WHO International survey on variations in practice of the management of the third stage of labour
Publication date: 2003
International survey on variations in practice of the management of the third stage of labour Mario R. Festin,1 Pisake Lumbiganon,2 Jorge E. Tolosa,3 Kathryn A. Finney,4 Katherine Ba-Thike,5 Tsungai Chipato,6 Hernando Gaita´n,7 Liangzhi Xu,8 Sompop Limpongsanurak,9 Suneeta Mittal,10 Abraham Peedicayil,11 Noor Pramono,12 Manorama Purwar,13 Sheela Shenoy,14 & Sean Daly15 Objective To determine the use of the active management of the third stage of labour in 15 university-based obstetric centres in ten developing and developed countries and to determine whether evidence-based practices were being used. Methods From March 1999 to December 1999, the Global Network for Perinatal and Reproductive Health (GNPRH) conducted an observational, cross-sectional survey to assess the use of the practice and its components. Prospective data on patient characteristics and the interventions used in the management of the third stage of labour were collected using standardized methods. Data on approximately 30 consecutive vaginal deliveries in each centre (452 in total) were included. Findings Significant intracountry and intercountry variation in the practice of the active management of the third stage of labour was found (111/452 deliveries used active management), which confirmed the existence of a large gap between knowledge and practice. Conclusion Areas identified for improvement are the urgent implementation of the evidence-based clinical management practice defined as the active management of the third stage of labour; increased accessibility to systematic reviews in developing countries; and the conduction of clinical trials that assess the impact of this intervention in other settings. Keywords Labor stage, Third/drug effects; Postpartum hemorrhage/drug therapy; Oxytocin/therapeutic use; Umbilical cord; Delivery, Obstetric/methods; Hospitals, University; Evidence-based medicine; Cross-sectional studies; Multicenter studies; Developed countries; Developing countries (source: MeSH, NLM ). Mots cle´s Troisie`me pe´riode accouchement/action des produits chimiques; He´morragie post partum/chimiothe´rapie; Oxytocine/usage the´rapeutique; Cordon ombilical; De´livrance, Obste´trique/me´thodes; Hoˆpital universitaire; Me´decine factuelle; Etude section efficace; Etude multicentrique; Pays de´veloppe´; Pays en de´veloppement (source: MeSH, INSERM). Palabras clave Tercer periodo del trabajo de parto/efectos de drogas; Hemorragia posparto/quimioterapia; Oxitocina/uso terape´utico; Cordo´n umbilical; Parto obste´trico/me´todos; Hospitales universitarios; Medicina basada en evidencia; Estudios transversales; Paı´ses desarrollados; Paı´ses en desarrollo (fuente: DeCS, BIREME ). Bulletin of the World Health Organization 2003;81:286-291. Voir page 290 le re´sume´ en franc¸ais. En la pa´gina 291 figura un resumen en espan˜ol. Introduction Post-partum haemorrhage (PPH) is the most common cause of maternal mortality and serious maternal morbidity world- wide, especially in the developing world, accounting for approximately half of the 600 000maternal deaths per year (1, 2). Interventions such as the active management of the third stage of labour, when performed routinely, have been shown to reduce the risk of PPH (maternal blood loss >500 ml) and severe PPH (maternal blood loss >1000 ml) (3). The 1 Professor in Obstetrics and Gynecology and Clinical Epidemiology, University of the Philippines Manila, College of Medicine-Philippine General Hospital, Pedro Gil Street, Ermita, Manila, Philippines (email: firstname.lastname@example.org, email@example.com). Correspondence should be addressed to this author. 2 Coordinator, Global Network for Perinatal and Reproductive Health; Professor Department of Obstetrics and Gynecology, Khon Kaen University, Thailand. 3 Coordinator, Global Network for Perinatal and Reproductive Health; Director, Division of Research in Reproductive Health; Assistant Professor of Obstetrics and Gynecology, Thomas Jefferson University, Philadelphia, PA, USA. 4 Global Network for Perinatal and Reproductive Health, Thomas Jefferson University, Philadelphia, PA, USA. 5 Adviser on RH/FP Programmes, UNFPA-Country Technical Services Team, Bangkok, Thailand. 6 Senior Lecturer, Department of Obstetrics and Gynaecology, University of Zimbabwe School of Medicine, Avondale, Harare, Zimbabwe. 