PATH & WHO & UNFPA Workshop 4 - Preparation of Site Master File Summary for Condom Prequalification

Publication date: 2008

Preparation of a Site Master File (SMF) Summary for Condom Prequalification Session 4: Session Objectives • Provide overview of all necessary components of a Site Master File (SMF) Summary • Identify key reference documents • Practice strengthening an SMF Purpose of Site Master File Summary • Provide UNFPA with advance knowledge of your manufacturing infrastructure • Helps determine readiness for site inspection Key Reference Documents • Prequalification Scheme for Male Latex Condoms—Annex 2 • Your company’s existing documents Introduction • An SMF for each manufacturing site must be submitted to UNFPA as part of the prequalification process • The information included in the SMF should come from existing documents in your organization • The information must be submitted in English • The SMF should be short (less than 25 pages on A4 paper) Cover Page • The cover page should include: –“Site Master File for [Company Name]” –Date of preparation –“Strictly Confidential” Table of Contents Key headings: – General information – Personnel – Premises and equipment – Documentation/certifications – Production – Quality control – Distribution, complaints, and product recall – Self inspection (internal audits) – Attachments (if any) General Information 1. Brief information on company, with information relevant to understanding manufacturing operations 2. Manufacturing activities conducted under ISO 13485 or other relevant standards 3. Any other manufacturing activities carried out on the site 4. Name and exact address of the site, including telephone, fax, and 24-hour telephone numbers General Information (continued) 5. Type of products manufactured on the site, mentioning the way they are manufactured 6. Short description of the site (size, location, and immediate environment and other manufacturing activities on the site) 7. Number of employees engaged in production, quality control, storage, and distribution 8. Use of outside scientific, analytical, or other technical assistance in relation to manufacture and analysis 9. Short description of the quality management system of the specified manufacturing site Personnel 1. Provide a copy of a current organizational chart showing quality assurance arrangements, including production and quality control 2. Provide qualifications, experience, and responsibilities of key personnel 3. Provide an outline of arrangements for in-service training and how records are maintained 4. Describe health requirements for personnel engaged in production 5. Describe personnel hygiene requirements Premises and Equipment 1. Simple plan or description of manufacturing areas with indication of scale 2. Nature of construction and finishes 3. Brief description of ventilation systems including steps taken to prevent product contamination and excessive exposure of staff to ammonia and dust 4. Special areas for handling compounding ingredients 5. Capacities at each stage of manufacture Premises and Equipment (continued) 6. Brief description of water systems, including sanitation and effluent treatment 7. Description of planned preventive maintenance programmes for premises and of the recording system 8. Brief description of major equipment used in production and control laboratories, including major computer systems used for production and quality control 9. Description of planned preventive maintenance programmes for equipment and of the recording system Premises and Equipment (continued) 10. Qualification and calibration, including the recording system and arrangements for computerized systems validation 11. Availability of written specifications and procedures for cleaning manufacturing areas and equipment Documentation 1. Arrangements for the preparation, revision, and distribution of necessary documentation for manufacture 2. Any other documentation related to product quality that is not mentioned elsewhere (e.g., microbiological controls on air and water) Production 1. Brief description of production operations using, wherever possible, flow sheets and charts specifying important parameters 2. Arrangements for the handling of starting materials, work in progress (WIP), packaging materials, and finished products, including sampling, quarantine, release, and storage 3. Arrangements for the handling of rejected materials and products 4. Brief description of general policy for process validation Quality Control 1. Description of the quality control system and of the activities of the quality control department. 2. Describe procedures for the release of finished products Distribution, Complaints, and Product Recall 1. Describe the arrangements and recording system related to distribution of products 2. Describe the arrangements for the handling of product complaints and product recalls Self-Inspection (Internal Audits) 1. Provide a short description of the self- inspection or internal audit system Attachments 1. Ensure that a list of attachments is included as a first page of this section 2. Ensure that each attachment is numbered as per your list so that it may be readily identified Questions? Practice Strengthening a Site Master File Small Group Exercise • Each group reviews sections of a SMF • For each section, note problems and suggestions for improving the adequacy of the SMF Session 4 Handout 1 Site Master File Daisy Condom Factory The WHO Prequalification Programme for Condoms: A Workshop for Male Latex Condom Manufacturers 1 Session 4 Handout 1 Contents 1. General Information 2. Personnel 3. Premises and Equipment 4. Documentation 5. Production 6. Quality Control 7. Distribution, Complaints, and Product Recall 8. Self-Inspection (internal audits) The WHO Prequalification Programme for Condoms: A Workshop for Male Latex Condom Manufacturers 2 Session 4 Handout 1 1. General Information Company name Daisy Condom Company Pvt. Contact person P. Kuppukrishna, Plant Manager Address Selamat Kampung Sarawak Malaysia Company established 2006 Technology origin Equipment purchased in China. Other products manufactured The company also makes finger cots. Designs of condom manufactured The condom company makes three sizes of condoms: 42 mm, 50 mm, and 75 mm. Smooth and dotted