Somalia Standard Treatment Guidelines and Training Manual on Rational Management and Use of Medicines at the Primary Health Care Level
Publication date: 2007
Somalia Standard Treatment Guidelines and Training Manual on Rational Management and Use of Medicines at the Primary Health Care Level Second edition These guidelines were produced in collaboration with the World Health Organization Somalia Standard Treatment Guidelines and Training Manual on Rational Management and Use of Medicines at the Primary Health Care Level Second edition WHO-EM/EDB/073/E Contents Foreword 7 Preface 9 Acknowledgements 13 Abbreviations 15 Part 1. Standard treatment guidelines Chapter 1. Bacterial infections 19 Meningitis 20 Pertussis 23 Tetanus 24 Typhoid fever 26 Chapter 2. Dental and oral diseases 29 Dental abscess 30 Dental caries 31 Periodontal disease 32 Chapter 3. Emergencies and trauma 35 Allergic shock 36 Bites 37 Bleeding 39 Burns 41 Convulsions 44 Fever 46 Fractures 48 Pain 49 Poisoning 50 Wounds 52 Chapter 4. Eye conditions 53 Conjunctivitis 54 Trachoma 56 Chapter 5. Gastrointestinal diseases 59 Diarrhoea and dehydration 60 Gastritis and peptic ulcer 74 Stomatitis 75 The mention of speciﬁc companies or of certain manufacturers’ products does not imply that they are endorsed or recommended by the World Health Organization in preference to others of a similar nature that are not mentioned. Errors and omissions excepted, the names of proprietary products are distinguished by initial capital letters. The World Health Organization does not warrant that the information contained in this publication is complete and correct and shall not be liable for any damages incurred as a result of its use. Design by Ahmed Salah Mostafa Printed by In Sight Graphics, Cairo, 2007 4 INTRODUCTION 5 Chapter 6. Nutritional disorders 77 Anaemia, iron deﬁciency 78 Micronutrient malnutrition 82 Pellagra (nicotinamide deﬁciency) 84 Protein–energy malnutrition 85 Moderate acute malnutrition 87 Severe acute malnutrition 89 Vitamin A deﬁciency (xerophthalmia) 92 Chapter 7. Obstetrics and gynaecology 95 Breast abscess 96 Breast infection 96 Cystitis 97 Postpartum haemorrhage 98 Sore nipples 99 Vaginal candidiasis 100 Chapter 8. Parasitic diseases 101 Amoebiasis 102 Ascariasis 103 Enterobiasis 104 Giardiasis 105 Hookworms 106 Kala-azar 108 Malaria 109 Schistosomiasis 118 Taeniasis 119 Trichuriasis 120 Chapter 9. Respiratory infections 123 Asthma 124 Bronchitis, acute 125 Bronchitis, chronic 126 Common cold 127 Otitis externa 128 Otitis media, acute 129 Otitis media, chronic 131 Tonsillitis 131 Pneumonia 132 Sinusitis, acute 136 Tuberculosis 137 Chapter 10. Syndromic management of sexually transmitted infections 147 Genital ulcer in men and women 148 Lower abdominal pain 150 Urethral discharge in men 152 Vaginal discharge 154 Summary treatment guideline 158 Chapter 11. Skin conditions 167 Abscess 168 Boils 169 Eczema 170 Herpes zoster 171 Impetigo 172 Ringworm 173 Scabies 174 Skin ulcer 176 Chapter 12. Viral infections 179 HIV/AIDS 180 Measles 195 Poliomyelitis 197 Viral hepatitis 198 Part 2. Training manual on rational management and use of medicines at the primary health care level Chapter 1. Health centre administration 203 Planning 204 Management 208 Chapter 2. Medicine management 213 Ordering and receiving of medicines 214 Storage and stock management of medicines 218 6 Good dispensing practices 225 Chapter 3. Rational use of medicines 229 Essential medicines concept 230 The Rational use of medicines 235 Use and misuse of injections and infusions 242 Non-medicine treatment 246 Making a diagnosis 251 The Rational use of tuberculosis medicines 258 Chapter 4. Medicine supervision guideline 261 How to investigate medicine use in health facilities 262 Annex 1 Somalia essential medicines list 2006 280 Foreword It is a great honour to write an introduction to this second edition of the manual, Somalia standard treatment guidelines and training manual on rational management and use of medicines at the primary health care level. The ﬁrst edition of this manual has been a major source of reference for many health workers in the ﬁeld since its publication in 1998. It has also been a useful tool to educate the Somali health professionals on the optimal use of medicines. Nine years after its publication, the WHO ofﬁce for Somalia is pleased to release an updated version of the manual in a pocket format—a request frequently made by the users. The essential medicines concept, fully and properly applied, can improve heath care and contribute to human development, but only if the medicines are of good quality, are safe, available, affordable and rationally used. It is close to 30 years since the inception of the concept of the essential medicines. Today, it is a universally accepted tool to lead people to better health with the available technology. More than 160 countries today have national essential medicine lists, while over 100 countries have national medicine policies in place or being developed. Access to essential medicines has grown from around 2 billion people in 1977 to close to 4 billion today. A concept which was associated with poor countries has now achieved wide recognition even among rich countries. Despite all the achievements, the concept still remains elusive to millions of people around the world, including for many Somalis. WHO studies show that irrational use of medicines, such as excessive use of antibiotics, overuse of injections, self-medication and the poor storage of pharmaceuticals, are major impediments to a healthy pharmaceutical sector—so is the case in Somalia. 8 WHO has taken the lead in improving the accessibility, optimal storage and proper use of medicines in Somalia. During the past few years, a large number of training courses have been held on essential medicines. WHO has rehabilitated and improved medicine warehouses in several parts of the country, including training of new staff. Access to vaccines and essential medicines, particularly in the areas of tuberculosis and malaria, has been improved. An essential medicines list covering both primary health care and hospital level, and a curriculum on the rational use of drugs at the primary health care level have been compiled. WHO could not have succeeded in all these activities without the full support, collaboration and interaction of the local health authorities, Somali health professionals, and other international organizations working in the health sector. WHO Somalia appreciates the time that many organizations and individuals took to share ideas, discuss their own practical experiences, and review drafts of these manuals. For all those who use it, we hope that this new edition of the manual, Somalia standard treatment guidelines and training manual on rational management and use of medicines at the primary health care level will continue to provide guidance to Somali health professionals on the optimal use of medicines. Dr Ibrahim Betelmal Former WHO Representative for Somalia, September 2006 Preface to the second edition Somalia standard treatment guidelines and training manual on rational management and use of medicines at the primary health care level has been written primarily for health professionals working in maternal and child health and outpatient facilities. However, the book will be of major help to any one working with medicines, particularly doctors, nurses and pharmacists working in hospitals as well as those in private clinics and pharmacies. Part 1: Somalia standard treatment guidelines describes the treatment aspects of diseases commonly encountered in Somalia. Each section consists of a short deﬁnition followed by common symptoms and signs of the disease, medicine treatment and prevention. The language is simple and is expected to pose no problems to the readers. This section is written in alphabetical order from Bacterial to Viral infections and readers can quickly refer to the section they are interested in. Part 2: Training manual on rational management and use of medicines at the primary health care level can be studied individually or in groups. It can also be used as a teaching companion on the rational management and use of medicines. The manual starts with a chapter on health centre management and administration, since proper management of a clinic or health centre is prerequisite for smooth running of services. A chapter on management of medicines, covering the areas of procurement, storage and dispensing, is followed by a chapter on rational use of medicines, including some important aspects of irrational practices such as misuse of injections, overuse of antibiotics and the importance of making a correct diagnosis. The ﬁnal chapter provides a methodology to investigate medicine use in health facilities. 10 INTRODUCTION 11 We are conﬁdent that this publication will prove to be of great assistance to all medicine prescribers and particularly to those in primary health care centres, and also to all health providers in the public and the private sector. Properly used, it is hoped it will reduce the misuse and irrational management and use of drugs in the country. This manual was ﬁrst published in 1998 under the title Somalia standard treatment guidelines and rational use of drugs at the primary health care level. This second edition has been thoroughly revised and made into a pocket format. Besides correcting some spelling mistakes and minor changes and additions to the text here and there, the title has been changed to reﬂect a change in structure of the book. Volume I of the ﬁrst edition now comprises Part 2. Training manual on rational management and use of medicines at primary health care level. Volume II now comprises Part 1. Somalia standard treatment guidelines. Within those revised sections the following are the main changes. Part 1 • A “REMINDER” is added for all diseases susceptible to outbreaks and which need to be reported. • New topics in this manual include sections on kala-azar, micronutrients and sexually transmitted diseases based on syndromic management. • Sections dealing with pneumonia, tuberculosis, emergencies and diarrhoea are replaced by more expanded chapters. • The section on protein energy malnutrition has been substantially revised and updated, the text shortened and the terms made more understandable. • The chapter on sexually transmitted diseases has been replaced with a section based on syndromic management. • The table summary of dosage recommendations has been deleted. • The following medicines are added to the new list: dexamethasone injection; silver sulfadiazine; ranitidine; zinc sulfate; cetrimide + chlorhexidine; dextrose 50%; insulin short acting, insulin medium acting; streptomycin; meglumine antimoniate injection; and tuberculosis medicines based on the ﬁxed dose combinations. • The following medicines are deleted from the new essential medicines list (Annex 1): syrup forms of amoxicillin and cotrimoxazole; zinc oxide; cimetidine; diazepam tablets; digoxin tablets; hydrocortisone eye ointment; metrifonate tablets; nystatin oral tablets; pilocarbine eye drops; tetanus immunoglobulin; tetracycline tablets; and ergometrine tablets. Part 2 • Chapter 2, a completely new section, 2.3 dealing with good dispensing practice, has been added. • Tables on medicine management dealing with medicine ordering and receiving have been deleted and replaced by text. Many readers expressed difﬁculty understanding these forms. Different books use different forms but since the content in those forms is largely the same, a simple text explaining the different parts of such forms is more easily understood. • Medicine supervision guideline – this section presents a medicine supervision guideline, which will help health providers and health administrators to enhance the quality of the work they are doing in the area of the rational use of medicines. The section presents a simple methodology to investigate the proper storage and use of medicines at the primary care level. Annexes • Annex 1 is the updated version of the Somalia Essential Medicines List. The medicines are classiﬁed according to the type of health facility where they should be used. i.e. level A health 12 facilities close to referral sites (hospitals), level B remote health facilities without the ability to refer urgently, and hospital referral sites. Medicines required for special programmes are also included. Yakoub Aden Abdi MD, PhD WHO Consultant on Essential Medicines Acknowledgements This new edition of the Somalia standard treatment guidelines and training manual on rational management and use of medicines at the primary health care level was revised and written by Dr Yakoub Aden Abdi, who served as a short term consultant for WHO Somalia. We would like to express to Dr Aden Abdi our sincere thanks for the valuable and oustanding work done during his assignment. Special thanks are due to Dr Stephen Lonsdale for the ﬁnal review and revision of this new edition of the guidelines and for his contribution as a short-term consultant in Somalia in the 1990s. Many people have contributed to the development of this manual. WHO Somalia appreciates the time that many organizations and individuals took to share ideas, discuss their own practical experiences, and review different drafts of the manual. Thanks are due to the WHO Somalia staff and to the Regional Ofﬁce for the Eastern Mediterranean for its continuous advice and technical guidance. We are sincerely thankful to all the different international organizations and nongovernmental organizations who contributed in one way or the other to the development of this manual. We are especially grateful to UNICEF Somalia, Food Security Assessment Unit, International Committee of the Red Cross (ICRC) and other international and national nongovernmental organizations working in Somalia . WHO Somalia highly appreciates the prominent role that the Essential Medicines Working Group of the Somali Aid Coordination Body (SACB) has played in the process of revising this manual. We are also thankful to the Health Sector Coordinator of the SACB and his team for all the meetings, good comments and constant support during the progress of this work. 14 Of course, the revision of this manual would not have been possible without the full support of the health authorities and Somali health professionals. We are particularly grateful to all the many Somali doctors and nurses whose comments enriched this new edition of the manual. WHO Ofﬁce for Somalia September 2006 Abbreviations AIDS acquired immunodeﬁciency syndrome ASA acetyl salicylic acid CSF cerebrospinal ﬂuid DOTS directly observed treatment, short-course DPT diphtheria–pertussis–tetanus EPI Expanded Programme on Immunization FIFO ﬁrst-in-ﬁrst-out g gram GV gentian violet HIV human immunodeﬁciency virus i.m. intramuscular INN internationally recognized ,,,,,,,,,,,,,,,non-proprietary names IU international units i.v. intravenous kg kilogram L litre LP lumbar puncture MCH maternal and child health mg milligram ml millilitre NSAID non-steroidal anti-inﬂammatory drug Oint. ointment OPD outpatient department ORS oral rehydration salts PEM protein–energy malnutrition PHC primary health care PID pelvic inﬂammatory disease PO per os (by mouth) PPH postpartum haemorrhage RBC red blood cells SACB Somali Aid Coordination Body SC subcutaneously STD sexually transmitted diseases TB tuberculosis TBA traditional birth attendants URI upper respiratory infection UTI urinary tract infections WBC white blood cells Part 1 Standard treatment guidelines Chapter 1 Bacterial infections • Meningitis • Pertussis • Tetanus • Typhoid fever PART 1 STANDARD TREATMENT GUIDELINES BACTERIAL INFECTIONS Chapter 1 - 21 PART 1 STANDARD TREATMENT GUIDELINES BACTERIAL INFECTIONS Chapter 1 - 21 REMEMBER! It is vital to exclude malaria. If it is not possible to exclude malaria treat the patient for both diseases. Take thin and thick blood slides and then give ﬁrst-line malaria treatment. Management a) Lumbar puncture (LP) not possible, patient can reach hospital within 3 hours: • Make a blood slide; • Give a single dose of ﬁrst-line malaria treatment (see under malaria); • REFER immediately with the blood slide. b) Lumbar puncture (LP) not possible, patient cannot reach hospital within 3 hours: • Make a blood slide; • Give a single dose of ﬁrst-line malaria treatment (see under malaria); • Give a single dose of benzylpenicillin intravenously (see below); • Give a single dose of chloramphenicol intramuscularly (see below); • REFER with blood slide; c) Lumbar puncture (LP) possible, patient cannot reach hospital within 3 hours: • Do a lumbar puncture without delay; • Make a blood slide; • Give a single dose of ﬁrst-line malaria treatment (see under malaria); • Give a single dose of benzylpenicillin intravenously (see below); • Give a single dose of chloramphenicol intramuscularly (see below); • REFER with blood slide and CSF in a sterile container. MENINGITIS is a notiﬁable disease Meningitis Description Meningitis is a serious infection of the membranes covering the brain (meninges). The disease may cause death if untreated. It is usually of bacterial origin, the most common organisms being Neisseria meningitides, Streptococcus pneumoniae and Haemophilus inﬂuenzae. Signs and symptoms In neonates Signs may be vague and non-speciﬁc Failure to suck Vomiting repeatedly Fever may be absent Bulging fontanel (may come late) Signs of shock In children >1 month and adults High fever Convulsions Headache and vomiting Neck stiffness (Kernig’s sign positive) Confusion Stiff neck or back (may be absent) Sensitivity to bright lights Rash (in meningococcal septicaemia) PART 1 STANDARD TREATMENT GUIDELINES BACTERIAL INFECTIONS Chapter 1 - 23 PART 1 STANDARD TREATMENT GUIDELINES BACTERIAL INFECTIONS Chapter 1 - 23 PERTUSSIS is a notiﬁable disease Pertussis (whooping cough) Description Whooping cough is a childhood disease characterized by paroxysmal cough, inspiratory whoops and tenacious sputum, which is caused by the bacterium Bordetella pertussis. In affected children it might lead to malnutrition. Signs and symptoms • Spasmodic cough, which is worse at night, and is often followed by choking and vomiting • Characteristic inspiratory whoops (occurring after the ﬁrst week of the illness) • Conjunctival haemorrhages (from coughing) • Infants less than 3 months may develop apnoeic episodes or periods of hypoxia (cyanosis) without cough, which may be fatal. Management • In the early stage (<1 week), erythromycin may help to prevent the spread of the disease to others. Give: 7.5–12 mg/kg every 6 hours for 7 days; • During the paroxysmal stage, antibiotics are of NO use. Treatment is largely symptomatic; • Advise the mother: • to ensure adequate hydration; Doses • Chloramphenicol, given intramuscularly: • Adults 1 g; • Children 25 mg/kg (neonates 6.25 mg/ kg, under 1 year 12.5 mg/kg); • Benzylpenicillin, given i.v. if possible, otherwise i.m.: • Adults 5 up to 14.4 g daily in divided doses; • Children 180–300mg/kg daily in 4–6 doses. REMEMBER! Meningococcal meningitis is a medical emergency and benzylpenecillin should be given immediately if the diagnosis is suspected Supportive treatment • Give diazepam slow i.v. or rectal if convulsions: • Adults: 10–40 mg; • Children under 3 years: maximum dose 5 mg; • Children over 3 years: maximum dose 10 mg; Repeat dosage if necessary; • Antipyretics such as aspirin or paracetamol; • Ensure hydration and nutrition (nasogastric, if necessary). REMEMBER! The importance of obtaining a CSF specimen for visual inspection to conﬁrm meningitis, even in the absence of laboratory facilities, cannot be overemphasized. A CSF can be safely obtained (using standard technique) with a sterile needle when spinal needles are not available. PART 1 STANDARD TREATMENT GUIDELINES BACTERIAL INFECTIONS Chapter 1 - 25 PART 1 STANDARD TREATMENT GUIDELINES BACTERIAL INFECTIONS Chapter 1 - 25 Signs and symptoms In infants Baby cannot suck Infected umbilicus Stiff body Irritability Spasms Cyanosis during spasms In older children Risus sardonicus (mocking smile) Trismus (lockjaw) Opisthotonos (stiff arched back) Spasms (initially induced by any stimuli but later spontaneous) Management • REFER as quickly as possible. If quick referral is not possible: • Nurse the patient in a place with minimal sensory stimuli; noise and unnecessary touching can provoke ﬁts; • Clean the umbilicus/wound with soap and water or antiseptic solution; • Control the spasms by: • Diazepam in a generous dose: start with 10-40 mg i.v. or rectal; • Repeat the dose if needed; • Give benzylpenicillin (i.m., or slow i.v.): • Adults: 1 million IU 6 hourly for 7 days; • Children: 50 000 IU/kg every 6 hours for 6 days. If available give human tetanus immuno- globulin 500 IU i.m. to neutralize free toxin. • to remove any tenacious strands of sputum from the oropharynx; • and most importantly to continue good nutrition of the child; • REFER infants less than 3 months, the very weak and malnourished and those with complications (e.g. pneumonia, convulsions, dehydration, malnutrition). REMEMBER! Cough medicines, sedatives, mucolytics and antihistamines are useless and must NOT be given. Prevention • Immunization (part of the DPT vaccination) • Avoid contact with other children with whooping cough • Consider giving close contacts of the child with pertussis prophylactic erythromycin. Tetanus Description A bacterial infection characterized by involuntary spasm, usually fatal if untreated. Tetanus bacteria live all around us in the air and in the ground. The port of entry is either an uncleaned wound or, in the case of neonates, the umbilical cord. The incubation period is between 2 and 60 days. PART 1 STANDARD TREATMENT GUIDELINES BACTERIAL INFECTIONS Chapter 1 - 27 PART 1 STANDARD TREATMENT GUIDELINES BACTERIAL INFECTIONS Chapter 1 - 27 • Mental confusion • Deafness • Splenomegaly, usually at the end of the ﬁrst week. Complications • Intestinal perforation • Intestinal bleeding • Acute cholecystitis • Sepsis • Pneumonia • Meningitis • Sepsis (typhoid abscess can occur almost anywhere) • Septic arthritis and osteomylitis • Renal disease (failure or nephritic syndrome). Management • Good nursing care is essential; • Observe closely for complications; • Treat fever and hydrate; • Antibiotic treatment: Chloramphenicol capsule 250 mg: • Adults: 500 mg 6-hourly for 14 days; • Children: 25 mg/kg 6-hourly for 14 days; Alternative: Cotrimoxazole (sulfamethoxazole + trimethoprim) orally: • Adults: 960 mg 12-hourly for 14 days; • Children: 24 mg/kg 12-hourly for 14 days; • If the patient cannot take oral medications and you cannot REFER, give the same dose i.v., but switch to oral therapy as soon as possible. If only horse antitenanus serum is available, give 10 000 IU i.v. (after a small subcutaneous test dose) and 750 IU/day to the wound for three days. Prevention • Education of traditional birth attendants (TBAs); • Cleanliness during delivery; • Vaccination of pregnant women with tetanus toxoid, once during the ﬁrst antenatal visit and the second at least 1 month after the ﬁrst and no later than 1 month before delivery; • Routine immunization of all children with DPT. TYPHOID is a notiﬁable disease Typhoid fever Deﬁnition Typhoid is a systemic illness caused by a bacterium, Salmonella typhi, which infects the small intestine and the blood stream via the lymphatic system. The infection may be transmitted in water and food and is dose related. Signs and symptoms • High fever which persists • Constipation in the early stage • Abdominal pain and diarrhoea in the second week of illness • Severe headache • Low pulse in the presence of high fever Chapter 2 Dental and oral diseases • Dental abscess • Dental caries • Periodontal disease PART 1 STANDARD TREATMENT GUIDELINES DENTAL AND ORAL DISEASES Chapter 2 - 31PART 1 STANDARD TREATMENT GUIDELINES DENTAL AND ORAL DISEASES Chapter 2 - 31 Dental abscess Description Dental abscess is a collection of pus around the affected tooth, which may spread into the surrounding tissue. A dental abscess may develop from gum disease or dental decay. Signs and symptoms • A constant throbbing pain • The tooth is painful when tapped with something hard • There may be tender swelling on the gum around the affected tooth • There may