7 Department of Obstetrics and Gynecology, Clinical Epidemiology Center, Universidad Nacional de Colombia, Instituto Materno Infanti Carrera, Bogota´, Colombia. 8 Professor of Obstetrics and Gynecology, The Second University Hospital, West China University of Medical Sciences, Sichuan, China. 9 Associate Professor of Obstetrics and Gynecology, King Chulalongkorn Memorial Hospital, Bangkok, Thailand. 10 Chair, Department of Obstetrics & Gynecology; Director in-Charge, WHO-CCR in Human Reproduction, Human Reproduction Research Centre-ICMR; Programme Director, All India Postpartum Programme, All India Institute of Medical Sciences, New Delhi, India. 11 Professor of Obstetrics & Gynecology, Christian Medical College & Hospital, Tamil Nadu, India. 12 Obstetrics/Gynecology, Diponegoro University, Semarang, Indonesia. 13 Professor of Obstetrics and Gynecology, Government Medical College, Nagpur, India. 14 Associate Professor in Obstetrics and Gynaecology, Government Medical College, Kerala, India. 15 Master/CEO, Coombe Women’s Hospital, Dublin, Ireland. Ref. No. 02-0246 Research 286 Bulletin of the World Health Organization 2003, 81 (4) intervention consists of three components: the administration of a prophylactic oxytocic during or after delivery of the baby, the early clamping and cutting of the umbilical cord on delivery, and the delivery of the placenta by controlled cord traction (4). One of the key components of active management, the use of oxytocic agents such as oxytocin, has been shown to be particularly effective in reducingmaternal blood loss associated with PPH (5). Furthermore, when used in combination with the other steps of active management, oxytocin was found to be more effective than prostaglandins such as misoprostol in reducing severe PPH (6). Although active management of the third stage of labour has been successful in reducing PPH, it might, as with other interventions administered during labour such as epidural anaesthesia, modify the ‘‘natural’’ or physiological progression of childbirth (3). As an alternative to active management, some clinicians advocate using the expectant management of the third stage of labour. It is a passive or physiological approach and involves waiting for signs of placental separation and allowing the placenta to deliver spontaneously or aided by gravity or nipple stimulation. Although this is popular in some northern European countries and in some hospitals and clinics in the United States and Canada, it is less effective in reducing the incidence of PPH than active management. In the Hinching- brooke randomized clinical trial of approximately 1500 parturients at low risk for PPH, the rate of PPHwas significantly lower in the activemanagement group (6.8%) than the expectant management group (16.5%) (7). An earlier study also found that the incidence of PPH in parturients who received physiological (expectant) management was significantly higher than in those who received all three components of active management (odds ratio 2.4, 95% confidence interval 1.6 to 3.7) (8). A review in the Cochrane Library lends further credence to the effectiveness of active management over expectant management (9). Five randomized controlled trials were identified, each designed to assess the effect of active manage- ment of the third stage of labour on maternal blood loss, PPH, and othermaternal and perinatal complications.Data from these trials suggests that, in a maternity hospital, active management is consistently associated with first, a reduced risk of maternal blood loss, PPH and severe PPH, prolonged third stage of labour, and maternal anaemia, and second, an increased risk of maternal nausea, vomiting, and raised blood pressure due to the use of ergometrine. This review concluded that routine ‘‘active management is superior to expectant management’’ in terms of blood loss, PPH, and other serious complications of the third stage of labour, and it recommends that ‘‘the activemanagement of the third stage should be the routine management of choice’’ for women expecting a single baby by vaginal delivery in a maternity hospital (9). Findings from the Cochrane review and other literature clearly indicate that the activemanagement of the third stage of labour is an effective tool in reducing PPH. However, there is an absence of studies assessing the impact of this intervention in developing countries. Poignantly, it is in developing countries, where PPH is a significant problem, that the active management of the third stage of labour could have a considerable impact. The Global Network for