textures are available. Principal markets • OEM manufacturer for retail brands in India and Malaysia (25%) • Tender supplier to IPPF (40%) • Daisy brand (35%) Contract suppliers The company does not purchase condoms from other suppliers. Normal working hours/shifts of each department • Compounding: 6 days x 2 shifts (16 hrs) • Dipping: 7 days x 3 shifts (24 hrs) • Electronic Testing (ET): 6 days x 3 shifts (24 hrs) • Laboratory/QA: 7 days x 2 shifts (16 hrs) Employment by department • Compounding: • Dipping:16 • ET: 64 • Foiling: 72 The WHO Prequalification Programme for Condoms: A Workshop for Male Latex Condom Manufacturers 3 Session 4 Handout 1 • Packing: 48 • Warehouse : 4 • Administrative: 10 Use of external organizations to provide calibration services, etc. • GSG Labs for equipment calibration • Biolab Sdn Bhd for bioburden tests Independent quality system or product approvals Yes - ISO 2. Personnel Organization chart See attachment A. Managers’ qualifications, experience, responsibilities, and length of service Mr. P. Kuppukrishna, Plant Manager • B. E. (IIT, Chennai), MBA (Loyola University, Hyderabad). Ten years of experience in condom manufacturing as production manager, then as plant manager. Previously assistant production manager for Karma Tyres. Mr. J. Srivaswamy, Production Manager • Higher diploma in chemistry (University of Ipoh). Five years with Daisy; previously quality manager for Smart Semiconductors. Training program used at the company The training program is fully described in Chapter 7 of the company’s quality manual. All employees are given induction training when they take up their appointment. It covers the company’s structure, quality policy, and objectives. Specific training is given to each staff member on his or her duties. An annual training program is used to cover both internal and external training. Copy of a typical training record for an employee See Annex B. Health and personnel hygiene requirements 1. All employees must have a medical examination prior to appointment. 2. All employees working in production must wear hair nets and gloves. 3. All employees working in production must wash their feet before entering the production area. The WHO Prequalification Programme for Condoms: A Workshop for Male Latex Condom Manufacturers 4 Session 4 Handout 1 The WHO Prequalification Programme for Condoms: A Workshop for Male Latex Condom Manufacturers 5 3. Premises and Equipment Plan of factory See Annex C. • The compounding area has extraction fans. • The dipping area has a 1-micron filter, and air is blown into the area through the filter. • The ET and foiling areas have ducted air conditioning, with 5-micron inlet filters. • The final packing areas have window air conditioners. Chemical storage All chemicals are stored in the raw materials store. Water treatment Compounding uses purified water. Preventative maintenance The company has monthly and annual maintenance programs covering all production equipment. Production equipment • 6 Richter double-sided dipping lines • 12 washing machines • 12 dryers • 30 ET machines • 15 foiling machines Calibration The factory has a schedule of calibration for all measuring equipment. Calibration is performed by external calibration companies on the basis of competitive quotes. Qualification of equipment Equipment is checked and tested before being used for production. Checks depend on the equipment itself, but involve a check of the specification, a check that the specification is adequate for the task, and a check that it performs as specified. Session 4 Handout 2 Daisy Condom Factory Case Study Exercise for Strengthening a Site Master File Summary Problems with Site Master File Summary 1. 2. 3. 4. Suggestions for Addressing Each Problem Above 1. 2. 3. 4. The WHO Prequalification Programme for Condoms: A Workshop for Male Latex Condom Manufacturers 4a - PPT - Site Master File Preparation of a �Site Master File �(SMF) Summary for Condom Prequalification Session Objectives Purpose of Site Master File Summary Key Reference Documents Introduction Cover Page Table of Contents General Information General Information �(continued) Personnel Premises and Equipment Premises and Equipment �(continued) Premises and Equipment �(continued) Documentation Production Quality Control Distribution, Complaints, �and Product Recall Self-Inspection �(Internal Audits) Attachments Slide Number 20 Practice Strengthening a �Site Master File 4b - H1 - SMF Case Study Site Master File Contents 1. General Information 2. Personnel 3. Premises and Equipment 4. Documentation 5. Production 6. Quality Control 7. Distribution, Complaints, and Product Recall 8. Self-Inspection (internal audits) 1. General Information Company name Daisy Condom Company Pvt. Other products manufactured Designs of condom manufactured Normal working hours/shifts of each department Employment by department Use of external organizations to provide calibration services, etc. Independent quality system or product approvals 2. Personnel Organization chart Managers’ qualifications, experience, responsibilities, and length of service Training program used at the company Copy of a typical training record for an employee Health and personnel hygiene requirements 3. Premises and Equipment Plan of factory Chemical storage Water treatment Preventative maintenance Production equipment Calibration Qualification of equipment 4c - H2 - Participant Exercise 4d - Trainers Aid - Exercise << /ASCII85EncodePages false /AllowTransparency false /AutoPositionEPSFiles true /AutoRotatePages /None /Binding /Left /CalGrayProfile (Dot Gain 20%) /CalRGBProfile (sRGB IEC61966-2.1) /CalCMYKProfile (U.S. Web Coated \050SWOP\051 v2) /sRGBProfile (sRGB IEC61966-2.1) /CannotEmbedFontPolicy /Error /CompatibilityLevel 1.4 /CompressObjects /Tags /CompressPages true /ConvertImagesToIndexed true /PassThroughJPEGImages true /CreateJobTicket false /DefaultRenderingIntent /Default /DetectBlends true /DetectCurves 0.0000 /ColorConversionStrategy /CMYK /DoThumbnails false /EmbedAllFonts true /EmbedOpenType false /ParseICCProfilesInComments true /EmbedJobOptions true /DSCReportingLevel 0 /EmitDSCWarnings false /EndPage -1 /ImageMemory 1048576 /LockDistillerParams false /MaxSubsetPct 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