be a discharge • The infection may spread through adjacent tissues causing facial or neck swelling or difﬁculty opening the mouth • There might be fever. Management • Give paracetamol 500 mg tablets: • Adults and children over 12 years: 1–2 tablets 6-hourly; • Children 8–12 years: 1 tablet 6-hourly; • Children: 3–7 years: ½ tablet 6-hourly; • Children: 1–2 years ¼ tablet 6-hourly; • Warm saline gargles; • If high fever, give penicillin v 500 mg 6- hourly and REFER. Dental caries Description The formation of holes in the teeth–decay of the teeth. This happens mainly as a result of poor oral hygiene (e.g. teeth not brushed) but could also be the result of trauma where bacteria attacks and corrodes the teeth. In adults khat chewing could be a major cause of tooth damage because of the high level of tannins in the khat leaves. Signs and symptoms • Pain after hot or cold foods or drinks • Pain may be intermittent, severe sharp or constant • A hole or black spot may be visible on the tooth. Management • Clean the hole in the tooth wall, removing all food particles; • Rinse the mouth with warm salt water; • Give paracetamol 500 mg tablets: • Adults and children over 12 years: 1–2 tablets 6-hourly; • Children 8–12 years: 1 tablet 6-hourly; • Children: 3–7 years: ½ tablet 6-hourly; • Children: 1–2 years ¼ tablet 6-hourly; • REFER for treatment to dental practitioner. Prevention • Brush teeth after every meal if possible and at bedtime; • Tooth decay and cavities must be corrected promptly; • Minimize sugar intake, particularly in children; PART 1 STANDARD TREATMENT GUIDELINES DENTAL AND ORAL DISEASES Chapter 2 - 33PART 1 STANDARD TREATMENT GUIDELINES DENTAL AND ORAL DISEASES Chapter 2 - 33 • Avoid cigarette smoking and khat chewing. Periodontal disease (gum disease) Deﬁnition Inﬂammation or degeneration of tissues that surround and support the teeth: gingiva, alveolar bone, periodontal ligament and cementum. Periodontal disease most commonly begins as gingivitis and progresses to periodontitis. Signs and symptoms • Bleeding of the gum • Bad smelling breath • The presence of plaque, especially around the necks of teeth and on the gum; • Calculus • Swollen red gums • Recession of the gums exposing the root of the teeth • The teeth may be loose in the gums. Treatment • Effective brushing to remove plaque; • Gargle with hot water and salt after meals and before bed; • Increased intake of fruits; • In case of pain, give paracetamol 500 mg tablets: • Adults and children over 12 years: 1–2 tablets 6-hourly; • Children 8–12 years: 1 tablet 6-hourly; • Children: 3–7 years: ½ tablet 6-hourly; • Children: 1–2 years ¼ tablet 6-hourly; • In severe cases, REFER. Prevention • Brush teeth after every meal if possible and at bedtime; • Tooth decay and cavities must be corrected promptly; • Minimize sugar intake, particularly in children; • Avoid cigarette smoking and khat chewing. Chapter 3 Emergencies and trauma Accidents causing major and minor injuries happen frequently. People with injuries will come to the health facility for advice and treatment. Injuries may take different forms and can be serious and life-threatening. There may be visible bleeding. Sometimes the bleeding may be in the internal organs and you cannot see it. The most common conditions, which might present acutely at the health facility, are: • Allergic shock • Bites • Bleeding • Burns • Convulsions • Fever • Fractures • Pain • Poisoning • Wounds PART 1 STANDARD TREATMENT GUIDELINES EMERGENCIES AND TRAUMA Chapter 3 - 37 Management • Lie patient down with legs elevated; • Clear the airway; • IMMEDIATELY inject 0.5 ml adrenaline 1:1000 (1 mg/ml) i.m. or 0.01 ml/kg in children; • This dose of adrenaline can be repeated every 10 minutes until the patient is better. • If despite your treatment the patient does not improve, REFER. Anaphylactic shock can be fatal. If you suspect that is what happening you must administer ADRENALINE WITHOUT DELAY. Administering adrenaline to someone not actually suffering an anaphylactic reaction is extremely unlikely to do harm. Withholding adrenaline from someone who is suffering an anaphylactic reaction may prove FATAL. Prevention • Use injections only when absolutely necessary; • Always ask for a history of medicine reaction before giving an injection. REMEMBER! In the management of anaphylaxis there are no contraindications to the use of adrenaline. Bites Description Animal bites can easily cause infections and severe pain. A very dangerous bite is that of Allergic shock Description Allergic shock is also called anaphylactic shock or anaphylaxis. This reaction is often caused by an injection of a medicine, but can also be caused by oral medication, food or by stings of bees and wasps. The reaction is most frequently seen with: • Antibiotics (penicillin injections are the most common) • Antitoxins made out of horse serum, e.g. • Snake antivenom • Tetanus antitoxin • Rabies antisera • Food (nuts, eggs, ﬁsh) • Bee stings. REMEMBER! The risk of a serious reaction is greater in a person who has previously been given these medicines or antisera, especially if this person had an allergic reaction such as itching, swelling or breathing difﬁculties (even if it was hours or days after the medicine was given). Signs and symptoms • Swelling of lips or itchy rash • Cool, clammy skin (cold sweat) • Weak, rapid pulse • Low blood pressure • Cyanosis • Difﬁculty in breathing; (asthma like symptoms) • Loss of consciousness • Tinnitus. PART 1 STANDARD TREATMENT GUIDELINES EMERGENCIES AND TRAUMA Chapter 3 - 39 Bleeding Description Bleeding may occur from external wounds or from body openings. In accidents bleeding may be happening internally without any initial signs. Management External bleeding To prevent a patient from losing a lot of blood and going into shock, it is important that the bleeding is stopped as soon as possible. Patients presenting with bleeding may be treated as follows: • If bleeding is from a limb, elevate the limb; • Apply pressure on the bleeding point for 5 minutes. For epistaxis (nose bleeding) squeezing the nostrils together with the head down is often sufﬁcient. On other sites, apply a pressure bandage if needed; • If you are skilled in stitching, you may arrest the bleeding by stitching a wound. If not, REFER the patient after applying a pressure bandage: put a sterile pad over the bleeding point and ﬁrmly apply a bandage over it (not too tight as this may prevent normal blood circulation). Internal bleeding In some accidents the patient may have suffered injuries of the internal organs. This is usually accompanied by bleeding, which cannot be seen. However, the nature of the injury and the signs and symptoms may give you an indication of the location and a rabid dog. When a patient presents with a bite wound you have to be cautious. Human bites usually cause severe infections. Management • Any patient presenting with bite wounds requires antibiotics; • Clean all bite wounds thoroughly with soap and water or an antiseptic; • Check the patient’s tetanus immunization status and treat accordingly; • Report a suspected rabid dog to the veterinary ofﬁcer or any other concerned authority. REFER the patient if rabies vaccination is required; • NEVER stitch a bite. Stitching locks the bacteria inside the wound and an infection is the inevitable result; • In a suspected poisonous snakebite, the wound should be cleaned as above, and the patient REFERRED. REMEMBER! Poisonous snakebites may have serious consequences. The patient may lose the affected limb or may even die. Always REFER immediately if a patient looks sick, shows difﬁcult breathing or has developed a large swelling of the bitten area within 2 hours after the bite. However do not panic, reassure the patient. Do not put a tight tourniquet on the affected limb and do not incise the wound. More damage may be done by stopping the blood circulation than the snakebite. PART 1 STANDARD TREATMENT GUIDELINES EMERGENCIES AND TRAUMA Chapter 3 - 41 Burns Description Burns can be serious wounds caused by open ﬁre, electricity or hot ﬂuids such as water, oil or porridge. A large burn is more dangerous than a small burn and a deep burn is more dangerous than a superﬁcial burn. A burn on the face or hand is more dangerous than a burn on the abdomen or on the back. For every burn you need to ask yourself three questions: • How big is the burn? • How deep is the burn? • Where is the burn? How big is the burn? A large burn causes more pain and more easily becomes infected. If the burn affects a large area, a lot of ﬂuid and protein are lost and the patient may go into shock. If the burn is more than twice the size of the patient’s hand size, then the patient is in danger of dehydration. You must give oral rehydration salts (ORS) and refer. A hand area is about 1% of the total body surface area. REMEMBER! If the area of the burn is more than twice the size of the patient’s hand, give ORS or any ﬂuid and REFER. How deep is the burn? The skin has two parts or layers. The thin outer layer is the epidermis. The thicker inner layer is called dermis, which contains the seriousness of the bleeding. Well-known causes of internal bleeding are: • Ruptured spleen (e.g. child fell out of a tree); • Lung tissue damage (e.g. fractured ribs); • Ruptured liver (e.g. road accidents); • Ectopic pregnancy (ask for date of last menstrual period); • Ruptured uterus (with or without postpartum haemorrhage). A patient with internal bleeding can easily go into shock. Therefore, if you suspect internal bleeding, ALWAYS LOOK FOR SIGNS OF SHOCK: • Rapid and weak pulse • Low or not measurable blood pressure • Fast shallow breathing • Restlessness • Cool, clammy skin • Cyanotic (blue) lips and /or nails • Thirst. REMEMBER! Do not remove any penetrating foreign bodies. Management of internal bleeding • Always REFER the patient immediately, accompanied by 1 or 2 blood donors and a nurse or medical assistant; • If possible, put up a drip of i.v. ﬂuid (normal saline if possible) and make it run fast; • Take blood for grouping and cross- matching if possible. PART 1 STANDARD TREATMENT GUIDELINES EMERGENCIES AND TRAUMA Chapter 3 - 43 • A large area of skin loss leaves tissue wide open to all forms of infections, including tetanus; • Shrinking of scar tissue can cause contractures. Management of burns First aid for burns • Keep the affected part in cold water for at least 15 minutes; • Give analgesics for pain (i.e. paracetamol); • Always REFER a patient with a THIRD degree burn; • DO NOT break the blisters in a SECOND degree burn, as they protect against infection; • Give ORS to every patient with a burnt body surface of more than the size of your two palms (2% of body surface) and REFER immediately. REMEMBER! Always cool the affected part with cold water for at least 15 minutes to prevent further damage. Treatment of burns • Clean the wound with soap and water; • Thoroughly rinse with plenty of water; • For burns on extremities apply silver sulfadiazine 1% cream for all partial thickness burns to prevent infection; • For partial thickness burns cover with sterile dressings, which can be changed from twice daily to once a week according to circumstances and the condition of the wound; • For facial burns and all third degree burns REFER; sweat glands and their follicles. Burns can be divided according to the layer involved: First-degree burn or superﬁcial burn: • Only reddening of the skin; Second-degree burn or partial thickness burn: • Superﬁcial partial thickness: reddening of the skin and blister or vesicle formation. Healing is without scars; • Deep partial thickness: the epidermis is destroyed but the hair follicles and sweat glands are still alive. These burns heal easily; Third degree burn or full thickness burn: • The dermis is completely destroyed and raw ﬂesh exposed; • Healing takes a long time and leaves scars. Through a deep burn the patient loses body ﬂuids, which contain much protein. In such a situation, replacement of ﬂuids will become necessary. Where is the burn? Burns on the face are serious because of the scars and deformities they may leave. Damage to the eyes may cause blindness. Burns on a hand may cause contractures, thereby limiting its function. If a patient has inhaled hot smoke, the respiratory tract may be burnt and pneumonia may develop. Complications of burns Patient with burns can suffer short-term as well as long-term complications: • Shock can occur, due a combination of body ﬂuids loss, severe pain and fever; PART 1 STANDARD TREATMENT GUIDELINES EMERGENCIES AND TRAUMA Chapter 3 - 45 • Cerebral meningitis • Metabolic cause: hypoglycaemia (severe malnutrition, neonate or patient being treated with i.v. quinine) • Epilepsy • Head injury • Malaria • Poisoning Management Stop the convulsion: • Give slow intravenous or rectal diazepam (2 ml amp, 5 mg/ml): • Children: 0.2–0.5mg/kg (max 5 mg infants, 10 mg children); • Adults: 10–20 mg. If needed, repeat after 10–20 minutes, maximum of 30 mg within 1 hour. Treatment of fever: • Tepid wet towels; • Give paracetamol tablets (500 mg): • Adults and children over 12 years: 1–2 tablets 6-hourly. • Children 8–12 years: 1 tablet 6-hourly. • Children: 3–7 years: ½ tablet 6-hourly. • Children: 1–2 years ¼ tablet 6-hourly. Treatment of the cause: • Cerebral malaria: see under malaria; • Meningitis: see under meningitis; • Hypoglycaemia: i.v. hypertonic solution; • 2 ml/kg, if you use dextrose 50% solution • 3 ml/kg, if you use dextrose 30% solution • Epilepsy: if genuine epilepsy is suspected, REFER for investigation and long-term management. • Provide pain relief for dressing changes with paracetamol. High-risk groups for burns • Children may fall into a ﬁre or upset hot ﬂuid over themselves; • An epileptic patient may fall into an open ﬁre; • People with leprosy may not feel that an object is burning hot. Prevention of burns Most of the victims of burns are children. Parents have to be taught how to prevent these burns: • Do not leave small children near open ﬁres or stoves, or hot liquids that may spill; • Turn handles of pans on the stove away so that children cannot reach them; • Keep parafﬁn lamps and matches out of reach of children. REMEMBER! Teach everyone who cares for children the danger of ﬁre. Convulsions Description Paroxysmal involuntary movements of cerebral origin with loss of consciousness often accompanied by biting of the tongue and/or involuntary release of urine. Possible causes • Hyperthermia (overheating), high fever due to any cause PART 1 STANDARD TREATMENT GUIDELINES EMERGENCIES AND TRAUMA Chapter 3 - 47 Possible causes to look for in cases of high fever in a patient Fever Possible causes Fever + shivering, sweating, headache Malaria Fever + general health impairment Typhoid Fever + neck stiffness, neurological signs Meningitis Fever + jaundice Hepatitis Fever + shock Septicaemia Fever + respiratory signs Pneumonia Bronchiolitis Epiglottitis Fever + bloody diarrhoea Dysentery Fever during last month of pregnancy Malaria Pyelonephritis Fever + general health impairment, adenopathies, chronic diarrhoea Opportunistic infection; AIDS Management • Investigate and treat the underlying cause; • General measures to control the fever: • Undress the patient; • Start tepid sponging of the skin (lukewarm, not cold); Supportive treatment: • Place the patient on his left side and ﬂex upper leg; (coma position) • Maintain a clear airway by removing secretions and vomit; • Ensure adequate nutrition and hydration (nasogastric tube if necessary); • During convulsions, put something in the mouth to avoid biting of the tongue; • When the patient is stabilized, REFER. Fever Description Fever is a symptom of an increased body temperature. Fever is present when the rectal temperature is above 37.0°C in the morning, and above 37.5°C in the evening. The corresponding axillary temperature would be above 37.5°C and 38.0°C, respectively. High fever in newborns and infants can cause serious and fatal complications such as convulsions, dehydration and death. PART 1 STANDARD TREATMENT GUIDELINES EMERGENCIES AND TRAUMA Chapter 3 - 49 This means splinting the affected part; • Do not move or bend the fractured part more than necessary. Testing for abnormal movement can cause more damage; • Give pain relief (i.e. paracetamol); • If the fracture has occurred in a large bone, such as the thigh or the pelvis, considerable internal blood loss may take place, and the patient may go into shock due to blood loss. Therefore for fractures of large bones i.v. ﬂuid is necessary; • REFER as quickly as possible. REMEMBER! Do not carry out primary closure in any case of open fracture. Pain Description Pain is a common symptom in many different conditions. It may alert the health worker to the possibility of an underlying medical problem. In some chronic diseases such as AIDS, cancer etc., pain may be persistent and disabling. Pain is a subjective experience and can be expressed differently by different people and depends on emotional and/or cultural factors. Signs and symptoms For a rational treatment of pain it is important to deﬁne the pain in terms of onset,duration, localization, radiation, nature, association with other systemic features and possible factors that induce it. • If high temperature (>40.0°C), give a tepid bath; • Advise the mother continuous feeding and hydration of the child; • Antipyretic treatment: paracetamol 500 mg tabs. • Adults: 1 g orally 6-hourly as required (max: 4 g/24 hours); • Children: 10 mg/kg 6-hourly as required (max: 4 doses/24 hours). If small children, crush the tablets and mix with a sweet drink; • If convulsions, give slow i.v. diazepam 0.2–0.5mg/kg (max. 5 mg infants, 10 mg children), if not possible give the same dose rectally. Repeat the dose after 10 minutes if necessary; • In unresolvable cases, REFER. Fractures Description Fractures may occur in any bone. They may include an open wound, in which case it is called an open or compound fracture, or the skin may be undamaged in which case it is called a simple fracture. There are many possible sites for fractures, and each should be dealt with in a speciﬁc way. Therefore, unless you have had speciﬁc training, follow the general principles listed, and REFER. Management • If there is an open wound, clean it as thoroughly as possible and dress it, but DO NOT SUTURE IT CLOSED; • Stabilize the fracture as best as you can. PART 1 STANDARD TREATMENT GUIDELINES EMERGENCIES AND TRAUMA Chapter 3 - 51 Management of poisoning • REFER ALL PATIENTS with suspected poisoning. If quick referral is not possible: • INDUCE VOMITING: • If tablets, capsules or other kinds of medicines have been swallowed; • If you are certain the poison is not corrosive or a hydrocarbon solvent; • DO NOT MAKE THE PATIENT VOMIT IF: • You suspect parafﬁn poisoning (SMELL). Give water/milk; • You suspect poisoning with a corrosive chemical e.g. bleach. Give water/milk; • If the patient is drowsy and may not have an adequate gag reﬂex; • If the poison was taken more than 1–2 hours previously. The best way of inducing vomiting is with syrup of ipecac 10 ml in children 1–10 years, 15 ml in children 12–16 years and 30 ml in adults. Give with 300–600 ml of water to drink. Prevention of poisoning • Keep medicines and chemicals out of the reach of children; • Do not put parafﬁn or other chemicals in empty mineral water bottles as children may drink by mistake. REMEMBER! Keep medicines and chemicals out of the reach of children. Management • Investigate and treat the cause; • Symptomatic therapy. Headache and joint pains: Paracetamol tablets (500 mg): • Children 8–12 years: 1 tablet 6-hourly; • Adults and children over 12 years: 1–2 tablets 6-hourly; • Children: 3–7 years: ½ tablet 6-hourly; • Children: 1–2 years ¼ tablet 6-hourly; If no relief add: • For adults ibuprofen tablets (400 mg) 8 hourly to be taken with food. • Children 8–12 years ½ tablet 8 hourly. • Children 3–7 years ¼ tablet 8 hourly. For acute severe pain, REFER immediately. Poisoning Description People who swallow something poisonous can become very ill and may even die. Many poisonings or intoxications occur in children. Signs and symptoms Symptoms of poisoning depend on the poison taken: • Drowsiness • Rapid respirations and cough • Vomiting or diarrhoea • Convulsions • Frothing at the mouth. PART 1 STANDARD TREATMENT GUIDELINES Wounds Description A wound is a break in the skin and/or damage to parts of the body under the skin often due to a violent impact. Signs and symptoms • Pain • Bruising and/bleeding • Sometimes there is major tissue damage. Management of wounds • Clean the wound thoroughly with soap and water or with an antiseptic like cetrimide + chlorhexidine solution; • Check the patient’s tetanus immunization status; • If not immunized and the wound is dirty, consider giving antitetanus serum or immunoglobulin if available; • If the wound is large and less than 6 hours old, sticking (suture) is indicated; • Dress the wound; • If you are not skilled or lack the necessary equipment, REFER the patient after dressing the wound. REMEMBER! Always clean wounds thoroughly and remove foreign bodies and dead tissue. Never suture a dirty wound. Chapter 4 Eye conditions • Conjunctivitis • Trachoma PART 1 STANDARD TREATMENT GUIDELINES EYE CONDITIONS Chapter 4 - 55PART 1 STANDARD TREATMENT GUIDELINES EYE CONDITIONS Chapter 4 - 55 Conjunctivitis Description Acute inﬂammation of the conjunctivae, which may be caused by infection (viral or bacterial), allergy, foreign body or chemical. Conjunctivitis causes redness, pus, and mild ‘burning’ in one or both eyes. Eyelids often stick together after sleep. It is especially common in children. Signs and symptoms • The eye becomes red • The infection may affect only one or both eyes • The infected eye(s) water(s) • There may be a purulent discharge ‘pus’ • Vision is normal Management Simple conjunctivitis • Regular eye washing with cooled boiled water; • NO need for antibiotics. Allergic conjunctivitis • Avoid the causative agent if possible; • Regular eye washing with cooled boiled water; • Chlorpheniramine 4 mg tablets: • Children 6 months to 1 year: ¼ tablet twice daily as required; • Children 1–5 years: ¼–½ tablet three times daily as required; • Children 5–12 years: ½–1 tablet 8-hourly as required; • Adults and children over 12 years: 1 tablet 8-hourly as required. Note! Allergic conjunctivitis is rare in children under 1 year. Purulent conjunctivitis • Apply tetracycline eye ointment 1% in both eyes, 8-hourly for 7 days. Opththalmia neonatorum (gonococcal) • Clean with normal saline or cooled boiled water; • In both eyes, apply tetracycline eye ointment 1%, 2 hourly initially; • Then REFER for further assessment; • Don’t forget that both parents need treatment for gonorrhoea as well. If not possible: • Give, benzylpenicillin (i.m.): 25 000 IU/kg 6- hourly for 7 days; • If newborn, review daily and treat the mother too. Prevention of ophthalmia neonatorum • Health education for mother; • Treat gonorrhoea in pregnancy; • Clean the eyes of all newborn babies as above; • Apply tetracycline 1% eye ointment to the eyes of all newborn babies at birth. REMEMBER! Opththalmia neonatorum is due to gonorrhoea contracted by the newborn from the mother at birth. Unless treated it will rapidly lead to blindness. PART 1 STANDARD TREATMENT GUIDELINES EYE CONDITIONS Chapter 4 - 57PART 1 STANDARD TREATMENT GUIDELINES EYE CONDITIONS Chapter 4 - 57 Foreign body on the cornea Particles of dust, dirt or loose eyelashes are the most common foreign bodies found in the eyes. They are often under the eyelid. Management • Irrigate the eye using clean warm water; • It may be possible to lift the foreign body off with a moistened swab or the corner of a clean cloth; • If the foreign body is under the upper lid ask the patient to look down. Grasp the eyelashes and pull the upper lid downwards and outwards over the lower lid; • Do not attempt to remove a foreign body embedded in the cornea; If you cannot remove the foreign body easily, apply tetracycline ointment, cover the eye and REFER. Trachoma Description Trachoma is a chronic infection of the eye caused by Chlamydia trachomatis. It begins like conjunctivitis but slowly gets worse. It spreads from person to person by hand or by ﬂies and is most common in places with poor