Perinatal and Reproductive Health (GNPRH) (10), formed in 1996 by obstetricians, paediatricians, and educators based in 13 countries, focuses on improving maternal and perinatal health outcomes using evidence-based clinical practices. It conducted a survey of the use of the active management of the third stage of labour in 15 university-based obstetrical care centres in ten countries. The objectives of the survey were first, to determine the use of the active management of the third stage of labour and its components in the tertiary care centres of the GNPRH and second, to determine whether evidence-based best practices were being used at these centres. Methods From March 1999 to December 1999, we conducted a pilot, observational, cross-sectional survey to determine the use of the active management of the third stage of labour in 15 university-based referral obstetric centres participating in the GNPRH. All the investigators who were part of the GNPRH in 1999 agreed to take part in the study. The study was submitted to and approved by the Institutional Review Board or Ethics Committee at each one of the institutions participating in the study. A specific sample size was not estimated a priori as it was agreed between the investigators that the enrolment of at least 30 consecutive women in labour in each setting would provide sufficient information to achieve the objective of the survey. Data collection To assess the use of the intervention, approximately 30 con- secutive vaginal deliveries in each centre were observed and recorded by an assigned clinician who was familiar with the definition of active management of the third stage of labour. A standardized data-collection instrument was used to collect data on the administration of oxytocics during delivery, controlled cord traction, and early cord clamping. Prophylactic oxytocic usage was defined as the administration of any oxytocic concurrently with the delivery of the anterior shoulder of the baby or immediately after the delivery of the fetus (9). Early cord clamping refers to clamping the umbilical cord immediately after delivery of the baby. Controlled cord traction refers to gentle effective pulling on the clamped umbilical cord after signs of separation and then every two to three minutes if unsuccessful. Each data-collection instrument received a sequential unique identifier number with no link to the medical record or the parturient’s name. Demographical information on factors such as age, parity, and gravity was obtained through a retrospective review of the parturient’s medical record. All women delivering during the period of the survey were considered eligible for the study, unless they delivered by caesarean section. Data management and analysis Data forms were reviewed by the investigator at each centre and were sent electronically to the University of the Philippines, Manila. Whenever needed, completion of missing items in the initial data was made at the centre and the file was again transmitted to Manila. Our primary outcome of interest was the global use of the three components of the active management of the third stage of labour. MS Excel (Microsoft 2000, version 9.0) was used to organize the data to assess the use of this evidence-based practice, and descriptive statistics such as frequencies were generated using the EpiInfo version 6.04 (CDC, 1995) statistical software package. 287Bulletin of the World Health Organization 2003, 81 (4) Variations in practice of the management of the third stage of labour Results A total of 452 vaginal deliveries were observed at 15 sites (21– 44 observations per site). The mean age of participants was 26 years (16–43 years), the median gravidity was 2 (0–13), and median parity was 1 (0–11). Use of the intervention There were high levels of intracountry and intercountry variability in the frequency of use of the active management of labour. Overall, the use of this intervention was low, and was practised in 111 out of 452 deliveries (24.6%) (Fig. 1). One centre, Dublin, had high use of all three components (98%). Five centres did not use the complete package (two in Bogota´, Trivandrum, New Delhi, and Yangon), as shown in Fig. 1, although Table 1 shows that some of these centres did receive one or two of the components. There waswide variation in the use of the components of the intervention (Table 1). Variations exist in the number of womenwho received additional dosages of oxytocin during the third stage of labour (4.6–100%), in the prophylactic