PATH & WHO & UNFPA Workshop Prequalification Programme in Procurement Practices: Session 13 PQ within the context of global fund procurements

Publication date: 2008

Session 13: Prequalification Within the Context of Global Fund Procurements Global Fund • Established in 2002 • Attracts and disburses additional resources to prevent and treat AIDS, tuberculosis (TB), and malaria • Six funding rounds to date • $7.74 billion approved • 450 grants to 136 countries Funds used in Global Fund procurement must meet the following quality standards: • Product is acceptable under the WHO Prequalification Programme, or • Product is authorized for use by a stringent regulatory authority, or • Product is manufactured under a WHO or stringent regulatory authority’s current good manufacturing practices (cGMP), with conditions • Standard C is a Global Fund option, but is not endorsed or recommended by WHO http://www.theglobalfund.org/en/about/procurement/quality/ Global Fund Quality Assurance Requirements Standard A: Prequalified by WHO • Product is listed as prequalified under the WHO Prequalification Programme Standard B: Stringent Regulatory Authority Product is authorized for use by a stringent regulatory authority in ICH or PIC/S member country: ICH = International Conference on Harmonization of Technical Requirements for Registration of Pharmaceuticals for Human Use • PIC/S = Pharmaceutical Inspection Convention and Pharmaceutical Inspection Co-operation Scheme http://www.theglobalfund.org/pdf/guidelines/List_of_Countries_ICH_PICS.pdf PIC/S and ICH Countries Australia Liechtenstein Austria Lithuania Austria Malaysia Belgium Luxembourg Belgium Netherlands Cyprus Malta Canada Norway Czech Republic Netherlands Czech Republic Poland Denmark Poland Denmark Portugal Estonia Slovakia Finland Romania Finland Slovenia France Singapore France Spain Germany Slovak Republic Germany Sweden Greece Spain Greece United Kingdom Hungary Sweden Hungary United States Iceland Switzerland Ireland Ireland South Africa Italy Italy United Kingdom Japan Latvia Latvia PIC/S Countries ICH Countries Requirement for Standards A and B • If two or more suppliers, for which standard A or B applies, can supply the required product within 90 days of order, then the product must be procured from this set of manufacturers (from Standard A or B) • If not, may request to use standards C1 or C2 Standard C • If A and B are not possible, the Global Fund allows for the following options: -C1: Suppliers who have submitted for prequalification and who have WHO/SA cGMP; or -C2: Suppliers who have not submitted for prequalification and who have WHO/SA cGMP • Requires concurrence and testing, arranged independently by the Global Fund Secretariat • WHO does not recommend or endorse this option, but acknowledges that there may be situations where such options may be necessary Day 3: Session 13 Handout PIC/S and ICH Countries with Stringent Regulatory Authorities July 2007 PIC/S The Pharmaceutical Inspection Convention and Pharmaceutical Inspection Co- operation Scheme (jointly referred to as PIC/S) are two international instruments between countries and pharmaceutical inspection authorities, which provide together an active and constructive cooperation in the field of GMP. PIC/S' mission is “to lead the international development, implementation and maintenance of harmonized Good Manufacturing Practice (GMP) standards and quality systems of inspectorates in the field of medicinal products.” This is to be achieved by developing and promoting harmonized GMP standards and guidance documents; training competent authorities, in particular inspectors; assessing (and reassessing) inspectorates; and facilitating the cooperation and networking for competent authorities and international organizations. PIC/S participating regulatory authorities (www.picscheme.org): Australia Austria Belgium Canada Czech Republic Denmark Finland France Germany Greece Hungary Iceland Ireland Italy Latvia Liechtenstein Malaysia Netherlands Norway Poland Portugal Romania Singapore Slovak Republic Spain Sweden Switzerland South Africa (July 07) United Kingdom ICH The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) is a unique project that brings together the regulatory authorities of Europe, Japan, and the United States and experts from the pharmaceutical industry in the three regions to discuss scientific and technical aspects of product registration. The purpose is to make recommendations on ways to achieve greater harmonisation in the interpretation and application of technical guidelines and requirements for product registration in order to reduce or obviate the need to duplicate the testing carried out during the research and development of new medicines. The objective of such harmonisation is a more economical use of human, animal, and material resources, and the elimination of unnecessary delay in the global development and availability of new medicines whilst maintaining safeguards on quality, safety and efficacy, and regulatory obligations to protect public health. The WHO Prequalification Programme for Essential Reproductive Health Medicines: A Workshop on Using the Programme in Procurement Practices Day 3: Session 13 Optional The WHO Prequalification Programme for Essential Reproductive Health Medicines: A Workshop on Using the Programme in Procurement Practices 2 ICH participating regulatory authorities (www.ich.org): European Union* Japan United States * Members include: Austria, Belgium, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, Poland, Slovakia, Slovenia, Spain, Sweden, the Netherlands, United Kingdom Day 3: Session 13 Resources Prequalification Within the Context of Global Fund Procurements Resource Materials • Manufacturers and Suppliers whose HIV-Related Medicines Have Been Found Acceptable, in Principle, for Procurement by UN Agencies. WHO Prequalification Programme. http://healthtech.who.int/pq/lists/hiv_suppliers.pdf • Global Fund Quality Assurance Policy. Global Fund. http://www.theglobalfund.org/pdf/guidelines/QA_Board_Decision_2007.pdf • Frequently-Asked Questions (FAQs) about Quality-Control Testing of Pharmaceutical Products Used in the Prevention and Treatment of HIV/AIDS, Tuberculosis and Malaria to be Purchased with Global Fund Resources. Global Fund. http://www.theglobalfund.org/pdf/guidelines/QCTestingPharmaceuticalProducts. pdf • Untangling the Web of Price Reductions: A Pricing Guide for the Purchase of ARVs for Developing Countries. Médecins Sans Frontières. http://www.accessmed-msf.org/fileadmin/user_upload/diseases/hiv- aids/Untangling_the_Web/UTW10_RSep_horizontal.pdf • International Drug Price Indicator Guide. MSH. http://erc.msh.org/dmpguide/pdf/DrugPriceGuide_2007_En.pdf The WHO Prequalification Programme for Essential Reproductive Health Medicines: A Workshop on Using the Programme in Procurement Practices 13a - PPT - Global Fund Session 13:�Prequalification Within the Context of Global Fund Procurements Global Fund Standard A: �Prequalified by WHO Standard B:�Stringent Regulatory Authority PIC/S and ICH Countries Requirement for Standards A and B Standard C 13b - Handout - PICS-ICH Countries 13c - Resource documents << /ASCII85EncodePages false /AllowTransparency false /AutoPositionEPSFiles true /AutoRotatePages /None /Binding /Left /CalGrayProfile (Dot Gain 20%) /CalRGBProfile (sRGB IEC61966-2.1) /CalCMYKProfile (U.S. Web Coated \050SWOP\051 v2) /sRGBProfile (sRGB IEC61966-2.1) /CannotEmbedFontPolicy /Error /CompatibilityLevel 1.4 /CompressObjects /Tags /CompressPages true /ConvertImagesToIndexed true /PassThroughJPEGImages true /CreateJobTicket false /DefaultRenderingIntent /Default 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