hygiene and sanitation. Trachoma may last for many months or years. If not treated in its early stages it can cause partial or total blindness. Signs and symptoms Stage 1 In the ﬁrst stage trachoma looks like conjunctivitis (red, watery or pus ﬁlled eyes). Stage 2 About two months later, small pinkish grey lumps appear inside the upper lids. In this stage you may also be able to see that the top of the cornea looks grey instead of brown. Stage 3 After several years, the pinkish grey lumps disappear, leaving white scars. These scars can: • make eyelids thick and keep them from opening fully; • pull the eyelashes down into the eye and scratch the eye surface, causing blindness. Stage 4 After several more years the cornea becomes even more grey and scarred, causing partial or complete blindness. The eyelids are deformed and they do not close normally over the eyes. The eyelashes turn inwards due to scarring, and they scratch the cornea. The eyelids no longer protect the eyes and repeated infections occur. Management Stage 1: Tetracycline eye ointment (1%) 3 times a day for 1 to 2 months depending on the response; Stage 2: Same treatment for 2-3 months; Stage 3: complete cure is no longer possible; • local disinfection; • tetracyline 1% eye ointment. Stage 4: Surgery, REFER PART 1 STANDARD TREATMENT GUIDELINES EYE CONDITIONS Chapter 4 - PB Prevention • Teach mothers to wash their children’s eyes daily with clean water; • Use sufﬁcient quantities of soap and water; • Personal hygiene (hand washing, eye washing); • Advise early attendance for treatment. Chapter 5 Gastrointestinal diseases • Diarrhoea and dehydration • Gastritis and peptic ulcer • Stomatitis PART 1 STANDARD TREATMENT GUIDELINES GASTROINTESTINAL DISEASES Chapter 5 - 61 PART 1 STANDARD TREATMENT GUIDELINES GASTROINTESTINAL DISEASES Chapter 5 - 61 Chronic diarrhoea Continuous or episodic diarrhoea lasting more than one month. This might indicate serious underlying diseases such as cancer of the bowel or HIV infection. For all patients suspected to have chronic diarrhoea REFER. The treatment of diarrhoea in known AIDS patients is described under the section dealing with HIV infection. Persistent diarrhoea A continuous or episodic diarrhoea lasting more than more than 14 days. In patients with persistent diarrhoea, REFER for further assessment. Acute diarrhoea in children Acute diarrhoeal disease can affect all people, but severity varies in different age groups. Dehydration occurs rapidly in children and is a common cause of death. Infants, weanlings and bottle-fed children are especially at risk. Travellers are also at risk. Signs and symptoms • The disease usually occurs in children under 2 years and is very serious in infants under 1 year. • The onset may be very abrupt. The severity of the attack varies from a mild rapidly cured condition to a fulminating fatal disease. • The stools are characteristically frequent, watery, and green or bright orange in colour. • Signs of dehydration which rapidly appear include: • Sudden weight loss • Dry mouth Diarrhoea and dehydration Description Diarrhoea is the passage of 3 or more loose stools in 24 hours. Frequent passing of normal consistent stools is not diarrhoea. Diarrhoea is most common in children, especially those between 6 months and 2 years of age. It is also common in babies under 6 months who are drinking cow’s milk or infant feeding formulas. People who have diarrhoea lose a lot of water and salt. The two main dangers of diarrhoea are dehydration, which can lead to sudden death and malnutrition. Children are more susceptible to the effects of dehydration. The most important parts of treatment of diarrhoea are prevention and treatment of dehydration and zinc supplementation. Causes of diarrhoea In children, diarrhoea is commonly caused by viruses and the only treatment is rehydration. Diarrhoea can however be caused by bacteria or parasites. The stools may contain blood, in which case the diarrhoea is called dysentery (bacillary or amoebic). Types of diarrhoea Acute diarrhoea A sudden onset of change in consistency and frequency of stools with or without vomiting in children. Acute diarrhoea is deﬁned as diarrhoea lasting less than 14 days. Acute diarrhoea in adults is usually self-limiting and is managed by ﬂuid replacement. PART 1 STANDARD TREATMENT GUIDELINES GASTROINTESTINAL DISEASES Chapter 5 - 63 PART 1 STANDARD TREATMENT GUIDELINES GASTROINTESTINAL DISEASES Chapter 5 - 63 How to assess your patient for rehydration “A” state 2 signs present “B” state 2 signs present “C” state 1. Look Condition Well alert Restless, irritable Lethargic or unconscious Eyes Normal and dry Sunken Very sunken Tears Present Absent Absent Mouth and tongue Moist Dry Very dry Thirst Drinks normally, not thirst Thirsty, drinks eagerly Drinks poorly or not able to drink 2. Feel Skin pinch Goes back quickly Goes back slowly Goes back very slowly 3. Decide No signs of dehydration Some signs of dehydration Severe dehydration 4. Hydration plan Plan A Plan B Plan C • Depressed fontanelle • The skin, when pinched, remains in a fold • Sunken and tearless eyes • Fast weak pulse and a low blood pressure Management The steps to treat diarrhoea are shown in the chart below. 1 Assess degree of dehydration Ask for symptoms and look for signs indicating other problems. 2 Select treatment and treat appropriately for degree of dehydration Treat for any other problems. 3 Counsel mother Teach mother to give ORS and zinc (if available). Explain good food choices, including breast- feeding. PART 1 STANDARD TREATMENT GUIDELINES GASTROINTESTINAL DISEASES Chapter 5 - 65 PART 1 STANDARD TREATMENT GUIDELINES GASTROINTESTINAL DISEASES Chapter 5 - 65 • If the child vomits, wait for 10 minutes. Then continue, but more slowly; • Continue giving extra ﬂuid until the diarrhoea stops. 2. Give zinc supplements (if available) • Tell the mother how much zinc to give: • Up to 6 months: give ½ tablet per day for 14 days; • 6 months or more: give 1 tablet per day for 14 days. • Show the mother how to give zinc supplements • Infants: dissolve the tablets in a small amount of expressed breastmilk, ORS or clean water, in a small cup or spoon. • Other children: tablets can be chewed or dissolved in a small amount of water in a cup or spoon • Remind the mother to give the zinc supplements for the full 14 days 3. Continue feeding 4. When to return see Counsel the mother PLAN A: Treat diarrhoea at home Counsel the mother on the 4 rules of home treatment (see below): Give extra ﬂuid, Give zinc supplements, Continue feeding, Inform when to return. 1. Give extra ﬂuid (as much as the child will take): • Tell the mother to: • Breastfeed the child frequently and for longer at each feed; • If the child is exclusively breastfed, give ORS or clean water in addition to breastmilk; • If the child is not exclusively breastfed, give one or more of the following: ORS solution, food-based ﬂuids (such as soup, rice water and yoghurt drinks) or clean water. It is especially important to give ORS at home when: • The child has been treated with Plan B or Plan C during this visit. • The child cannot return to a clinic if the diarrhoea gets worse. • Teach the mother how to mix and give ORS. Give the mother 2 packets of ORS to use at home. • Show the mother how much ﬂuid to give in addition to the usual ﬂuid intake: • Up to 2 years: give 50 to 100 ml after each loose stool; • 2 years or more: give 100 to 200 ml after each loose stool. • Tell the mother to: • Give frequent small sips from a cup; PART 1 STANDARD TREATMENT GUIDELINES GASTROINTESTINAL DISEASES Chapter 5 - 67 PART 1 STANDARD TREATMENT GUIDELINES GASTROINTESTINAL DISEASES Chapter 5 - 67 • Begin feeding the child in clinic. • After 4 hours • Reassess the child and classify the child for dehydration; • Select the appropriate plan to continue treatment; • Begin feeding the child in clinic. • If the mother must leave before completing treatment: • Show her how to prepare ORS solution at home; • Show her how much ORS to give to ﬁnish the 4-hour treatment at home; • Give her enough ORS packets to complete rehydration. Also give 2 packets as recommended in Plan A; • Explain the 4 rules of home treatment: 1. Give extra ﬂuid 2. Give zinc supplements 3. Continue feeding 4. When to return See Plan A for recommended ﬂuids and Counsel the mother PLAN B: Treat some dehydration with ORS Give in clinic recommended amount of ORS over 4-hour period: • Determine amount of ORS to give during ﬁrst 4 hours. Age* Weight Give Up to 4 months <6 kg 200–400 ml 4 months up to 12 months 6–<10 kg 400–700 ml 12 months up to 2 years 10–<12 kg 700–900 ml 2 years up to 5 years 12–9 kg 900–1400 ml *Use the child’s age only when you do not know the weight. The approximate amount of ORS required (in ml) can be calculated by multiplying the child’s weight (in kg) times 75. • If the child wants more ORS than shown, give more; • For infants under 6 months who are not breastfed, also give 100–200 ml clean water during this period. • Show the mother how to give ORS solution: • Give frequent small sips from a cup; • If the child vomits, wait 10 minutes. Then continue, but more slowly; PART 1 STANDARD TREATMENT GUIDELINES GASTROINTESTINAL DISEASES Chapter 5 - 69 PART 1 STANDARD TREATMENT GUIDELINES GASTROINTESTINAL DISEASES Chapter 5 - 69 Start ﬂuid immediately. If the child can drink, give ORS by mouth while the drip is set up. Give 100 ml/kg Ringer’s Lactate Solution (or, if not available, normal saline), divided as follows: AGE First give 30 ml/kg in: Then give 70 ml/kg in: Infants (under 12 months) 1 hour* 6 hours Children (12 months up to 5 years) 30 minutes* 2 ½ hours *Repeat once if radial pulse is still very weak or not detectable. • Reassess the child every 1–2 hours. If hydration status is not improving, give the IV drip more rapidly. • Also give ORS (about 5 ml/kg/hour) as soon as the child can drink: usually after 3–4 hours (infants) or 1–2 hours (children). • Reassess an infant after 6 hours and a child after 3 hours. • Classify dehydration. Then choose the appropriate plan (A, B, C) to continue treatment. • Refer URGENTLY to hospital for IV treatment. • If the child can drink, provide the mother with ORS solution and show her how to give frequent sips during the trip. • Start dehydration by tube (or mouth) with ORS solution by giving 20 ml/kg/hour (total of 120 ml/kg). • Reassess the child every 1–2 hours: • If there is repeated vomiting or increasing abdominal distension, give the ﬂuid more slowly. • If hydration status is not improving after 3 hours, send the child for i.v. therapy • After 6 hours, reassess the child. Classify dehydration, then choose the appropriate plan(A, B, or C) to continue treatment. PLAN C: Treat severe dehydration quickly Follow the arrows. If the answer is “yes”, go across. If the answer is “no”, go down. START HERE Can you give intravenous (IV) ﬂuid immediately? NO YES Is IV treatment available nearby (within 30 minutes)? NO YES Are you trained to use a nasogastric (NG) tube for rehydration? NO YES Can the child drink? NO YES Refer URGENTLY to hospital for IV or NG treatment PART 1 STANDARD TREATMENT GUIDELINES GASTROINTESTINAL DISEASES Chapter 5 - 71 PART 1 STANDARD TREATMENT GUIDELINES GASTROINTESTINAL DISEASES Chapter 5 - 71 They are only indicated in dysentery (bacillary or amoebic). • Adsorbents: Adsorbents (such as kaolin, pectin activated charcoal) are not useful for the treatment of diarrhoea and should not be given. • Antimotility medicines: Antimotility medicines (such as loperamide) have no place in the treatment of diarrhoea in children less than 5 years old. They can be dangerous and even fatal if used improperly in infants. In adults they can give symptomatic relief, but they may only prolong the illness by delaying the elimination of the organism causing the diarrhoea. REMEMBER! Antidiarrhoeal medicines and antiemetics should never be used. None has proven practical value. Some are dangerous. For patients with bloody diarrhoea. REFER. Prevention of diarrhoea • Breastfeeding – Infants should be exclusively breastfed during the ﬁrst 6 months. Breastfeeding should be continued until at least 2 years of age, but complementary foods should normally be started at 6 months of age. If breastfeeding is not possible, cow’s milk or milk formula should be given from a cup. Feeding bottles and teats should never be used. • Use of safe water: Using clean water also protected from contamination can reduce the risk of diarrhoea. • Hand washing: Hands can easily spread diarrhoeal diseases. The risk of diarrhoea Note! If possible, observe the child at least 6 hours after dehydration to be sure the mother can maintain hydration by giving the child ORS solution by mouth Counsel the mother • Food – Assess the child’s feeding Is the mother breast feeding? How often? Does the child take other food or ﬂuids? What does he/she take? How much and how often? • Fluid – Advise the mother to increase ﬂuid during illness. Giving extra ﬂuid can be life saving. Give ﬂuid according to Plan A or Plan B. Show the mother how to prepare ORS. • When to return – Advise the mother when to return to the health worker If the diarrhoea persists for more than 5 days. If there is blood in the stool. If the child is drinking poorly or vomiting. • Counsel the mother about feeding problems If the child is not feeding well, breastfeed more frequently and for longer, if possible. Give soft, varied, appetizing favourite foods to encourage the child to eat as much as possible. • Counsel the mother about her own health. Check that the mother is well and does not have diarrhoea or other illness (HIV) Other treatments • Antibiotics: Antibiotics are not effective against most diarrhoea-causing organisms. Their indiscriminate use will make some people sicker, increase medicine resistance and deplete meagre resources (money). PART 1 STANDARD TREATMENT GUIDELINES GASTROINTESTINAL DISEASES Chapter 5 - 73 PART 1 STANDARD TREATMENT GUIDELINES GASTROINTESTINAL DISEASES Chapter 5 - 73 Age Morning Evening Total number of tablets/ day (never give less) Less than 2 months (< 5 kg) (Do not give to a premature or jaundiced baby!) ¼ tab (Crush tablet with a spoon and mix with water) ¼ tab (Crush tablet with a spoon mix with water) ½ 2 months to 12 months (6–9 kg) ½ tab ½ tab 1 12 months to 5 years (10–19 kg) 1 tablet 1 tablet 2 5 years to 10 years (20–30 kg) 1 ½ tablets 1 ½ tablets 3 Adults (more than 30 kg) 2 tablets 2 tablets 4 REMEMBER The very young (<5 years), the very old, and the very sick should be treated in a hospital if there is still bloody diarrhoea after 5 days, give metronidazole for amoebic diarrhoea can be substantially reduced by regular hand washing of the whole family. • Use of latrines and safe disposal of stools. • Measles immunization. Bloody diarrhoea Patients with acute bloody diarrhoea, especially if there is fever, usually have bacillary dysentery (Shigella). They should be treated according to the schedule below. If possible conﬁrm that there is blood in the stool. • Give: cotrimoxazole 480 mg (sulfamethoxazole + trimethoprim) • Children: If you know the weight of the child, give trimethoprim (TMP) 5 mg/kg + sulfamethoxazole (SMX) 25 mg/kg twice daily. • The dosage below refers to tablets for adults, each containing 80 mg TMP + 400 mg SMX two times a day for 5 days (Remember: Patients must complete the full course of 5 days) PART 1 STANDARD TREATMENT GUIDELINES GASTROINTESTINAL DISEASES Chapter 5 - 75 PART 1 STANDARD TREATMENT GUIDELINES GASTROINTESTINAL DISEASES Chapter 5 - 75 Stomatitis Description Stomatitis is an inﬂammation of the oral mucosa, with or without infection, frequently found in infants. Possible causes include Candida albicans, herpes simplex or vitamin deﬁciency. If severe, it can lead to malnutrition. Always treat carefully, and explain the treatment to the mother. Oral candidiasis is seen in patients with AIDS, malnutrition, diabetes or taking long-term antibiotics. Signs and symptoms • Sore mouth, dysphagia, anorexia, nausea, vomiting; • Depending on the aetiology, there might be red mucus, aphthous vesicles or white plaques. Management • Candidiasis (characterized by white plaques: common in infants) • Adults: The patient should take nystatin tablets 100 000 IU every 8 hours after food for 10 days (vaginal tablets are also available); • Children: Nystatin oral suspension 2 drops in the mouth after each feed for at least 10 days. If nystatin oral suspension is not available use 0.5% gentian violet aqueous solution topically; • Treat any underlying disease (e.g. malaria, pneumonia). • In severe forms, consider HIV infection, REFER. Gastritis and peptic ulcer Description Inﬂammatory or ulcerative lesions of the gastro-intestinal mucosae. Signs and symptoms • Epigastric pain sometimes made worse and sometimes relieved by food; • Acid regurgitation, nausea. Management • Avoid spices, tobacco, carbonated drinks, tea and coffee; • Eat small but frequent meals; • Reduce stressful factors; • Check if the patient is taking medicines likely to be associated with dyspepsia i.e. aspirin, ibuprofen; • Symptomatic treatment: • Aluminium hydroxide: give 2 tablets chewed and swallowed 1 hour after meals or as needed; • If the condition does not settle or is recurrent REFER (for Helicobacter testing, other causes). REMEMBER! Acetylsalicylic acid is contraindicated in patients with a history of peptic ulcer. PART 1 STANDARD TREATMENT GUIDELINES GASTROINTESTINAL DISEASES Chapter 5 - PB • Herpes simplex (common in older children and adults) • Oral toilet and apply 0.5% gentian violet aqueous solution; • Give paracetamol 500 mg tablets as required: • Adults and children over 12 years: 1–2 tablets 6-hourly; • Children 8–12 years: 1 tablet 6-hourly; • Children: 3–7 years: ½ tablet 6-hourly; • Children: 1–2 years ¼ tablet 6-hourly; • Continue feeding and ensure good hydration; • Treat any underlying illness (e.g. malaria, pneumonia) • In severe cases, REFER. • Scurvy (vitamin C deﬁciency) (haemorrhagic stomatitis with bone and joint pains in the lower limbs) • Oral toilet; • Apply 0.5% gentian violet aqueous solution; • Give vitamin C (ascorbic acid) tablets: • Adults: 500–1000 mg daily divided in 3 doses for 2 to 3 weeks; • Children: 100–300 mg daily divided in 3 doses for 2 to 3 weeks; • Nutritional education. Chapter 6 Nutrition disorders • Anaemia, iron deﬁciency • Micronutrient malnutrition • Pellagra (nicotinamide deﬁciency) • Protein–energy malnutrition • Moderate acute malnutrition • Severe acute malnutrition • Vitamin A deﬁciency (xerophthalmia) PART 1 STANDARD TREATMENT GUIDELINES NUTRITION DISORDERS Chapter 6 - 79 Treatment General measures • Eat food rich in iron, e.g. meat, ﬁsh, chicken, liver and vegetables; • Exclusive breastfeeding for 6 months; • Increased consumption of iron absorption enhancers e.g. lemon, citrus fruits (oranges, grapefruits, mango). Speciﬁc treatment • Adults: Exclude underlying disease. Give iron 60 mg + folic acid 400 microgram orally every 8 hours for at least 3 months. • Pregnant women: 120 mg iron + 800 microgram folic acid (2 tablets) to be taken for 3 months followed by preventive regime. • Children <2 years: 30 mg iron + 200 microgram folic acid (½ tablet) daily to be taken for 3 months. • Children 2–12 years: 60 mg ferrous sulfate + 400 microgram folic acid (1 tablet) daily for 3 months. Anaemia, iron deﬁciency Deﬁnition Anaemia is deﬁned as low concentrations of haemoglobin (below 12 g/100 ml in males, 11 g/100 ml in females). Causes • Nutritional deﬁciencies (i.e. not eating foods rich in iron and/or folic acid or deﬁcient in vitamin A). In children it can also come from breast-feeding or bottle- feeding after 6 months without giving complementary foods. There may be poor absorption of iron and vitamins due to malabsorption (chronic diarrhoea or AIDs). • Excessive blood loss (due to menstrual bleeding, gastrointestinal bleeding, hookworm infestations, schistosoma haematobium infection). • Elevated iron needs (i.e. during pregnancy). • Haemolysis (due to malaria, glucose 6 phosphate deﬁciency). Signs and symptoms • Pale insides of eyelids, gums, palms, tongue • White ﬁngernails • Weakness and fatigue • In very severe cases there might be swelling of face and feet, rapid heartbeat and shortness of breath. PART 1 STANDARD TREATMENT GUIDELINES NUTRITION DISORDERS Chapter 6 - 81 Prevention of iron deﬁciency anaemia Age group Indications for supplementation Dosage schedules per day Duration Low birth weight infants Universal supplementation Iron: 2 mg/kg body weight From 2–23 months of age Children 6–23 months Where the diet does not include foods fortiﬁed with iron or where anaemia prevalence is above 40% Iron: 2 mg/kg body weight/kg From 6–23 months of age Children 24–59 months Where anaemia prevalence is above 40% Iron: 2 mg/kg body weight/kg up to 30 mg 3 months School-age children (above 60 months) Where anaemia prevalence is above 40% Iron: 30 mg/day Folic acid: 200 µg/ day 3 months Women of child- bearing age Where anaemia prevalence is above 40% Iron: 60 mg/day Folic acid: 400 µg/ day 3 months Pregnant women Universal supplementation Iron: 60 mg/day Folic acid: 400 µg/ day As soon as possible after gestation, starting no later than the 3rd month, and continuing for the rest of pregnancy Lactating women Where anaemia prevalence is above 40% Iron: 60 mg/day Folic acid: 400 µg/ day 3 months postpartum PART 1 STANDARD TREATMENT GUIDELINES NUTRITION DISORDERS Chapter 6 - 83 Poverty, lack of access to a variety of foods, lack of knowledge of optimal dietary practices and high incidence of infectious diseases are some of the factors which lead to micronutrient malnutrition. In Somalia, the deﬁciencies of greatest public health signiﬁcance are those of vitamin A, iron and iodine. Other important micronutrients include nicotinamide, zinc, vitamin D and calcium. Vitamin A deﬁciency is most common in young children. Untreated, it can lead to blindness and death. Iron deﬁciency anaemia (IDA) is the most common dietary deﬁciency in Somalia affecting mostly children and women of childbearing age. IDA is a signiﬁcant factor in the high maternal and neonatal death rates in Somalia. Iodine deﬁciency disorder occurs in mountainous and ﬂood plain areas where iodine has been washed away from soils. It is the most common cause of preventable mental retardation, including low IQ (intelligence quotient). Severe iodine deﬁciency can lead to cretinism, stillbirth and birth defects. Management The treatment of vitamin A deﬁciency, iron deﬁciency anaemia (IDA) and nicotinamide deﬁciency (pellagra) are described in their respective sections under this chapter. Universal salt iodization (USI) is the recommended intervention for preventing and correcting iodine deﬁciency disorder (IDD). REMEMBER! Intake of tetracycline reduces the absorption of iron. Avoid taking them together. Iron taken in excess doses can also be toxic. Prevention • De-worming must take place as part of the anaemia prevention and control strategy. Also consumption of fortiﬁed foods enhances anaemia control at community level. • Eating food rich in iron such as meat (spleen, kidney, liver), chicken, ﬁsh, eggs, legumes (beans, peas) and dark green leafy vegetables. Micronutrient malnutrition Description Micronutrients are nutrients (vitamins and minerals), which the body needs in minute quantities for growth, development and maintenance. Vitamin and mineral deﬁciencies have a signiﬁcant impact on human welfare and on the economic development of communities and nations. These deﬁciencies can lead to serious health problems, including reduced resistance to infectious disease, blindness, lethargy, reduced learning capacity, mental retardation and, and in some cases, death. Among the debilitating consequences of these dietary deﬁciencies is loss of human capital and worker productivity. Unlike many other impediments, micronutrients can be reduced with relatively small investments in public health, agriculture and education. PART 1 STANDARD TREATMENT GUIDELINES NUTRITION DISORDERS Chapter 6 - 85 • At a later stage the lesions become dark, rough and scaly. There is a clear border between the healthy and the diseased skin. • A child with pellagra is usually underweight. • Diarrhoea often with a sore tongue and other GI symptoms may occur. • In adults