use of an oxytocic agent (0–100%), in the practice of controlled cord traction (13.3–100%), and in the number of induced/ augmented deliveries (0–60%). Most centres administered some form of oxytocic during the third stage of labour, but overall prophylactic oxytocic usage was only 44% (0–100%) (Fig. 2). In total, 40.4% of the deliveries were induced or augmented; however, only 26.5% of these parturients received additional oxytocin after the delivery of the baby, but before the delivery of the placenta. Two centres (New Delhi and Philadelphia) had a high percentage of induced/ augmented deliveries, with 61.9% and 60% of labours induced/augmented, respectively. These two centres also reported low prophylactic oxytocic usage (19.0% and 13.3%, respectively). Oxytocics In 12 of 15 centres, the mother received an oxytocic drug after the infant was delivered. Oxytocin was the most commonly used oxytocic (53.6%) — used either as an intravenous bolus or as a continuation as a drip that had been started to augment labour — followed by ergometrine (38.2%). Ten centres reported using ergometrine and oxytocin in any sequence during at least one delivery, and only the centre in Harare reported using ergometrine in combination with oxytocin (syntometrine). Prostaglandins (2.4%) were used only in Chengdu, Manila, Nagpur, Vellore, Yangon, and Dublin. Early cord clamping was a common practice (79.4%) in the centres surveyed, with the exception of the two centres in Bogota´ and the centre in Yangon, where it was used in only 40.9%, 20.6%, and 0% of the deliveries, respectively. Controlled cord traction was practiced in 70.1% of deliveries. Blood loss Data on blood loss was recorded in 73.9% of the deliveries, with some variations in the method of estimation. Clinical estimation was used in most (86.5%) of these deliveries; blood volume (10.2%) and weight (3.3%) were measured in other deliveries. These variations in themethod of estimation limited our ability to accurately assess the amount of blood loss in our survey population. Discussion This cross-sectional study uncovered substantial global variation in the use of the active management of labour as an intervention to reduce maternal PPH, especially in the use of oxytocic drugs and controlled cord traction. This is in spite of previous research showing that it is an effective evidence- based practice. The variation might be partly due to different levels of knowledge about the active management. Benefits and applications of active management The benefits of active management of the third stage of labour are well defined and have been disseminated through various sources, including the Cochrane Collaboration and the WHO Reproductive Health Library. The active management of the third stage of labour by itself is a relatively simple, inexpensive intervention that can be applied to a variety of environments. It has been shown to be effective in several randomized clinical trials and is supported in the Cochrane Library where it is described as being an effective measure in preventing PPH. The intervention could have a considerable impact on reducing PPH in many resource-poor nations. There is an urgent need for randomized clinical trials to be conducted in the developing world that examine the possible effect of active management on PPH and that identify which components of the intervention are effective in reducing PPH (8). Although this study was based at tertiary care institu- tions, it is probably unlikely that the active intervention is used at other levels of the healthcare systems such as primary healthcare centres. Practitioners based at tertiary centres often instruct clinicians who are students, residents, or fellows and who are located at the primary healthcare centres. Our data could have important applications in other areas, such as rural areas and birthing homes, where access to the immediate management of complications of the third stage of labour (such as PPH) might not be readily available. Furthermore, the 288 Bulletin of the World Health Organization 2003, 81 (4) Research practice of active management, whenever possible, might prevent such complications, although the available evidence for its application in such situations is not clear. Use of oxytocics Oxytocic agents have to be administered parenterally, which could create barriers to using this component of active management, both from a logistical and cost perspective. Unijecte, a prefilled single-dose injection system invented by the Program for