PATH & WHO & UNFPA Workshop 8 - Sampling and Acceptable Quality Limits

Publication date: 2008

Session 8: Sampling and Acceptable Quality Limits (AQL) Objectives • Understand what you can infer from sample testing • Understand how to choose a sample size and make inferences about the finished product from ISO 2859-1 • Learn options for conducting and interpreting sample tests during production What is Statistics? • Set of techniques for reducing large quantities of numerical data to a size and form which can be interpreted • Provides formal rules for interpretation • Intuitive interpretation may be done from summary statistics or graphs Why Statistics Are Important • The acceptability of your finished product is assessed by testing a sample • Testing samples during production ensures good quality and helps eliminate waste • Sampling approach based on production stage Statistics, Certification, and Prequalification • Under ISO 13485, Clause 8, factories must collect and analyze appropriate data for: – Conformity to requirements – Trends in production – Opportunities for corrective action Why Do Sampling and Not 100% Testing? • Many tests are destructive, so 100% testing is impossible • Testing is costly • Testers get bored and lose concentration Statistics in Acceptance Testing How statistical concepts are used in ISO 4074 What is the Aim of the Tests in ISO 4074? • Purchasers must accept a small proportion of noncomplying condoms because no manufacturer can make perfect condoms • The standard limits the proportion of noncomplying condoms to: - 1.5% for inflation - 0.25% for holes • These limits are called the AQL Acceptable Quality Limit (AQL) • MAXIMUM acceptable proportion defective in production process (specified in ISO 4074 for each test) • Frequency of lot rejections increases as process average exceeds AQL • Manufacturers expected to make the process average as low as possible • (The process average is the long term average proportion defective) How Are the Tests Assessed? • The test for holes inherently an attributes test • The inflation test is turned into an attributes test • Sample sizes and pass/fail limits can be calculated BUT • Most people use tables in standards, especially ISO 2859-1 Example Using the Holes Test • Do our condoms pass the holes test? • Postulate “null hypothesis” that condoms just meet the requirements • Calculate the probability of finding 0, 1, 2, 3, 4…….holes • If the probability of finding more than x holes is less than (say) 5%, and you find more than x holes, then sufficient to say the lot fails Sampling Example • There’s a box with 100 things in it • You can’t see into the box, but you can reach in • Some of the things are red; some are white • You reach in and take ten things out randomly • What will you get? Sampling Example                                                                                                     Sampling Result Could be any of:                               • All white OR • All red OR • OR any number of red things between 2 and 9 • The most likely outcome is: 1 red one and 9 white ones • But the result may or may not be indicative of the what’s in the box Sampling “Error” • The smaller the sample, the more “fuzzy” the result • Can reduce risk of “error” by using larger sample • From the binomial distribution, you can calculate the sample size needed to give any chosen risk of rejecting a marginal batch, and of accepting a batch that has a given level of defects Possible Outcomes of Sample Test Test result ► Product ▼ Sample passes (accept hypothesis) Sample fails (reject hypothesis) Product is good Correct decision Type 1 or α error Product is bad Type 2 or β error Correct decision Questions? Ways to Choose Sampling Plans • Do a calculation based on Type 1 and Type 2 error risks • Use ISO 2859–1 • Use ISO 2859–2 (receipt testing) • Use ISO 2859–3 (skip-lot schemes) • Choose custom scheme • ISO 2859–1 is most commonly used Sampling in Practice • Use standards for sample sizes and accept/reject criteria (ie don’t do the maths yourself) • For attributes testing, ISO 2859-1 is commonly used for final release inspection • Generally requires 95% to 99% certainty that the product is bad before rejecting it Sampling Choices • How certain do we