there can be dementia or, more often, anxiety and depression. Management • Nicotinamide 50 mg tablets: Adults and children: 2 tablets 8-hourly for 28 days or until healing occurs. Note! Nicotinamide is not included in the Somalia primary health care essential medicines list and patients who have pellagra should be REFERRED to hospital for investigation and treatment. Prevention Educate people to eat foods rich in niacin such as beans, meat, groundnuts, ﬁsh, eggs and vegetables. Protein–energy malnutrition Description Malnutrition severely increases a child’s risk of death. Protein–energy malnutrition (PEM) is identiﬁed by the lack of growth of the child. A child will stop growing for weeks or even months and may be suffering from acute Prevention and control • Food-based interventions, particularly fortiﬁcation programmes, such as salt iodization, and use of concentrated micronutrient supplements; • A mix of accompanying programmes for infection control; • Community participation, including education, communication and information exchange; • Private sector involvement. Pellagra (nicotinamide deﬁciency) Description Pellagra is a form of malnutrition that affects the skin and sometimes the digestive and nervous systems. It is common in places where people eat a lot of maize (corn), or other starchy foods and not enough beans, meat, eggs, vegetables and other bodybuilders and protective foods. This can also occur among refugees or displaced persons fed on inadequate diet. The condition is due to nicotinamide (vitamin B3) deﬁciency. Signs and symptoms • Lesions appear only on skin exposed to sunshine. • In the initial stage painful, symmetrical red lesions can be found on the forehead, top of the cheeks, on the front of the neck, on the outer parts of lower arms and on the lower legs. PART 1 STANDARD TREATMENT GUIDELINES NUTRITION DISORDERS Chapter 6 - 87 The cut-off-points for z-scores (standard deviation scores) are: • A z-score between –2 and –3 indicates moderate severe malnutrition; • A z-score below –3 shows severe acute malnutrition; • The presence of oedema is also indicative of kwashiorkor. The cut-off-points for MUAC are: • 110 mm to 124 mm for moderate acute malnutrition; • <110 mm for severe acute malnutrition. Moderate acute malnutrition A child who is less than 75% of the expected weight-for-height (W/H) with a z-score between –2 and –3 (or MUAC between 110 to 124 mm). Signs and symptoms • The child is thin with mild muscle wasting; • The child plays less because of lack of energy. Management If there is a supplementary feeding programme then admit the child to this programme. If there is no supplementary feeding programme, then follow the same steps shown below. malnutrition before showing any visible signs, but even when mildly malnourished, the child’s risk of death from illness is dramatically increased. Therefore, there are some steps that need to be considered in order to prevent malnutrition and to identify and treat cases at an early stage. Weight, height and age are three measurements that can be combined to form indicators of the nutritional status. These indicators are weight-for-age (W/A), height-for-age (H/A), and weight-for-height (W/H). One more indicator to mention is the mid upper arm circumference (MUAC). REMEMBER! Weight-for-height is recommended by WHO as the indicator of acute malnutrition, but other indicators can be used if necessary. In surveys, there are some cut-off points that can help us in determining what level of acute malnutrition the child is suffering from. These are based on z-scores. A z-score or standard deviation score is the number of standard deviations (SD) below or above the mean value of a reference population. The z- score of weight-for-height of an individual is given by the following formula: individual’s weight – median value of reference population SD value of reference population You will need to know the SD and median value of your reference population to calculate the individual’s z-score. PART 1 STANDARD TREATMENT GUIDELINES NUTRITION DISORDERS Chapter 6 - 89 REMEMBER! When the child shows no improvement because of underlying disease, the child should be referred to a treatment-feeding centre (TFC) or to hospital for specialized care. Severe acute malnutrition Children with severe malnutrition look sick, weak and unhappy. Their weights are less than 70% of the expected weight for height (W/H) with a z-score below –3 (or MUAC <110 mm). In this stage you will ﬁnd signs of marasmus and/or kwashiorkor. Signs and symptoms Marasmus results from prolonged starvation. It may also result from chronic or recurring infections with marginal food intake. The main sign is a severe wasting and the child appears very thin and has no fat. The affected child is very thin (“skin and bones”), most of the fat and muscle mass having been expended to provide energy. There is severe wasting of the shoulders, arms, buttocks and thighs, with no visible rib outlines. Associated signs • A thin “old man” face • “Baggy pants” (the loose skin of the buttocks hanging down) • Affected children may appear to be alert in spite of their condition • There is no oedema (swelling that pits on pressure) of the lower extremities • Ribs are very prominent. 1. Give the child energy-dense food rich in proteins and micronutrients that would provide 150–200 kcal/kg body weight/ day. Advise the mother to give family food to which extra oil is added. If you have Supermix, add more Supermix to the water than usual, and add oil or fat. It is important to: • Feed the child frequently, 6–8 meals per day • Continue breastfeeding • Continue feeding even if the child is vomiting or has diarrhoea. 2. Treat infections: Follow instructions under treatment of moderate acute malnutrition. 3. Immunize the child, if not immunized. 4. Correct micronutrient deﬁciencies: • Give iron and folate tablets during the second week of treatment as ½ or 1 tablet per day; • Give the child vitamin A as follows: • Under 6 months, 50 000 IU if not breastfed; • 6–12 months, 100 000 IU; • 1–5 years, 200 000 IU; • Give the child 100 mg/day vitamin C (two 50 mg tablets) if scurvy is a risk and no fresh food is available. 5. Give the child 500 mg mebendazole as a single dose after the second week if hookworm/whipworm are a problem in children in your area, and if the child is 2 years of age or older, and if the child has not had a dose in the previous 6 months; 6. Treat dehydration by giving ORS. PART 1 STANDARD TREATMENT GUIDELINES NUTRITION DISORDERS Chapter 6 - 91 Marasmic kwashiorkor (mixed form) is a mixed form of PEM, and manifests as oedema occurring in children who may or may not have other signs of kwashiorkor Management • REFER Prevention • Encourage breastfeeding up to 2 years. • Introduce a weaning diet at 4–6 months, using locally available foods, appropriately prepared for the child. • Food for young children should be soft, mashed, with a mixture of different ingredients, like cereals with pulses, milk, vegetables and fruits, meat, ﬁsh or eggs. Make sure that the food is energy dense by adding oil or sugar. • All children aged 6–11 months should be given a dose of 100 000 IU of vitamin A every 4–6 months. Their parents should be counselled on increasing their dietary intake of vitamin A rich food such as dark green leafy vegetables etc. • Immunize all children and monitor their growth monthly. • Encourage family planning. • Encourage a balanced diet for pregnant and lactating women. • All mothers should be given 200 000 IU of vitamin A within 40 days of delivery. • Encourage nutrition education in schools and villages. Kwashiorkor usually affects children aged 1–4 years, although it also occurs in older children and adults. The main sign is oedema, usually starting in the legs and feet and spreading, in more advanced cases, to the hands and face. Oedema may be detected by the production of a deﬁnite pit as a result of moderate pressure for 3 seconds with the thumb over the lower end of the tibia and the dorsum of foot. Because of oedema, children with kwashiorkor may look “fat” so that their parents regard them as well fed. Associated signs • Hair changes: loss of pigmentation; curly hair becomes straight, fairer, ﬁner and easy to break off; • Skin lesions and hypo-pigmentation: dark skin may become lighter in some places especially in the skin folds; outer layers of skin may peel off and ulceration may occur; the lesions may resemble burns; • Children with kwashiorkor are usually apathetic, miserable, and irritable. They show no signs of hunger, and it is difﬁcult to persuade them to eat. REMEMBER! Remember that these signs happen at a late stage and that the child may be acutely malnourished before showing any of these signs. In some cases, oedema may be the only visible sign, while in others all the signs may be present. PART 1 STANDARD TREATMENT GUIDELINES NUTRITION DISORDERS Chapter 6 - 93 Treatment Infants (6–11 months) Children (1–6 years) Immediately 100 000 IU 200 000 IU Following day 100 000 IU 200 000 IU Two weeks later 100 000 IU 200 000 IU Treat all children with prolonged or severe diarrhoea, acute respiratory infection, chickenpox, severe malaria and/or other infections: Age Dosage Infants below 6 months, if not breastfed 50 000 IU, as a single dose Infants 6–11 months 100 000 IU, as a single dose; Children > 12 months 200 000 IU, as a single dose Treat all children with measles without eye signs: Age Dosage Infants < 6 months 50 000 IU, on day 1; repeat dose on day 2 Infants 6–11 months 100 000 IU, on day 1; repeat dose on day 2; Children > 12 months 200 000 IU, on day 1; repeat dose on day 2; Vitamin A deﬁciency (xerophthalmia) Deﬁnition Xeropthalmia is a nutritional deﬁciency of vitamin A and is mainly seen in children. It is associated with decreased intake especially in seasons when or areas where vitamin A rich foods are not available or as a consequence of certain diseases, e.g. measles. In xerophthalmia the eye loses its shine and begins to wrinkle. Signs and symptoms Stage 1 • Initially the person cannot see in the dark (night blindness) Stage 2 • The patient develops dry eyes (xerophthalmia); • The white part of the eyes loses its shine and begins to wrinkle; • Patches of grey bubbles (Bitots spots) may form in the eyes; Stage 3 • The sclera becomes more grey; • The conjunctiva becomes more folded; • The cornea becomes cloudy (opaque); • Cornea ulcerates easily (keratomalacia); Treatment Treat all forms of xerophthalmia, although only stage 1 and 2 may be completely reversible. PART 1 STANDARD TREATMENT GUIDELINES Prevention • Infants: 6–11 months 100 000 IU, every 6 months; • Children: 12–59 months 200 000 IU, every 6 months; • Pregnant women: 10 000 IU, daily (as soon as pregnancy is detected); • Postpartum women: 200 000 IU, single dose within 8 weeks of delivery; • Eating food rich in vitamin A such as breast milk, animal products (cheese, butter, eggs, milk, meat), green vegetables and fruits. Chapter 7 Obstetrics and gynaecology • Breast abscess • Breast infection (mastitis) • Cystitis • Postpartum haemorrhage • Sore nipples • Vaginal candidiasis PART 1 STANDARD TREATMENT GUIDELINES OBSTETRICS AND GYNAECOLOGY Chapter 7 - 97 Signs and symptoms • Hot, painful and swollen breast (the swelling may be of one sector of the breast due to a blocked duct) • No ﬁrm lump present with touching. Management • Give doxycycline 200 mg orally on ﬁrst day and then 100 mg daily for a further 6 days. • Give analgesics for pain: paracetamol 500 mg 6-hourly as required. • Express regularly to avoid engorgement. • Apply hot compresses and a constriction bandage to relieve pain in the affected breast. Cystitis Description Infection of the bladder and urethra. Very frequent in women. Signs and symptoms • Pain during urination • Polyuria (increased urination) • Nocturia (getting up in the night to urinate) • Cloudy and bad smelling urine • There may be haematuria (blood in the urine). Management • Exclude schistosomiasis in endemic areas. • Advise increased intake of ﬂuids. • Antibiotics: Breast abscess Description Breast abscess is the formation of a cavity full of pus in the breast. It is usually a complication of a breast infection. Signs and symptoms • Part of the breast becomes hot, swollen and very painful • A ﬁrm lump can be felt, usually with ﬂuctuation • Lymph nodes in the armpit are often sore and swollen • Fever. Management • If the breast abscess does not respond to antibiotics, REFER for surgery. • If the condition is bad and quick referral is not possible, give doxycycline 200 mg orally on ﬁrst day and then 100 mg daily until the patient reaches a hospital (doxycycline is given no more than 6 days). • Give analgesics for pain: paracetamol 500 mg tablet; 2 tablets 6-hourly as required. Breast infection (mastitis) Description Mastitis is a bacterial infection of the breast and is usually associated with lactation, but it may occur in the absence of lactation. PART 1 STANDARD TREATMENT GUIDELINES OBSTETRICS AND GYNAECOLOGY Chapter 7 - 99 • Immediately give oxytocin 10 units intramuscularly. Alternatively, ergometrine 0.2 mg (1 ml) intramuscularly. • Dose may be repeated if necessary in half an hour to an hour; • If this fails REFER. If immediate referral is not possible give i.v. ﬂuids (normal saline) and REFER. Sore nipples Description Sore nipples develop when a baby sucks mainly from the nipples and does not take the whole nipple and the areola into its mouth. The nipple might show cracks, ﬁssures and bleed easily. Management • It is important to keep breastfeeding the baby. • Stop breastfeeding only if the nipple oozes a lot of blood or pus. • In that case milk the breast by hand until the nipples heal. • Give the expressed milk to the baby using a spoon. • When breast feeding, make sure that the nipple and the areola goes into baby’s mouth. • Do not apply ointments or antiseptics onto the nipples. • Keep the breast clean. • Non-pregnant: Cotrimoxazole 960 mg (sulfamethoxazole + trimethoprim) (2 tablets) orally every 12 hours for 7 days; • Pregnant: amoxycillin 250 mg: 500 mg 8- hourly for 7 days. If no response, REFER. • Children and men with recurrent cystitis should be REFERRED. Postpartum haemorrhage Deﬁnition Postpartum haemorrhage (PPH) is a loss of 500 ml or more of blood from the genital tract after delivery and includes all occurrences of bleeding within 24 hours after delivery. The bleeding may be due to perineal tears, cervical tear or poorly contracted uterus. Signs and symptoms • Vaginal blood loss of more than 500 ml within 24 hours • There may be signs of shock • Pallor • Fast pulse rate • Low or no measurable blood pressure • The patient feels cold. Management • Examine the completeness of the placenta: • Suture tears immediately; • Make sure that no placenta remains in the uterus; • Rub the uterus to stimulate contraction. PART 1 STANDARD TREATMENT GUIDELINES Prevention Breast-feeding. Vaginal candidiasis Description Vaginal candidiasis is a fungal infection of the vagina. It is common, particularly in those who are pregnant, taking antibiotics, diabetic, taking birth control pills or with HIV/AIDS. Signs and symptoms • White discharge, which smells like baking bread • Itching • The lips of the vagina often look bright red and hurt • Burning during urination Management • Nystatin pessary 100 000 IU: Insert 1 pessary into the vagina every 12 hours for 7 days, then once in the evening for further 7 days. • If not available, apply gentian violet solution for 14 days. • Advise to refrain from sexual intercourse during treatment. • Treat the sexual partner with gentian violet solution 0.5% to the penis every 12 hours for 7 days. • If the above treatment does not help, REFER. Chapter 8 Parasitic diseases • Amoebiasis • Ascariasis • Enterobiasis • Giardiasis • Hookworms • Kala-azar • Malaria • Schistosomiasis • Taeniasis • Trichuriasis PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 103PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 103 REMEMBER! Rapid onset of bloody diarrhoea with fever and severe abdominal pains may suggest bacterial dysentery (Shigella). For differential diagnosis see Chapter 5. Management • Asymptomatic patients need no treatment. • Symptomatic patients give metronidazole 250 mg tablets: • Adults: 750 mg 8-hourly for 7 days. • Children: 15 mg/kg 8-hourly for 7 days. Prevention • Boiling of water (chlorination does not kill the cysts). • Proper faecal disposal. Ascariasis (round worms) Deﬁnition Ascariasis is one of the commonest helminthic infections of the small intestine in Somalia. Mode of transmission is oral. Children are usually more frequently and more heavily infected than adults for the simple reason that they put everything into their mouth. The disease is caused by a type of worm (Ascaris lumbricoides), which belongs to the family Nematodes. Ascaris is a long and round worm, thus sometimes called round worms. A female ascaris can produce up to 200 000 eggs daily. Amoebiasis Description Amoebiasis is an infection of the colon caused by Entamoeba histolytica transmitted by oral ingestion of cysts. Infection with amoebae is in most cases without any symptoms. Under certain circumstances the amoebae may invade the bowel wall causing amoebic dysentery. The infection can be spread to other organs, especially the liver, where it causes liver abscess. Signs and symptoms • Commonly asymptomatic • When the amoeba invades the tissue symptoms may include: • Intermittent diarrhoea and constipation • Flatulence • Mild cramping abdominal pain • Tenderness over the liver • Stools may contain mucus and blood. • In amoebic dysentery there will be: • Episodes of frequent semi-ﬂuid or ﬂuid stools that contain blood, ﬂecks of mucus, and active trophozoite • No, or only slight, fever • Patient may become emaciated and anaemic • The onset is slow; the attacks are episodic and can last up to 6 weeks. PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 105PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 105 Signs and symptoms • Pruritus ani is a characteristic symptom, which provokes intense scratching of the perianal-anal region, resulting in secondary bacterial infection. • The patient might also suffer: • sleep disturbance, restlessness, loss of appetite, weight loss • vulvitis or appendicitis. Management Mebendazole 100 mg tablets: Adults and children: give a single dose of 100 mg repeated after 2 weeks. Prevention • Personal hygiene • Bathing and hand washing • Cutting nails short • Washing underwear, nightclothes and bedclothes • Less crowded living conditions • Correct faeces disposal • It is important to treat whole family. Giardiasis Deﬁnition Giardiasis is an infection of the small intestine by a ﬂagellated protozoal parasite, Giardia lambia. The mode of transmission is oral ingestion of the cysts. Signs and symptoms • Vague abdominal discomfort • The adult worm may be vomited or come out with the stool upsetting the patient (and the parents) • Intestinal obstruction may occur in very heavy infections • Ascariasis may lead to malnutrition. Treatment Mebendazole 100 mg tablets: give 1 tablet twice daily for 3 days. Prevention • Environmental measures • Provision of clean water supply • Proper disposal of faeces. • Health education • Proper use of latrines, including hand washing • Washing of hands before handling food • Washing of fruits and vegetables before eating. Enterobiasis (thread worms) Deﬁnition Enterobiasis is a benign intestinal disease caused by Enterobius vermicularis (thread or pinworm). The worms emerge from the anus at night to lay their eggs. Infection is often direct transfer of eggs from the anus to the mouth after the person scratches the anus or perianal region. PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 107PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 107 Signs and symptoms • Asymptomatic in the majority of the patients • Ground itch at the site of penetration • Gastrointestinal tract: dyspepsia, abdominal pain, abdominal distension, sometimes diarrhoea • In heavy infections, iron deﬁciency anaemia develops • Anaemia due to hookworms is slow, and the patient can be walking with Hb less than 5 g % (walking anaemia). REMEMBER Hookworm causes loss of IRON and anaemia Management • Correction of anaemia • Adults: Iron tablet 60 mg + folic acid 400 microgram three times daily with for 2–3 months. • Children: Iron tablet 30 mg + folic acid 200 mg three times daily with meals for 2 months. • Deworming • Adults and children over 1 year: Mebendazole 100 mg twice daily for 3 days or 500 mg as a single dose. Prevention • Wearing of shoes. • Correct disposal of faeces. • Health education for mothers. Signs and symptoms • The majority of patients are asymptomatic • In symptomatic patients there may be: • Diarrhoea • Malabsorption resulting in fatty offensive stools which look like porridge • Weight loss • The disease may be self-limiting or prolonged. Treatment Metronidazole 500 mg tablets: • Adults: 2 g given orally as a single dose once daily for 3 days. • Children: 5 mg/kg orally 8-hourly for 5 days. Prevention • Cooking of food and boiling of water kills the cysts rapidly. Hookworms Description Hookworms consist of Ancylostoma duodenale and Necator americanus. The adult worms are attached to the walls of the duodenum with hook-like teeth in their buccal cavity where they suck human blood. The mode of transmission is through the skin usually of the feet. PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 109PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 109 Management • If kala-azar is suspected, REFER. Prevention • Avoid/reduce contact with sand ﬂies using bed nets, insect repellents and protective clothes with long sleeves. Malaria Deﬁnition Malaria is an acute infective illness caused by protozoa of the genus Plasmodium. The infection is often accompanied by attacks of fever, which may be periodic. Malaria is an important cause of fever, convulsions, anaemia and death. In pregnancy it results in low birth weight, abortion and maternal death. Malaria is also a major cause of economic loss through working and learning days lost. There are four different species of the malaria parasite, which infect man. These are: Plasmodium falciparum, Plasmodium malaria, Plasmodium vivax, and Plasmodium ovale. P. falciparum is responsible for approximately 90% of malaria cases in Somalia. The epidemiological feature of malaria in Somalia is divided into: hypoendemic (North), meso- endemic to hypoendemic in the Centre and South and hyper-endemic in the riverine areas of the Juba and Shabelle rivers. The incubation period for P. falciparum is 9 to 13 days, and more than 15 days for the other three forms. Kala-azar Description Leishmania spp. are responsible for several clinically distinctive diseases characterized by chronic inﬂammatory inﬁltration, focal necrosis and ﬁbrosis. In some, the lesions are localized to the point of inoculation (cutaneous) but, in others, the parasite becomes widely disseminated (visceral). Worldwide, some 12 million people are estimated to be infected and over 2 million new cases occur each year. All types of leishmaniasis are transmitted by the same biting vector, the female sand ﬂy. Visceral leishmaniasis (kala-azar) is caused by a parasite of the Leishmania donovani and is endemic in south-west Asia, the Indian subcontinent, China, the Mediterranean area, East Africa and Central and South America. Visceral leishmaniasis is the most serious form and is fatal if left untreated. Signs and symptoms Early phase • Chronic irregular fever • Malaise • Anorexia • Cough • Diarrhoea • Secondary infection Later stage • Progressive enlargement of the spleen, liver and occasionally lymphnodes • Anaemia • Emaciation PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 111PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 111 as a result of inadequate treatment or no treatment may suffer several weeks or months of poor health, which is characterized by febrile episodes, anaemia and weakness. A patient should be considered as having severe malaria if any one or more of the following are observed and the patient is living in or gives a history of travel to malaria endemic area: • Altered consciousness (e.g. sleepy, confused, in coma, etc) • Not able to drink or eat