Appropriate Technology in Health (PATH), might improve access to and the safety of parenteral administration. Currently, the technology is being evaluated in maternity units in Angola and Indonesia as a tool for administering oxytocin for active management of the third stage of labour (11). The ability of the oxytocics to reduce blood loss is thought to be aided greatly by the other two components of the intervention — early cord clamping and controlled cord traction (2). In addition, future studies should examine the use of better methods of blood loss estimation to evaluate the impact of the use of active management of the third stage of labour. Limitations of the study Despite uncovering substantial variations in the practice of the active management of the third stage of labour, the present study had some minor limitations. These included its descriptive nature, small sample size per centre, lack of double entry of the data, limited training of the study personnel on standardized data collection procedures related to this project, and participation of the survey population involved in other research projects. For example, during the time of this survey, the centre inYangonwas also participating in theBaby Friendly Hospital Initiative, which required that the infant be placed on the mother’s abdomen immediately following delivery. As a result, the centre’s standard practice of early cord clamping was interrupted during the time of this study. Availability of information Although variation in clinical practices such as the use of the activemanagement of the third stage of labour across centres is to be expected, our data show a significant lack of implementation of evidence-based clinical practices, specifi- cally with the active management of the third stage of labour, that have proven to be useful, and which could result in improved care if used. Moreover, there is a gap between the knowledge derived from publication of systematic reviews and its use in developing countries. At the time of this survey (1999), many of the centres involvedmight not have had access to systematic reviews such as the Cochrane database or the WHO Reproductive Health Library. There is a need to make practitioners aware of the results of investigations that would show efficient methods of reducing morbidity and mortality during delivery. Dissemination of information about effective, evidence-based clinical practices is lacking, especially in developing countries, and mechanisms for their implementa- tion need to be established and monitored over time. Looking to the future In an effort to address the gap between the existence of information on evidence-based best practices and the implementation of these practices, each of the investigators involved in this study will present the results of the survey at their centres and specifically discuss the data of their own centre with all the healthcare providers and students. We expect to conduct a follow-up survey to monitor whether practice has changed as a result of these activities. Guidelines, where not already in place, should be established indicating who should administer oxytocic agents, which have to be Table 1. Use of the components of the third stage of labour by centre Centre Prophylactic Early cord Controlled oxytocic clamping cord usage (n)a (n)a traction (n)a Chengdu (n = 30) 28 (93.3) 30 (100.0) 20 (66.7) Bogota´ (1) n = 22) 2 (9.1) 9 (40.9) 17 (77.3) Bogota´ (2) n = 34) 6 (17.6) 8 (23.5) 18 (52.9) Manila (n = 30) 11 (36.7) 29 (96.7) 26 (86.7) Khon Kaen (n = 30) 25 (83.3) 28 (93.3) 4 (13.3) Bangkok (n = 30) 12 (40.0) 25 (83.3) 23 (76.7) Nagpur (n = 30) 3 (10.0) 30 (100.0) 30 (100.0) Trivandrum (n = 30) 0 (0.0) 30 (100.0) 23 (76.7) Vellore (n = 30) 6 (20.0) 21 (70.0) 27 (90.0) New Delhi (n = 21) 4 (19.0) 20 (95.2) 8 (38.1) Semarang (n = 30) 7 (23.3) 30 (100.0) 16 (53.3) Philadelphia (n = 30) 4 (13.3) 29 (96.7) 25 (83.3) Yangon (n = 31) 23 (74.2) 0 (0.0b) 13 (41.9) Harare (n = 44) 38 (86.4) 39 (88.6) 39 (88.6) Dublin (n = 30) 30 (100.0) 30 (100.0) 28 (93.3) Total (n = 452) 199 (44.0) 358 (79.2) 317 (70.1) a Figures in parentheses are percentages. b The practice of early cord-clamping was interrupted in Yangon during the period of this survey, due to the assessment of an intervention that involved placing the infant on the mother’s abdomen immediately following delivery. 