need to be that an accepted batch really is good? – This determines the “inspection level” – ISO 2859–1 allows seven levels – ISO 4074 stipulates inspection levels for each test • ISO 4074 requires use of ISO 2859-1 More Sampling Choices… • Which method of sampling do we want? • Single, double, or multiple? • Do we use normal, tightened, or reduced sampling? Inspection Levels • Three levels for general use: – GII: default choice – GIII: for critical defects – GI: if cost dictates • Four “special” levels: S1 to S4 – Use these for less important properties Single, Double, or Multiple Sampling? • Overall outcome is the same • Multiple sampling requires fewest samples; single requires most • With very good or very bad batches, multiple sampling requires very few samples • With marginal batches, multiple requires the most samples • Single sampling is simplest to implement; double, next; multiple, most complex Normal, Tightened, or Reduced? • Sampling starts with normal sampling • If two out of any five consecutive batches fail, ISO 2859–1 REQUIRES a change to tightened inspection • After five batches in a row pass, then you can switch back to normal inspection • These switches are mandatory Normal, Tightened, or Reduced? (continued) • You MAY implement reduced sampling if the sampling score is >30: • Normally this means ten consecutive batches have passed on normal inspection one step tighter than required, and production sampling is continuous • If a batch fails, or if production becomes irregular, then you must switch back to normal sampling Steps for Using ISO 2859–1 • Know the AQL for the test • Choose the inspection level or follow product standard or specification • Know the batch size • Go to the first table and get the code letter • Decide on single, double, or multiple • Look at the test history to decide on normal, tightened, or reduced • Go to the appropriate table to find sample size and pass/fail numbers Effectiveness of Sample Testing • Very bad batches will most likely be rejected • Good batches will most likely be accepted • Marginally unacceptable batches are more likely to be accepted than rejected • BUT – if you are operating at, say 1.5 times the AQL, you can expect say 10% percent rejections Passing the Tests • If the process average equals the AQL, 1 lot in 20 to 1 in 100 will be rejected • To ensure that products are almost never rejected due to chance, the process average should be 0.3 times the AQL Questions? Small Group Exercise In-Process Testing Why Test During Production? • As condoms move through production, investment in them grows • Good to identify problems early in the process • Better to get information by sublot and take corrective action if needed Attributes and Variables Tests • The tests in ISO 4074 are all attributes tests • Information is lost in transforming data for assessment on the basis of variables Attributes and Variables Tests (continued) • Attributes tests good for regulatory purposes • Loss of data usually means larger samples • For manufacturing purposes, use of the actual data (variables) yields more information from smaller sample size • ISO 3951: sampling by variables Approaches to Using Variables in Manufacturing • Use ISO 3951 Two variants: - The s method - The sigma (σ) method • Use control charts (also good for attributes) ISO 3951 • Analogous to ISO 2859–1 • Uses same AQLs • Uses same inspection levels • Uses similar switching rules • Relies on normal or near-normal distribution • Variants – s method: if the process SD is not known – Sigma (σ) method: if the process SD is known Using ISO 3951 • Establish acceptability limits • Know your sublot size • Select your sampling level • Find the sample size • Calculate the quality statistics • Look at limits in ISO 3951 tables Using ISO 3951: Sample Size ISO 3951: s Method Normal Use of ISO 3951 • Use s method (simpler, fewer assumptions) • Remember assumption of normality • Acceptability limits must be determined • Even if not used, gives a good guide to sample size for control charts Control Charts • A simple, visual method of keeping track of product quality • You plot mean and SD results (or number of holes) as a function of time (or sublot) • You establish warning and action levels in advance • You