or breastfeed in the case of small children • Convulsions or recent history of convulsions • Persistent vomiting • Haemoglobinuria (dark urine, “coca-cola urine”) • Treatment failure within 2–3 days • Spontaneous bleeding, gum bleeding, epistasis • Failure to pass urine in the last 24 hours • Respiratory problems (i.e. pulmonary oedema, difﬁcult breathing) • Jaundice • High temperature (rectal temperature >39°C) • Systolic blood pressure <80 mmHg, where there is no i.v. ﬂuid or if the patient does not respond to i.v. ﬂuid administration. Special risk groups • Children under 5 years of age • Pregnant women, especially in their ﬁrst pregnancy • Travellers from non-malarious areas (no immunity) Signs and symptoms • Onset of attack may resemble a ﬂu-like illness with several days of fever, headache, aching joints and general malaise. The classical presentation is chills, shivering, high fever and sweating which does not always occur, especially in primary attacks of P. falciparum malaria. • In infants there may be only poor appetite, restlessness and loss of interest in the surroundings. • For the ﬁrst few days, the fever is usually irregular or even continuous and in some cases (P. falciparum) the fever may not ever settle into the classical periodicity of every 48 or 72 hours. • After the primary attack there usually follows an afebrile interval. Further attacks similar to the ﬁrst occur every 48 or 72 hours (the latter in P. malariae only). After each attack, there is another afebrile period. • In P. falciparum infections the symptoms (headache, fever, nausea, vomiting) are usually much more severe than with other malarial infections (P. vivax etc). The mortality is much greater and there is a greater tendency to rapidly develop complications (coma, renal failure and haemolytic anaemia, jaundice). Those that survive but have continuing infection PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 113PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 113 Dose schedule by age (ACT) Age in years Weight in kg Protocol (3 days) Day 1 Day 2 Day 3 SP (500 mg + 25 mg tab) AS (50 mg tab) AS (50 mg tab) AS (50 mg tab) < 1 5–10 ½ ½ ½ ½ 1–<3 10–14 1 1 1 1 3–<5 15–19 1 2 2 2 5–11 20–35 2 3 3 3 12+ 36+ 3 4 4 4 Malaria treatment is preferably based on deﬁnitive laboratory diagnosis. Where laboratory diagnosis is not available, then for all cases aged 5 and above, clinical diagnosis must be conﬁrmed by RDT (rapid diagnostic test) and positive cases treated. REMEMBER! In meso- and hyperendemic areas (south and central Somalia) for children under the age of 5, the treatment is recommended to be given based on sound clinical signs and symptoms and regardless of RDT (rapid diagnostic test) results. Supportive treatment • Treat all other additional conditions such as dehydration, high fever and anaemia as required, as described in the respective chapters in this manual. WARNING! Severe/complicated malaria is a medical emergency requiring dedicated attention from the most qualiﬁed health staff. In most areas, women and children under 5 are the most susceptible group. Management Uncomplicated malaria Medicine treatment: 1st treatment of choice Artenisinin-based combination therapy ( A C T ) : A r t e s u n a t e + s u l f a d o x i n e - pyrimethamine tablets. Artesunate (AS) 50 mg tablets and SP (sulfadoxine 500 mg + pyrimethamine 25 mg) tablets. SP is given in a single dose on the ﬁrst day in combination with artesunate. Then artesunate is given for 2 more days. REMEMBER! The ﬁrst treatment is provided under direct observation treatment (DOT). PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 115PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 115 Complicated malaria If the patient shows one or more of the signs and symptoms of severe malaria (see above), REFER immediately. Before referral: • Give oral quinine, if the patient can swallow. • Reduce fever by sponging and by giving paracetamol, if patient can swallow. • Give ﬂuids such as ORS, if patient can swallow. • Where there is possible, administer 5% glucose. • Record all your ﬁndings and medicines given in a referral slip and REFER. Where immediate referral is not possible and intravenous (i.v.) administration is possible, give quinine i.v. as follows: • Loading dose: Quinine salt 20 mg/kg by infusion in 500 ml 5% dextrose (if not available, physiological saline may be used) over 4 hours. • Maintenance doses: 12 hours after the loading dose, give quinine salt 10 mg/kg in dextrose saline over 4 hours. Repeat the same dose of quinine salt (i.e. 10mg/kg) every 8 hours until the patient can take oral medication. If referral is still not possible, continue treatment with quinine salt 10 mg/kg i.v. in dextrose over 8-hourly (if i.v. is not possible, give quinine i.m. in the same doses). Transfer to oral therapy as soon as the patient can swallow for a total of 7 days. Follow-up • If a patient who has taken the full course of ACT returns to the health facility with fever, suspect medicine failure. • Do blood examination for malaria parasites where possible. • Treat any other suspected cause of his/her fever or REFER. • If medicine failure is concluded, give oral quinine (2nd treatment of choice) as shown in the table below. • Quinine tablets (each tablet containing 300 mg, recommended total dose: 10 mg/kg, 8-hourly for 7 days) A g e W ei g ht (k g ) Number of tablets (300 mg tab) 7 day protocol D 1 D 2 D 3 D 4 D 5 D 6 D 7 <1 year 5–6 ¼ ¼ ¼ ¼ ¼ ¼ ¼ 1–4 years 11–14 ½ ½ ½ ½ ½ ½ ½ 5–7 years 19–24 1 1 1 1 1 1 1 8–10 years 25–35 1 ¼ 1 ¼ 1 ¼ 1 ¼ 1 ¼ 1 ¼ 1 ¼ 11–15 years 37–50 1 ½ 1 ½ 1 ½ 1 ½ 1 ½ 1 ½ 1 ½ Above 15 years >50 2 2 2 2 2 2 2 PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 117PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 117 and 40–50 ml/kg in children, except in severely dehydrated patients. • Ensure adequate nutrition (nasogastric feeding if necessary). • If the anaemia is severe enough to require blood transfusion, REFER. • Check the lungs (auscultation) for pulmonary oedema. • Check for respiratory infection, which requires antibiotic therapy. • Record urine output, to detect anuria (renal failure). This will require ﬂuid restriction. Prevention • Insecticide-treated nets (ITNs). • Intermittent preventive treatment (IPT) in high transmission areas (recommended only in southern and central zones): at least two courses of doses of 3 tablets of SP during second and third trimester of pregnancy. Minimum of 4 weeks to be observed between the two doses. A third dose in case of pregnancy with HIV/AIDS preferably between 28 to 32 weeks is recommended. • Effective case management of malarial illness. • In known cases of sulfonamide hypersensitivity quinine may be given. REMEMBER! There is no clinical evidence that sulfadoxine-pyrimethamine is hazardous to the fetus. The combination does not pose either any signiﬁcant risk to breastfeeding infants. Treatment of convulsions • Lie the patient on his left side, upper leg ﬂexed. • Keep upper airway clear by removing any secretions or vomit. • Then give intravenous diazepam 5 mg/ml: • Adults: 0.15 mg/kg, maximum 10 mg by slow i.v. injection (over 2–3 minutes); if injection is not possible, give 0.5–1.0 mg/kg rectally. • Children: 0.5 mg rectally by means of syringe without needle. • If still has ﬁts after 10 minutes, repeat same dose. Treatment of hyperpyrexia • Cold sponging, tepid wet towels • Paracetamol as needed. Treatment of hypoglycaemia • Give 40% or 50% glucose, 50 ml (0.1 mg/ kg for children) by intravenous bolus injection. • Follow with an intravenous infusion of 5%. • Continue to monitor the patient where possible by blood testing. REMEMBER! Hypoglycaemia may recur even after intravenous bolus dose of 50% glucose. Complementary measures • Fluid balance: record inputs and outputs of ﬂuids. • Guard against excessive hydration if not sure of the integrity of the renal function. Do not exceed 2000–2500 ml/day in adults PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 119PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 119 Signs and symptoms • At the site of penetration there is dermatitis with itching papules and local oedema (cercarial dermatitis). • During maturation of the parasite, the patient may experience abdominal pain, and transient generalized urticaria (Katayama syndrome). There is also an eosinophylia. • When the disease is established there is haematuria. Late complications • Obstruction to and dilation of the ureter (hydroureter) and hydronephrosis possibly leading to kidney failure; • Calciﬁcation of the bladder which may lead to pyelonephrosis (infection of kidneys); • Cancer of the bladder. Management Praziquantel 600 mg tablets: 40 mg/kg as a single dose. Prevention • Avoid contact with contaminated water. • Health education. Taeniasis Description Taeniasis is an infection of the small intestine by Taenia saginata or Taenia solium. Taeniasis in Somalia is caused by Taenia saginata (beef tapeworm). People get infected by eating raw or only lightly cooked beef infected with the cysticera. • Attend antenatal clinic (for pregnant women). • Eliminate mosquito breeding sites around home. • Avoid mosquito bites, i.e. using mosquito bed nets, coils. • Wear long sleeves, long trousers and socks if outside between dusk and dawn. • Ensure good compliance with prophylaxis/ treatment. • Contact the health centre if you suspect you have malaria. Schistosomiasis Description Schistosomiasis is a chronic disease caused by trematodes of the genus Schistosoma, which infect the large bowel (intestinal schistosomiasis) or the urinary bladder (urinary schistosomiasis). In Somalia, only urinary schistosomiasis caused by Schistosoma haematobium is found. It is endemic in the areas between the two rivers, Shabelle and Jubba. The disease is transmitted by the penetration of cercariae into the human skin during contact with infected water. The adult parasite harbours in the urinary bladder. It produces hundreds of eggs per day many of which pass out in the urine while the remainder are deposited around the small capillaries of the urinary bladder causing tissue damage. PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 121PART 1 STANDARD TREATMENT GUIDELINES PARASITIC DISEASES Chapter 8 - 121 Signs and symptoms • Light infections are usually asymptomatic. • In heavy infections there might be: • Abdominal discomfort • Bloody diarrhoea (without fever) • Loss of weight or stinting of growth • Anaemia • Rectal prolapse. Management • Mebendazole 100 mg tablets: Adults and children: 100 mg twice daily for 3 days. Prevention: • Proper disposal of faeces • Personal hygiene • Health education Signs and symptoms Most patients remain asymptomatic, however, some might suffer: • Loss of weight. • Abdominal discomfort. • Pruritus ani (itching around the anus). • Segments of the parasite may be passed with stools. Management • Niclosamide (PO): • Adults 2 g (1 g, then 1 g one hour later). • Child: 30 mg/kg as a single dose. Note: Niclosamide is not included in the primary health care essential medicine list. Such patients should therefore be referred. Prevention • Health education • Correct cooking of meat • Correct disposal of faeces Trichuriasis Description Trichuriasis is a nematode infection of the large intestine. Trichuriasis is caused by Trichuris trichuria (whipworm) and is usually asymptomatic. The mode of transmission is by eating contaminated soil or food. Therefore it is commonest in children. Chapter 9 Respiratory infections • Asthma • Bronchitis (acute and chronic) • Common cold • Otitis (externa, interna, acute and chronic) • Tonsillitis • Pneumonia • Sinusitis, acute • Tuberculosis PART 1 STANDARD TREATMENT GUIDELINES RESPIRATORY INFECTIONS Chapter 9 - 125 Asthma Description This consists of attacks of reversible narrowing of the small airways, causing difﬁculty in breathing, with expiratory wheezing. At ﬁrst it is due to spasm, and then to mucosal swelling. In long and severe attacks (status asthmaticus) the bronchi are blocked with plugs as well. Asthma is often due to allergy and this type is more common in young people. The disease can be provoked by exercise, cold weather, smoking, infection or psychological causes. Signs and symptoms • Expiratory wheezing (rhonchi) • Cough • Expiratory dyspnoea “difﬁculty in expiration” • Whistling or hissing sounds (sibilants) “heard in the lungs through a stethoscope” • The temperature is often normal. Management • Uncomplicated asthma • Salbutamol orally (4 mg tablets) as required: • Adults: 0.3 mg/kg/day, in three divided doses • Children 1–9 years: ¼ tablet 8-hourly • Children 10 years or more: 2 tablets 8- hourly as required • Maintain treatment for 5 days, and then decrease gradually. • Status asthmaticus, REFER, if not possible: • Let the patient sit in orthopnoeic position “in a sitting position”; • Reassurance and hydration; • Give adrenaline 1% solution (epinephrine): • Children under 1 year: 0.1 ml i.m. • Children 1–5 years: 0.2 ml i.m. • Children 6–15 years: 0.5 ml i.m. • >15 years: 1.0 ml i.m. • Repeat same dose after 30 minutes, if deemed necessary. Do not give more than 3 injections per day. • Then treat as in uncomplicated asthma. Bronchitis, acute Description Acute inﬂammation of the tracheobronchial tree (the tubes leading to the lungs, through which air passes when a person breathes) generally self-limiting and with eventual complete healing and return of function. Though commonly mild, bronchitis may be serious in weak, debilitated patients and in those with chronic lung or heart disease. Signs and symptoms • Often preceded by symptoms of upper respiratory infections (URI) • Cough, dry ﬁrst, then productive • Mild fever • Wheezing or musical noise sounds (rhonchi) heard in the lungs through a stethoscope • No marked dyspnoea “lack of air”. PART 1 STANDARD TREATMENT GUIDELINES RESPIRATORY INFECTIONS Chapter 9 - 127 Management • General • Rest until fever subsides • Abundant ﬂuid intake. • Analgesics • Paracetamol 500 mg tablets: • Adults and children over 12 years: 1–2 tablets 6-hourly; • Children 8–12 years: 1 tablet 6-hourly; • Children 3–7 years: ½ tablet 6-hourly; • Children 1–2 years: ¼ tablet 6-hourly; • Acetylsalicylic acid 300 mg tablet: • Adults and children over 16 years: 1–3 tablets 6-hourly. • Antibiotics: in patients who may have superinfections (with purulent sputum, or persistent high fever) or with poor basic health (malnutrition, measles, anaemia, cardiac disease, elderly), or dyspnoeic. • cotrimoxazole 480mg (sulfamethoxazole + trimethoprim) tablets. • Adults and children over 12 years: 2 tablets 12-hourly for 5 days • Children under 12 years old: 30 mg/kg 12-hourly for 5 days. REMEMBER! Acetylsalicylic acid is contraindicated in patients with a history of peptic ulcer. Bronchitis, chronic Description Chronic inﬂammation of the bronchial mucosa of irritant (tobacco) or allergic (asthma) origin, progressing towards chronic respiratory failure. Signs and symptoms • Morning cough, clear sputum, bronchial rales (soft crackling sounds heard in the lungs through a stethoscope) • Exclude tuberculosis. Management • Discourage cigarette smoking. • NO ANTIBIOTICS. Common cold Description Common cold is a viral infection of the nasopharyngeal mucosa. Colds are frequent and seasonal. Signs and symptoms • Runny nose • Often with mild fever • Coughing and sneezing. Management • NO antibiotics • General measures • Rest • Lots of ﬂuids • Keep the patient warm • For those patients with fever give analgesic • Paracetamol (500 mg tablets) as required: • Adults and children over 12 years: 1–2 tablets 6-hourly; PART 1 STANDARD TREATMENT GUIDELINES RESPIRATORY INFECTIONS Chapter 9 - 129 • Children 8–12 years: 1 tablet 6-hourly; • Children 3–7 years: ½ tablet 6-hourly; • Children 1–2 years: ¼ tablet 6-hourly; • Acetylsalicylic acid (aspirin: 300 mg tablets) as required; • Adults and children over 16 years old: 1–3 tablets 6-hourly; • Alternatively ibuprofen can be used. REMEMBER! Analgesics should not be given for more than 3 days. Prolonged fever may indicate other more serious conditions which require further investigation. REMEMBER! Aspirin is contraindicated in: • Children under 16 years (danger of Reye’s syndrome) • Patients with a history of gastrointestinal pain or ulceration. • Patients with a history of allergy to aspirin • Pregnant women Asprin must not be taken on an empty stomach. Otitis externa Description An acute inﬂammation of the meatus of the external ear. The cause might be due to the presence of a foreign body. Signs and symptoms • Pain, provoked especially by the traction of the pinna • Redness of the outer ear canal • There may be a discharge • Eardrum, if examined appears normal. Management • Remove foreign body if present in the ear. • Advise the patient to keep the ear dry and avoid scratching or poking anything into the ear canal. • If discharge, clean with normal saline. • Apply gentian 0.5% violet with cotton bud or similar for 3–5 days. • Analgesic (see common cold). • If discharge unilateral and foul smelling REFER (danger of cholesteatoma). Otitis media, acute Description An acute inﬂammation of the middle ear. Usually bacterial but can also be of viral origin. It is usually a complication of upper respiratory infection (URI). It is most common in young children, particularly from age 3 months to 3 years, caused by secondary tracking of the infection from the nasopharynx (nose/throat) via the Eustachian tube. Signs and symptoms • Fever, which may reach above 40°C • Severe pain and agitation • Nausea, vomiting and diarrhoea may occur in young children • Deafness • Otorrhea (pus) may occur due to perforation of the eardrum. PART 1 STANDARD TREATMENT GUIDELINES RESPIRATORY INFECTIONS Chapter 9 - 131 Management • General management: • Clean the ear daily (never probe into the ear) • Treat fever and pain with analgesics (see common cold) • Phenoxymethylpenicillin (penicillin v; 250 mg tablets): • Adults and children over 12 years: 2 tablets 6-hourly for 10 days • Children: • 5–10 kg (or up to 1 year): ¼ tablet 6 hourly for 10 days. • 10–30 kg (1–5 years): ½ tablet 6- hourly for 10 days. • >30 kg (or 6–12 years): 1 tablet 6- hourly for 10 days. • For penicillin allergic patients: Give erythromycin 250 mg tablets before meals: • Adults and children over 8 years: 1–2 tablets 6-hourly for 10 days. • Children 5–10 kg (or up to 1 year): ¼ tablet 6-hourly for 10 days. • Children: 10–15 kg (or up to 2 years): ½ tablet 6-hourly for 10 days. • Children over 15 kg (2-8 years): 1 tablet 6-hourly for 10 days. Follow-up • No response, REFER especially very young children. If immediate REFERRAL is not possible start giving amoxycillin 15 mg/kg 8-hourly and REFER. Otitis media, chronic Description A chronic infection of the middle ear with perforation of the eardrum (tympanic membrane). Signs and symptoms • Otorrhea (chronic discharge) for 2 weeks or more • Hearing loss. Management • Wash with normal saline once daily. • If fever or pain, give analgesics (see common cold). • NO antibiotics. • If painful swelling behind the ear or no improvement after 4 weeks’ treatment, REFER. Tonsillitis Description Tonsillitis is an infection and inﬂammation of the tonsils. Signs and symptoms • Fever • Sore throat • Adenopathy (enlargement of the tonsils) • White exudates on the throat. PART 1 STANDARD TREATMENT GUIDELINES RESPIRATORY INFECTIONS Chapter 9 - 133 Management • Phenoxymethylpenicillin (penicillin v; 250 mg tablets): • Adults and children over 12 years: 2 tablets 6-hourly for 10 days. • Children: • 5–10 kg (or up to 1 year): ¼ tablet 6-hourly for 10 days. • 10–30 kg (1–5 years): ½ tablet 6-hourly for 10 days. • >30 kg (or 6–12 years): 1 tablet 6-hourly for 10 days. • For penicillin allergic patients: Give erythromycin 250 mg tablets before meals: • Adults and children over 8 years: 1–2 tablets 6-hourly for 10 days. • Children 5–10 kg (or up to 1 year): ¼ tablet 6-hourly for 10 days. • Children: 10–15 kg (or up to 2 years): ½ tablet 6-hourly for 10 days. • Children over 15 kg (2–8 years): 1 tab 6- hourly for 10 days. • Analgesia (see common cold). Caution • In severe cases, especially in cases of quinsy, REFER. Pneumonia Description Pneumonia is a major cause of death, particularly in young children. However death can be prevented by correct diagnosis and management. Young infants die more quickly than older children. Management of these infants is therefore different from that of older children. If infants under 2 months have pneumonia they should always be referred after initial treatment. There is no ordinary pneumonia for infants—it is all severe or very severe. In children over 2 months and adults mild pneumonia can be managed without referral. Pneumonia in children Classify children according to the severity of the illness into: • no pneumonia—fever and cough • mild pneumonia—fever, cough and rapid breathing • severe pneumonia—fever, cough, rapid breathing and chest wall recession • very severe pneumonia—severe pneumonia with danger signs. To diagnose pneumonia, the key sign to check is the breathing rate. If it is more than the following, then a diagnosis of pneumonia should be made. • 60 or more breaths per minute if under 2 months • 50 or more breaths per minute if 2 months to 1 year • 40 or more breaths per minute if 1 year to 2 years. Since infants might have unspeciﬁc signs and symptoms look for the following danger signs. If any one of them is present, the infant has very severe pneumonia. PART 1 STANDARD TREATMENT GUIDELINES RESPIRATORY INFECTIONS Chapter 9 - 135 Danger signs • Failure to feed • Convulsions • Abnormally sleepy or difﬁcult to wake • Stridor in calm child • Grunting • Apnoea. For older children you need to assess the severity. The key sign for this is to look for rib retraction. If present the child should be referred as above. If there is no rib retraction, then the child can be managed at the health centre. Management of pneumonia in infants • In infants with suspected pneumonia, REFER immediately. • Before referral, give a stat dose of benzyl penicillin. • Keep the child warm. • Ensure adequate hydration. • Continue feeding. Management of pneumonia in older children • In older children with rib retraction, REFER immediately. • For others with no danger signs: • Give cotrimoxazole 480 mg (sulfamethoxazole + trimethoprim) for 5 days. • Treat fever, if present. • If over 12 months treat wheezing, if present, with salbutamol (see asthma). • Advise the mother on home care management: Feed the child • Continue to feed the child during illness. • Increase feeding after illness. • Clear nose if it interferes with feeding. Increase ﬂuids • Offer the child extra ﬂuids to drink. • Increase breast-feeding. • Watch for danger signs and REFER if they occur. • Advise mother to return for review in 2 days, or earlier if the child is getting worse. REMEMBER! Most children with cough of difﬁcult breathing who do not have any danger sign or signs of pheumonia have a simple cough or cold. If coughing for more than 30 days, REFER. Pneumonia in adults (and older children) Pneumonia in adults and older children, if it starts with a sudden onset, is usually caused by pneumococcus. If it does not respond to treatment then you must consider tuberculosis or opportunistic infection due to HIV. Signs and symptoms • High fever (>39°C) • Cough • Respiratory distress • Chest pain • Tachypnoea • Examination shows dullness to percussion, diminished breath sounds, crepitations and sometimes bronchial breath sounds. Management PART 1 STANDARD TREATMENT GUIDELINES RESPIRATORY INFECTIONS Chapter 9 - 137 • In severe pneumonia in adults and older children, start giving benzyl penicillin injection 2 million IU i.m. and REFER. • In less severe pneumonia in adults and older children give tablet phenoxymethyl penicillin 500 mg, 8-hourly. • For penicillin allergic patients: Give erythromycin 250 mg tablets, 2 tablets 6-hourly. • Paracetamol 500 mg, 1–2 tablets orally 6 hourly as required, If the condition doses not respond to treatment: • Consider tuberculosis, REFER. • Consider opportunistic infection due to HIV, REFER. Sinusitis, acute Description Sinuses are hollows in the bone that open into the nose. Sinusitis is an inﬂammation of these hollows particularly those above or below the eyes. It is often a complication