289Bulletin of the World Health Organization 2003, 81 (4) Variations in practice of the management of the third stage of labour administered parenterally. Such guidelines would need to be established at all levels of care, including tertiary care centres such as those that were part of this study. The use of simple quality improvement models, using process and outcome indicators, to identify and optimize key systems of care for women in labour and during delivery, including a system for using the active management of the third stage of labour, should be implemented. Feedback on a regular basis to the practicing clinicians or healthcare providers involved with labour and delivery would also be beneficial. Further study is needed on ways of increasing the accessibility, availability, and use of systematic reviews at healthcare centres in developing countries. All the centres involved in this study now have access to the Cochrane Reviews and the WHO Reproductive Health Library, which provide evidence-based reviews on various practices to improve maternal health. Access to systematic reviews is being improved by organizations like the Health InterNetwork Access to Research Initiative (12). A follow-up study to determine the impact of such improvement to access to information for best practices would be useful after a notable period of time. Established networks such as the GNPRH should be used as vehicles for the rapid dissemination of existing evaluations available through systematic reviews and to encourage the use of such information in routine clinical practice. The findings of this study on the variations of the management of the third stage of labour should encourage the centres (and others, also) involved in this study to evaluate current practices and to determine how new evidence-based recommendations might be implemented in their respective settings. Acknowledgements We thank Dr Walter Prendiville, and Dr Jerker Liljestrand, for providing technical assistance in the design of the study, and Dr Prendiville for reviewing drafts of this document. We also acknowledge the following at each centre participating in the study: West China University of Medical Sciences: Associate Professor Xun Zhang, Lecturer Jing Wang, Scientific Research Section of Second University Hospital, Head Nurse Hui Zhu, Head Nurse Tangchun Li, and the Second University Hospital. Universidad Nacional de Colombia, Instituto Materno Infantil: Assistant Professor Dr Amparo Dı´az and Clinica Carlos Lleras, Colombia: Assistant Professor Dr Andres Rubio. Central Women’s Hospital, Yangon: Dr Aye Aye Than. All India Institute of Medical Sciences: Dr Vinod K. Paul, Additional Professor, Department of Pediatrics and Dr Vimallamma, Senior Resident, Department of Obstetrics & Gynecology. Government Medical College: Dr Rajshree Patil and Dr Rajesh Gajbhiye. Christian Medical College and Hospital: Mrs Rosalyn Vasanth. University of the Philippines Manila: Dr Debbie Dy-Meguizo, Dr Felicisimo Rey Castillo, Dr Joselito Santiago, and the Philippine General Hospital. Khon Kaen University: Dr Jadsada Thinkhamrop. Chulalongkorn University Bangkok: Assistant Professor Surasith Chaithongwongwatthana. Financial support: This project was supported by the Rockefeller Foundation, the International Clinical Epidemiol- ogy Network (INCLEN), the United States Agency for International Development (USAID) and Thomas Jefferson University. Conflicts of interest: none declared. Re´sume´ Enqueˆte internationale sur les variations relatives aux pratiques de prise en charge de la troisie`me phase du travail Objectif Evaluer l’utilisation de la prise en charge active de la troisie`me phase du travail dans 15 centres d’obste´trique des hoˆpitaux universitaires de dix pays en de´veloppement ou de´veloppe´s, et de´terminer si des pratiques reposant sur des bases factuelles sont applique´es. Me´thodes De mars a` de´cembre 1999, le re´seau mondial de sante´ pe´rinatale et ge´ne´sique (GNPRH) a re´alise´ une e´tude d’observation transversale pour e´valuer l’application de la prise en charge active de la troisie`me phase du travail et de ses divers e´le´ments. Des donne´es prospectives sur les patientes et sur les interventions mises en œuvre dans la prise en charge de la troisie`me phase du travail ont e´te´ recueillies selon des me´thodes standardise´es. Les donne´es relatives a` une trentaine d’accouchements par voie basse re´alise´s successive- ment dans chaque centre (452 au total) ont e´te´ incluses dans l’e´tude. Re´sultats On a observe´ une variation inter- et intra-pays significative au niveau de la pratique de la prise en charge active de la troisie`me phase du travail (utilise´e dans 111 accouchements sur 452), ce qui confirme l’existence d’un e´cart important entre les connaissances et leur mise en application. Conclusion Parmi les points a` ame´liorer figurent la mise en œuvre dans les plus brefs de´lais de la pratique de prise en charge clinique reposant sur des bases factuelles, de´finie comme prise en charge active de la troisie`me phase du travail, un meilleur acce`s des pays en de´veloppement aux publications faisant le point de la question et la re´alisation d’essais cliniques destine´s a` e´valuer l’impact de cette intervention dans d’autres contextes. 