium hydroxide, Mixture/Tablet (17) Purgative Drugs (a) Magnesium hydroxide mixture (Hydrated magnesium oxide, 550 mg/10 mL) (b) Magnesium sulphate - Granules/Sachets/Mixture Granules/Sachet, 5 g, Mixture, 4 g/10 mL (c) Senna - Granules/Tablets (18) Anti-diarrhoeal Drugs (a) Oral rehydration salts (19) Contraceptives (a) Condoms (b) Foaming Tablets (20) Vitamins, Minerals and Nutritionals: (a) Ascorbic acid (Vitamin C) - Tablets Tablets, 100 mg Ascorbic acid (Vitamin C) Syrup 100 mg per 5 mL (b) B Complex Vitamins - Capsules/Tablets/Syrup Page 36 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. (c) Cod liver oil - Capsules/Syrup (d) Multivitamins - Capsules/Tablets/Syrup/Drops (e) Calcium salts (i) Calcium gluconate - Tablets, 600 mg (ii) Calcium lactate - tablets, 300 mg (f) Folic acid, Tablet, 5 mg (g) Glucose - powder for oral use (21) Dressings (a) Absorbent Gauze (b) Cotton/Crepe bandages (c) Cotton Wool (d) Elastic Plaster Dressings. VIII. CHANGES MADE IN REVISING THE LIST Appendix 1 Approved Doses for Vitamins Vitamins Age/Physiological State Daily Dosage Vitamin A Children 1,500 - 5,000 Units Adults 5,000 - 10,000 Units Pregnancy 5,000 - 6,000 Units Lactation 5,000 - 10,000 Units Deficiency 25,000 - 50,000 Units Vitamin B1 (Thiamine) Children 0.3 - 1 mg Adults 1 - 1.3 mg Deficiency: - (a) Children 5.0 - 50 mg (b) Adults 200 - 300 mg Vitamin B2 (Ribiflavine) Children 1.0 - 1.8 mg Adults 0.3 - 1 mg Deficiency: - (a) Adults 5.0 - 30 mg Vitamin B6 (Pyridoxine HCl) Children 0.3 - 0.6 mg Adults 1.0 - 2.0 mg Deficiency: - (a) Children 20 - 50 mg (b) Adults 50 - 400 mg Page 37 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. Footnote: - Formulations containing various specified amounts of vitamins are accepted provided the formulations satisfy the vitamin requirements of the age and the physiological state of the intended user. Appendix 2 Restricted List of Drugs ESSENTIAL DRUGS LIST FOURTH REVISION 2003 Vitamin B12 (Cyanocobalamin) Children 0.3 - 2 micrograms Adults 2.0 - 3.0 micrograms Deficiency: - (a) Adults 50 - 1,000 micrograms Vitamin C (Ascorbic Acid) Children 50 - 200 mg Adults 250 - 1,000 mg Folic Acid Children 40 - 200 micrograms Adults 200 - 5,000 micrograms Vitamin D (Cholecalciferol) Children 2.5 - 5 micrograms Adults 25 - 50 micrograms Vitamin E Children 3.0 - 15 mg Adults 50 - 200 mg Deficiency: - (a) Children 1,000 - 2,000 mg Biotin Adults 100 - 300 mg Nicotinamide Adults 15 - 30 mg (Prophylaxis) Deficiency: - (a) Adults 50 - 250 mg (Therapeutic) Pantothenic Acid Children 0.5 - 3.5 mg Adults 1.0 - 7 mg Name of Drug Dosage Forms and Strengths 2.2 Narcotic Antagonists (Drugs for Treatment of Opioid Dependence) Methadone - Tablet, 5 mg 6.6 Antimalarial Drugs Halofantrine - Tablet, (hydrochloride) 250 mg Syrup, 100 mg/5 mL 6.8 Antibacterial Drugs Azithromycin - Capsule, 250 mg - Capsule, Tablet, 200 mg Ofloxacin - Injection, IV, 100 mg/50 mL, 200 mg/100 mL 6.11 Systemic