of viral upper respiratory tract infections. Signs and symptoms • Headache • Pain/tenderness of involved sinus • Thick purulent, yellowish mucoid discharge from nose (catarrh) • Fever. Management • Analgesics (see common cold). • Antibiotics: • Phenoxymethylpenicillin (penicillin v; 250 mg tablets): • Adults and children (>12 years): 2 tabs 6-hourly for 10 days. • Children: • 5–10 kg (or up to 1 year): ¼ tablet 6-hourly for 10 days. • 10–30 kg (1–5 years): ½ tablet 6- hourly for 10 days. • >30 kg (or 6–12 years): 1 tablet 6- hourly for 10 days. • For penicillin allergic patients: Give cotrimoxazole 480 mg (sulfamethoxazole + trimethoprim) tablets. • Adults and children over 12 years old): 2 tabs12-hourly for 5 days. • Children under 12 years old: 30 mg/ kg 12-hourly for 5 days. Alternatively give erythromycin (see Otitis media for dosage). • Poor response after 5 days, REFER. REMEMBER! Acetylsalicylic acid is contraindicated in patients with a history of peptic ulcer. Tuberculosis Description Tuberculosis (TB) is a serious public health, social and economic problem. TB is caused by Mycobacterium tuberculosis. TB bacteria can strike the lungs (pulmonary TB) or any other parts of the body, such as the PART 1 STANDARD TREATMENT GUIDELINES RESPIRATORY INFECTIONS Chapter 9 - 139 glands of the neck, abdomen, joints and bones (extrapulmonary). However in most patients it affects the lungs. TB is a chronic (long lasting), contagious (easily spread) disease that anyone can get. TB most often affects people between 15 and 35 years of age, especially those who are weak, poorly nourished, or with lowered resistance or immunity (e.g. HIV infection). TB is curable, yet thousands of people needlessly die from this disease. Worldwide TB kills close to 2 million people each year. The DOTS (directly observed therapy, short course) strategy has been proven to cure more than 85% of cases in Somalia. The treatment of TB may be complicated by the presence of HIV infection. In some African countries more than 50% of TB cases are among HIV positive patients. Signs and symptoms • Chronic cough (more than 2 to 3 weeks) which is not responsive to antibiotics • Haemoptysis (coughing blood or blood stained sputum • Loss of weight and appetite • Low grade fever • Night sweats, even when the weather is cold • Tiredness • Enlarged cervical lymph nodes (especially children). Management TB treatment not only saves lives, but also prevents the spread of infection and development of drug-resistant TB. Successful TB treatment requires 6–8 months of a combination of medicines taken daily. Remembering to take the medicines for 6 to 8 months can be a problem. This is why the DOT strategy was introduced. DOT means that every dose of treatment taken is witnessed to ensure it is swallowed. Care providers should sympathetically explain the importance of completing the treatment. REMEMBER! The relationship between the care provider and the patient is a major determinant of whether the patient will complete the treatment or not. Treatment of TB should not be started until a ﬁrm diagnosis has been made. Priority to treat is given to smear-positive cases, then to smear-negative and extrapulmonary cases. Fixed dose combination (FDC) Medicine Dose form Strength/tablet Isoniazid + rifampicin (HR) Tablet 75 mg + 150 mg Isoniazid + rifampicin + pyrazinamide + ethambutol (HRZE) Tablet 75 mg + 150 mg + 400 mg + 275 mg There are four types of treatment regimen (3 categories). PART 1 STANDARD TREATMENT GUIDELINES RESPIRATORY INFECTIONS Chapter 9 - 141 Category 1 (Short course regime) New smear-positive patients; new smear- negative pulmonary TB with extensive parenchymal involvement; severe concomitant HIV disease or severe forms of extrapulmonary TB. TB treatment regimen for category 1 Weight of patient (Pre- treatment weight) Initial phase Daily for 2 months Continuation phase Daily for 4 months HRZE HR 30–39 kg 2 2 40–54 kg 3 3 55–70 kg 4 4 >70 kg 5 5 Category 2 (Retreatment regime) Previously treated sputum smear-positive PTB: • relapse • treatment after interruption • treatment failure. TB treatment regimen for category 2 Weight of patient (Pre- treatment weight) Initial phase Daily for Continuation phase 3 months 2 months Daily for 5 months HRZE S 1 g vial HR E 400 mg 30–39 kg 2 0.5 2 1.5 40–54 kg 3 0.75 3 2 55–70 kg 4 1 4 3 >70 kg 5 1 5 3 S: streptomycin E: ethambutol Category 3 (Standard regime) New smear-negative PTB (other than in Category 1) and less severe forms of extrapulmonary TB. Treatment is the same as category 1. Category 4 (Individualized regime) Chronic and multidrug-resistant (MDR) TB cases (still sputum-positive after supervised re-treatment). This group needs specially designed treatment and care and should be referred to a specialized TB centre. PART 1 STANDARD TREATMENT GUIDELINES RESPIRATORY INFECTIONS Chapter 9 - 143 REMEMBER! TB medicines may have side effects. Dangerous ones include skin rashes and itching, skin and/or eyes turn yellow, repeated vomiting, deafness, dizziness and eyesight problems. If you suspect any one of these symptoms, STOP treatment and send the patient to a doctor. How to monitor TB patient by sputum examination Category 1 (6 month regimen) Category 2 (8 month regimen) Category 3 (6 month regimen) 2nd month 3rd month End 2nd month 5th month 5th month 6th month 8th month Action in case of interruption of treatment Interruption for less than one month: • Trace patient • Solve the cause of interruption • Continue treatment and prolong it to compensate for missed doses Interruption for one to two months Action 1 Action 2 • Trace patient • Solve the cause of interruption • Do 3 sputum smears. While waiting, continue treatment If smears negative or extra- pulmonary Continue treatment and prolong it to compensate for missed doses If one or more smears positive Treatment received: <5 months Continue treatment and prolong it to compensate for missed doses >5 months Category 1: Start category 2 Category 2: Refer for community- based services (may evolve to chronic) Interruption for two months or more (defaulter) • Do 3 sputum smears • Solve the cause of interruption, if possible • No treatment while waiting for results Negative smears or extra- pulmonary Clinical decision on individual basis whether to re-treat or continue treatment, or no further treatment. One or more smears positive Category 1 Start Category 1 Category 2 Refer for community- based services (may evolve to chronic) PART 1 STANDARD TREATMENT GUIDELINES RESPIRATORY INFECTIONS Chapter 9 - 145 Treatment regimens in special groups Pregnant women: It is important to ask a woman before she starts anti-TB chemotherapy if she is pregnant. Most anti- TB medicines are safe for use in pregnant women. The exception is streptomycin, which is ototoxic to the fetus, should not be used in pregnancy and can be replaced by ethambutol. It is important to explain to pregnant women that successful treatment of TB with the recommended standardized regimen is important for a successful outcome of pregnancy. Breastfeeding women: Breastfeeding women with TB should receive a full course of anti- TB chemotherapy. Chemotherapy prevents the transmission of tubercle bacilli to the baby. All TB medicines are compatible with breastfeeding. Household contacts It is very important to check all household members of TB patients to see if they have active TB or not. If they have active TB, they must be treated. Children under 6 years who do not have active TB may need preventive chemotherapy (isoniazid INH for 6 months). Please consult the TB centre. HIV/TB TB is one of the most common opportunistic infections among people living with HIV/ AIDS. All TB patients need to be provided with HIV counselling and testing as appropriate. Please consult the concerned health facilities. Prevention • Any patient suspected to have tuberculosis, should be referred to the nearest tuberculosis centre. • BCG under EPI should be given to every newborn baby. • Improve housing and nutritional status. • Trace contacts (including at school or work if appropriate). REMEMBER! TB spreads to other people when someone with TB coughs or sneezes. Chapter 10 Syndromic management of sexually transmitted infections • Genital ulcer in men and women • Lower abdominal pain in women • Urethral discharge in men • Vaginal discharge PART 1 STANDARD TREATMENT GUIDELINES SEXUALLY TRANSMITTED INFECTIONS Chapter 10 - 149 past episodes of similar lesions. Otherwise you should assume that the ulcer might be chancroid or syphilis, and treat for both. The ulcer in chancroid is painful and in syphilis it is painless. Signs and symptoms • One or more ulcerative lesions in the genitalia • Genital ulcers may be painful or painless • Ulcers are frequently accompanied by inguinal lymphadenopathy Management • Counsel on compliance and risk reduction. • Provide and promote the use of condoms. • Notify partner and treat both with: • Benzathine benzylpenicillin i.m. 2.4 million IU immediately (half into each buttock). Alternative regimens for penicillin-allergic non-pregnant patients: doxycycline, 100 mg orally, twice daily for 14 days or tetracycline, 500 mg orally, 4 times daily for 14 days. Alternative regimens for penicillin- allergic/pregnant: erythromycin, 500 mg orally, 4 times daily for 14 days. + • Ciproﬂoxacin, 500 mg orally, twice daily for 3 days (or erythromycin base, 500 mg orally, 4 times daily for 7 days; or azithromycin, 1 g orally, as a single dose). Alternative regimen: ceftriaxone, 250mg by intramuscular injection, as a single dose. Note: ciproﬂoxacin is contraindicated in pregnancy and is not recommended for use in children and adolescents. A fundamental problem in the management of most sexually transmitted infections is the difﬁculty in making an accurate diagnosis. Thus, in areas with limited laboratory resources sexually transmitted infections are identiﬁed and treated together in the form of signs and symptoms (syndromes). In health facilities where laboratory diagnosis is possible, treat as shown in the table provided at the end of this chapter. All patients with sexually transmitted infections should be counselled on: • compliance with treatment; • prevention of the complications of sexually transmitted infections; • risk reduction for acquiring sexually transmitted infections; • promotion and provision of condoms and demonstration of their use; • tracing and management of sexual contacts. Genital ulcer in men and women Description Loss of continuity of skin producing one or more ulcerative lesions on the genitalia. The three commonest causes in Africa are: • Chancroid (Haemophilus ducreyi); • Syphylis (Treponema pallidum); • Genital herpes (herpes simplex 2 virus). Classical herpes lesions can be recognized by their appearance, a painful cluster of vesicles that then develop into small punched out ulcers. The patient often gives a history of PART 1 STANDARD TREATMENT GUIDELINES SEXUALLY TRANSMITTED INFECTIONS Chapter 10 - 151 • Pain during sexual intercourse (dyspareunia) • Vaginal discharge • Menometrorrhagia • Dysuria • Fever • Sometimes nausea and vomiting • Pelvic tenderness is often prominent on bimanual examination of the cervix. REMEMBER! Untreated PID may have long-term sequelae (infertility atc.) It should be considered as a possible diagnosis in all sexually active women complaining of lower abdominal pain. Management • If an intrauterine device is in place, it should be removed. • Counsel on compliance and risk reduction. • Provide and promote the use of condoms. • Notify partner and treat both with: • Ciproﬂoxacin, 500 mg orally, as a single dose (or ceftriaxone, 125 mg by intramuscular injection, as a single dose or ceﬁxime,400 mg orally,as a single dose or spectinomycin, 2 g by intramuscular injection, as a single dose. Note: • Ciproﬂoxacin is contraindicated in pregnancy and is not recommended for use in children and adolescents. • There are variations in the anti- gonococcal activity of individual quinolones, and it is important to use only the most active. + • Acyclovir, 200 mg orally, 5 times daily for 7 days (or acyclovir, 400 mg orally, 3 times daily for 7 days or valaciclovir, 1 g orally, twice daily for 7 days or famciclovir, 250 mg orally, 3 times daily for 7 days). • Ask to return after 1 week. Referral • No response after 7 days. Lower abdominal pain in women Description Lower abdominal pain or pelvic inﬂammatory disease (PID) is a general name for pelvic infections in women (e.g. salpingitis, endometritis, parametritis, oophoritis, pelvic peritonitis) caused by microorganisms, which generally ascend from the lower genital tract and invade the endometrium, the fallopian tubes, the ovaries and the peritoneum. The most common cause for PID is infection of the tubes or uterus with the following organisms: • Neisseria gonorrhoeae • Chlamydia trachomatis • Anaerobic organisms. Trauma to the endocervical canal from an intrauterine device may facilitate the ascent of these organisms into the endometrial cavity. Signs and symptoms • Abdominal pain PART 1 STANDARD TREATMENT GUIDELINES SEXUALLY TRANSMITTED INFECTIONS Chapter 10 - 153 Sometimes if the patient has given himself some treatment or has recently urinated, there may be no discharge to be seen. However the history of dysuria or uncomfortable urination may indicate it has been present. The commonest causes of urethral discharge are: • Neisseria gonorrhoeae • Chlamydia trachomatis. Signs and symptoms • Small or large amounts of mucus or pus at the end of the penis • Staining of the underwear • Burning/pain on passing urine. Management • Counsel on compliance and risk reduction. • Provide and promote the use of condoms. • Notify partner and treat patient and partner with: • Ciproﬂoxacin, 500 mg orally, as a single dose (or ceftriaxone, 125 mg by intramuscular injection, as a single dose or ceﬁxime,400 mg orally,as a single dose or spectinomycin, 2 g by intramuscular injection, as a single dose). Note: • Ciproﬂoxacin is contraindicated in pregnancy and is not recommended for use in children and adolescents. • There are variations in the anti- gonococcal activity of individual quinolones, and it is important to use only the most active. + • Doxycycline 100 mg orally twice daily, or tetracycline, 500 mg orally, 4 times daily for 14 days (In pregnant women, give instead erythromycin 500 mg twice daily for 14 days). + • Metronidazole 400–500 mg orally, twice daily for 14 days. Note: Patients taking metronidazole should be cautioned to avoid alcohol. REMEMBER! Ask the patient to come back after 72 hours and REFER IMMEDIATELY if the condition has not improved. Since the diagnosis of PID is difﬁcult and untreated PID can have long-term sequelae to the patient, hospitalization of patients with suspected PID should be seriously considered when: • the diagnosis is uncertain; • surgical emergencies such as appendicitis and ectopic pregnancy cannot be excluded; • a pelvic abscess is suspected; • severe illness precludes management on an outpatient regimen; or • the patient has failed to respond to outpatient therapy. Urethral discharge in men Description Presence of a discharge in the anterior urethra, sometimes accompanied by dysuria or discomfort, is a urethral discharge. PART 1 STANDARD TREATMENT GUIDELINES SEXUALLY TRANSMITTED INFECTIONS Chapter 10 - 155 amount of vaginal secretion attributable to vaginal or cervical infection. Vaginal discharge may be accompanied by pruritus, genital swelling, dysuria, and lower abdominal or back pain. The discharge may be caused by trichomonas or candidiasis, but it is impossible to rule out gonorrhoea and chlamydia. The discharge may be purulent or offensive. Occasionally it can be caused by a forgotten tampon. Signs and symptoms • Excessive vaginal secretion often purulent or offensive • Staining of underwear • Itching or redness of the vulva • Burning or pain on passing urine • Lower abdominal pain. Management If the patient’s sexual partner(s) has symptoms then it is very likely that the patient is infected with gonorrhoea or chlamydia. Otherwise to avoid treating all women with discharge for all four problems (gonorrhoea, Chlamydia, Candida and Trichomonas) it is necessary to carry out some risk assessment. If the woman fulﬁls any two of the following criteria she is considered to be a high risk and should be treated for all: • Under 21 years old • Unmarried • Has more than one sexual partner; or • Has had a new sexual partner in the last two months. In addition • Counsel on compliance and risk reduction. + • Doxycycline 100 mg orally twice daily for 7 days (or azithromycin, 1 g orally, in a single dose). Alternative regimen: • Amoxicillin, 500 mg orally, 3 times a day for 7 days or erythromycin, 500 mg orally, 4 times a day for 7 days or tetracycline, 500 mg orally, 4 times a day for 7 days. Note: • Doxycycline and other tetracyclines are contraindicated duting pregnancy and lactation. • Current evidence indicates that 1 g single-dose therapy of azithromycin is efﬁcacious for chlamydial infection. • There is evidence that extending the duration of treatment beyond 7 days does not improve the cure rate in uncomplicated chlamydial infection. • Erythromycin should not be taken on an empty stomach. • Ask to return in 1 week. REMEMBER! Patients should be advised to return if symptoms persist 1 week after starting treatment. Vaginal discharge Description Sexually transmitted disease (STD)-related vaginal discharge is deﬁned as a change in colour, odour and/or an increase in the PART 1 STANDARD TREATMENT GUIDELINES SEXUALLY TRANSMITTED INFECTIONS Chapter 10 - 157 + • Metronidazole 2 g as a single dose OR 400 mg 12 hourly for 7 days. If candidiasis is suspected add: • Nystatin pessaries, 100 000 IU, two inserted nightly for 2 weeks. • If still no improvement, REFER. • Provide and promote the use of condoms. • Notify partner and treat them both with: • Ciproﬂoxacin, 500 mg orally, as a single dose (or ceftriaxone, 125 mg by intramuscular injection, as a single dose or ceﬁxime,400 mg orally,as a single dose or spectinomycin, 2 g by intramuscular injection, as a single dose). Note: • Ciproﬂoxacin is contraindicated in pregnancy and is not recommended for use in children and adolescents. • There are variations in the anti- gonococcal activity of individual quinolones, and it is important to use only the most active. + • Doxycycline 100 mg orally twice daily for 7 days; (or azithromycin, 1 g orally, in a single dose) Alternative regimen: • Amoxicillin, 500 mg orally, 3 times a day for 7 days or erythromycin, 500 mg orally, 4 times a day for 7 days or tetracycline, 500 mg orally, 4 times a day for 7 days. Note: • Doxycycline and other tetracyclines are contraindicated duting pregnancy and lactation. • Current evidence indicates that 1 g single-dose therapy of azithromycin is efﬁcacious for chlamydial infection. • There is evidence that extending the duration of treatment beyond 7 days does not improve the cure rate in uncomplicated chlamydial infection. • Erythromycin should not be taken on an empty stomach- PART 1 STANDARD TREATMENT GUIDELINES SEXUALLY TRANSMITTED INFECTIONS Chapter 10 - 159 Summary treatment guideline for areas with possibilities of laboratory diagnosis Sexually transmitted diseases Signs and symptoms Diagnosis Treatment Chlamydial infection (Lymphogranuloma venereum) • Small painless papules on the penis or vulva • Papules are followed by buboes in the groin which ultimately breakdown forming many ﬁstulae Microscopic diagnosis Doxycycline, 100 mg twice daily for 14 days Pregnancy/children <8 years Erythromycin 500 mg four times daily for 14 days Fluctuant lymph nodes should be aspirated through healthy skin Alternative regimen: tetracycline, 500 mg orally, 4 times daily for 14 days Tetracyclines are contraindicated in pregnancy Genital herpes • Multiple, painful, shallow ulcers, which clear in two weeks • Ulcers may be accompanied by watery vaginal discharge Medical history Clinical presentation Identiﬁcation of the virus through culture Keep lesions clean Apply affected areas with gentian violet Avoid sexual contact while lesions are present Acyclovir, 200 mg orally, 5 times daily for 7 days (or acyclovir, 400 mg orally, 3 times daily for 7 days or valaciclovir, 1 g orally, twice daily for 7 days or famciclovir, 250 mg orally, 3 times daily for 7 days) PART 1 STANDARD TREATMENT GUIDELINES SEXUALLY TRANSMITTED INFECTIONS Chapter 10 - 161 Summary treatment guideline for areas with possibilities of laboratory diagnosis Sexually transmitted diseases Signs and symptoms Diagnosis Treatment Gonorrhoea Women: • Purulent vaginal discharge • Pain on passing urine Men: • Pain on passing urine • Purulent urethral discharge • May present with painful swollen scrotum Bacteriological examination Ciproﬂoxacin, 500 mg orally, as a single dose (or ceftriaxone, 125 mg by intramuscular injection, as a single dose or ceﬁxime, 400 mg orally, as a single dose or spectinomycin, 2 g by intramuscular injection, as a single dose. Note: ciproﬂoxacin is contraindicated in pregnancy and is not recommended for use in children and adolescents. There are variations in the anti-gonococcal activity of individual quinolones, and it is important to use only the most active. Opthalmia neonatorum: Infants with conﬁrmed opthalmia neonatorum should receive instillation of tetracycline eye ointment 1% into the eyes and then REFER. Recommended regimen for infants born to mothers with gonococcal infection: ceftriaxone 50 mg/kg by intramuscular injection, as a single dose, to a maximum of 125 mg. PART 1 STANDARD TREATMENT GUIDELINES SEXUALLY TRANSMITTED INFECTIONS Chapter 10 - 163 Summary treatment guideline for areas with possibilities of laboratory diagnosis Sexually transmitted diseases Signs and symptoms Diagnosis Treatment Trichomoniasis Women: Frothy (bubbly), foul, smelling, greenish vaginal discharge Men may also have urethral discharge Microscopic examination Metronidazole 2 g, one single oral dose or 500 mg 12-hourly for 7 days In pregnant women (1st trimester) symptomatic treatment with clotrimazole can be prescribed Candidiasis (yeast infection) • Curd-like whitish vaginal discharge • Vaginal and/or vulval itching Clinical diagnosis by symptoms Microscopic examination of vaginal smears Miconazole, 500 mg intravaginally, as a single dose or clotrimazole, 500 mg intravaginally, as a single dose or ﬂuconazole, 150 mg orally, as a single dose Alternative regimen: Nystatin pessaries 100 000 IU, two inserted nightly for 2 weeks Treat partner similarly for 7 days Chancroid • Painful ulcers on the external genitalia • Enlarged inguinal lymph nodes Clinical diagnosis by symptoms and signs Microscopic examination Ciproﬂoxacin, 500 mg orally, twice daily for 3 days (or erythromycin base, 500 mg orally, 4 times daily for 7 days; or azithromycin, 1 g orally, as a single dose). Alternative regimen: ceftriaxone, 250 mg by intramuscular injection, as a single dose Fluctuant lymph nodes may need to be aspirated through intact skin PART 1 STANDARD TREATMENT GUIDELINES SEXUALLY TRANSMITTED INFECTIONS Chapter 10 - 165 Summary treatment guideline for areas with possibilities of laboratory diagnosis Sexually transmitted diseases Signs and symptoms Diagnosis Treatment Syphilis Early syphilis: Painless ulcers on the external genitalia of women or men Several months later: non-itchy body rash. Late syphilis: May be asymptomatic. After many years, there may be deﬁciency in muscle coordination; paralysis; numbness; gradual blindness; and dementia. Microscopic diagnosis of the spirochette Serological diagnosis (becomes positive two weeks after the appearance of the primary infection) Early stage: Benzathine benzyl penicillin 2.4 million IU in a single dose, injected i.m. one half into each buttock. Alternatively procaine benzylpenicillin, 1.2 million IU i.m. daily for 2 weeks Late stage: Benzathine benzylpenicillin 2.4 million IU i.m. once weekly for 3 consecutive weeks, or i.m. procaine benzylpenicillin, 1.2 million IU daily for 2 weeks Chapter 11 Skin conditions • Abscess • Boils • Eczema • Herpes zoster • Impetigo • Ringworm • Scabies • Skin ulcer PART 1 STANDARD TREATMENT GUIDELINES SKIN CONDITIONS Chapter 11 - 169 PART 1 STANDARD TREATMENT GUIDELINES SKIN CONDITIONS Chapter 11 - 169 Abscess Description An abscess is an infection