observe the control chart for trends Control Charts (continued) • Proven for reducing scrap rate • Effective for defect prevention • Prevents unnecessary process adjustments • Provides diagnostic information • Shows stability of important parameters over time • Easy to draw in spreadsheets Types of Control Charts • Shewhart control chart – Checks on whether process is in statistical control • Acceptance control chart – Uses accept/reject • Adaptive control chart – Employs predictive methods to vary process conditions Data Plotted in Control Charts • Mean • Range • Standard deviation • Proportion or percent • Counts, counts per unit, etc. • Quality scores Basic Volume Control Chart Mean Volume Control Chart 0 5 10 15 20 25 30 35 40 45 50 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 Bin No V o l u m e ( L ) Volume SD Control Chart Volume SD Control Chart 0 1 2 3 4 5 6 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 Bin No V o l u m e ( L ) Volume Control Chart With Action Limits Mean Volume Control Chart 0 5 10 15 20 25 30 35 40 45 50 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 Bin No V o l u m e ( L ) Volume Control Chart With Warning and Action Limits Mean Volume Control Chart 0 5 10 15 20 25 30 35 40 45 50 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 Bin No V o l u m e ( L ) Volume SD Control Chart With Warning & Action Limits Volume SD Control Chart 0 1 2 3 4 5 6 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 Bin No V o l u m e ( L ) Control Chart for Holes Control Chart for Holes 0 1 2 3 4 5 1 3 5 7 9 11 13 15 17 19 21 23 25 27 29 Bin No H o l e s Interpreting Control Charts • Needs to be adapted to the process and the chart • Typical rules—take action if: – 1 or more points outside the action limit – A run (~7 points) trending towards limit – 2 of 3 consecutive points outside warning limit – 4 of 5 consecutive points beyond 1σ limit – Anything else unusual Setting Limits for Variables and Attributes • Limits in examples were 2σ for warning, 3σ for action - σ refers to SD of means • Other limits may be appropriate in some circumstances • Limits for SD are best set by experience • The wider the limits, the more tolerant the control Other Techniques • Add moving average to control charts • Construct control chart using only moving average • Use a cumulative sum (CUSUM) control chart • Looks at totals over a run of bins • Can detect relatively small shifts in process average much earlier than Shewhart charts Small Group Exercise Session 8 Handout 1 Statistics Session Group Exercise 1. In the final release test for holes, a factory tests 315 condoms per lot. The results for a series of lots are shown on the next page. Indicate which ones pass and which ones fail. 2. Examine the sampling tables, and describe the difference between normal and tightened inspections in terms of sample size and pass/fail limits. 3. A factory has a bin size of 9000. It wants to check on its product bin by bin before foiling, using ISO 2859-1 and the same inspection levels as in ISO 4074. The release batch size is 24 bins. • If they use single sampling, what are the sample sizes for holes and inflation and what are the pass/fail limits? • How many condoms per batch are tested in this process? How does it compare with final release testing? • As a result of technical improvements, they were able to raise the speed of the machine, and the bin size was raised to 11,000 (the batch is still 24 bins). What are the new sample sizes and pass/fail limits? 4. Repeat Question 3, using a double sampling plan. 5. Use the tables and graphs in ISO 2859-1 to estimate the probability that a sample with 1 percent holes will be accepted for both the bin sizes above and for the whole batch. The tables and graphs you need are located after the multiple sampling tables and are organized by sample size. 6. Return to Question 3 and use the tables from ISO 3951 to see what the sample size would be if we were using the s method for inflation. The WHO Prequalification Programme for Condoms: 1 A Workshop for Male Latex Condom Manufacturers Session 8 Handout 1 The WHO Prequalification Programme for Condoms: A Workshop for Male Latex Condom Manufacturers 2 Lot No. Holes Result? 