290 Bulletin of the World Health Organization 2003, 81 (4) Research Resumen Estudio internacional sobre las diferencias en el manejo de la tercera fase del parto Objetivo Determinar el grado de implantacio´n del manejo activo de la tercera fase del parto en 15 centros obste´tricos universitarios en diez paı´ses en desarrollo y desarrollados, observando si se empleaban pra´cticas basadas en la evidencia. Me´todos Entre marzo de 1999 y diciembre de 1999, la Red Mundial para la Salud Perinatal y Reproductiva (GNPRH) realizo´ un estudio observacional transversal para evaluar el grado de implementacio´n de la citada pra´ctica y sus componentes. Utilizando me´todos normalizados, se reunieron datos prospectivos sobre las caracterı´sticas de las pacientes y las intervenciones de manejo de la tercera fase del parto. Se incluyeron los datos de aproximadamente 30 partos vaginales consecutivos en cada centro (452 en total). Resultados Se observaron diferencias significativas intrapaı´ses e interpaı´ses en la pra´ctica del manejo activo de la tercera fase del parto (hubo manejo activo en 111 de 452 partos), lo que confirmo´ la existencia de una amplia brecha entre los conocimientos y la pra´ctica. Conclusio´n Los a´mbitos de mejora identificados son la aplicacio´n urgente de las pra´cticas de manejo clı´nico basadas en la evidencia, concretadas en en el manjeo activo de la tercera fase del parto, la ampliacio´n del acceso a los exa´menes sistema´ticos en los paı´ses en desarrollo, y la realizacio´n de ensayos clı´nicos orientados a evaluar el impacto de esta intervencio´n en otros entornos. References 1. Joint WHO/UNFPA/UNICEF/World Bank statement. Reduction of maternal mortality. Geneva: World Health Organization; 1997. 2. Khan QG, John IS, Wani S, Doherty T, Sibai BM. Controlled cord traction versus minimal intervention techniques in delivery of the placenta: a randomized controlled trial. American Journal of Obstetrics and Gynecology 1997;177: 770-4. 3. Prendiville WJ. The prevention of post partum haemorrhage: optimising routine management of the third stage of labour. European Journal of Obstetrics and Gynecology and Reproductive Biology 1996;69:19-24. 4. Brucker MC. Management of the third stage of labor: an evidence-based approach. Journal of Midwifery and Women’s Health 2001;46:381-92. 5. Prendiville W, Elbourne DR, Chalmers I. The effect of routine oxytocic administration in the management of the third stage of labour: an overview of the evidence from controlled trials. British Journal of Obstetrics and Gynecology 1988;95:3-16. 6. Gulmezoglu AM, Villar, J, Ngoc NTN, Piaggio G, Carroli G, Adetoro L, et al. For the WHO Collaborative Group to evaluate misoprostol in the management of the third stage of labor. WHO multicentre randomized trial of misoprostol in the management of the third stage of labour. Lancet 2001;358:689-95. 7. Rogers J, Wood J, McCandish R, Ayers S, Truesdale A, Elbourne D. Active versus expectant management of third stage of labour: the Hinchingbrooke Randomized Controlled Trial. Lancet 1998;351:693-9. 8. Prendiville WJ, Harding JE, Elbourne DR, Stirrat GM. The Bristol third stage trial: active versus physiological management of third stage of labor. BMJ 1988;297:1295-300. 9. Prendiville WJ, Elbourne D, McDonald S. Active versus expectant management in the third stage of labour (Cochrane Review). The Cochrane Library, Issue 1. Oxford: Update Software; 2001. 10. The Global Network for Perinatal and Reproductive Health (GNPRH)-2002. http://www.tju.edu/obgyn/rih/global.cfm 11. Program for Appropriate Technology in Health (PATH). Status Report on the Unijecte Prefilled Injection Device. Seattle: PATH; 2000. 12. Health InterNetwork. http://www.healthinternetwork.net 291Bulletin of the World Health Organization 2003, 81 (4) Variations in practice of the management of the third stage of labour
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