that forms a sac of pus under the skin. Sometimes it results from a puncture wound, or an injection given with a dirty needle. An abscess cavity is not accessible to antibiotics. Treatment is thus surgical only. Signs and symptoms • A ﬁrm, hot and painful swelling, which has developed in a few days and has a soft centre which ﬂuctuates (feels ﬂuid). Management • Disinfect the skin surface with chlorhexidine. • Make a cut in the top of the abscess using a sterile scalpel. • Open the abscess further with a forceps. • Do not use the scalpel for opening further, since a nerve or artery may be cut. • Drain the abscess of pus and put the tip of a sterile gauze swab into the abscess cavity. • Apply cold compress for a few minutes then cover the wound with a dressing. • Remove the gauze after 1 day. REMEMBER! All other abscesses in deeper parts of the body, such as in breasts, muscle, root of tooth or neck should be REFERRED Boils Description A boil is a bacterial infection and usually starts in places where hair grows. When the infection localizes, pus accumulates and an abscess develops. Signs and symptoms • Pain, redness and swelling • Pustule in the site of a hair follicle. Management • Put hot packs (compresses) over the boil several times a day. • Let the boil break and drain itself. NEVER SQUEEZE the boil since this may cause the infection to spread to other parts of the body. • If the infection spreads to cause swollen nodes and fever give antibiotics (see under Scabies). • For the treatment of pain: • Paracetamol (500 mg tablets): • Adults and children over 12 years: 1–2 tablets 6 hourly. • Children 8–12 years: 1 tablet 6 hourly. • Children: 3–7 years: ½ tablet 6 hourly. • Children: 1–2 years ¼ tablet 6 hourly. • Acetylsalicylic acid (ASA, aspirin: 300 mg tablets): • Adults: 1–3 tablets 4–6 hourly. • Children (older than 12 years): 1 tablet 4–6 hourly. • Alternatively ibuprofen can be used. PART 1 STANDARD TREATMENT GUIDELINES SKIN CONDITIONS Chapter 11 - 171 PART 1 STANDARD TREATMENT GUIDELINES SKIN CONDITIONS Chapter 11 - 171 Eczema Description Eczema (dermatitis) is an acute or chronic inﬂammation of the skin. It can be caused by contact between human skin with certain chemicals, such as nickel, cement and rubber. This is called contact dermatitis and is due to speciﬁc sensitization of the skin. Long-term contact with other substances having an irritant effect can also cause eczema (irritant dermatitis). The other forms of eczema most commonly encountered can be divided into: Atopic eczema This type is most common in children. In babies it is localized on the face, but in older children on elbows, wrists and knees. Children with atopic eczema may also have asthma. Seborrhoeic eczema This is an acute or subacute dermatitis common in adults. It is common in areas of the body with much sebaceous activity, such as the scalp, behind the ears, the face - particularly around the nose, the eyebrows and mouth, the front of the breast bone (sternum), and between the shoulder blades (scapulae). Eczema frequently has a chronic course. Most children grow out of it after some years. In chronic eczema the skin is dry, thickened and hyperpigmented. Management • The main principle of treatment is to avoid the skin drying out. • Cold compresses will help acute irritant rashes. • Patients should be advised to apply vegetable oils or petroleum jelly to dry irritant rashes (not machine or engine oils). • Avoid the use of soap on the skin. • Avoid wearing abrasive clothing (woollens etc.) • Paint the sores with gentian violet. • In chronic cases: Use benzoic acid 6% + salicylic acid 3% ointment twice daily. • Avoid scratching and cut ﬁngernails regularly, especially those of small children. • In case of itching give chlorpheniramine 4 mg tablets: • Adults and children over 12 years: 1 tablet 6-hourly as required. • Children 5–12 years: ½ tablet repeated if necessary 6-hourly. • Children 1–5 years: ¼ tablet repeated if necessary 6-hourly. • If there is a superinfection treat with antibiotics (see under Scabies). If the condition does not improve, REFER. Herpes zoster (shingles) Description A line or patch of very painful blisters that appear all of a sudden on one side PART 1 STANDARD TREATMENT GUIDELINES SKIN CONDITIONS Chapter 11 - 173 PART 1 STANDARD TREATMENT GUIDELINES SKIN CONDITIONS Chapter 11 - 173 (unilateral) of the body conﬁned to an area served by a nerve. It is most common on the back, chest, neck, or face. The blisters last 2 to 3 weeks then heal spontaneously although scars may remain. The disease usually affects people who have had chickenpox before. The virus remains in the central nervous system. Herpes zoster is not a dangerous disease, but could be a sign of other serious conditions such as AIDS and cancer. Young people with severe herpes zoster are usually HIV positive. Management • Clean the lesions with antiseptic. • Give analgesics: see section on Boils. • If there is bacterial superinfection give antibiotics: see section on Scabies. • If analgesics do not control the pain or if the eye is affected, REFER. Impetigo Description Impetigo is a superﬁcial but highly contagious infection of the skin, usually caused by streptococci or Staphylococci aureus, and most often seen in infants or schoolchildren. Hot weather, malnutrition and poor hygiene contribute to it. Symptoms and signs • It affects mainly exposed parts of the body (face, nose, arms, legs, etc.) • Typical golden-yellow crusts. Management • Clean the crusts away with soap and water or an antiseptic solution. • Dry the skin. • Apply gentian violet solution 0.5%. • Advise the patient to wash their hands frequently and not to touch the lesions. • If no response or the patient is severely ill, has fever or has swollen glands, give oral antibiotics (see under Scabies) • If there is no improvement, REFER. Ringworm Description Ringworm is a fungal infection of the skin, commonly found in children. Although ringworm sores heal spontaneously as a child grows older, this may take a long time. The best way to prevent ringworm is careful and regular personal hygiene (soap and water). Signs and symptoms • Pale, round and scaly patches found on the scalp • On the body the patches are round with thickened edges and scales in the centre of the patch. Management • Wash the skin thoroughly with soap and water. • Then apply Whiteﬁeld’s (benzoic acid 6% + salicylic acid 3%) ointment to the sores. • Wash clothes daily in hot water during the treatment. PART 1 STANDARD TREATMENT GUIDELINES SKIN CONDITIONS Chapter 11 - 175 PART 1 STANDARD TREATMENT GUIDELINES SKIN CONDITIONS Chapter 11 - 175 • For better access to the sores, shave the hair on the scalp. • Inform the parent that ringworms heal slowly. • In severe cases, REFER. Scabies Description Scabies is a parasitic skin disease caused by a mite, Sarcoptes scabies. The female mite enters the skin and makes a small tunnel or burrow. The disease is characterized by severe itching with typical distribution. The disease is spread by direct close body contact. Signs and symptoms • Skin lesions itch severely, especially at night. • Secondary infection is very common due to scratching. • The whole family is often affected. • Typical distribution: Anterior axillary fold, nipples, lower abdomen in women, belt line (umbilicus), wrists and elbows, between the ﬁngers, external genitalia, thighs and buttocks. SEVERE ITCHING + TYPICAL DISTRIBUTION = SCABIES Management • Wash the whole body with a mild soap and dry. • Apply benzyl benzoate emulsion to whole body (from the neck downwards, not the face or scalp): • Children and adults: 25 % emulsion. • Infants less than 6 months: 12.5% emulsion (take 10 ml of the 25% solution and add 10 ml of water). • Allow to dry, then put on clothes. • Wash off the next morning with soap and water. • Repeat the process for 3 days. • Wash all clothes and bedding in boiling water and dry in the sun. • Give antibiotics to those with severe secondary infection: • Phenoxymethylpenicillin (penicillin v; 250 mg tablets): • Adults: 2 tablets 6-hourly for 10 days. • Children: • 5–10 kg: ¼ tablet 6-hourly for 10 days. • 10–30 kg: ½ tablet 6-hourly for 10 days. • >30 kg: 1 tablet 6-hourly for 10 days. Prevention • Regular bathing with soap • Washing of clothes • Health education • Always treat the whole family. PART 1 STANDARD TREATMENT GUIDELINES SKIN CONDITIONS Chapter 11 - 177 PART 1 STANDARD TREATMENT GUIDELINES SKIN CONDITIONS Chapter 11 - 177 Skin ulcer Description A skin ulcer is a chronic break in the skin that may be long lasting because of difﬁculties in healing. Skin ulcers are rare in small children, but more common in older children and adults. Ulcers appear more frequently on the lower limbs. Sometimes there may be an underlying cause such as tuberculosis, leprosy, diabetes or varicose veins. In these cases often poor blood circulation delays healing. If a varicose ulcer is near a vein it can subsequently erode the vein causing profuse bleeding. Signs and symptoms • An ulcer maybe painful or painless. • The healing skin around an ulcer of the leg is often dark blue, shiny and very thin. • With varicose ulcers, the foot is often swollen. • Ulcers can be of any size. • Sometimes an ulcer can be infected and discharge pus. Management • Clean the ulcer with antiseptic. • Keep the foot up, as high and as often as possible. • If the ulcer is discharging pus, apply dressings with normal saline. These dressings need to be changed 2-3 times daily. • On the leg a ﬁrm elastic bandage from the toes to above the ulcer can reduce swelling and help healing. • If local treatment fails give: • Phenoxymethylpenicillin (penicillin v; 250 mg tablets): • Adults: 2 tablets 6-hourly for 10 days • Children: • 5–10 kg give 62.5 mg 6-hourly for 10 days • 10–30 kg give 125 mg 6-hourly for 10 days • >30 kg give 250 mg 6-hourly for 10 days. • For penicillin allergic patients: Give erythromycin tablets before meals: • Children 5–10 kg: 62.5 mg 6-hourly for 10 days • Children: 10–15 kg: 125 mg 6-hourly for 10 days • Adults and children over 15 kg: 250 mg 6-hourly for 10 days. • For pain give analgesia – see section on Boils. • If you suspect an underlying disease, REFER the patient Prevention • Correct hygiene. • Treat ulcers at an early stage. Chapter 12 Viral infections • HIV/AIDS • Measles • Poliomyelitis • Viral hepatitis PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 181PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 181 HIV/AIDS is a notiﬁable disease HIV/AIDS Description AIDS–Acquired immune deﬁciency syndrome–is a disease caused by the human immunodeﬁciency virus (HIV), which kills or impairs cells of the immune system and progressively destroys the body’s ability to ﬁght infections and certain cancers.Today 40 million people around the world are infected with HIV. Although the prevalence of HIV infection in Somalia is low (about 0.9%), it is estimated that 40 000–60 000 Somalis are living with HIV/AIDS. Presently there is no cure against HIV virus. Clinical care of patients with HIV/AIDS includes diagnosis, counselling, prevention and treatment of opportunistic infections, and where possible the use of antiretroviral therapy (ART) . Modes of transmission The HIV virus is transmitted from person to person through: • Exchange of HIV-infected body ﬂuids such as semen, vaginal ﬂuid and blood during unprotected sexual contact with a person infected with the virus; • Transfusion of blood infected with HIV virus; • Use of HIV-contaminated injection needles, and sharp infected instruments for tonsillectomy, circumcision etc. • From an infected mother to her child either during pregnancy, at birth or during breastfeeding; • Accidentally, although rarely, in persons working with biological samples infected with the HIV virus. REMEMBER! HIV cannot be transmitted through shaking hands, hugging, kissing, sharing cups, eating and cooking utensils or through the air. The virus is also not transmitted by insect bites such as mosquitoes, lice, bedbugs. Phases of HIV infection Three phases may be identiﬁed during the course of HIV infection. Seroconversion This phase occurs 2 weeks to 3 weeks following contamination. During this period the virus replicates rapidly in the body. The acute seroconversion illness usually presents as ﬂu-like (fever, body aches, sore throat and enlarged glands). Asymptomatic phase During this period, which can last for many years the person can remain asymptomatic, but can still transmit HIV to sexual partners. The person might not even know that he/ she has HIV infection. Symptomatic HIV infection, including AIDS In this phase the patient’s immune system starts to decrease and the person begins to show signs and symptoms related to HIV infection including malaise, fevers, night sweats, and diarrhoea. The patient might experience skin and mucous problems and recurrent bacterial infections. The latest PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 183PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 183 stage of the disease is characterized by the development of severe opportunistic infections deﬁning AIDS and low CD4 cell count. Diagnosis of HIV at the PHC level (no laboratory diagnosis) The diagnosis of HIV infection requires two positive HIV tests. If HIV testing is not available, it is still important to know when to consider HIV-related illness and refer the suspected patients for HIV testing. The table opposite includes clinical signs of possible HIV infection: • If HIV status is unknown, advise to be tested for HIV infection • If patient has signs in bold in the blue box, these signs indicate HIV clinical stage 3 or 4. Patient is likely eligible for ART. HIV testing is urgent • Repeated infections • Herpes zoster • Skin conditions including prurigo, seborrhoea • Lymphadenopathy (PGL)—painless swelling in neck and armpit • Kaposi lesions (painless dark or purple lumps on skin or palate) • Severe bacterial infection—pneumonia or muscle infection • Tuberculosis—pulmonary or extrapulmonary • Oral thrush or oral hairy leukoplakia • Gum/mouth ulcers • Oesophageal thrush • Weight loss more than 10% without other explanation • More than 1 month: • Diarrhoea (unexplained) • Vaginal candidiasis • Unexplained fever • Herpes simplex ulceration (genital or oral) Other indications suggesting possible infection: • Other sexually transmitted infections • A spouse or partner or child • known to be HIV positive • has HIV or HIV-related illness • Unexplained death of young partner • Injecting drug use • High risk occupation • Sexually active person with multiple partners living in high HIV-burden area PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 185PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 185 Counselling If you suspect someone to have HIV/AIDS REFER immediately and explain to the client where to go for HIV counselling and testing. Before referral • Explain how HIV is transmitted (unprotected sex, blood transfusions, infected syringes and razor blades, mother to child transmission etc). • Explain how HIV is NOT transmitted. • Explain HIV testing, that it is voluntary and the patient has the right to refuse. • Reassure that test results are kept conﬁdential. • Counsel on safer sex including correct and consistent use of condoms. • Discuss the advantages of knowing HIV status. • Arrange to see the client after the test. REMEMBER! HIV/AIDS is a sensitive issue. People should be counselled privately and compassionately. Post-test counselling • If HIV-negative, advise on safer sex practices, abstinence etc. • If HIV-positive: • Provide post-test information and support. • Advise on advantages of knowing HIV status (prevention of re-infection, early access to treatment, choices about future pregnancies, etc). • Explore the personal and community support systems. • Explain how a person with HIV can protect himself/herself from becoming sick by maintaining a “healthy lifestyle”, by eating healthy food, avoiding or decreasing tobacco, taking regular exercise etc. • Advise to seek prompt treatment for any infections (cough, fever, skin infections or diarrhoea). • For sero-positive mothers, discuss issues regarding: • the risks of getting pregnant and its implications for the child and the health of the mother with HIV; • the beneﬁt of exclusive breastfeeding versus the risk; • routine vaccination of children with HIV; • Encourage regular follow-up if positive. REMEMBER! Patients and familly members should receive education on HIV infection and be advised how to handle blood and other body ﬂuids from the patient. Management of HIV-related infection Chronic diarrhoea Chronic diarrhoea is deﬁned as 3 or more loose motions a day, intermittent or continuous, lasting more than 2 weeks. In the majority of cases, no cause may be found and treatment is thus largely symptomatic. For the treatment of diarrhoea refer to the relevant chapter in this manual. PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 187PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 187 In patients who do not respond to treatment REFER. Prevention of diarrhoea consists of attention to personal hygiene (hand-washing), drinking boiled water, and eating ONLY thoroughly cooked meat and vegetables. Persistent fever A recurrent or persistent fever is deﬁned as elevation of temperature (>37.5°C) for duration of 2 or more weeks. • Give analgesics in full dose, i.e. paracetamol 1g every 6 hours. • If no response, treat as malaria according to national recommendations. • If no response give, give cotrimoxazole 480 mg (sulfamethoxazole + trimethoprim) 2 tablets twice daily for 5 days. • If no response or if the patient has altered mental state, stiff neck or deep rapid breathing, REFER immediately. Lymphadenopathy • If it is due to local or regional infection, treat as indicated. • If non-itchy skin rash/evidence of resistant genital ulcer consider syphilis: give benzathine penicillin 2.4 million IU weekly × 3 doses. • If allergic to penicillin give doxycycline 100 mg tablets twice daily for 2 weeks; • For pregnant women give erythromycin 500 mg tablets four times daily for 2 weeks; • If the patient has also fever, weight loss, unilateral ﬂuctuant nodes in increasing size, consider tuberculosis, lymphoma or Kaposi’s sarcoma, REFER. • Persistent generalized lymphoadenopathy, REFER. Respiratory infections Present as cough (acute, persistent or worsening) and/or dyspnoea, which may be accompanied by chest pain. Pneumonia and pulmonary tuberculosis are the most common causes of lower respiratory tract infections. Consider TB if there is cough for more than 2 weeks, weight loss, haemoptysis, sweats etc Cough without dyspnoea or tachypnoea and associated with runny nose is usually indicative of upper respiratory tract infection of viral origin. Adults • Give cotrimoxazole 480 mg (sulfamethoxazole + trimethoprim) 2 tablets twice daily for 5 days. • If no response, or receiving cotrimoxazole prophylaxis, give amoxycillin 500 mg tablets three times daily for 5 days. • If no response, REFER. • If there is severe dyspnoea or respiratory distress or there is a suspicion of TB, REFER. Children • Give cotrimoxazole (sulfamethoxazole + trimethoprim) 24 mg/kg 12-hourly for 5 days. • If no improvement after 48 hours of treatment for severe pneumonia, treat as pneumocystis pneumonia (PCP), REFER. PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 189PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 189 • If there is an upper respiratory tract infection (URTI) without fever, advise mother on HOME CARE. Oral lesions (thrush) Many different conditions involving the oral cavity are encountered in patients with symptomatic HIV infection and these include Candida albicans, the most common cause of oral thrush. It is characterized by white sloughs covering many areas of superﬁcial ulceration on the gums, palate and tongue. In severe cases, the lesions extend into the lower pharynx and oesophagus to cause nausea, dysphagea, and epigastric pain. • Nystatin: one tablet 500 000 IU x 4 daily (sucked or chewed). Therapy should be continued for at least 48 hours after symptoms have resolved. If nystatin oral tablets are not available, vaginal tablets or gentian violet can be prescribed. • Gentian violet: local application of gentian violet 1% aqueous solution twice daily for 1 week. • For oral thrush which does not respond to ﬁrst line antifungal,or when it is associated with dysphagia, REFER if alternative drugs are not available (e.g miconazole gum patch, ﬂuconazole) • Since other causes may be involved such as herpes simplex virus infection, if no improvement within 7 days, REFER. Central nervous system disorders Patients with HIV infection may present with a broad range of mental and neurological disorders such as confusion, psychosis, dementia, depression, peripheral neuropathy, etc. These could be due to the HIV itself, concomitant malaria, meningitis, other infections, hypoxia, metabolic causes or even medicine toxicity. If mental or neurological disturbance is suspected, REFER for correct diagnosis and prompt treatment. Many patients with HIV will experience reactions such as anxiety, which can itself cause mental and physical symptoms. Such patients are best treated with reassurance, counselling, home care and social support. HIV-associated skin diseases Many patients with HIV infection (80%–90%) develop dermatological conditions, which may be very disabling, disﬁguring and even life threatening. They may be caused by bacterial, viral (i.e. herpes zoster lesions), fungal (i.e. oral thrush), tumours (i.e. Kaposi’s sarcoma) and medicine reactions (i.e. Stevens- Johnson syndrome). For the treatment of these disorders refer to relevant chapters in this manual. For very severe cases and those which do not respond to treatment, REFER: Failure to thrive (FTT) • Severe malnutrition is a common feature of end stage HIV disease. It is very important to rule out associated TB. If TB is suspected, REFER. • Identify any other associated problems such as persistent diarrhoea, oral thrush, and respiratory conditions and treat accordingly. • If able to feed and not severely malnourished, treat as recommended in the chapter on malnutrition. • Review after 2–4 weeks. If not improving, REFER. PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 191PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 191 Pain relief For the management of pain relief, refer to the relevant section in this manual. In severe cases that do not respond to full doses of ordinary analgesics, REFER. Prevention of opportunistic infections: cotrimoxazole prophylaxis Giving cotrimoxazole daily to HIV infected patients prevents the occurrence of a number of opportunistic infections, and reduces mortality. It does not replace antiretroviral treatment but should be part of the standard HIV care for adults and children. • In adults with symptomatic HIV infection, give cotrimoxazole double strength (960 mg) or two single strength (480 mg) tablets daily. • Cotrimoxazole prophylaxis is also recommended for all children born to an HIV-infected mother, starting at 6 weeks of age, until infection can be excluded and in HIV-infected children clinically symptomatic, REFER. Medicine treatment of HIV/AIDS HIV has no cure. Antiretroviral medicines (ARV) suppress viral replication, improve symptoms, and prolong life. Effective therapy requires combination of three or four medicines simultaneously to be taken every day for the rest of life. Still the medicines may cease to work after some time, especially if the adherence to treatment is not good. In order to simplify treatment, facilitate storage and distribution, and improve patient compliance to treatment, WHO recommends ﬁxed-dosage combination (FDC). The decision about which medicines to make available in a particular country or area, depends on a number of different factors. These include the availability, price of medicines, the numbers of pills per dose, the side-effects, and laboratory monitoring requirements. Most ARV medicines have various adverse effects and patients need careful and continuous monitoring by trained health professionals. PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 193PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 193 Current recommended treatment protocols in Somalia