Antifungal Drugs Terbinafine - Tablet, (hydrochloride), 250 mg 6.13 ARVs Supplementary List Stavudine plus Lamivudine plus Nevirapine - FIRST LINE Page 38 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. Didanosine - SECOND LINE Tablet, 100 mg, 150 mg, 200 mg Ritonavir plus Lopinavir (RTV-LPV) - SECOND LINE - ALTERNATIVE (OR THIRD LINE) Capsule, Ritonavir, 33.3 mg plus Lopinavir 133.3 mg - Oral solution, Ritonavir, 100 mg plus Lopinavir, 400 mg/5 mL Efavirenz - Capsule, 50 mg, 100 mg 8. ANTINEOPLASTIC AND IMMUNOSUPPRESSIVE DRUGS Stilboestrol - Tablet, 0.5 mg, 1 mg, 5 mg, 25 mg 11.1 Antianaemia Drugs Iron dextran - Injection equivalent to 50 mg iron/mL, in 2 mL ampoule 12.4 Medicines Used in Heart failure Dopamine - Injection (hydrochloride), 40 mg/mL in 5 mL vial 14.2 Anti-inflammatory and Antipruritic Drugs Clobetasol - Cream, Ointment, (propionate), 0.05% Fluocinolone - Cream, Ointment (acetonide), 0.025% 14.8 Sunscreen Agents Aminobenzoic acid - Lotion, 5% - Cream, 5% - Paste, 5% Titanium dioxide - Cream, 20 -25% - Paste, 20 - 25% 15.1 Gastric Function Corticotrophin - Injection (tetracosactide), 250 ug (acetate)/mL - Injection (aqueous suspension), tetracosactide 1 mg (acetate)/mL with Zinc phosphate complex Histamine phosphate - Injection, 2.75 mg/mL in ampoule Pengrastrin - Injection, 0.25 mg/mL ampoule 15.2 Myasthenia Gravis Edrophonium - Injection, (chloride), 10 mg/mL 15.6 Diagnostic Agents For Endocrine Disorders Luteinizing Hormone - Releasing Hormone (LH-RH) - Injection, 0.1 mg/mL in 1 mL ampoule Metyrapone - Capsule, Tablet, 250 mg Thyrotrophin Hormone (TRH) - Injection, 0.2 mg/mL 19.1 Corticosteroids and Synthetic Substitutes Fludrocortisone - Tablet, 0.1 mg Methylprednisolone - Injection, (acetate), 40 mg/mL in 1 mL, 2 mL & 5 mL vials Triamcinolone - Injection, (acetonide), 10 mg/mL, 40 mg/mL, IM, IA, ID Page 39 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2. 19.2 Oestrogens/Androgens Mesterolone - Tablet, 25 mg Testosterone - Injection, 200 mg in 1 mL Stilboestrol - Tablet, 0.5 mg, 1 mg, 5 mg, 25 mg 19.6 Drugs Acting on Pituitary Ovarian Axis Chorionic Gonadotrophin - Injection powder, 500 Units, 1000 Units, in ampoule Danazol - Capsules, 100 mg, 200 mg Epimestrol - Tablet, 5 mg Follicle-Stimulating Hormone (FSH) plus Luteinizing Hormone (LH) - Injection powder for reconstitution, human FSH, 75 Units plus human LH, 75 Units 19.8 Antidiuretic Hormones Desmopressin - Injection, 4 micrograms/mL - Nasal Spray, 10 micrograms/metered spray - Intr-nasal solution, 100 micrograms/mL Vasopressin - Injection, 20 units/mL in 1 mL ampoule 25.3 Antipsychotics (Major Tranquillizers) Fluoxetine - Capsule, 20 mg - Oral solution, 20 mg/5 mL Lithium carbonate - Capsule, Tablet, 300 mg Pimozide - Tablet, 4 mg, 10 mg Page 40 of 40img.html 2007-05-17file://J:\DivData\ALLDOCS\MoniqueRenevier\EMLs from countries\Nigeria\EDL_2.

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