9324591 1 9324592 0 9324593 1 9324594 2 9324595 1 9324596 3 9324597 2 9324598 1 9324599 2 9324600 3 9324601 2 9324602 1 9324603 0 9324604 1 9324605 2 9324606 1 9324607 0 9324608 1 9324609 1 9324610 1 9324611 2 9324612 1 9324613 2 9324614 1 9324615 1 9324616 0 9324617 1 9324618 0 9324619 3 9324620 2 9324621 2 9324622 1 9324623 2 9324624 3 9324625 2 9324626 1 9324627 1 9324628 1 9324629 0 9324630 1 9324631 0 9324632 2 Session 8 Handout 2 Overview of ISO 3951 Sampling Methods: s, Sigma, and R ISO 3951 • Analogous to ISO 2859-1. • Uses same AQLs. • Uses same inspection levels. • Uses similar switching rules. • Variants: – s method: if the process Standard Deviation (SD) is not known. – σ method: if the process SD is known. – R method: if the sample size is < 10. Using ISO 3951 1. Know your sublot size (e.g., 6000). 2. Select your sampling level (e.g., GI). 3. Find the sample size (depends on AQL for Φ method). 4. Establish acceptability limits. 5. Calculate the quality statistics. 6. Look at limits in ISO 3951 tables. Using the s Method 1. Determine the specification limits in advance. • There may be one or two, U and L. • Example: 45 and 20 L volume. 2. Test the sample. 3. Calculate the mean (x), the SD (s), and the “quality statistics” (QU and QL) as follows. 4. Compare QU and QL with the limits (k) given in the appropriate table of ISO 3951. • Both values must be greater than the value of k for the sample to be acceptable. Q U x s Q x L s x mean s SD U S = − = − = = The WHO Prequalification Programme for Condoms: 1 A Workshop for Male Latex Condom Manufacturers Session 8 Handout 2 The WHO Prequalification Programme for Condoms: A Workshop for Male Latex Condom Manufacturers 2 Using the Sigma Method • Use exactly the same method as for the s method, but use the sample size and tables for the σ method. • As σ, U, L, and k are known in advance, the only unknown is the mean. • Thus, for the upper limit, the sample is acceptable if the mean <U-k σ. Using the R Method Same as above method if sample <10 8a - Sampling and Quality Limits Session 8:��Sampling and �Acceptable Quality Limits (AQL) Objectives What is Statistics? Why Statistics Are Important Statistics, Certification, and Prequalification Why Do Sampling and Not 100% Testing? Statistics in �Acceptance Testing What is the Aim of the Tests in ISO 4074? Acceptable Quality Limit�(AQL) How Are the Tests Assessed? Example Using the �Holes Test Sampling Example Sampling Example Sampling Result Sampling “Error” Possible Outcomes of Sample Test Slide Number 17 Questions? Ways to Choose �Sampling Plans Sampling in Practice Sampling Choices More Sampling Choices… Inspection Levels Single, Double, or Multiple Sampling? Normal, Tightened, or Reduced? Normal, Tightened, or Reduced? �(continued) Steps for Using ISO 2859–1 Slide Number 28 Slide Number 29 Slide Number 30 Slide Number 31 Slide Number 32 Slide Number 33 Slide Number 34 Slide Number 35 Effectiveness �of Sample Testing Passing the Tests Questions? Small Group Exercise In-Process Testing Why Test During Production? Attributes and �Variables Tests Attributes and �Variables Tests (continued) Approaches to Using Variables in Manufacturing ISO 3951 Using ISO 3951 Using ISO 3951: Sample Size ISO 3951: s Method Normal Use of ISO 3951 Control Charts Control Charts (continued) Types of Control Charts Data Plotted in Control �Charts Basic Volume Control Chart Volume SD Control Chart Volume Control Chart With Action Limits Volume Control Chart With Warning and Action Limits Volume SD Control Chart�With Warning & Action Limits Control Chart for Holes Interpreting Control Charts Setting Limits for �Variables and Attributes Other Techniques Small Group Exercise 8b - H1 - Group Exercise 8d - H2 - Sampling Methods << /ASCII85EncodePages false /AllowTransparency false /AutoPositionEPSFiles true /AutoRotatePages /None /Binding /Left /CalGrayProfile (Dot Gain 20%) /CalRGBProfile (sRGB IEC61966-2.1) /CalCMYKProfile (U.S. Web Coated \050SWOP\051 v2) /sRGBProfile (sRGB IEC61966-2.1) /CannotEmbedFontPolicy /Error 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<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> /ENU (Use these settings to create Adobe PDF documents best suited for high-quality prepress printing. 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