Patient group Currently recommended treatment protocols Use in women of child bearing age or who are pregnant Comments Adults and adolescents and children >3 years and/or >10 kg d4T+3TC+NVP (First line standard) Yes d4T+3TC+EFZ (First line non-standard (Option A)) No Particularly for patients with TB co- infection and those unable to tolerate nevirapine. AZT+3TC+NVP (First line non-standard (Option B1)) Yes Particularly for patients with peripheral neuropathy at initiation of therapy or following treatment with the stavudine- containing standard ﬁrst- line regimen AZT+3TC+EFR (First line non-standard (Option B2) No Children <3 years and/or <10 kg AZT+3TC+NVP Post- exposure prophylaxis AZT+3TC for 28 days • d4T (NRTI) alternative name stavudine • ZDV (NRTI) alternative names zidovudine or AZT • EFZ (NNRTI) alternative name efavirenz • NVP (NNRTI) alternative name nevirapine • 3TC (NRTI) alternative name lamivudine REMEMBER! HIV/AIDS HAS NO CURE. Current treatment improves condition but is life-long and may have side-effects. Prevention of HIV infection Within the health care services, prevention means NEVER using unsterilized needles, syringes, razor blades, scalpels etc, and never using unscreened blood for transfusion. The main preventive method however is to promote safe sexual practices. Safe sexual practices mean: • Abstinence from sex, if possible • Faithful and ONLY one partner (non-HIV infected) • Prompt treatment of sexually transmitted infections. • Consistent use of condoms. Health worker safety Health workers should consider EVERY person to be potentially infected with HIV. Thus all health workers should observe the following precautions while handling biological materials from patients: • Thoroughly wash hands with soap and water before and after all procedures. • Protective gloves should be worn during procedures at risk of blood exposure and when handling body ﬂuids. PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 195PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 195 • If a health worker has a cut or wound, an occlusive dressing should be applied and protective gloves worn. • When signiﬁcant contact with the patient’s body ﬂuids is anticipated, a suitable waterproof apron should be worn. • Laboratory staff should not pipette by mouth. • There should be careful and proper handling of needles and other sharp instruments. Reusable needles and syringes should be: • Kept prior to sterilization in water, preferably containing disinfectant. • Cleaned with water, and then • Fully sterilized using an autoclave, or if not available by prolonged boiling (for at least 30 minutes). MEASLES is a notiﬁable disease Measles Description An acute infectious disease caused by a paramyxo virus. It occurs in children, usually between 6 months and 3 years who have not been immunized. Measles is very infectious for 7 days before and for 2 days after appearance of the rash. Signs and symptoms • High fever (present before the rash) • Conjunctitivitis • Running nose, cough and sore mouth • Blotchy rash starting from the head and neck down the body • Diarrhoea. Complications Early complications Late complications Laryngitis Keratoconjunctivitis Bronchopneumonia Malnutrition Otitis media Deafness from chronic otitis media Febrile ﬁts Meningitis and encephalitis Stomatitis Activation of latent tuberculosis PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 197PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 197 Management In uncomplicated cases • NO antibiotics. • Wash eyes with clean water. • Treat sores in and around mouth with gentian violet paint and encourage oral hygiene. • Tepid sponging and analgesics for fever: • Paracetamol (500 mg tablets) as required: • Adults and children over 12 years: 1–2 tablets 4–6 hourly. • Children 8–12 years: 1 tablet 4–6 hourly. • Children 3–7 years: ½ tablet 4–6 hourly. • Children 1–2 years ¼ tablet 4–6 hourly. • Acetylsalicylic acid (ASA, aspirin: 300 mg tablets) as required with or after food: • Adults: 1–3 tablet 4–6 hourly • Children (older than 12 years): 1 tablet 4–6 hourly • Alternatively give ibuprofen. • Maintain nutritional intake (continue breastfeeding). • Give vitamin A: • Children > 1 year: 200 000 units stat on day 1, 2 and 8. • Children < 1 year: 100 000 units stat on day 1, 2 and 8. • In the case of bronchitis or otitis media, give antibiotics: • Amoxicillin 250 mg tablets): • Adults: 2 tablets 8-hourly for 10 days. • Children: • 5–10 kg, give ¼ tablet 8-hourly for 10 days. • 10–30 kg, give ½ tablet 8-hourly for 10 days. • >30 kg, give 1 tablet 8-hourly for 10 days. • For penicillin allergic patients give: Erythromycin tablets before meals: • Children 5–10 kg: 62.5 mg 6-hourly for 10 days. • Children 10–15 kg: 125 mg 6-hourly for 10 days. • Adults and children over 15 kg: 250 mg tabs 6-hourly for 10 days. • Observe closely for complications such as croup, unresponsive bronchitis or pneumonia, malnutrition and severe dehydration. • In complicated cases, REFER. Prevention • Vaccination with measles vaccine at 9 months. • Quarantine measures (to avoid spread of infection). POLIOMYELITIS is a notiﬁable disease Poliomyelitis Description An acute viral infection, which causes weakness or ﬂaccid paralysis of certain muscles, especially the legs. Transmission is faeco-oral. PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 199PART 1 STANDARD TREATMENT GUIDELINES VIRAL INFECTIONS Chapter 12 - 199 Signs and symptoms • Febrile, ﬂu-like illness • Asymmetric weakness or paralysis of muscle groups. Management • NO SPECIFIC TREATMENT. • Bed rest; activity in the ﬁrst two weeks may increase paralysis. • Do not give any injections during early illness (risk of paralysis). • Treatment of the fever. • Nursing care for paralytic cases and physiotherapy once signs have stabilized. Prevention • Vaccination • Quarantine measures (to avoid spread of infection). VIRAL HEPATITIS is a notiﬁable disease Viral hepatitis Description Viral hepatitis is a systemic disease that predominantly harms the liver. There is usually fever, with marked loss of appetite at the onset followed by jaundice. However, many cases might remain asymptomatic. There are three main types of viral hepatitis termed as A, B, C. All three types may have a similar clinical disease pattern but are due to completely different viral agents. Type A is spread by oral faecal transmission. This disease is usually mild in children but more serious in older people. Type B is usually sexually transmitted and can be rapidly fatal. Type C occurs mainly in injecting drug users and generally takes a chronic course ﬁnally resulting in chronic liver failure or hepatoma. Signs and symptoms (mainly types A and B) • Acute loss of appetite • Sometimes pain on the right side of the abdomen, below the ribs • May have fever • After few days the eyes may turn yellow “jaundice” • Sight and smell of food may cause vomiting • Urine turns dark yellow (like tea) and stools become whitish. Management • NO MEDICINE IS USEFUL. ANTIBIOTICS SHOULD NOT BE GIVEN. • Advise rest and ensure adequate intake of glucose or other liquids. • Good diet—especially fruits and vegetables. • NO ALCOHOL for at least three months. • In serious cases, REFER Part 2 Training manual on rational management and use of medicines at the primary health care level Chapter 1 Health centre administration • Planning management No matter where you are working or what you are working with, you cannot do your work efﬁciently without ﬁrst organizing it.This chapter will teach you how you can organize your daily activities, so that you do not end up one day in a managerial crisis. References: 1. The Malawi prescribers companion. Malawi, Ministry of Health, 1993. 2. United States of America Management Sciences for Health in collaboration with WHO. Managing drug supply. The selection, procurement, distribution, and use of pharmaceuticals. Second edition. Kumarin Press, 1997. PART 2 RATIONAL MANAGEMENT AND USE OF MEDICINES HEALTH CENTRE ADMINISTRATION Chapter 1 - 205 Step 1: Where are you now? First deﬁne: • Your catchment area • Your catchment population • Community characteristics • Major health problems and priorities • Human and ﬁnancial resources Catchment area Every health centre serves people from a certain area. This area has its own characteristics, such as mountains, rivers, roads, towns, villages, farms, schools, markets, etc. As a health worker, it is of a paramount importance that you know quite well the characteristics of your catchment area. This knowledge will help you draw a map, which could be vital for your daily activities in the centre. Catchment population Knowing the number of people in your area will help you plan in terms of medicines, vaccinations, deliveries etc. Although it might not be possible to get accurate statistics in many parts of the country, still it is important that you work hard to get a rough estimate of the number of people living in your area. Using the data in your centre from earlier years, you can break the catchment population into age groups. This will give you a rough idea of the age distribution of your patients Population structure For the success of your work and good relations with the people in the area, it is important that you are well aware of the Planning Learning objectives At the end of the session, participants will be able to: • Plan their work more effectively • Assess the needs and priorities of their health centres • Develop plans of action which can lead them to their targets • Develop good relationships with their patients and between themselves. Location: Class room/health centre Planning Planning is a process where one thinks ahead of time how one will execute a particular job at some point in the future. For example, if I want to order medicines for my clinic there are a few things I ought to know before just ordering the medicines. These include the type of diseases common in my area, the yearly/monthly incidence of those diseases etc. In this way I am planning. The process of planning consists of four main steps: Step 1: Where are you now? You assess your needs and priorities Step 2: Where do you want to go? You set up a target/s Step 3: How do you get there? You draw up a plan of action Step 4: How do you know you have got there? You develop a monitoring system to evaluate your progress PART 2 RATIONAL MANAGEMENT AND USE OF MEDICINES HEALTH CENTRE ADMINISTRATION Chapter 1 - 207 Example of a target: To fully immunize 80% of children under 1 year old before the end of the next year. This is a clear, measurable target that has a deﬁned time-frame and can be achieved. Step 3: How do you get there? Here you draw up a plan of action that will take you to your goal. Think of travelling from Mogadishu to Hargeisa. The type of transportation you take will depend, for example, on your pocket, desire, speed and safety. Similarly you should think of the following factors to prepare your health centre to achieve a certain goal: • Resources: List all the necessary resources in terms of equipment, supplies, ﬁnancing, transport etc. • Job description: Allocate tasks among the staff • Time-frame: Set realistic dates by which the activities have to be executed • Community involvement: discuss your plan with the community early on • Staff motivation: involve all the staff in the clinic from the start. REMEMBER! Prioritize your work. It is better to do one job well, than to have a number of jobs half completed. Step 4: How do you know you have got there? It is very easy to forget your target if you do not have the means to continuously check your work. You can easily be distracted by characteristics of the people in the area such as their occupation, beliefs, customs etc. Such knowledge will not only help your relationship with the people in the area but will also help you understand their health problems and risk factors. Health problems It is very important you routinely register all the people who come into your clinic and document their health complaints accurately in accordance with your local or national morbidity register if one exists. Analyse the data regularly, for example every three months, to get a grasp of the health situation in the area. In this way, you will get a good idea of the most common diseases in the area, which need your attention and preparation. In this way you will also become aware of what types of health problems you can expect at different times of the year. Step 2: Where do you want to go? At this stage you know your area, the characteristics of your population and the common diseases in your area. Now you need to deﬁne the goal or target you want to achieve at a certain time in the future. Your goal must be realistic, measurable and achievable within a speciﬁc time-frame. All the members of the staff should be well aware of this and work towards it. They should be conditioned towards this goal by displaying the message as well as your progress in your health centre. PART 2 RATIONAL MANAGEMENT AND USE OF MEDICINES HEALTH CENTRE ADMINISTRATION Chapter 1 - 209 whole time. Here you are not irresponsible but you are suffering from one problem– –poor management! Management is executing things properly and as planned. It is not necessary that you do all the work by yourself, but you should see to it that it is done. Apart from your medical duties, as the person in-charge of the health centre you are also responsible for the day-to-day running of the health centre. Thus, you can be overwhelmed by other tasks if you are not focused and have priorities in your work. Sometimes you must delegate some of the work to other competent people. REMEMBER! Management is getting things done. To improve management at your health centre you need to develop the following characteristics. 1. Arrange a decent working environment Although space is a major problem in most health centres in Somalia, it is still important to have an environment which helps you to execute your work effectively and protects the privacy of your patients. Most patients would like to be alone with you to discuss intimate problems or for physical examination. It is important to utilize the space available to you as effectively as possible, i.e. by dividing the rooms with screens as appropriate. Label all doors in a language the people understand. 2. Plan your work regularly In order to plan effectively, your ﬁrst priority is to make a list of all the tasks that must other events. It is possible that you might overestimate your successes without any objective evaluation. Thus it is important that you have the means to monitor your progress routinely. All the staff should be kept abreast of the progress and alerted for any setbacks. You can even develop, for example, charts or graphs, which show the progress of your work. These should be displayed on the walls of your health centre so that everyone can see what progress is being made. Different activities will have different charts or graphs, e.g., one for EPI, another one for MCH etc. Group work Participants discuss with the moderator how to collect population data, develop a sketch map of an area, and draw graphs and charts of the population characteristics. Management Learning objectives At the end of the session, participants will be able to: • Manage time more effectively and efﬁciently • Delegate responsibility • Create teamwork • Involve the community in every step in the plan of action Location: Class room/health centre Management Imagine yourself discovering at the end of your working day that you have not fulﬁlled half of your planned activities scheduled for that day despite being very busy the PART 2 RATIONAL MANAGEMENT AND USE OF MEDICINES HEALTH CENTRE ADMINISTRATION Chapter 1 - 211 3. Delegate responsibility Being responsible does not mean doing everything yourself. It might actually be seen as irresponsible if you fail to complete work due to lack of time, while other competent staff, with time, are available. Delegate as much and as often as possible to your staff. However check that things are being done properly while being supportive and encouraging. Try to develop teamwork at your health clinic. All the staff in the clinic have a part to play in working towards one goal. When one person is not available, there should be another one willing to take his/her place. In this way you also win the conﬁdence and the support of the community you are serving. REMEMBER! Praise in public, criticise in private. Group exercise Participants discuss with the moderator the process of delegating responsibility, when to praise or criticise staff and how to manage time more effectively. be done daily, weekly and monthly at the health centre. Sit down and discuss this with the staff of the health centre. What are the most important tasks? Does everyone know what tasks they should be doing during a given period? A staff meeting is an important venue at which to organize the work of the health centre. Such meetings should take place once a week. They should be short and brief. Minutes from all meetings should be kept. The meeting will be an opportunity to monitor progress and to discuss problems that have occurred recently, and how to solve them and avoid them recurring. These problems may be personal or related to the health services at your health centre. Although there is nothing wrong with showing another person a mistake that he/ she has made, in a constructive way, try not to criticise in the presence of fellow health workers. On the contrary, praise in public for good work accomplished. In the meetings, you should decide, which problems need to be solved ﬁrst; in other words, which problem has the highest priority? Then write down who will be responsible for what. Separate meetings may be held each month where members from the community (elders, women, teachers, community leaders etc) are invited to attend. Here the community members (ensuring fair representation of all groups, especially women and other vulnerable groups) will get a chance to meet with you and your staff and discuss their wishes and concerns. For this reason it is vital to have a health centre committee where such problems can be discussed. Chapter 2 Management of medicines • Ordering and receiving of medicines • Storage and stock management of medicines • Good dispensing practices References: 1. The Malawi prescriber’s companion. Malawi, Ministry of Health, 1993. 2. United States of America Management Sciences for Health in collaboration with WHO. Managing drug supply. The selection, procurement, distribution, and use of pharmaceuticals. Second edition. Kumarin Press, 1997. PART 2 RATIONAL MANAGEMENT AND USE OF MEDICINES MANAGEMENT OF MEDICINES Chapter 2 - 215 Ordering and receiving medicines Learning objectives At the end of the session, participants will be able to: • Determine the average monthly consumption and regular inventory • List the important steps in receiving medicines • Be familiar with proper ways of ﬁlling requisitions as well as delivery notes • Understand the appropriate actions needed to dispose of damaged or expired medicines Location: Classroom/health centre Ordering of medicines Once the required medicines are selected, proper medicine order forms must be ﬁlled in to request the medicines. It is very important that proper calculations have been made to order the required amount of medicines for a speciﬁed period. Order forms The format of the order forms may vary according to the level of the health care facility. In general some or all of the following terms are likely to be found on the order forms: • Item or stock number: This is a number used to identify a speciﬁc item in terms of its description and often unit of issue. • Description: Medicine name, size and the dosage form (e.g. label, mixture, injections, etc). • Unit: The pack size of an item indicates how many tablets are in each unit (e.g. 1000, 500, 250, or 100 tablets), or how many injections are in each unit (e.g. one ampoule) or how many doses of eye ointment are in each unit (e.g. one tube 3.5 g). The unit is usually a course of treatment or a month’s supply. • Monthly consumption: This is the average number of units of an item, which are used over a period of one month (based on several months’ consumption). • Minimum stock level: This is the number of units which must be in stock in order to last until the next delivery plus the safety stock which is the number of units needed to cover an unforeseen delay before an expected delivery. When the amount of an item left in your medicinestore has reached the minimum stock level, it is time to order a new supply. • Order quantity: This is the number of units required to be ordered to build up the stock to the minimum stock level plus the average monthly consumption. • Amount ordered: This is the amount of units ordered, which is normally the same as the order quantity. • Amount issued: This is the number of units that is actually issued. • Amount in stock: This is the number of units in stock at the health unit at the time of placing the order. Delivery of medicines There are two main delivery systems: • kit system • indent system. PART 2 RATIONAL MANAGEMENT AND USE OF MEDICINES MANAGEMENT OF MEDICINES Chapter 2 - 217 Kit system This is favoured by some organizations, e.g. UNICEF. A standard kit is regularly sent to each health facility based on their perceived needs. Advantages • Rational selection of a limited range of essential medicines • Simpliﬁed supply and storage management • Easy to prepare and deliver particularly in an emergency • Reduced risk of theft • More rational prescribing Disadvantages • Less ﬂexible than the indent system • Difﬁculty to suit to regional variability in morbidity, which may lead to substantial wastage of certain medicines • Possibilities of stock-outs and surpluses A kit-based system is a temporary solution and a more ﬂexible system should be instituted as soon as it becomes possible to deﬁne medicines needs more precisely. Indent system Each health unit requests at regular periods the amount of medicines that they feel they require for that period. Advantages • Less wastage • Supply matches demand. Disadvantages • More difﬁcult to organize • Requires approval of ofﬁcer-in-charge • Requires tight diagnosis and medicine control usage (prescribing) to avoid over- prescribing. Indent procedure • Check that the quantity delivered corresponds to the quantity supplied as indicated on the delivery note. • Check each item and tick it off. Each medicine should be checked for: • Packaging • Label • Expiry date • General appearance Any item that has damaged packaging, is unlabelled, or has passed its expiry date or is of doubtful appearance should be returned to the supplier as soon as possible for destruction. Delivery note This must be signed by the person in charge of the warehouse, e.g. assistant pharmacist and it should be countersigned and dated by the health staff receiving the consignment of medicines. One copy of the delivery note should be kept by the recipient while another copy should be sent back to the supplier. Receipt of medicines When medicine supplies arrive they should carefully be checked for: • Identity: Make sure the items ﬁt exactly the same description as those that were ordered. • Quantity: Ensure that the number of units of each item supplied is as indicated on the order form. PART 2 RATIONAL MANAGEMENT AND USE OF MEDICINES MANAGEMENT OF MEDICINES Chapter 2 - 219 • Condition: Check each item carefully for damage or signs of deterioration. The person in-charge should only sign the receipt of the order once he/she is satisiﬁed with each of the above controls. Any discrepancies should be noted in writing on the order form copy and followed up. Group exercise • Participants should discuss the relative merits of the indent and kit system in relation to their particular needs. • Participants should discuss the reasons for the accurate completion of delivery and requisition notes. Storage and stock management of medicines Learning objectives At the end of the session, participants will be able to: • Appreciate the importance of storing medicines properly • State the practice and principles of stock management Location: Classroom/health centre Storage of
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